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Protein

2-aminohexano-6-lactam racemase

Gene
N/A
Organism
Achromobacter obae
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

catalyzes the interconversion of L-alpha-amino-epsilon-caprolactam and D-alpha-amino-epsilon-caprolactam.1 Publication

Catalytic activityi

(S)-2-aminohexano-6-lactam = (R)-2-aminohexano-6-lactam.1 Publication

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1371 Publication1
Binding sitei137Pyridoxal phosphateBy similarity1
Binding sitei295Pyridoxal phosphate1 Publication1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BRENDAi5.1.1.15. 76.

Names & Taxonomyi

Protein namesi
Recommended name:
2-aminohexano-6-lactam racemase (EC:5.1.1.15)
Alternative name(s):
2-amino-hexano-6-lactam racemase
Alpha-amino-epsilon-caprolactam racemase
OrganismiAchromobacter obae
Taxonomic identifieri37486 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeAchromobacter

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004304441 – 4362-aminohexano-6-lactam racemaseAdd BLAST436

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei267N6-(pyridoxal phosphate)lysine1

Interactioni

Subunit structurei

Monomer.1 Publication

Structurei

Secondary structure

1436
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 12Combined sources8
Helixi15 – 17Combined sources3
Beta strandi25 – 31Combined sources7
Beta strandi33 – 36Combined sources4
Beta strandi41 – 46Combined sources6
Turni47 – 51Combined sources5
Helixi59 – 70Combined sources12
Beta strandi77 – 82Combined sources6
Helixi83 – 94Combined sources12
Turni95 – 97Combined sources3
Turni99 – 101Combined sources3
Beta strandi102 – 109Combined sources8
Helixi110 – 125Combined sources16
Beta strandi129 – 133Combined sources5
Helixi142 – 145Combined sources4
Beta strandi150 – 153Combined sources4
Beta strandi162 – 165Combined sources4
Beta strandi170 – 172Combined sources3
Helixi181 – 192Combined sources12
Beta strandi199 – 204Combined sources6
Beta strandi206 – 209Combined sources4
Turni210 – 212Combined sources3
Helixi220 – 230Combined sources11
Beta strandi234 – 238Combined sources5
Turni240 – 242Combined sources3
Turni244 – 247Combined sources4
Beta strandi248 – 251Combined sources4
Helixi252 – 255Combined sources4
Beta strandi261 – 265Combined sources5
Helixi267 – 270Combined sources4
Beta strandi276 – 281Combined sources6
Helixi282 – 285Combined sources4
Beta strandi289 – 292Combined sources4
Turni295 – 298Combined sources4
Helixi300 – 315Combined sources16
Helixi318 – 339Combined sources22
Beta strandi343 – 349Combined sources7
Beta strandi352 – 360Combined sources9
Turni361 – 364Combined sources4
Helixi368 – 381Combined sources14
Beta strandi386 – 389Combined sources4
Beta strandi394 – 397Combined sources4
Helixi405 – 420Combined sources16
Helixi421 – 424Combined sources4
Helixi427 – 431Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ZUKX-ray2.41A/B1-436[»]
3DXVX-ray2.21A/B1-436[»]
3DXWX-ray2.41A/B1-436[»]
ProteinModelPortaliQ7M181.
SMRiQ7M181.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7M181.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni110 – 111Pyridoxal phosphate binding2
Regioni238 – 241Pyridoxal phosphate bindingBy similarity4

Sequence similaritiesi

Family and domain databases

CDDicd00610. OAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7M181-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKALYDRDG AAIGNLQKLR FFPLAISGGR GARLIEENGR ELIDLSGAWG
60 70 80 90 100
AASLGYGHPA IVAAVSAAAA NPAGATILSA SNAPAVTLAE RLLASFPGEG
110 120 130 140 150
THKIWFGHSG SDANEAAYRA IVKATGRSGV IAFAGAYHGC TVGSMAFSGH
160 170 180 190 200
SVQADAAKAD GLILLPYPDP YRPYRNDPTG DAILTLLTEK LAAVPAGSIG
210 220 230 240 250
AAFIEPIQSD GGLIVPPDGF LRKFADICRA HGILVVCDEV KVGLARSGRL
260 270 280 290 300
HCFEHEGFVP DILVLGKGLG GGLPLSAVIA PAEILDCASA FAMQTLHGNP
310 320 330 340 350
ISAAAGLAVL ETIDRDDLPA MAERKGRLLR DGLSELAKRH PLIGDIRGRG
360 370 380 390 400
LACGMELVCD RQSREPARAE TAKLIYRAYQ LGLVVYYVGM NGNVLEFTPP
410 420 430
LTITETDIHK ALDLLDRAFS ELSAVSNEEI AQFAGW
Length:436
Mass (Da):45,699
Last modified:December 15, 2003 - v1
Checksum:i85D1FC7936F7DDE5
GO

Sequence databases

PIRiJC1497.

Cross-referencesi

Sequence databases

PIRiJC1497.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ZUKX-ray2.41A/B1-436[»]
3DXVX-ray2.21A/B1-436[»]
3DXWX-ray2.41A/B1-436[»]
ProteinModelPortaliQ7M181.
SMRiQ7M181.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi5.1.1.15. 76.

Miscellaneous databases

EvolutionaryTraceiQ7M181.

Family and domain databases

CDDicd00610. OAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACLR_ACHOB
AccessioniPrimary (citable) accession number: Q7M181
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 2014
Last sequence update: December 15, 2003
Last modified: November 2, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.