Reviewed, UniProtKB/Swiss-Prot Q7M334 (PA21B_RABIT)

Names and origin

Protein names

Recommended name:
    Phospholipase A2
    EC=3.1.1.4
Alternative name(s):
    Phosphatidylcholine 2-acylhydrolase 1B
    Group IB phospholipase A2

Gene names

Name:

PLA2G1B

Organism

Oryctolagus cuniculus (Rabbit)

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	144 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides By similarity.
Catalytic activity	Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.
Cofactor	Binds 1 calcium ion per subunit By similarity.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the phospholipase A2 family.

Ontologies

Keywords
Biological process	Lipid degradation
Cellular component	Secreted
Domain	Signal
Ligand	Calcium Metal-binding
Molecular function	Hydrolase
PTM	Disulfide bond
Gene Ontology (GO)
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 15	15	By similarity
	Propeptide	16 – 22	7	Activation peptide		PRO_0000022745
	Chain	23 – 144	122	Phospholipase A2		PRO_0000022746
Sites
	Active site	70	1	By similarity
	Active site	121	1	By similarity
	Metal binding	50	1	Calcium; via carbonyl oxygen By similarity
	Metal binding	52	1	Calcium; via carbonyl oxygen By similarity
	Metal binding	54	1	Calcium; via carbonyl oxygen By similarity
	Metal binding	71	1	Calcium By similarity
Amino acid modifications
	Disulfide bond	33 ↔ 99		By similarity
	Disulfide bond	49 ↔ 144		By similarity
	Disulfide bond	51 ↔ 67		By similarity
	Disulfide bond	66 ↔ 127		By similarity
	Disulfide bond	73 ↔ 120		By similarity
	Disulfide bond	83 ↔ 113		By similarity
	Disulfide bond	106 ↔ 118		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7M334-1 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: DF404C1F28AE932A	FASTA	144	15,733
	10 20 30 40 50 60 MKFLVLAALL TAGTAASGVS PTALWQFRGM IQCTIPGSSP YLEFNGYGCY CGLGGSGTPV 70 80 90 100 110 120 DELDRCCQTH DQCYTQAKKL SSCSFLVDNP YTNSYSYSCS GTTVTCSSKN KECEAFICDC 130 140 DRKAAICFSK RPYNKEYKPI SKYC

References

[1]	"Cloning and expression of rabbit pancreatic phospholipase A2." Kumar V.B. Biochem. Biophys. Res. Commun. 192:683-692(1993) [PubMed: 7916604] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Pancreas.

Cross-references

Sequence databases
PIR	JN0480.
3D structure databases
SMR	Q7M334. Positions 18-144.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7M334.
Genome annotation databases
Ensembl	ENSOCUT00000001103; ENSOCUP00000000957; ENSOCUG00000001105; Oryctolagus cuniculus. [Genome view]
Phylogenomic databases
eggNOG	maNOG19875.
HOVERGEN	Q7M334.
Enzyme and pathway databases
BRENDA	3.1.1.4. 255.
Family and domain databases
InterPro	IPR016090. Phospholipase_A2. IPR013090. Phospholipase_A2_AS. IPR001211. Phospholipase_A2_euk. [Graphical view]
Gene3D	G3DSA:1.20.90.10. Phospholipase_A2. 1 hit.
PANTHER	PTHR11716. Phospholipase_A2. 1 hit.
Pfam	PF00068. Phospholip_A2_1. 1 hit. [Graphical view]
PRINTS	PR00389. PHPHLIPASEA2.
SMART	SM00085. PA2c. 1 hit. [Graphical view]
PROSITE	PS00119. PA2_ASP. 1 hit. PS00118. PA2_HIS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PA21B_RABIT

Accession

Primary (citable) accession number: Q7M334

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
Last sequence update:	December 15, 2003
Last modified:	February 9, 2010
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)