Reviewed, UniProtKB/Swiss-Prot Q7LZQ2 (LYSC_AIXSP)

Names and origin

Protein names

Recommended name:
    Lysozyme C
    EC=3.2.1.17
Alternative name(s):
    1,4-beta-N-acetylmuramidase C

Gene names

Name:

LYZ

Organism

Aix sponsa (Wood duck)

Taxonomic identifier

8833 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Anseriformes › Anatidae › Aix

Protein attributes

Sequence length	129 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents By similarity.
Catalytic activity	Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
Subunit structure	Monomer By similarity.
Miscellaneous	Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.
Sequence similarities	Belongs to the glycosyl hydrolase 22 family.

Ontologies

Keywords
Molecular function	Antimicrobial Bacteriolytic enzyme Glycosidase Hydrolase
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	cell wall macromolecule catabolic process Inferred from electronic annotation. Source: InterPro cytolysis Inferred from electronic annotation. Source: UniProtKB-KW defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	lysozyme activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 129	129	Lysozyme C		PRO_0000208858
Sites
	Active site	35	1	By similarity
	Active site	52	1	By similarity
Amino acid modifications
	Disulfide bond	6 ↔ 127		By similarity
	Disulfide bond	30 ↔ 115		By similarity
	Disulfide bond	64 ↔ 80		By similarity
	Disulfide bond	76 ↔ 94		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7LZQ2-1 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 037CFDF01A2FEAD0	FASTA	129	14,476
	10 20 30 40 50 60 KVYERCELAA AMKRLGLDNY RGYSLGNWVC AAKYESNFNT QATNRNTDGS TDYGILEINS 70 80 90 100 110 120 RWWCNDGKTP GAKNVCGIPC SVLLRSDITE AVKCAKRIVS DGNGMNAWVA WRNRCKGTDV SRWIRGCRL

References

[1]	Araki T., Torikata T. Submitted (MAY-1997) to the PIR data bank Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases
PIR	JC5380.
3D structure databases
SMR	Q7LZQ2. Positions 1-129.
ModBase	Search...
Protein family/group databases
CAZy	GH22. Glycoside Hydrolase Family 22.
Phylogenomic databases
HOVERGEN	Q7LZQ2.
Enzyme and pathway databases
BRENDA	3.2.1.17. 3216.
Family and domain databases
InterPro	IPR001916. Glyco_hydro_22. IPR019799. Glyco_hydro_22_CS. IPR000974. Glyco_hydro_22_lys. [Graphical view]
Pfam	PF00062. Lys. 1 hit. [Graphical view]
PRINTS	PR00137. LYSOZYME. PR00135. LYZLACT.
SMART	SM00263. LYZ1. 1 hit. [Graphical view]
PROSITE	PS00128. LACTALBUMIN_LYSOZYME_1. 1 hit. PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LYSC_AIXSP

Accession

Primary (citable) accession number: Q7LZQ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
Last sequence update:	December 15, 2003
Last modified:	June 16, 2009
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)