Reviewed, UniProtKB/Swiss-Prot Q7LZR3 (LYG_CASCA)

Names and origin

Protein names	Recommended name:     Lysozyme g     EC=3.2.1.17 Alternative name(s):     1,4-beta-N-acetylmuramidase     Goose-type lysozyme
Organism	Casuarius casuarius (Australian cassowary) (Double-wattled cassowary)
Taxonomic identifier	8787 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Palaeognathae › Casuariiformes › Casuariidae › Casuarius

Protein attributes

Sequence length	185 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
Subcellular location	Secreted.
Miscellaneous	Shows preference for N-acetylmuramic acid residues that are substituted with a peptide moiety. It acts only as a glycanohydrolase By similarity.
Sequence similarities	Belongs to the glycosyl hydrolase 23 family.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Antimicrobial Bacteriolytic enzyme Glycosidase Hydrolase
PTM	Disulfide bond Pyrrolidone carboxylic acid
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	cell wall macromolecule catabolic process Inferred from electronic annotation. Source: InterPro cytolysis Inferred from electronic annotation. Source: UniProtKB-KW defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	lysozyme activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 185	185	Lysozyme g		PRO_0000193514
Sites
	Active site	73	1	By similarity
	Active site	86	1	By similarity
Amino acid modifications
	Modified residue	1	1	Pyrrolidone carboxylic acid
	Disulfide bond	4 ↔ 60		By similarity
	Disulfide bond	18 ↔ 29		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7LZR3-1 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 0522F8187896F53A	FASTA	185	20,426
	10 20 30 40 50 60 QTGCYGVVNR IDTTGASCET AKPEKLNYCG VAASRKIAEG DLQSMDRYKT LIKKVGQKLC 70 80 90 100 110 120 VDPAVIAGII SRESHAGKAL KDGWGDNGNG FGLMQVDKRS HTPVGKWNGE RHLTQGTEIL 130 140 150 160 170 180 ISMIKKIQKK FPRWTKEQQL KGGISAYNAG SGNVRTYERM DIGTTHNDYA NDVVARAQYY KQHGY

References

[1]	Thammasirirak S., Torikata T., Takami K., Murata K., Araki T. Submitted (OCT-2000) to the PIR data bank Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases
PIR	A59351.
3D structure databases
SMR	Q7LZR3. Positions 1-185.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q7LZR3.
Family and domain databases
InterPro	IPR002152. Glyco_hydro_23. IPR008258. Lytic_TGlycosylase-like_cat. [Graphical view]
Pfam	PF01464. SLT. 1 hit. [Graphical view]
PIRSF	PIRSF001065. Lysozyme_g. 1 hit.
PRINTS	PR00749. LYSOZYMEG.
ProtoNet	Search...

Entry information

Entry name

LYG_CASCA

Accession

Primary (citable) accession number: Q7LZR3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
Last sequence update:	December 15, 2003
Last modified:	June 16, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)