Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Chymotrypsin-C

Gene

CTRC

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has chymotrypsin-type protease activity and hypocalcemic activity.By similarity

Catalytic activityi

Preferential cleavage: Leu-|-Xaa, Tyr-|-Xaa, Phe-|-Xaa, Met-|-Xaa, Trp-|-Xaa, Gln-|-Xaa, Asn-|-Xaa.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei74Charge relay systemBy similarity1
Active sitei121Charge relay systemBy similarity1
Active sitei216Charge relay systemBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

ReactomeiR-BTA-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism

Protein family/group databases

MEROPSiS01.157

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsin-C (EC:3.4.21.2)
Alternative name(s):
bPTLP
Gene namesi
Name:CTRC
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 16

Organism-specific databases

VGNCiVGNC:27811 CTRC

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Add BLAST16
PropeptideiPRO_000028861417 – 29Activation peptide1 PublicationAdd BLAST13
ChainiPRO_000028861530 – 268Chymotrypsin-CAdd BLAST239

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi17 ↔ 141PROSITE-ProRule annotation
Glycosylationi25N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi59 ↔ 75PROSITE-ProRule annotation
Disulfide bondi155 ↔ 222PROSITE-ProRule annotation
Disulfide bondi186 ↔ 202PROSITE-ProRule annotation
Disulfide bondi212 ↔ 243PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ7M3E1
PRIDEiQ7M3E1

Expressioni

Tissue specificityi

Pancreas.2 Publications

Gene expression databases

BgeeiENSBTAG00000024497

Interactioni

Subunit structurei

Monomer. The zymogen is secreted as a ternary complex composed of procarboxypeptidase A, chymotrypsinogen C and proproteinase E.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000033942

Structurei

Secondary structure

1268
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi26 – 29Combined sources4
Beta strandi44 – 51Combined sources8
Beta strandi54 – 65Combined sources12
Beta strandi68 – 71Combined sources4
Helixi73 – 75Combined sources3
Beta strandi82 – 87Combined sources6
Beta strandi100 – 109Combined sources10
Turni115 – 118Combined sources4
Beta strandi123 – 129Combined sources7
Beta strandi154 – 157Combined sources4
Beta strandi177 – 179Combined sources3
Helixi183 – 186Combined sources4
Turni189 – 195Combined sources7
Beta strandi200 – 203Combined sources4
Beta strandi219 – 225Combined sources7
Beta strandi227 – 237Combined sources11
Beta strandi250 – 254Combined sources5
Helixi255 – 258Combined sources4
Helixi259 – 265Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PYTX-ray2.35D17-268[»]
ProteinModelPortaliQ7M3E1
SMRiQ7M3E1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7M3E1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 268Peptidase S1PROSITE-ProRule annotationAdd BLAST239

Sequence similaritiesi

Belongs to the peptidase S1 family. Elastase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000119027
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiQ7M3E1
KOiK01311
OMAiDTWRHTC
OrthoDBiEOG091G0DF7
TreeFamiTF330455

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7M3E1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGITVFTTF LAYASSCGAP IFQPNLSARV VGGEDAIPHS WPWQISLQYL
60 70 80 90 100
RDNTWRHTCG GTLITPNHVL TAAHCISNTL TYRVALGKNN LEVEDEAGSL
110 120 130 140 150
YVGVDTIFVH EKWNSFLVRN DIALIKLAET VELSDTIQVA CLPEEGSLLP
160 170 180 190 200
QDYPCFVTGW GRLYTNGPIA AELQQGLQPV VDYATCSQRD WWGTTVKETM
210 220 230 240 250
VCAGGDGVIS ACNGDSGGPL NCQAENGNWD VRGIVSFGSG LSCNTFKKPT
260
VFTRVSAYID WINQKLQL
Length:268
Mass (Da):29,255
Last modified:May 29, 2007 - v2
Checksum:i7B006994F91A04D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC134798 mRNA Translation: AAI34799.1
BC142035 mRNA Translation: AAI42036.1
CK771392 mRNA No translation available.
PIRiPU0036
RefSeqiNP_001092435.1, NM_001098965.1
UniGeneiBt.45270

Genome annotation databases

EnsembliENSBTAT00000034040; ENSBTAP00000033942; ENSBTAG00000024497
GeneIDi514047
KEGGibta:514047

Similar proteinsi

Entry informationi

Entry nameiCTRC_BOVIN
AccessioniPrimary (citable) accession number: Q7M3E1
Secondary accession number(s): A5PJB3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: March 28, 2018
This is version 82 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health