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Q7M3V4 (PAO1_VESOR) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Orientotoxin-1

EC=3.1.1.5
Alternative name(s):
Lysophospholipase
Orientotoxin I
OrganismVespa orientalis (Oriental hornet)
Taxonomic identifier7447 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaeVespinaeVespa

Protein attributes

Sequence length152 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Neurotoxin of presynaptic effect which degrades lysophospholipids.

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Ontologies

Keywords
   Biological processLipid degradation
Lipid metabolism
   Cellular componentSecreted
   Molecular functionHydrolase
Neurotoxin
Presynaptic neurotoxin
Toxin
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processlipid catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentother organism presynaptic membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionlysophospholipase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 152152Orientotoxin-1
PRO_0000058226

Sequences

Sequence LengthMass (Da)Tools
Q7M3V4 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 34ED8FA20D978032

FASTA15216,929
        10         20         30         40         50         60 
FNPCPYSDDT VKMIILTEQN KKQDFYTLDT IGEHNQFNKL TAKSQVVFIV WQTGIGDAIT 

        70         80         90        100        110        120 
ARAGYIFLLD SGLAMLVDKY QMAPVASDIK LCNAGCYCKP TYVISVKKAI QFAWEHKCVG 

       130        140        150 
IRCSDPGVPT DGLSGRPHYG ETLHKVRSYN GK 

« Hide

References

[1]"Amino acid sequence of orientotoxin I and orientotoxin II from the hornet Vespa orientalis venom."
Korneev A.S., Salikhov S.I., Tuychibaev M.U.
Bioorg. Khim. 15:127-129(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Venom.

Cross-references

Sequence databases

PIRJN0426.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

ProtoNetSearch...

Entry information

Entry namePAO1_VESOR
AccessionPrimary (citable) accession number: Q7M3V4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: December 15, 2003
Last modified: October 16, 2013
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program