Q7M0Z3 (ARGI_BREBE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginase
EC=3.5.3.1

Gene names

Name:

rocF

Organism

Brevibacillus brevis (Bacillus brevis)

Taxonomic identifier

1393 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Paenibacillaceae › Brevibacillus

Protein attributes

Sequence length	298 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	L-arginine + H2O = L-ornithine + urea.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Pathway	Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.
Sequence similarities	Belongs to the arginase family.

Ontologies

Keywords
Biological process	Arginine metabolism
Ligand	Manganese Metal-binding
Molecular function	Hydrolase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	arginine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	arginase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 298	298	Arginase		PRO_0000173713
Regions
	Region	123 – 127	5	Substrate binding By similarity
	Region	134 – 136	3	Substrate binding By similarity
Sites
	Metal binding	98	1	Manganese 1 By similarity
	Metal binding	121	1	Manganese 1 By similarity
	Metal binding	121	1	Manganese 2 By similarity
	Metal binding	123	1	Manganese 2 By similarity
	Metal binding	125	1	Manganese 1 By similarity
	Metal binding	225	1	Manganese 1 By similarity
	Metal binding	225	1	Manganese 2 By similarity
	Metal binding	227	1	Manganese 2 By similarity
	Binding site	177	1	Substrate By similarity
	Binding site	270	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7M0Z3 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: E7D2FB198B9DD5E0	FASTA	298	31,879
	10 20 30 40 50 60 MNKNMSIVGV PMDLGADRRG VDMGPSAIRY AGVVARLEKM GFNIEDRGDI FVTLPHHFTE 70 80 90 100 110 120 TENHKYLDEV VEANEKLANV VSDIMTAGRF PLVLGGDHSI ALGTIAGVAK HVKNLGVICL 130 140 150 160 170 180 DAHGDLNTGA TSPSGNIHGM PLAASLGYGH ERLTNIGGYT PKVKAENVVI IGARDLDQGE 190 200 210 220 230 240 RELIKRIGMK VFTMHEIDKL GMARVMDEAI AHVSKNTDGV HLSLDLDGLD PHDAPGVGTP 250 260 270 280 290 VIGGISYREG HVSLEMLADA DILCSAEFVE VNPILDRENM TARVAVALMS SVFGDKLL

References

[1]	"Molecular cloning and nucleotide sequence of the arginase gene of Bacillus brevis TT02-8 and its expression in Escherichia coli." Shimotohno K.W., Miwa I., Endo T. Biosci. Biotechnol. Biochem. 61:1459-1464(1997) [PubMed: 9339546] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-36. Strain: TT02-8.
+	Additional computationally mapped references.

Cross-references

Sequence databases
PIR	JC5866.
3D structure databases
ProteinModelPortal	Q7M0Z3.
SMR	Q7M0Z3. Positions 3-298.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR014033. Arginase_subgr. IPR006035. Ureohydrolase. IPR023696. Ureohydrolase_domain. IPR020855. Ureohydrolase_Mn_BS. [Graphical view]
Gene3D	G3DSA:3.40.800.10. Ureohydrolase. 1 hit.
PANTHER	PTHR11358:SF2. Arginase_sub. 1 hit. PTHR11358. Ureohydrolase. 1 hit.
Pfam	PF00491. Arginase. 1 hit. [Graphical view]
PIRSF	PIRSF036979. Arginase. 1 hit.
PRINTS	PR00116. ARGINASE.
TIGRFAMs	TIGR01229. RocF_arginase. 1 hit.
PROSITE	PS01053. ARGINASE_1. 1 hit. PS51409. ARGINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGI_BREBE

Accession

Primary (citable) accession number: Q7M0Z3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	December 15, 2003
Last modified:	July 27, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program