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Protein

Apolipoprotein E

Gene

APOE

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein E
Short name:
Apo-E
Gene namesi
Name:APOE
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Unplaced

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chylomicron, HDL, Secreted, VLDL

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818By similarityAdd
BLAST
Chaini19 – 316298Apolipoprotein EPRO_0000001997Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei142 – 1421Methionine sulfoxideBy similarity
Modified residuei146 – 1461PhosphoserineBy similarity
Glycosylationi211 – 2111O-linked (GalNAc...)By similarity
Glycosylationi309 – 3091O-linked (GalNAc...)By similarity
Glycosylationi310 – 3101O-linked (GalNAc...)By similarity

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Glycoprotein, Oxidation, Phosphoprotein

Expressioni

Tissue specificityi

Secreted in plasma.

Structurei

3D structure databases

ProteinModelPortaliQ7M2U8.
SMRiQ7M2U8. Positions 29-202.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati79 – 100221Add
BLAST
Repeati101 – 122222Add
BLAST
Repeati123 – 144223Add
BLAST
Repeati145 – 166224Add
BLAST
Repeati167 – 188225Add
BLAST
Repeati189 – 210226Add
BLAST
Repeati211 – 232227Add
BLAST
Repeati233 – 254228Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni79 – 2541768 X 22 AA approximate tandem repeatsAdd
BLAST
Regioni157 – 16711LDL receptor bindingBy similarityAdd
BLAST
Regioni161 – 1644Heparin-bindingBy similarity
Regioni228 – 2358Heparin-bindingBy similarity

Sequence similaritiesi

Belongs to the apolipoprotein A1/A4/E family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

HOVERGENiHBG010582.

Family and domain databases

InterProiIPR000074. ApoA_E.
[Graphical view]
PfamiPF01442. Apolipoprotein. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7M2U8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLWVALVV ALLAGCQADM EGELGSEEPL PPEQPRGQDS QPWEQVLGRL
60 70 80 90 100
WDYLRWVQTL SDQVQEELLN TQVIQELTVL MEETMKEVKA YREELEGQLA
110 120 130 140 150
PMAQETQARV SKELQAAQAR LGSDMEDLRN RLAQYRSEVQ AMLGQSTEEL
160 170 180 190 200
RARMASHLRK LRKRLLRDAD DLKKRLAVYQ AGASEGAERS VSAIRERLRP
210 220 230 240 250
LVEQSQSRAA TLSTQVGQPL LDRAEAWRQK LHGRLEEVGV RAQDRLDKMR
260 270 280 290 300
QQLEEVRSKV EEQGSQIRLQ AEAFQARLRS WFEPLVEDMQ RQWAGLVEKV
310
QLALHLSPTS PPSENH
Length:316
Mass (Da):36,215
Last modified:December 15, 2003 - v1
Checksum:iE3D223DA0C595A2C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti258 – 2581S → A.1 Publication

Sequence databases

PIRiJC6549.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

PIRiJC6549.

3D structure databases

ProteinModelPortaliQ7M2U8.
SMRiQ7M2U8. Positions 29-202.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG010582.

Family and domain databases

InterProiIPR000074. ApoA_E.
[Graphical view]
PfamiPF01442. Apolipoprotein. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of the sheep apolipoprotein E (ApoE) gene and allelic variations of the ApoE gene in scrapie Suffolk sheep."
    Komatsu Y., Horiuchi M., Ishiguro N., Matsui T., Shinagawa M.
    Gene 208:131-138(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE, VARIANT ALA-258.

Entry informationi

Entry nameiAPOE_SHEEP
AccessioniPrimary (citable) accession number: Q7M2U8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: December 15, 2003
Last modified: December 9, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.