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Q7M317 (CAH1_PANTR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Carbonic anhydrase 1
EC=4.2.1.1
Alternative name(s):
Carbonate dehydratase I
Carbonic anhydrase I
Short name=CA-I
Gene names
Name:CA1
OrganismPan troglodytes (Chimpanzee)
Taxonomic identifier9598 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Reversible hydration of carbon dioxide.

Catalytic activity

H2CO3 = CO2 + H2O.

Cofactor

Zinc By similarity.

Enzyme regulation

Inhibited by acetazolamide By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the alpha-carbonic anhydrase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandMetal-binding
Zinc
   Molecular functionLyase
   PTMAcetylation
Gene Ontology (GO)
   Biological processone-carbon metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functioncarbonate dehydratase activity

Inferred from electronic annotation. Source: EC

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 261260Carbonic anhydrase 1
PRO_0000077414

Regions

Region200 – 2012Substrate binding By similarity

Sites

Active site651Proton acceptor By similarity
Active site1291 By similarity
Metal binding951Zinc; catalytic By similarity
Metal binding971Zinc; catalytic By similarity
Metal binding1201Zinc; catalytic By similarity
Binding site2001Substrate By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7M317 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 5370F84FEADCBC5B

FASTA26128,911
        10         20         30         40         50         60 
MASPDWGYDD KNGPEQWSKL YPIANGNNQS PVDIKTSETK HDTSLKPISV SYNPATAKEI 

        70         80         90        100        110        120 
INVGHSFHVN FEDNDNRSVL KGGPFSDSYR LFQFHFHWGS TNEHGSEHTV DGVKYSAELH 

       130        140        150        160        170        180 
IAHWNSAKYS NLAEAASKAD GLAVIGVLMK VGEANPKLQK VLDALQAIKT KGKRAPFTNF 

       190        200        210        220        230        240 
DPSTLLPSSL DFWTYPGSLT HPPLYESVTW IICKESISVS SEQLAQFRSL LSNVEGDNAV 

       250        260 
PMQHNNRPTQ PLKGRTVRAS F

« Hide

References

[1]"Characterization of the genes encoding carbonic anhydrase I of chimpanzee and gorilla: comparative analysis of 5' flanking erythroid-specific promoter sequences."
Epperly B.R., Bergenhem N.C.H., Venta P.J., Tashian R.E.
Gene 131:249-253(1993) [PubMed: 8406018] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

PIRJN0835.
RefSeqNP_001182062.1. NM_001195133.1.
UniGenePtr.6278.

3D structure databases

ProteinModelPortalQ7M317.
SMRQ7M317. Positions 2-261.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSPTRT00000037732; ENSPTRP00000034875; ENSPTRG00000020387.
GeneID464264.
KEGGptr:464264.

Organism-specific databases

CTD759.

Phylogenomic databases

eggNOGprNOG05689.
GeneTreeENSGT00560000076828.
HOVERGENHBG002837.
InParanoidQ7M317.
OMAHNNRPPQ.
OrthoDBEOG4X97HR.
PhylomeDBQ7M317.

Family and domain databases

InterProIPR001148. a_carbonic_anhydrase.
IPR023561. Carbonic_anhydrase_a-class.
IPR018338. Carbonic_anhydrase_a-class_CS.
IPR018442. Carbonic_anhydrase_CA1.
[Graphical view]
Gene3DG3DSA:3.10.200.10. Euk_COanhd. 1 hit.
KOK01672.
PANTHERPTHR18952:SF30. Carbonic_anhydrase_CA1. 1 hit.
PTHR18952. Euk_COanhd. 1 hit.
PfamPF00194. Carb_anhydrase. 1 hit.
[Graphical view]
SMARTSM01057. Carb_anhydrase. 1 hit.
[Graphical view]
SUPFAMSSF51069. Euk_COanhd. 1 hit.
PROSITEPS00162. ALPHA_CA_1. 1 hit.
PS51144. ALPHA_CA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCAH1_PANTR
AccessionPrimary (citable) accession number: Q7M317
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: January 23, 2007
Last modified: January 25, 2012
This is version 64 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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