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Protein

Apolipoprotein E

Gene

APOE

Organism
Zalophus californianus (California sealion)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHeparin-binding
Biological processLipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein E
Short name:
Apo-E
Gene namesi
Name:APOE
OrganismiZalophus californianus (California sealion)
Taxonomic identifieri9704 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaOtariidaeZalophus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chylomicron, HDL, Secreted, VLDL

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000000199919 – 329Apolipoprotein EAdd BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei155Methionine sulfoxideBy similarity1
Modified residuei159PhosphoserineBy similarity1
Glycosylationi322O-linked (GalNAc...) threonineBy similarity1

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Glycoprotein, Oxidation, Phosphoprotein

Proteomic databases

PRIDEiQ7M2U7.

Expressioni

Tissue specificityi

Secreted in plasma.

Structurei

3D structure databases

ProteinModelPortaliQ7M2U7.
SMRiQ7M2U7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati92 – 1131Add BLAST22
Repeati114 – 1352Add BLAST22
Repeati136 – 1573Add BLAST22
Repeati158 – 1794Add BLAST22
Repeati180 – 2015Add BLAST22
Repeati202 – 2236Add BLAST22
Repeati224 – 2457Add BLAST22
Repeati246 – 2678Add BLAST22

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni92 – 2678 X 22 AA approximate tandem repeatsAdd BLAST176
Regioni170 – 180LDL receptor bindingBy similarityAdd BLAST11
Regioni174 – 177Heparin-bindingBy similarity4
Regioni241 – 248Heparin-bindingBy similarity8

Sequence similaritiesi

Belongs to the apolipoprotein A1/A4/E family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

HOVERGENiHBG010582.

Family and domain databases

InterProiView protein in InterPro
IPR000074. ApoA_E.
PfamiView protein in Pfam
PF01442. Apolipoprotein. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7M2U7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLWAALVV ALLAGCWADV EPESPLEENL EPELEPKREL EQEVEPEAGW
60 70 80 90 100
QAGQPWELAL ARFWDYLRWV QTLSDQVQEE VLSNQVTQEL TTLMEETMKE
110 120 130 140 150
IKAYRAELEE QLGPMASETQ ARVAKELQAA QARLRSDMED VRTRLSQYRG
160 170 180 190 200
EVQAMLGQST EELRARFASH MRKLRKRVLR DAEDLQKRLA VYRAGVREGA
210 220 230 240 250
ERSVSTIRER LWPLLEQART RHAKVDALAT QPLRERVNAL GQQLRGRLEE
260 270 280 290 300
VGSRARSHLD EVREQMEEVQ AKMEEQANQM RQQAEAFQAR LKGWFEPLVE
310 320
DMQRQWAVLV EKVQAAVGTS PTTPPVETK
Length:329
Mass (Da):37,946
Last modified:December 15, 2003 - v1
Checksum:i2FF0F154FA2750E3
GO

Sequence databases

PIRiJC5566.

Similar proteinsi

Entry informationi

Entry nameiAPOE_ZALCA
AccessioniPrimary (citable) accession number: Q7M2U7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: December 15, 2003
Last modified: May 10, 2017
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families