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Protein

Phospholipase A2 taicatoxin

Gene
N/A
Organism
Oxyuranus scutellatus scutellatus (Australian taipan) (Coastal taipan)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Heterotrimer: blocks the voltage-dependent L-type calcium channels from the heart, and the small conductance calcium-activated potassium channels in the chromaffin cells and in the brain. Is very toxic to mice.
Monomer: Snake venom phospholipase A2 (PLA2) that has neurotoxic activities. Voltage-dependently affects ionic currents in chick (Gallus domesticus) dorsal root ganglion cells. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.

Catalytic activityi

Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.PROSITE-ProRule annotation

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalcium-activated potassium channel impairing toxin, Hydrolase, Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin
Biological processLipid degradation, Lipid metabolism
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipase A2 taicatoxin (EC:3.1.1.4)
Short name:
TCX
Short name:
svPLA2
Alternative name(s):
Phosphatidylcholine 2-acylhydrolase
OrganismiOxyuranus scutellatus scutellatus (Australian taipan) (Coastal taipan)
Taxonomic identifieri8667 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeAcanthophiinaeOxyuranus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Toxic dosei

LD50 of the monomer is 500 µg/kg to mice.
LD50 of the heterotrimer is 50-100 µg/kg to mice.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000408515‹1 – ›27Phospholipase A2 taicatoxinAdd BLAST›27

Post-translational modificationi

Contains 7 disulfide bonds.By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.2 Publications

Interactioni

Subunit structurei

Heterotrimer composed of an alpha-neurotoxin-like peptide of 8 kDa (AC P0CJ35), this neurotoxic phospholipase of 16 kDa and a serine protease inhibitor of 7 kDa (AC B7S4N9) at an approximate stoichiometry of 1:1:4; non-covalently linked.1 Publication

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR016090. PLipase_A2_dom.
SUPFAMiSSF48619. SSF48619. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q7LZG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20 
NLAQFGFMIR CANGGSRSAL DYADYGC
Length:27
Mass (Da):2,901
Last modified:December 15, 2003 - v1
Checksum:iA74F18ACB843133C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei271

Sequence databases

PIRiA34280.
S21101.

Cross-referencesi

Web resourcesi

Wikipedia

Taicatoxin entry

Sequence databases

PIRiA34280.
S21101.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR016090. PLipase_A2_dom.
SUPFAMiSSF48619. SSF48619. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPA2T_OXYSC
AccessioniPrimary (citable) accession number: Q7LZG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: December 15, 2003
Last modified: April 12, 2017
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.