Q7M3Y3 (TNNI_CHLNI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Troponin I Short name=TnI
Organism	Chlamys nipponensis akazara (Akazara scallop) (Japanese scallop)
Taxonomic identifier	6571 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Lophotrochozoa › Mollusca › Bivalvia › Pteriomorphia › Pectinoida › Pectinoidea › Pectinidae › Chlamys › Chlamys nipponensis

Protein attributes

Sequence length	292 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Sequence similarities	Belongs to the troponin I family.

Ontologies

Keywords
Ligand	Actin-binding Calcium Metal-binding
Molecular function	Muscle protein
PTM	Acetylation
Technical term	3D-structure Direct protein sequencing
Gene Ontology (GO)
Cellular_component	troponin complex Inferred from electronic annotation. Source: InterPro
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 292

292

Troponin I

PRO_0000186160

Regions

Calcium binding

240 – 251

12

By similarity

Region

237 – 250

14

Actin-binding By similarity

Amino acid modifications

Modified residue

1

1

N-acetylserine Probable

Experimental info

Sequence conflict

279

1

E → I AA sequence Ref.1

Sequence conflict

291

1

N → G in BAA23775. Ref.2

Secondary structure

1

.

.

.

292

Helix Strand Turn

Details...

Helix

146 – 164

19

Sequences

	Sequence		Length	Mass (Da)
	Q7M3Y3 [UniParc]. Last modified May 10, 2004. Version 2. Checksum: 9C869796019A5620	FASTA	292	34,636
	10 20 30 40 50 60 SSLEERRAAR AARRRKQDEN EGGEEQEETT SRRSRRRQQE DEEDSYSAPA EPAYDAEAEN 70 80 90 100 110 120 RRRQQQEEEE AAARAAEEEY NRQQEELRRQ RQEEERQRRE EEQRRQQEEE ERLRLEREEQ 130 140 150 160 170 180 EREEEARRMA EEQKKKKKKG LGGLSPEKKK MLKKLIMQKA AEDLANEAKA KAEAKEKYIN 190 200 210 220 230 240 DLVPKFSTDG KDVAALQALC KDFHKRLASL EEDVYDWEAK IRKQDFEINE LTLKVNDTKG 250 260 270 280 290 KFVKPVLRKV NKTESKLDKI QRKEAKKSDF RDNLKSSREH EADKEGGEGE NE

References

[1]	"Amino acid sequence of troponin-I from Akazara scallop striated adductor muscle." Tanaka H., Ojima T., Nishita K. J. Biochem. 124:304-310(1998) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE, PROBABLE ACETYLATION AT SER-1.
[2]	"cDNA for Akazara scallop troponin I." Nishita K., Ojima T., Soejima T. Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-292.
[3]	"Amino acid sequence of C-terminal 17 kDa CNBr-fragment of Akazara scallop troponin-I." Ojima T., Tanaka H., Nishita K. J. Biochem. 117:158-162(1995) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 158-292.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB009368 mRNA. Translation: BAA23775.1.

PIR

JE0233.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3TZ1	X-ray	1.80	B	143-166	[»]

ProteinModelPortal

Q7M3Y3.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

InterPro

IPR001978. Troponin.
[Graphical view]

Pfam

PF00992. Troponin. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

TNNI_CHLNI

Accession

Primary (citable) accession number: Q7M3Y3
Secondary accession number(s): O44077, Q9TXE2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
Last sequence update:	May 10, 2004
Last modified:	May 1, 2013
This is version 34 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)