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Protein

Acetylcholinesterase

Gene

ACHE

Organism
Naja oxiana (Central Asian cobra) (Oxus cobra)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.

Catalytic activityi

Acetylcholine + H2O = choline + acetate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei76Acyl-ester intermediatePROSITE-ProRule annotation1
Active sitei132Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase, Toxin

Keywords - Biological processi

Neurotransmitter degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylcholinesterase (EC:3.1.1.7)
Short name:
AChE
Gene namesi
Name:ACHE
OrganismiNaja oxiana (Central Asian cobra) (Oxus cobra)
Taxonomic identifieri8657 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeElapinaeNaja

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Secreted, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000408518‹1 – ›181AcetylcholinesteraseAdd BLAST›181

Post-translational modificationi

The N-terminus is blocked.By similarity

Expressioni

Tissue specificityi

Expressed by the venom gland. Is also probably expressed by liver and muscle.

Structurei

3D structure databases

ProteinModelPortaliQ7LZG1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Fragments.

Q7LZG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SELKVATQTG FVRGLSLPVL AGHVSAHLGV PFAEPFLRPE PVKPGAEMWN
60 70 80 90 100
PNLNIWVPSG RVGAFXFLTV TLFGESAGAA SVGMXLLSTQ RAILQSGAPN
110 120 130 140 150
APWAQVQPAE SRFPFVPVID GEFFPLGVNK DEGSFGVPGF SKXXESLINQ
160 170 180
AVPHANDIYT DWQDQDNGGL PLTGNPTXPH N
Length:181
Mass (Da):19,255
Last modified:May 31, 2011 - v2
Checksum:i19AB68C1423C4BD2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-adjacent residuesi35 – 36Curated2
Non-adjacent residuesi44 – 45Curated2
Non-adjacent residuesi52 – 53Curated2
Non-adjacent residuesi61 – 62Curated2
Non-adjacent residuesi68 – 69Curated2
Non-adjacent residuesi91 – 92Curated2
Non-adjacent residuesi125 – 126Curated2
Non-adjacent residuesi135 – 136Curated2
Non-adjacent residuesi151 – 152Curated2
Non-adjacent residuesi158 – 159Curated2
Non-adjacent residuesi168 – 169Curated2
Non-adjacent residuesi172 – 173Curated2
Non-terminal residuei1811

Sequence databases

PIRiA39022.
A41117.

Cross-referencesi

Sequence databases

PIRiA39022.
A41117.

3D structure databases

ProteinModelPortaliQ7LZG1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiACES_NAJOX
AccessioniPrimary (citable) accession number: Q7LZG1
Secondary accession number(s): Q7LZ27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: May 31, 2011
Last modified: January 7, 2015
This is version 44 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.