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Q7M3Y3

- TNNI_CHLNI

UniProt

Q7M3Y3 - TNNI_CHLNI

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Protein
Troponin I
Gene
N/A
Organism
Chlamys nipponensis akazara (Akazara scallop) (Japanese scallop)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi240 – 25112 By similarity
Add
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Actin-binding, Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin I
Short name:
TnI
OrganismiChlamys nipponensis akazara (Akazara scallop) (Japanese scallop)
Taxonomic identifieri6571 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaBivalviaPteriomorphiaPectinoidaPectinoideaPectinidaeChlamys

Subcellular locationi

GO - Cellular componenti

  1. troponin complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Troponin I
PRO_0000186160Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylserine Inferred

Keywords - PTMi

Acetylation

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi146 – 16419

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3TZ1X-ray1.80B143-166[»]
ProteinModelPortaliQ7M3Y3.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni237 – 25014Actin-binding By similarity
Add
BLAST

Sequence similaritiesi

Belongs to the troponin I family.

Family and domain databases

InterProiIPR001978. Troponin.
[Graphical view]
PfamiPF00992. Troponin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7M3Y3-1 [UniParc]FASTAAdd to Basket

« Hide

SSLEERRAAR AARRRKQDEN EGGEEQEETT SRRSRRRQQE DEEDSYSAPA    50
EPAYDAEAEN RRRQQQEEEE AAARAAEEEY NRQQEELRRQ RQEEERQRRE 100
EEQRRQQEEE ERLRLEREEQ EREEEARRMA EEQKKKKKKG LGGLSPEKKK 150
MLKKLIMQKA AEDLANEAKA KAEAKEKYIN DLVPKFSTDG KDVAALQALC 200
KDFHKRLASL EEDVYDWEAK IRKQDFEINE LTLKVNDTKG KFVKPVLRKV 250
NKTESKLDKI QRKEAKKSDF RDNLKSSREH EADKEGGEGE NE 292
Length:292
Mass (Da):34,636
Last modified:May 10, 2004 - v2
Checksum:i9C869796019A5620
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti279 – 2791E → I AA sequence 1 Publication
Sequence conflicti291 – 2911N → G in BAA23775. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB009368 mRNA. Translation: BAA23775.1.
PIRiJE0233.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB009368 mRNA. Translation: BAA23775.1 .
PIRi JE0233.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3TZ1 X-ray 1.80 B 143-166 [» ]
ProteinModelPortali Q7M3Y3.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR001978. Troponin.
[Graphical view ]
Pfami PF00992. Troponin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Amino acid sequence of troponin-I from Akazara scallop striated adductor muscle."
    Tanaka H., Ojima T., Nishita K.
    J. Biochem. 124:304-310(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, ACETYLATION AT SER-1.
  2. "cDNA for Akazara scallop troponin I."
    Nishita K., Ojima T., Soejima T.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-292.
  3. "Amino acid sequence of C-terminal 17 kDa CNBr-fragment of Akazara scallop troponin-I."
    Ojima T., Tanaka H., Nishita K.
    J. Biochem. 117:158-162(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 158-292.

Entry informationi

Entry nameiTNNI_CHLNI
AccessioniPrimary (citable) accession number: Q7M3Y3
Secondary accession number(s): O44077, Q9TXE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: July 9, 2014
This is version 36 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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