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Protein

39S ribosomal protein L14, mitochondrial

Gene

Mrpl14

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May form part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1, intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-RNO-5389840 Mitochondrial translation elongation
R-RNO-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L14, mitochondrial
Short name:
L14mt
Short name:
MRP-L14
Alternative name(s):
39S ribosomal protein L32, mitochondrial
Short name:
L32mt
Short name:
MRP-L32
Gene namesi
Name:Mrpl14
Synonyms:Rpml32
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi1306240 Mrpl14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 30Mitochondrion1 PublicationAdd BLAST30
ChainiPRO_000026113631 – 14539S ribosomal protein L14, mitochondrialAdd BLAST115

Proteomic databases

PaxDbiQ7M0E7
PRIDEiQ7M0E7

PTM databases

iPTMnetiQ7M0E7
PhosphoSitePlusiQ7M0E7

Expressioni

Gene expression databases

BgeeiENSRNOG00000019734
GenevisibleiQ7M0E7 RN

Interactioni

Subunit structurei

Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Interacts with MALSU1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026716

Structurei

3D structure databases

ProteinModelPortaliQ7M0E7
SMRiQ7M0E7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3441 Eukaryota
ENOG4111JDP LUCA
GeneTreeiENSGT00390000001121
HOGENOMiHOG000183701
HOVERGENiHBG088508
InParanoidiQ7M0E7
KOiK02874
OMAiHRMPGPR
OrthoDBiEOG091G1144
PhylomeDBiQ7M0E7
TreeFamiTF324586

Family and domain databases

Gene3Di2.40.150.20, 1 hit
HAMAPiMF_01367 Ribosomal_L14, 1 hit
InterProiView protein in InterPro
IPR036853 Ribosomal_L14_sf
IPR000218 Ribosomal_L14P
PfamiView protein in Pfam
PF00238 Ribosomal_L14, 1 hit
SMARTiView protein in SMART
SM01374 Ribosomal_L14, 1 hit
SUPFAMiSSF50193 SSF50193, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7M0E7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVLTGLFGF FAYVRGAVSQ RCFSTSGSLS AIQKMTRVRV VDNSALGNTP
60 70 80 90 100
YHRPPRCIHV YNKSGVGKVG DQILLAIRGQ KKKALIVGHR MPGSRMTPKF
110 120 130 140
DSNNVVLIED NGNPVGTRIK IPIPTSLRRR EGEYSKVLAI AQNFV
Length:145
Mass (Da):15,913
Last modified:November 28, 2006 - v2
Checksum:i3AF4E7FF76436D23
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57C → E AA sequence (PubMed:9857009).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03068353 Genomic DNA No translation available.
PIRiS78418
RefSeqiNP_001100360.1, NM_001106890.2
NP_001258060.1, NM_001271131.1
XP_006244574.1, XM_006244512.3
XP_008765072.1, XM_008766850.2
UniGeneiRn.35669

Genome annotation databases

EnsembliENSRNOT00000026716; ENSRNOP00000026716; ENSRNOG00000019734
ENSRNOT00000087528; ENSRNOP00000072412; ENSRNOG00000019734
GeneIDi301250
KEGGirno:301250
UCSCiRGD:1306240 rat

Similar proteinsi

Entry informationi

Entry nameiRM14_RAT
AccessioniPrimary (citable) accession number: Q7M0E7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: May 23, 2018
This is version 93 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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