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Protein
Submitted name:

Alpha amylase

Gene

amyA

Organism
Pyrococcus woesei
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi49Magnesium 1; via carbonyl oxygenCombined sources1
Metal bindingi58Zinc 1Combined sources1
Metal bindingi61Zinc 1Combined sources1
Metal bindingi105Magnesium 1Combined sources1
Metal bindingi105Zinc 2Combined sources1
Metal bindingi113Magnesium 1Combined sources1
Metal bindingi113Zinc 2Combined sources1
Metal bindingi135CalciumCombined sources1
Metal bindingi172Zinc 3; via tele nitrogenCombined sources1
Metal bindingi177Zinc 3; via tele nitrogenCombined sources1
Metal bindingi180CalciumCombined sources1
Metal bindingi182Calcium; via carbonyl oxygenCombined sources1
Metal bindingi189CalciumCombined sources1
Metal bindingi191Zinc 3Combined sources1
Metal bindingi227Calcium; via carbonyl oxygenCombined sources1
Metal bindingi277Magnesium 2Combined sources1
Metal bindingi277Zinc 4Combined sources1
Metal bindingi281Magnesium 2Combined sources1
Metal bindingi281Zinc 4Combined sources1
Metal bindingi317Magnesium 2; via carbonyl oxygenCombined sources1
Metal bindingi317Zinc 4Combined sources1
Metal bindingi343Zinc 1Combined sources1
Binding sitei345GlucoseCombined sources1
Metal bindingi348Zinc 1Combined sources1
Metal bindingi372Magnesium 3Combined sources1
Metal bindingi372Zinc 5Combined sources1
Metal bindingi374Magnesium 3Combined sources1
Metal bindingi374Zinc 5Combined sources1
Metal bindingi375Magnesium 3Combined sources1
Metal bindingi375Zinc 5Combined sources1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidaseImported, Hydrolase
LigandCalciumCombined sources, MagnesiumCombined sources, Metal-bindingCombined sources, ZincCombined sources

Protein family/group databases

CAZyiGH13. Glycoside Hydrolase Family 13.

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha amylaseImported (EC:3.2.1.1Imported)
Gene namesi
Name:amyAImported
OrganismiPyrococcus woeseiImported
Taxonomic identifieri2262 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi178 ↔ 179Combined sources
Disulfide bondi413 ↔ 457Combined sources

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MWOX-ray2.20A26-460[»]
1MXDX-ray2.00A26-460[»]
1MXGX-ray1.60A26-460[»]
ProteinModelPortaliQ7LYT7.
SMRiQ7LYT7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 380AamyInterPro annotationAdd BLAST346

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni316 – 321Glucose bindingCombined sources6

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProiView protein in InterPro
IPR013776. A-amylase_thermo.
IPR015237. Alpha-amylase_C_pro.
IPR006046. Alpha_amylase.
IPR006047. Glyco_hydro_13_cat_dom.
IPR013780. Glyco_hydro_b.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
PfamiView protein in Pfam
PF00128. Alpha-amylase. 1 hit.
PF09154. DUF1939. 1 hit.
PIRSFiPIRSF001021. Alph-amls_thrmst. 1 hit.
PRINTSiPR00110. ALPHAAMYLASE.
SMARTiView protein in SMART
SM00642. Aamy. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7LYT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIKKLTPLL TLLLFFIVLA SPVSAAKYLE LEEGGVIMQA FYWDVPGGGI
60 70 80 90 100
WWDHIRSKIP EWYEAGISAI WLPPPSKGMS GGYSMGYDPY DYFDLGEYYQ
110 120 130 140 150
KGTVETRFGS KEELVRLIQT AHAYGIKVIA DVVINHRAGG DLEWNPFVGD
160 170 180 190 200
YTWTDFSKVA SGKYTANYLD FHPNELHCCD EGTFGGFPDI CHHKEWDQYW
210 220 230 240 250
LWKSNESYAA YLRSIGFDGW RFDYVKGYGA WVVRDWLNWW GGWAVGEYWD
260 270 280 290 300
TNVDALLSWA YESGAKVFDF PLYYKMDEAF DNNNIPALVY ALQNGQTVVS
310 320 330 340 350
RDPFKAVTFV ANHDTDIIWN KYPAYAFILT YEGQPVIFYR DFEEWLNKDK
360 370 380 390 400
LINLIWIHDH LAGGSTTIVY YDNDELIFVR NGDSRRPGLI TYINLSPNWV
410 420 430 440 450
GRWVYVPKFA GACIHEYTGN LGGWVDKRVD SSGWVYLEAP PHDPANGYYG
460
YSVWSYCGVG
Length:460
Mass (Da):52,910
Last modified:July 5, 2004 - v1
Checksum:i0E0A2AEB5FCAF541
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177906 Genomic DNA. Translation: AAD54338.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177906 Genomic DNA. Translation: AAD54338.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MWOX-ray2.20A26-460[»]
1MXDX-ray2.00A26-460[»]
1MXGX-ray1.60A26-460[»]
ProteinModelPortaliQ7LYT7.
SMRiQ7LYT7.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH13. Glycoside Hydrolase Family 13.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProiView protein in InterPro
IPR013776. A-amylase_thermo.
IPR015237. Alpha-amylase_C_pro.
IPR006046. Alpha_amylase.
IPR006047. Glyco_hydro_13_cat_dom.
IPR013780. Glyco_hydro_b.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
PfamiView protein in Pfam
PF00128. Alpha-amylase. 1 hit.
PF09154. DUF1939. 1 hit.
PIRSFiPIRSF001021. Alph-amls_thrmst. 1 hit.
PRINTSiPR00110. ALPHAAMYLASE.
SMARTiView protein in SMART
SM00642. Aamy. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ7LYT7_PYRWO
AccessioniPrimary (citable) accession number: Q7LYT7
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: February 15, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.