Q7M366 (Q7M366_SHEEP) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Steroid 21-monooxygenase cytochrome P450 21A1 PIR A43349 EC=1.14.99.10 PIR A43349
Organism	Ovis aries (Sheep) PIR A43349
Taxonomic identifier	9940 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Ovis

Protein attributes

Sequence length	497 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the cytochrome P450 family. RuleBase RU000461

Ontologies

Keywords
Ligand	Heme RuleBase RU000461 Iron Metal-binding
Molecular function	Monooxygenase RuleBase RU000461 Oxidoreductase
Gene Ontology (GO)
Molecular_function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro steroid 21-monooxygenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q7M366 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: DC70D4EA38BF9687	FASTA	497	56,177
	10 20 30 40 50 60 MVLAGLLLLL LTLLAGAHLL WGRWKLRNLH LPPLVPGFLH LLQPNLPIHL LSLTQKLGPV 70 80 90 100 110 120 YRLRLGLQEV VVLNSKRTIE EAMIRKWVDF AGRPQIPSYK LVSQRCQDIS LGDYSLLWKA 130 140 150 160 170 180 HKKLTRSALL LGTRSSMEPW VEQLTQEFCE RMRVQAGAPV TIQKEFSLLT CSIICYLTFG 190 200 210 220 230 240 DKEDTLVHAF HDCVQDLMKT WDHWSIQILD MVPFLRLFPN PGLWRLKKAI ENRDHMVEKQ 250 260 270 280 290 300 LRRHKESMVA GQWRDMMDYM LQGVGRQRVE EGPGQLLEGH VHMSVVDLFI GGTETKASTL 310 320 330 340 350 360 SWAVAFLLHH PEIQRRLQEE LDRELGPGAS CSGVTYKDRA RLPLLNATIA EVLRLRPVVP 370 380 390 400 410 420 LALPHRTTRP SSIFGYDIPE GMVVIPNLQG AHLDETVWEQ PHEFRPDRFL EPGANTSALA 430 440 450 460 470 480 FGCGARVCLG ESLARLELFV VLLRLLQAFT LLPPPGGALP SLQPDPYCGV NLKVQPFQVR 490 LQPRGVEAGA WESTSAQ

References

[1]	"The structure and activity of two cytochrome P450c21 proteins encoded in the ovine adrenal cortex." Crawford R.J., Hammond V.E., Connell J.M., Coghlan J.P. J. Biol. Chem. 267:16212-16218(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
PIR	A43349.
3D structure databases
HSSP	HSSP built from PDB template 1DT6 based on UniProtKB P00179.
ProteinModelPortal	Q7M366.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG106944.
Family and domain databases
Gene3D	1.10.630.10. 1 hit.
InterPro	IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. [Graphical view]
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR00385. P450.
SUPFAM	SSF48264. Cytochrome_P450. 1 hit.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q7M366_SHEEP

Accession

Primary (citable) accession number: Q7M366

Entry history

Integrated into UniProtKB/TrEMBL:	December 15, 2003
Last sequence update:	December 15, 2003
Last modified:	April 3, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)