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Protein

Destrin

Gene

Dstn

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Destrin
Alternative name(s):
Actin-depolymerizing factor
Short name:
ADF
Gene namesi
Name:Dstn
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1588366. Dstn.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00002149212 – 165DestrinAdd BLAST164

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine2 Publications1
Modified residuei3PhosphoserineCombined sources1 Publication1
Modified residuei19N6-acetyllysineBy similarity1

Post-translational modificationi

ISGylated.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ7M0E3.
PRIDEiQ7M0E3.

PTM databases

iPTMnetiQ7M0E3.
PhosphoSitePlusiQ7M0E3.

Expressioni

Gene expression databases

BgeeiENSRNOG00000005924.
GenevisibleiQ7M0E3. RN.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ7M0E3. 1 interactor.
MINTiMINT-4568380.
STRINGi10116.ENSRNOP00000007794.

Structurei

3D structure databases

ProteinModelPortaliQ7M0E3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 153ADF-HPROSITE-ProRule annotationAdd BLAST150

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi30 – 34Nuclear localization signalSequence analysis5

Sequence similaritiesi

Belongs to the actin-binding proteins ADF family.Curated
Contains 1 ADF-H domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1735. Eukaryota.
ENOG41122P5. LUCA.
GeneTreeiENSGT00440000033289.
HOGENOMiHOG000039697.
HOVERGENiHBG000381.
InParanoidiQ7M0E3.
KOiK10363.
OMAiKHEYQAN.
OrthoDBiEOG091G0PWC.
PhylomeDBiQ7M0E3.
TreeFamiTF328601.

Family and domain databases

CDDicd11286. ADF_cofilin_like. 1 hit.
Gene3Di3.40.20.10. 1 hit.
InterProiIPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR017904. ADF/Cofilin.
IPR029924. Dstn.
[Graphical view]
PANTHERiPTHR11913. PTHR11913. 1 hit.
PTHR11913:SF18. PTHR11913:SF18. 1 hit.
PfamiPF00241. Cofilin_ADF. 1 hit.
[Graphical view]
PRINTSiPR00006. COFILIN.
SMARTiSM00102. ADF. 1 hit.
[Graphical view]
PROSITEiPS51263. ADF_H. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7M0E3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGVQVADE VCRIFYDMKV RKCSTPEEIK KRKKAVIFCL SADKKCIVVE
60 70 80 90 100
EGKEILVGDV GVTITDPFKH FVGMLPEKDC RYALYDASFE TKESRKEELM
110 120 130 140 150
FFLWAPEQAP LKSKMIYASS KDAIKKKFPG IKHEYQANGP EDLNRTSIAE
160
KLGGSLIVAF EGSPV
Length:165
Mass (Da):18,534
Last modified:February 20, 2007 - v3
Checksum:iD395B8A5642A0D79
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti114K → L AA sequence (PubMed:9877327).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CF111187 mRNA. No translation available.
PIRiJE0223.
RefSeqiNP_001028838.1. NM_001033666.1.
UniGeneiRn.102412.

Genome annotation databases

EnsembliENSRNOT00000007794; ENSRNOP00000007794; ENSRNOG00000005924.
GeneIDi502674.
KEGGirno:502674.
UCSCiRGD:1588366. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CF111187 mRNA. No translation available.
PIRiJE0223.
RefSeqiNP_001028838.1. NM_001033666.1.
UniGeneiRn.102412.

3D structure databases

ProteinModelPortaliQ7M0E3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ7M0E3. 1 interactor.
MINTiMINT-4568380.
STRINGi10116.ENSRNOP00000007794.

PTM databases

iPTMnetiQ7M0E3.
PhosphoSitePlusiQ7M0E3.

Proteomic databases

PaxDbiQ7M0E3.
PRIDEiQ7M0E3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000007794; ENSRNOP00000007794; ENSRNOG00000005924.
GeneIDi502674.
KEGGirno:502674.
UCSCiRGD:1588366. rat.

Organism-specific databases

CTDi11034.
RGDi1588366. Dstn.

Phylogenomic databases

eggNOGiKOG1735. Eukaryota.
ENOG41122P5. LUCA.
GeneTreeiENSGT00440000033289.
HOGENOMiHOG000039697.
HOVERGENiHBG000381.
InParanoidiQ7M0E3.
KOiK10363.
OMAiKHEYQAN.
OrthoDBiEOG091G0PWC.
PhylomeDBiQ7M0E3.
TreeFamiTF328601.

Miscellaneous databases

PROiQ7M0E3.

Gene expression databases

BgeeiENSRNOG00000005924.
GenevisibleiQ7M0E3. RN.

Family and domain databases

CDDicd11286. ADF_cofilin_like. 1 hit.
Gene3Di3.40.20.10. 1 hit.
InterProiIPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR017904. ADF/Cofilin.
IPR029924. Dstn.
[Graphical view]
PANTHERiPTHR11913. PTHR11913. 1 hit.
PTHR11913:SF18. PTHR11913:SF18. 1 hit.
PfamiPF00241. Cofilin_ADF. 1 hit.
[Graphical view]
PRINTSiPR00006. COFILIN.
SMARTiSM00102. ADF. 1 hit.
[Graphical view]
PROSITEiPS51263. ADF_H. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDEST_RAT
AccessioniPrimary (citable) accession number: Q7M0E3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: February 20, 2007
Last modified: November 2, 2016
This is version 94 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.