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Q7M181

- ACLR_ACHOB

UniProt

Q7M181 - ACLR_ACHOB

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Protein

2-aminohexano-6-lactam racemase

Gene
N/A
Organism
Achromobacter obae
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

catalyzes the interconversion of L-alpha-amino-epsilon-caprolactam and D-alpha-amino-epsilon-caprolactam.1 Publication

Catalytic activityi

(S)-2-aminohexano-6-lactam = (R)-2-aminohexano-6-lactam.1 Publication

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei137 – 13711 Publication
Binding sitei137 – 1371Pyridoxal phosphateBy similarity
Binding sitei295 – 2951Pyridoxal phosphate1 Publication

GO - Molecular functioni

  1. 2-aminohexano-6-lactam racemase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
2-aminohexano-6-lactam racemase (EC:5.1.1.15)
Alternative name(s):
2-amino-hexano-6-lactam racemase
Alpha-amino-epsilon-caprolactam racemase
OrganismiAchromobacter obae
Taxonomic identifieri37486 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeAchromobacter

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4364362-aminohexano-6-lactam racemasePRO_0000430444Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei267 – 2671N6-(pyridoxal phosphate)lysine

Interactioni

Subunit structurei

Monomer.1 Publication

Structurei

Secondary structure

1
436
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 128Combined sources
Helixi15 – 173Combined sources
Beta strandi25 – 317Combined sources
Beta strandi33 – 364Combined sources
Beta strandi41 – 466Combined sources
Turni47 – 515Combined sources
Helixi59 – 7012Combined sources
Beta strandi77 – 826Combined sources
Helixi83 – 9412Combined sources
Turni95 – 973Combined sources
Turni99 – 1013Combined sources
Beta strandi102 – 1098Combined sources
Helixi110 – 12516Combined sources
Beta strandi129 – 1335Combined sources
Helixi142 – 1454Combined sources
Beta strandi162 – 1654Combined sources
Beta strandi170 – 1723Combined sources
Helixi181 – 19212Combined sources
Beta strandi199 – 2046Combined sources
Beta strandi206 – 2094Combined sources
Turni210 – 2123Combined sources
Helixi220 – 23011Combined sources
Beta strandi234 – 2385Combined sources
Turni240 – 2423Combined sources
Turni244 – 2474Combined sources
Beta strandi248 – 2514Combined sources
Helixi252 – 2554Combined sources
Beta strandi261 – 2655Combined sources
Helixi267 – 2704Combined sources
Beta strandi276 – 2816Combined sources
Helixi282 – 2854Combined sources
Beta strandi289 – 2924Combined sources
Turni295 – 2984Combined sources
Helixi300 – 31516Combined sources
Helixi318 – 33922Combined sources
Beta strandi343 – 3497Combined sources
Beta strandi352 – 3609Combined sources
Turni361 – 3644Combined sources
Helixi368 – 38114Combined sources
Beta strandi386 – 3894Combined sources
Beta strandi394 – 3974Combined sources
Helixi405 – 42016Combined sources
Helixi421 – 4244Combined sources
Helixi427 – 4315Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ZUKX-ray2.41A/B1-436[»]
3DXVX-ray2.21A/B1-436[»]
3DXWX-ray2.41A/B1-436[»]
ProteinModelPortaliQ7M181.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7M181.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni110 – 1112Pyridoxal phosphate binding
Regioni238 – 2414Pyridoxal phosphate bindingBy similarity

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7M181-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKALYDRDG AAIGNLQKLR FFPLAISGGR GARLIEENGR ELIDLSGAWG
60 70 80 90 100
AASLGYGHPA IVAAVSAAAA NPAGATILSA SNAPAVTLAE RLLASFPGEG
110 120 130 140 150
THKIWFGHSG SDANEAAYRA IVKATGRSGV IAFAGAYHGC TVGSMAFSGH
160 170 180 190 200
SVQADAAKAD GLILLPYPDP YRPYRNDPTG DAILTLLTEK LAAVPAGSIG
210 220 230 240 250
AAFIEPIQSD GGLIVPPDGF LRKFADICRA HGILVVCDEV KVGLARSGRL
260 270 280 290 300
HCFEHEGFVP DILVLGKGLG GGLPLSAVIA PAEILDCASA FAMQTLHGNP
310 320 330 340 350
ISAAAGLAVL ETIDRDDLPA MAERKGRLLR DGLSELAKRH PLIGDIRGRG
360 370 380 390 400
LACGMELVCD RQSREPARAE TAKLIYRAYQ LGLVVYYVGM NGNVLEFTPP
410 420 430
LTITETDIHK ALDLLDRAFS ELSAVSNEEI AQFAGW
Length:436
Mass (Da):45,699
Last modified:December 15, 2003 - v1
Checksum:i85D1FC7936F7DDE5
GO

Sequence databases

PIRiJC1497.

Cross-referencesi

Sequence databases

PIRi JC1497.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2ZUK X-ray 2.41 A/B 1-436 [» ]
3DXV X-ray 2.21 A/B 1-436 [» ]
3DXW X-ray 2.41 A/B 1-436 [» ]
ProteinModelPortali Q7M181.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q7M181.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Alpha-amino-epsilon-caprolactam racemase for L-lysine production."
    Naoko N., Oshihara W., Yanai A.
    (In) Korpela T., Christen P. (eds.); Biochemistry of Vitamin B6, pp.449-452, Birkhauser Verlag, Basel (1987)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Mechanism of alpha-amino-epsilon-caprolactam racemase reaction."
    Ahmed S.A., Esaki N., Tanaka H., Soda K.
    Biochemistry 25:385-388(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: CATALYTIC ACTIVITY.
  3. "Finding Sequences for over 270 Orphan Enzymes."
    Shearer A.G., Altman T., Rhee C.D.
    PLoS ONE 9:E97250-E97250(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  4. "The novel structure of a pyridoxal 5'-phosphate-dependent fold-type I racemase, alpha-amino-epsilon-caprolactam racemase from Achromobacter obae."
    Okazaki S., Suzuki A., Mizushima T., Kawano T., Komeda H., Asano Y., Yamane T.
    Biochemistry 48:941-950(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.21 ANGSTROMS) IN COMPLEX WITH PYRIDOXAL PHOSPHATE AND EPSILON-CAPROLACTAM, PYRIDOXAL PHOSPHATE AT LYS-267, ACTIVE SITE, FUNCTION, SUBUNIT.

Entry informationi

Entry nameiACLR_ACHOB
AccessioniPrimary (citable) accession number: Q7M181
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 2014
Last sequence update: December 15, 2003
Last modified: November 26, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3