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Q7M0E3 (DEST_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Destrin
Alternative name(s):
Actin-depolymerizing factor
Short name=ADF
Gene names
Name:Dstn
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length165 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner.

Post-translational modification

ISGylated By similarity.

Sequence similarities

Belongs to the actin-binding proteins ADF family.

Contains 1 ADF-H domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.2
Chain2 – 165164Destrin
PRO_0000214921

Regions

Domain4 – 153150ADF-H
Motif30 – 345Nuclear localization signal Potential

Amino acid modifications

Modified residue21N-acetylalanine Ref.2 Ref.4
Modified residue31Phosphoserine Ref.2
Modified residue191N6-acetyllysine By similarity

Experimental info

Sequence conflict1141K → L AA sequence Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q7M0E3 [UniParc].

Last modified February 20, 2007. Version 3.
Checksum: D395B8A5642A0D79

FASTA16518,534
        10         20         30         40         50         60 
MASGVQVADE VCRIFYDMKV RKCSTPEEIK KRKKAVIFCL SADKKCIVVE EGKEILVGDV 

        70         80         90        100        110        120 
GVTITDPFKH FVGMLPEKDC RYALYDASFE TKESRKEELM FFLWAPEQAP LKSKMIYASS 

       130        140        150        160 
KDAIKKKFPG IKHEYQANGP EDLNRTSIAE KLGGSLIVAF EGSPV 

« Hide

References

[1]"Gene expression analysis in response to lung toxicants: I. Sequencing and microarray development."
Shultz M.A., Zhang L., Gu Y.-Z., Baker G.L., Fannuchi M.V., Padua A.M., Gurske W.A., Morin D., Penn S.G., Jovanovich S.B., Plopper C.G., Buckpitt A.R.
Am. J. Respir. Cell Mol. Biol. 30:296-310(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Lung.
[2]"Complete amino acid sequences and phosphorylation sites, determined by Edman degradation and mass spectrometry, of rat parotid destrin- and cofilin-like proteins."
Kanamori T., Suzuki M., Titani K.
Arch. Oral Biol. 43:955-967(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-165, ACETYLATION AT ALA-2, PHOSPHORYLATION AT SER-3, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Parotid gland.
[3]Lubec G., Afjehi-Sadat L., Diao W., Kang S.U.
Submitted (JUL-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 46-69; 82-92 AND 133-145, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: Sprague-Dawley.
Tissue: Brain, Hippocampus and Spinal cord.
[4]Lubec G., Chen W.-Q.
Submitted (FEB-2007) to UniProtKB
Cited for: ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CF111187 mRNA. No translation available.
PIRJE0223.
RefSeqNP_001028838.1. NM_001033666.1.
UniGeneRn.102412.

3D structure databases

ProteinModelPortalQ7M0E3.
SMRQ7M0E3. Positions 2-165.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ7M0E3. 1 interaction.
MINTMINT-4568380.
STRING10116.ENSRNOP00000007794.

PTM databases

PhosphoSiteQ7M0E3.

Proteomic databases

PaxDbQ7M0E3.
PRIDEQ7M0E3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000007794; ENSRNOP00000007794; ENSRNOG00000005924.
GeneID502674.
KEGGrno:502674.
UCSCRGD:1588366. rat.

Organism-specific databases

CTD11034.
RGD1588366. Dstn.

Phylogenomic databases

eggNOGNOG294392.
GeneTreeENSGT00440000033289.
HOGENOMHOG000039697.
HOVERGENHBG000381.
InParanoidQ7M0E3.
KOK10363.
OMAQMLPEKD.
OrthoDBEOG7353Z9.
PhylomeDBQ7M0E3.
TreeFamTF328601.

Gene expression databases

GenevestigatorQ7M0E3.

Family and domain databases

InterProIPR002108. ADF-H.
IPR017904. ADF/Cofilin/Destrin.
[Graphical view]
PANTHERPTHR11913. PTHR11913. 1 hit.
PfamPF00241. Cofilin_ADF. 1 hit.
[Graphical view]
PRINTSPR00006. COFILIN.
SMARTSM00102. ADF. 1 hit.
[Graphical view]
PROSITEPS51263. ADF_H. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio712150.

Entry information

Entry nameDEST_RAT
AccessionPrimary (citable) accession number: Q7M0E3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: February 20, 2007
Last modified: April 16, 2014
This is version 78 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families