Q7M323 (PLMN_CAPHI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Plasminogen
EC=3.4.21.7

Gene names

Name:

PLG

Organism

Capra hircus (Goat)

Taxonomic identifier

9925 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Capra

Protein attributes

Sequence length	123 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells By similarity.
Catalytic activity	Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa; higher selectivity than trypsin. Converts fibrin into soluble products.
Enzyme regulation	Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin. Cannot be activated with streptokinase By similarity.
Subunit structure	Interacts with CSPG4 and AMOT. Interacts (via the Kringle domains) with HRG; the interaction tethers PLG to the cell surface and enhances its activation By similarity.
Subcellular location	Secreted By similarity. Note: Locates to the cell surface where it is proteolytically cleaved to produce the active plasmin. Interaction with HRG tethers it to the cell surface By similarity.
Domain	Kringle domains mediate interaction with CSPG4 By similarity.
Miscellaneous	Plasmin is inactivated by alpha-2-antiplasmin immediately after dissociation from the clot By similarity.
Sequence similarities	Belongs to the peptidase S1 family. Plasminogen subfamily. Contains at least 1 kringle domain.

Ontologies

Keywords
Biological process	Blood coagulation Fibrinolysis Tissue remodeling
Cellular component	Secreted
Domain	Kringle
Molecular function	Hydrolase Protease Serine protease
PTM	Disulfide bond Zymogen
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	blood coagulation Inferred from electronic annotation. Source: UniProtKB-KW fibrinolysis Inferred from electronic annotation. Source: UniProtKB-KW proteolysis Inferred from electronic annotation. Source: UniProtKB-KW tissue remodeling Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	serine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›123	›123	Plasminogen		PRO_0000088703
Regions
	Domain	40 – 118	79	Kringle
Amino acid modifications
	Disulfide bond	41 ↔ 118		By similarity
	Disulfide bond	62 ↔ 101		By similarity
	Disulfide bond	90 ↔ 113		By similarity
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	123	1

Sequences

	Sequence		Length	Mass (Da)
	Q7M323 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: E53432C4DA0AC07C	FASTA	123	13,908
	10 20 30 40 50 60 DLLDDYVNTQ GASLLTLSRK KLAGRSVEDC AAKCEEEAQD CYHGNGQSYR GTSSTTVTGR 70 80 90 100 110 120 KCQSWSSMIP HRHQKTPESY PNAGLTMNYC RNPDADKSPW CYTTDPRVRW EFCNLKKCSE DSE

References

[1]	"Structural aspects of the plasminogen of various species." Schaller J., Rickli E.E. Enzyme 40:63-69(1988) [PubMed: 3168975] [Abstract] Cited for: PROTEIN SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
PIR	C61545.
3D structure databases
ProteinModelPortal	Q7M323.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG105989.
Family and domain databases
InterPro	IPR000001. Kringle. IPR013806. Kringle-like. IPR018056. Kringle_CS. [Graphical view]
Gene3D	G3DSA:2.40.20.10. Kringle. 1 hit.
Pfam	PF00051. Kringle. 1 hit. [Graphical view]
PRINTS	PR00018. KRINGLE.
SMART	SM00130. KR. 1 hit. [Graphical view]
SUPFAM	SSF57440. Kringle-like. 1 hit.
PROSITE	PS00021. KRINGLE_1. 1 hit. PS50070. KRINGLE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PLMN_CAPHI

Accession

Primary (citable) accession number: Q7M323

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2004
Last sequence update:	December 15, 2003
Last modified:	November 16, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program