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Q7M3Y3

- TNNI_CHLNI

UniProt

Q7M3Y3 - TNNI_CHLNI

Protein

Troponin I

Gene
N/A
Organism
Chlamys nipponensis akazara (Akazara scallop) (Japanese scallop)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 2 (10 May 2004)
      Previous versions | rss
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    Functioni

    Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi240 – 25112By similarityAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Muscle protein

    Keywords - Ligandi

    Actin-binding, Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Troponin I
    Short name:
    TnI
    OrganismiChlamys nipponensis akazara (Akazara scallop) (Japanese scallop)
    Taxonomic identifieri6571 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaBivalviaPteriomorphiaPectinoidaPectinoideaPectinidaeChlamys

    Subcellular locationi

    GO - Cellular componenti

    1. troponin complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 292292Troponin IPRO_0000186160Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylserine1 Publication

    Keywords - PTMi

    Acetylation

    Structurei

    Secondary structure

    1
    292
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi146 – 16419

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3TZ1X-ray1.80B143-166[»]
    ProteinModelPortaliQ7M3Y3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni237 – 25014Actin-bindingBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the troponin I family.Curated

    Family and domain databases

    InterProiIPR001978. Troponin.
    [Graphical view]
    PfamiPF00992. Troponin. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7M3Y3-1 [UniParc]FASTAAdd to Basket

    « Hide

    SSLEERRAAR AARRRKQDEN EGGEEQEETT SRRSRRRQQE DEEDSYSAPA    50
    EPAYDAEAEN RRRQQQEEEE AAARAAEEEY NRQQEELRRQ RQEEERQRRE 100
    EEQRRQQEEE ERLRLEREEQ EREEEARRMA EEQKKKKKKG LGGLSPEKKK 150
    MLKKLIMQKA AEDLANEAKA KAEAKEKYIN DLVPKFSTDG KDVAALQALC 200
    KDFHKRLASL EEDVYDWEAK IRKQDFEINE LTLKVNDTKG KFVKPVLRKV 250
    NKTESKLDKI QRKEAKKSDF RDNLKSSREH EADKEGGEGE NE 292
    Length:292
    Mass (Da):34,636
    Last modified:May 10, 2004 - v2
    Checksum:i9C869796019A5620
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti279 – 2791E → I AA sequence (PubMed:9685719)Curated
    Sequence conflicti291 – 2911N → G in BAA23775. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB009368 mRNA. Translation: BAA23775.1.
    PIRiJE0233.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB009368 mRNA. Translation: BAA23775.1 .
    PIRi JE0233.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3TZ1 X-ray 1.80 B 143-166 [» ]
    ProteinModelPortali Q7M3Y3.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR001978. Troponin.
    [Graphical view ]
    Pfami PF00992. Troponin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Amino acid sequence of troponin-I from Akazara scallop striated adductor muscle."
      Tanaka H., Ojima T., Nishita K.
      J. Biochem. 124:304-310(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, ACETYLATION AT SER-1.
    2. "cDNA for Akazara scallop troponin I."
      Nishita K., Ojima T., Soejima T.
      Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-292.
    3. "Amino acid sequence of C-terminal 17 kDa CNBr-fragment of Akazara scallop troponin-I."
      Ojima T., Tanaka H., Nishita K.
      J. Biochem. 117:158-162(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 158-292.

    Entry informationi

    Entry nameiTNNI_CHLNI
    AccessioniPrimary (citable) accession number: Q7M3Y3
    Secondary accession number(s): O44077, Q9TXE2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: May 10, 2004
    Last modified: October 1, 2014
    This is version 37 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3