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Protein

Orientotoxin-1

Gene
N/A
Organism
Vespa orientalis (Oriental hornet)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Neurotoxin of presynaptic effect which degrades lysophospholipids.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Neurotoxin, Presynaptic neurotoxin, Toxin

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Orientotoxin-1 (EC:3.1.1.5)
Alternative name(s):
Lysophospholipase
Orientotoxin I
OrganismiVespa orientalis (Oriental hornet)
Taxonomic identifieri7447 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaeVespinaeVespa

Subcellular locationi

GO - Cellular componenti

  1. other organism presynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 152152Orientotoxin-1PRO_0000058226Add
BLAST

Expressioni

Tissue specificityi

Expressed by the venom gland.

Sequencei

Sequence statusi: Complete.

Q7M3V4-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
FNPCPYSDDT VKMIILTEQN KKQDFYTLDT IGEHNQFNKL TAKSQVVFIV
60 70 80 90 100
WQTGIGDAIT ARAGYIFLLD SGLAMLVDKY QMAPVASDIK LCNAGCYCKP
110 120 130 140 150
TYVISVKKAI QFAWEHKCVG IRCSDPGVPT DGLSGRPHYG ETLHKVRSYN

GK
Length:152
Mass (Da):16,929
Last modified:December 15, 2003 - v1
Checksum:i34ED8FA20D978032
GO

Sequence databases

PIRiJN0426.

Cross-referencesi

Sequence databases

PIRiJN0426.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "Amino acid sequence of orientotoxin I and orientotoxin II from the hornet Vespa orientalis venom."
    Korneev A.S., Salikhov S.I., Tuychibaev M.U.
    Bioorg. Khim. 15:127-129(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Venom.

Entry informationi

Entry nameiPAO1_VESOR
AccessioniPrimary (citable) accession number: Q7M3V4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: December 15, 2003
Last modified: October 16, 2013
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.