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Q7M3Y3 (TNNI_CHLNI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Troponin I

Short name=TnI
OrganismChlamys nipponensis akazara (Akazara scallop) (Japanese scallop)
Taxonomic identifier6571 [NCBI]
Taxonomic lineageEukaryotaMetazoaLophotrochozoaMolluscaBivalviaPteriomorphiaPectinoidaPectinoideaPectinidaeChlamys

Protein attributes

Sequence length292 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Sequence similarities

Belongs to the troponin I family.

Ontologies

Keywords
   LigandActin-binding
Calcium
Metal-binding
   Molecular functionMuscle protein
   PTMAcetylation
   Technical term3D-structure
Direct protein sequencing
Gene Ontology (GO)
   Cellular_componenttroponin complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 292292Troponin I
PRO_0000186160

Regions

Calcium binding240 – 25112 By similarity
Region237 – 25014Actin-binding By similarity

Amino acid modifications

Modified residue11N-acetylserine Probable

Experimental info

Sequence conflict2791E → I AA sequence Ref.1
Sequence conflict2911N → G in BAA23775. Ref.2

Secondary structure

... 292
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q7M3Y3 [UniParc].

Last modified May 10, 2004. Version 2.
Checksum: 9C869796019A5620

FASTA29234,636
        10         20         30         40         50         60 
SSLEERRAAR AARRRKQDEN EGGEEQEETT SRRSRRRQQE DEEDSYSAPA EPAYDAEAEN 

        70         80         90        100        110        120 
RRRQQQEEEE AAARAAEEEY NRQQEELRRQ RQEEERQRRE EEQRRQQEEE ERLRLEREEQ 

       130        140        150        160        170        180 
EREEEARRMA EEQKKKKKKG LGGLSPEKKK MLKKLIMQKA AEDLANEAKA KAEAKEKYIN 

       190        200        210        220        230        240 
DLVPKFSTDG KDVAALQALC KDFHKRLASL EEDVYDWEAK IRKQDFEINE LTLKVNDTKG 

       250        260        270        280        290 
KFVKPVLRKV NKTESKLDKI QRKEAKKSDF RDNLKSSREH EADKEGGEGE NE 

« Hide

References

[1]"Amino acid sequence of troponin-I from Akazara scallop striated adductor muscle."
Tanaka H., Ojima T., Nishita K.
J. Biochem. 124:304-310(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, ACETYLATION AT SER-1.
[2]"cDNA for Akazara scallop troponin I."
Nishita K., Ojima T., Soejima T.
Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-292.
[3]"Amino acid sequence of C-terminal 17 kDa CNBr-fragment of Akazara scallop troponin-I."
Ojima T., Tanaka H., Nishita K.
J. Biochem. 117:158-162(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 158-292.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB009368 mRNA. Translation: BAA23775.1.
PIRJE0233.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3TZ1X-ray1.80B143-166[»]
ProteinModelPortalQ7M3Y3.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR001978. Troponin.
[Graphical view]
PfamPF00992. Troponin. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTNNI_CHLNI
AccessionPrimary (citable) accession number: Q7M3Y3
Secondary accession number(s): O44077, Q9TXE2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: April 16, 2014
This is version 35 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references