Q7M303 (FGF1_SHEEP) Reviewed, UniProtKB/Swiss-Prot
Last modified October 16, 2013. Version 53. History...
Names and origin
|Protein names||Recommended name:|
Fibroblast growth factor 1
Acidic fibroblast growth factor
Heparin-binding growth factor 1
|Organism||Ovis aries (Sheep)|
|Taxonomic identifier||9940 [NCBI]|
|Taxonomic lineage||Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Ovis|
|Sequence length||155 AA.|
|Sequence processing||The displayed sequence is further processed into a mature form.|
|Protein existence||Evidence at transcript level|
General annotation (Comments)
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro By similarity.
Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP1. Part of a Cu2+-dependent multiprotein aggregate containing FGF1, S100A13 and SYT1. Interacts with SYT1. Interacts with S100A13 By similarity. Interacts with LRRC59 By similarity. Interacts with CSNKA, CSNKB and FIBP By similarity. While binding with LRRC59, CSNKA and FIBP seem mutually exclusive, CSNKB and FIBP may cooperatively interact with FGF1 By similarity.
Secreted. Cytoplasm By similarity. Cytoplasm › cell cortex By similarity. Cytoplasm › cytosol By similarity. Nucleus By similarity. Note: Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu2+ ions and S100A13. Secreted in a complex with SYT1. Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59 By similarity.
In the nucleus, phosphorylated by PKC/PRKCD By similarity.
Belongs to the heparin-binding growth factors family.
Sequence annotation (Features)
|Feature key||Position(s)||Length||Description||Graphical view||Feature identifier|
|Initiator methionine||1||1||Removed By similarity|
|Propeptide||2 – 15||14||By similarity||PRO_0000008918|
|Chain||16 – 155||140||Fibroblast growth factor 1||PRO_0000008919|
|Region||127 – 143||17||Heparin-binding By similarity|
|Binding site||33||1||Heparin By similarity|
Amino acid modifications
|Modified residue||2||1||N-acetylalanine By similarity|
|||"Primary structure of ovine fibroblast growth factor-1 deduced by protein and cDNA analysis."|
Grieb T.W., Ring M., Brown E., Palmer C., Belle N., Donjerkovic D., Chang H., Yun J., Subramanian R., Forozan F., Guo Y., Vertes A., Winkles J.A., Burgess W.H.
Biochem. Biophys. Res. Commun. 246:182-191(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
|RefSeq||XP_004008958.1. XM_004008909.1. |
3D structure databases
|SMR||Q7M303. Positions 5-155. |
Protocols and materials databases
Genome annotation databases
Family and domain databases
|InterPro||IPR008996. Cytokine_IL1-like. |
|PANTHER||PTHR11486. PTHR11486. 1 hit. |
PTHR11486:SF14. PTHR11486:SF14. 1 hit.
|Pfam||PF00167. FGF. 1 hit. |
|PRINTS||PR00263. HBGFFGF. |
|SMART||SM00442. FGF. 1 hit. |
|SUPFAM||SSF50353. SSF50353. 1 hit. |
|PROSITE||PS00247. HBGF_FGF. 1 hit. |
|Accession||Primary (citable) accession number: Q7M303|
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Chordata Protein Annotation Program|
Index of protein domains and families