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Q7M303

- FGF1_SHEEP

UniProt

Q7M303 - FGF1_SHEEP

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Protein
Fibroblast growth factor 1
Gene
FGF1
Organism
Ovis aries (Sheep)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331Heparin By similarity

GO - Molecular functioni

  1. S100 protein binding Source: UniProtKB
  2. fibroblast growth factor receptor binding Source: UniProtKB
  3. growth factor activity Source: UniProtKB
  4. heparin binding Source: UniProtKB

GO - Biological processi

  1. angiogenesis Source: UniProtKB-KW
  2. branch elongation involved in ureteric bud branching Source: UniProtKB
  3. cellular response to heat Source: UniProtKB
  4. fibroblast growth factor receptor signaling pathway Source: UniProtKB
  5. lung development Source: Ensembl
  6. mesonephric epithelium development Source: UniProtKB
  7. organ induction Source: Ensembl
  8. positive regulation of angiogenesis Source: UniProtKB
  9. positive regulation of cell division Source: UniProtKB
  10. positive regulation of cell migration Source: UniProtKB
  11. positive regulation of cell proliferation Source: UniProtKB
  12. positive regulation of cholesterol biosynthetic process Source: UniProtKB
  13. positive regulation of epithelial cell proliferation Source: Ensembl
  14. positive regulation of intracellular signal transduction Source: UniProtKB
  15. positive regulation of protein phosphorylation Source: Ensembl
  16. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor, Mitogen

Keywords - Biological processi

Angiogenesis, Differentiation

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 1
Short name:
FGF-1
Alternative name(s):
Acidic fibroblast growth factor
Short name:
aFGF
Heparin-binding growth factor 1
Short name:
HBGF-1
Gene namesi
Name:FGF1
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
ProteomesiUP000002356: Chromosome 5

Subcellular locationi

Secreted. Cytoplasm By similarity. Cytoplasmcell cortex By similarity. Cytoplasmcytosol By similarity. Nucleus By similarity
Note: Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu2+ ions and S100A13. Secreted in a complex with SYT1. Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59 By similarity.

GO - Cellular componenti

  1. cell cortex Source: UniProtKB-SubCell
  2. cytosol Source: UniProtKB
  3. extracellular region Source: UniProtKB
  4. extracellular space Source: UniProtKB
  5. nucleus Source: UniProtKB-SubCell
  6. proteinaceous extracellular matrix Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Propeptidei2 – 1514 By similarity
PRO_0000008918Add
BLAST
Chaini16 – 155140Fibroblast growth factor 1
PRO_0000008919Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity

Post-translational modificationi

In the nucleus, phosphorylated by PKC/PRKCD By similarity.

Keywords - PTMi

Acetylation, Phosphoprotein

Interactioni

Subunit structurei

Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP1. Part of a Cu2+-dependent multiprotein aggregate containing FGF1, S100A13 and SYT1. Interacts with SYT1. Interacts with S100A13 By similarity. Interacts with LRRC59 By similarity. Interacts with CSNKA, CSNKB and FIBP By similarity. While binding with LRRC59, CSNKA and FIBP seem mutually exclusive, CSNKB and FIBP may cooperatively interact with FGF1 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ7M303.
SMRiQ7M303. Positions 5-155.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni127 – 14317Heparin-binding By similarity
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00730000110923.
HOVERGENiHBG007580.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028210. FGF1.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF65. PTHR11486:SF65. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7M303-1 [UniParc]FASTAAdd to Basket

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MAEGETTTFR ALTEKFNLPL GNYKKPKLLY CSNGGYFLRI LPDGRVDGTK    50
DRSDQHIQLQ LYAESIGEVY IKSTETGQFL AMDTNGLLYG SQTPSEECLF 100
LERLEENHYN TYISKKHAEK NWFIGLKKNG SSKLGPRTHF GQKAILFLPL 150
PVSSD 155
Length:155
Mass (Da):17,557
Last modified:December 15, 2003 - v1
Checksum:iFE7CDEC3D35008EF
GO

Sequence databases

PIRiJW0055.
RefSeqiXP_004008958.1. XM_004008909.1.
XP_004008959.1. XM_004008910.1.

Genome annotation databases

EnsembliENSOART00000001988; ENSOARP00000001941; ENSOARG00000001851.
GeneIDi101109353.

Cross-referencesi

Sequence databases

PIRi JW0055.
RefSeqi XP_004008958.1. XM_004008909.1.
XP_004008959.1. XM_004008910.1.

3D structure databases

ProteinModelPortali Q7M303.
SMRi Q7M303. Positions 5-155.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSOART00000001988 ; ENSOARP00000001941 ; ENSOARG00000001851 .
GeneIDi 101109353.

Organism-specific databases

CTDi 2246.

Phylogenomic databases

GeneTreei ENSGT00730000110923.
HOVERGENi HBG007580.

Family and domain databases

InterProi IPR008996. Cytokine_IL1-like.
IPR028210. FGF1.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view ]
PANTHERi PTHR11486. PTHR11486. 1 hit.
PTHR11486:SF65. PTHR11486:SF65. 1 hit.
Pfami PF00167. FGF. 1 hit.
[Graphical view ]
PRINTSi PR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTi SM00442. FGF. 1 hit.
[Graphical view ]
SUPFAMi SSF50353. SSF50353. 1 hit.
PROSITEi PS00247. HBGF_FGF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiFGF1_SHEEP
AccessioniPrimary (citable) accession number: Q7M303
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: December 15, 2003
Last modified: July 9, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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