Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q7M303

- FGF1_SHEEP

UniProt

Q7M303 - FGF1_SHEEP

Protein

Fibroblast growth factor 1

Gene

FGF1

Organism
Ovis aries (Sheep)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei33 – 331HeparinBy similarity

    GO - Molecular functioni

    1. fibroblast growth factor receptor binding Source: UniProtKB
    2. growth factor activity Source: UniProtKB
    3. heparin binding Source: UniProtKB
    4. S100 protein binding Source: UniProtKB

    GO - Biological processi

    1. angiogenesis Source: UniProtKB-KW
    2. branch elongation involved in ureteric bud branching Source: UniProtKB
    3. cellular response to heat Source: UniProtKB
    4. fibroblast growth factor receptor signaling pathway Source: UniProtKB
    5. lung development Source: Ensembl
    6. mesonephric epithelium development Source: UniProtKB
    7. organ induction Source: Ensembl
    8. positive regulation of angiogenesis Source: UniProtKB
    9. positive regulation of cell division Source: UniProtKB
    10. positive regulation of cell migration Source: UniProtKB
    11. positive regulation of cell proliferation Source: UniProtKB
    12. positive regulation of cholesterol biosynthetic process Source: UniProtKB
    13. positive regulation of epithelial cell proliferation Source: Ensembl
    14. positive regulation of intracellular signal transduction Source: UniProtKB
    15. positive regulation of protein phosphorylation Source: Ensembl
    16. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein, Growth factor, Mitogen

    Keywords - Biological processi

    Angiogenesis, Differentiation

    Keywords - Ligandi

    Heparin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibroblast growth factor 1
    Short name:
    FGF-1
    Alternative name(s):
    Acidic fibroblast growth factor
    Short name:
    aFGF
    Heparin-binding growth factor 1
    Short name:
    HBGF-1
    Gene namesi
    Name:FGF1
    OrganismiOvis aries (Sheep)
    Taxonomic identifieri9940 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
    ProteomesiUP000002356: Chromosome 5

    Subcellular locationi

    Secreted. Cytoplasm By similarity. Cytoplasmcell cortex By similarity. Cytoplasmcytosol By similarity. Nucleus By similarity
    Note: Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu2+ ions and S100A13. Secreted in a complex with SYT1. Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59 By similarity.By similarity

    GO - Cellular componenti

    1. cell cortex Source: UniProtKB-SubCell
    2. cytosol Source: UniProtKB
    3. extracellular region Source: UniProtKB
    4. extracellular space Source: UniProtKB
    5. nucleus Source: UniProtKB-SubCell
    6. proteinaceous extracellular matrix Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Propeptidei2 – 1514By similarityPRO_0000008918Add
    BLAST
    Chaini16 – 155140Fibroblast growth factor 1PRO_0000008919Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Post-translational modificationi

    In the nucleus, phosphorylated by PKC/PRKCD.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Interactioni

    Subunit structurei

    Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP1. Part of a Cu2+-dependent multiprotein aggregate containing FGF1, S100A13 and SYT1. Interacts with SYT1. Interacts with S100A13 By similarity. Interacts with LRRC59 By similarity. Interacts with CSNKA, CSNKB and FIBP By similarity. While binding with LRRC59, CSNKA and FIBP seem mutually exclusive, CSNKB and FIBP may cooperatively interact with FGF1 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ7M303.
    SMRiQ7M303. Positions 5-155.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni127 – 14317Heparin-bindingBy similarityAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    GeneTreeiENSGT00730000110923.
    HOVERGENiHBG007580.

    Family and domain databases

    InterProiIPR008996. Cytokine_IL1-like.
    IPR028210. FGF1.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view]
    PANTHERiPTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF65. PTHR11486:SF65. 1 hit.
    PfamiPF00167. FGF. 1 hit.
    [Graphical view]
    PRINTSiPR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTiSM00442. FGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF50353. SSF50353. 1 hit.
    PROSITEiPS00247. HBGF_FGF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7M303-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEGETTTFR ALTEKFNLPL GNYKKPKLLY CSNGGYFLRI LPDGRVDGTK    50
    DRSDQHIQLQ LYAESIGEVY IKSTETGQFL AMDTNGLLYG SQTPSEECLF 100
    LERLEENHYN TYISKKHAEK NWFIGLKKNG SSKLGPRTHF GQKAILFLPL 150
    PVSSD 155
    Length:155
    Mass (Da):17,557
    Last modified:December 15, 2003 - v1
    Checksum:iFE7CDEC3D35008EF
    GO

    Sequence databases

    PIRiJW0055.
    RefSeqiXP_004008958.1. XM_004008909.1.
    XP_004008959.1. XM_004008910.1.

    Genome annotation databases

    EnsembliENSOART00000001988; ENSOARP00000001941; ENSOARG00000001851.
    GeneIDi101109353.

    Cross-referencesi

    Sequence databases

    PIRi JW0055.
    RefSeqi XP_004008958.1. XM_004008909.1.
    XP_004008959.1. XM_004008910.1.

    3D structure databases

    ProteinModelPortali Q7M303.
    SMRi Q7M303. Positions 5-155.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSOART00000001988 ; ENSOARP00000001941 ; ENSOARG00000001851 .
    GeneIDi 101109353.

    Organism-specific databases

    CTDi 2246.

    Phylogenomic databases

    GeneTreei ENSGT00730000110923.
    HOVERGENi HBG007580.

    Family and domain databases

    InterProi IPR008996. Cytokine_IL1-like.
    IPR028210. FGF1.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view ]
    PANTHERi PTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF65. PTHR11486:SF65. 1 hit.
    Pfami PF00167. FGF. 1 hit.
    [Graphical view ]
    PRINTSi PR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTi SM00442. FGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50353. SSF50353. 1 hit.
    PROSITEi PS00247. HBGF_FGF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiFGF1_SHEEP
    AccessioniPrimary (citable) accession number: Q7M303
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3