Reviewed, UniProtKB/Swiss-Prot Q7M316 (CAH1_GORGO)

Names and origin

Protein names

Recommended name:
    Carbonic anhydrase 1
    EC=4.2.1.1
Alternative name(s):
    Carbonic anhydrase I
      Short name=CA-I
    Carbonate dehydratase I

Gene names

Name:

CA1

Organism

Gorilla gorilla gorilla (Lowland gorilla)

Taxonomic identifier

9595 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Gorilla

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Reversible hydration of carbon dioxide.
Catalytic activity	H2CO3 = CO2 + H2O.
Cofactor	Zinc By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the alpha-carbonic anhydrase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Zinc
Molecular function	Lyase
PTM	Acetylation
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	carbonate dehydratase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 261	260	Carbonic anhydrase 1		PRO_0000077407
Sites
	Metal binding	95	1	Zinc; catalytic By similarity
	Metal binding	97	1	Zinc; catalytic By similarity
	Metal binding	120	1	Zinc; catalytic By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7M316-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: AB9AA1F95A9BF2E6	FASTA	261	28,881
	10 20 30 40 50 60 MASPDWGYDD KNGPEQWSKL YPIANGNNQS PVDIKTSETK HDTSLKPISV SYNPATAKEI 70 80 90 100 110 120 INVGHSFHVT FEDNDNRSVL KGGPLSDSYR LFQFHFHWGS TNEHGSEHTV DGVKYSAELH 130 140 150 160 170 180 LTHWNSAKYS SLAEAASKAD GLAVIGVLMK VGEANPKLQK ILDALQAIKT KGKRAPFTNF 190 200 210 220 230 240 DPSTLLPSSL DFWTYPGSLT HPPLYESVTW IICKESISVS SEQLAQFRSL LSNVEGDNAV 250 260 PMQHNNRPTQ PLKGRTVRAS F

References

[1]

"Characterization of the genes encoding carbonic anhydrase I of chimpanzee and gorilla: comparative analysis of 5' flanking erythroid-specific promoter sequences." Epperly B.R., Bergenhem N.C.H., Venta P.J., Tashian R.E. Gene 131:249-253(1993) [PubMed: 8406018] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
PIR	JN0836.
3D structure databases
SMR	Q7M316. Positions 2-261.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q7M316.
Enzyme and pathway databases
BRENDA	4.2.1.1. 299462.
Family and domain databases
InterPro	IPR001148. Carbonic_anhydrase_a-class_cat. IPR018442. Carbonic_anhydrase_CA1. [Graphical view]
Gene3D	G3DSA:3.10.200.10. Euk_COanhd. 1 hit.
PANTHER	PTHR18952:SF30. Carbonic_anhydrase_CA1. 1 hit. PTHR18952. Euk_COanhd. 1 hit.
Pfam	PF00194. Carb_anhydrase. 1 hit. [Graphical view]
PROSITE	PS00162. ALPHA_CA_1. False negative. PS51144. ALPHA_CA_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CAH1_GORGO

Accession

Primary (citable) accession number: Q7M316

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2004
Last sequence update:	January 23, 2007
Last modified:	January 19, 2010
This is version 37 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)