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Protein

Beige protein homolog 1

Gene

lvs1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in protein sorting and cell wall formation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri2550 – 260455FYVE-typeAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Beige protein homolog 1
Gene namesi
Name:lvs1
ORF Names:SPBC28E12.06c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC28E12.06c.
PomBaseiSPBC28E12.06c. lvs1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • membrane Source: UniProtKB-SubCell
  • protein complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 26092609Beige protein homolog 1PRO_0000372305Add
BLAST

Proteomic databases

MaxQBiQ7LKZ7.
PRIDEiQ7LKZ7.

Structurei

3D structure databases

ProteinModelPortaliQ7LKZ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1735 – 1870136BEACH-type PHPROSITE-ProRule annotationAdd
BLAST
Domaini1907 – 2202296BEACHPROSITE-ProRule annotationAdd
BLAST
Repeati2249 – 229042WD 1Add
BLAST
Repeati2294 – 233239WD 2Add
BLAST
Repeati2340 – 237940WD 3Add
BLAST
Repeati2429 – 247547WD 4Add
BLAST
Repeati2507 – 254640WD 5Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1182 – 11854Poly-Ser

Sequence similaritiesi

Contains 1 BEACH domain.PROSITE-ProRule annotation
Contains 1 BEACH-type PH domain.PROSITE-ProRule annotation
Contains 1 FYVE-type zinc finger.Curated
Contains 5 WD repeats.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri2550 – 260455FYVE-typeAdd
BLAST

Keywords - Domaini

Repeat, WD repeat, Zinc-finger

Phylogenomic databases

InParanoidiQ7LKZ7.
OMAiEIVNVWQ.
OrthoDBiEOG7CK3G4.
PhylomeDBiQ7LKZ7.

Family and domain databases

Gene3Di1.10.1540.10. 1 hit.
2.130.10.10. 1 hit.
2.30.29.40. 1 hit.
2.60.120.200. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR000409. BEACH_dom.
IPR013320. ConA-like_dom.
IPR023362. PH-BEACH_dom.
IPR011993. PH_dom-like.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
IPR000306. Znf_FYVE.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF02138. Beach. 1 hit.
PF14844. PH_BEACH. 1 hit.
[Graphical view]
SMARTiSM01026. Beach. 1 hit.
SM00064. FYVE. 1 hit.
SM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF50729. SSF50729. 2 hits.
SSF50978. SSF50978. 1 hit.
SSF57903. SSF57903. 1 hit.
SSF81837. SSF81837. 1 hit.
PROSITEiPS50197. BEACH. 1 hit.
PS51783. PH_BEACH. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7LKZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRKANAYSK SVELLSRLEG CPSEKVLLEE LRKLRGFIRN DIPSNFFPQL
60 70 80 90 100
FITDNGFAAI KKAVTKLNFQ SLLSLDIFEC CLQILGIATS YTILRSWLLS
110 120 130 140 150
RKHIEAWIEL AIRRMFYSFC AIQDDSNISI YAIGTSSKTD SSIQAASPNE
160 170 180 190 200
DLKSEGAQEI DSQSETVSIS SDVDYDEDRK DLKKAKICSA YYLKTRLLLA
210 220 230 240 250
VLSFAQNDST FSLLKLVPSL QDNTNASLVE LSRVVEAAIQ KLSIKPLAFP
260 270 280 290 300
NVLPQVLLLC PSISIFNLIL LHLRALIRSS PENAIKIGYS KTMHFLLTYL
310 320 330 340 350
FEPPTSFPLS DVSKDLLNEI TLHCATFGVS NASTAKVLRT YLKTKSEFLR
360 370 380 390 400
TWLLKALSHL VAPSFYFNPS TKGYSSIDFT LSSPVMPING YSVSLWLNIE
410 420 430 440 450
SLMNDDGNYA PTTLFLISDF LKSTLFRLLL DASKKTVVVH IGSSKDTCVV
460 470 480 490 500
NFSTPITNFF SKIYKDNPSL NPPSWHLITL VHRNEKSSLP NLELYIDGSA
510 520 530 540 550
VERAACPYPF LSSTLQPLYV SLGPSIGSRN QSTPSTLAPN VAETDALVSE
560 570 580 590 600
NTGAASQKTS KSYKTNDSLK VPPLVPLLIG TTRFFPVPLV SSQIAIISSL
610 620 630 640 650
GPSYSGCFQG PINDYMTYKA STALTLEIQD SKSNTEDLLH SIQAFSRSPI
660 670 680 690 700
AFMSCARDYV DIMDLQLSDF CSFSVLETLK KLENQYYSHV YINRAVSSYD
710 720 730 740 750
KAFSAEQPSF GVSSGSVTPI IMQSISDAIY NIGGSSILLE LVGTAETEAE
760 770 780 790 800
LNFGLQVFFS SIEDNWRFSE NVEQTHSFEI LAQILHSKSH LLVSEETLKI
810 820 830 840 850
IALMSGVHHT RFKHPLVMNP LLFRYLILDF DLWSKAPNSN LFVQQLGYIV
860 870 880 890 900
SLIENNDYAG FNVKRLMKMQ ILKKLLTAMR NCLFHKDLLP ILRLLFKVLM
910 920 930 940 950
TSAFVSENIR SVATYIIYAS QATGKSKPIR RSSVSIAVDR SDSNYISIKE
960 970 980 990 1000
SGYAICEEFI DLLIKSNGEP SFLRRFSSMI TPAWLLFLLR QQDIHYFICG
1010 1020 1030 1040 1050
IRLLNQSICS LGSSFLSKFS QKFHGFLILH DNLKDHIHLE ELWLNLLFLS
1060 1070 1080 1090 1100
LGLGIRSVQF RTDLTYKQKL DFVLKNELDN ILPLSEVFPS LFHAIQATLE
1110 1120 1130 1140 1150
KVSNVNGKLN SENVAALRYA DDTMSFLVTL QTTYSFELTL NYDFSELLTK
1160 1170 1180 1190 1200
VVFPFLSPVD TITAEQEMRD LLHNIRQPLP RSSSSKTFGE GIKKSVRKFS
1210 1220 1230 1240 1250
MSGSFKRVVT PLGTQLRKDI LNDSITDMEN TSSFTASFPQ SDQALQYFDN
1260 1270 1280 1290 1300
FTVQYAEAKD VIKGLLFSIL TCIYNRITSG QGFSYSRLLV YLPPSQIEKK
1310 1320 1330 1340 1350
STFFSGILRS TMSKLIEAVK NDKLLLAEPS ILANISYIFT KFIRMHLLGY
1360 1370 1380 1390 1400
LKGSWLEIVD DLGSLLEEII SRPDFLAKLP KNGRNAAMNM YSCFLDLFLL
1410 1420 1430 1440 1450
EVSDLKQTEC NAQSDKIIKS ITYWQSLLFN SKTYQKDLFS LLWYAVYIMV
1460 1470 1480 1490 1500
ETTTGVVRLQ AVDAWRLLFL HSPGYLSDIA KTCNNDPRFA YEICKTLDND
1510 1520 1530 1540 1550
SDKFVRWLDD NAAEVNQFML SCFFCRWEDF LKQQHKLADE EASLLQFSRL
1560 1570 1580 1590 1600
EHLRKQLAQN TFNENILNES SASYHVWISS LFALECNRFK KMSQDQSDQE
1610 1620 1630 1640 1650
NFVAAALLSQ KNELSHENSI LGSKTTSWEL DSTEGSERMR KRLMPCLLQS
1660 1670 1680 1690 1700
SELDSKLEAR SSGARRNRSF DTSVEAPVSL TNEEKQAATL ILPSQEETLH
1710 1720 1730 1740 1750
DAARSDSNNS MEDEEDDVDE EDKEDKNRTV MRSIESGDSI QDVYNVSRIF
1760 1770 1780 1790 1800
GLEATEGILL LGKQYLYLMD NFFLRSDNEI VDVNDNSIID ERDPYLQLLH
1810 1820 1830 1840 1850
LQSLSSSGKV RRHISKENNW HWDFIDLSLV LKRFYLLRDV GLELFFKDGR
1860 1870 1880 1890 1900
SFLTILSNTK NRDSLYQKLV ARAPGADVLS TSHFATSMSR DLGKANGKSN
1910 1920 1930 1940 1950
FLSSKLANAL SFSTTHPATK RWERREISNF NYLQIVNTLA GRTYNDLTQY
1960 1970 1980 1990 2000
PVFPWVIADY TSKELDLNNP KTYRNFCKPM GAQHPERESQ FNERYDLLLG
2010 2020 2030 2040 2050
LNDSQQQPFH YGTHYSSAMI VCSYLIRLRP FVDSYLALQG GQFDHADRLF
2060 2070 2080 2090 2100
YSIEQAWRSS SKENMADVRE LIPEFFYLSE MFINGNGFDF GSRQKESTPI
2110 2120 2130 2140 2150
NDVILPPWAK GDPAIFVQKN REALESKYVS AHLHEWIDLV FGCKQRGDEA
2160 2170 2180 2190 2200
VAATNVFHHL SYQGAIDLEN IENEFELAAA VGIIHNFGQT PKQVFKKPHP
2210 2220 2230 2240 2250
QRGPDFTDTP LGPYLFGRFE DSIHLLFQSC SPIIRICKKV AHIQYDPSKD
2260 2270 2280 2290 2300
EVGAFAADYT PLGPNTFLAW GRVDNTVQLI SDQLDKQPVM FEELHSEKIT
2310 2320 2330 2340 2350
HVVACDERTF LTASLDLTLR LWTLSTNKPI KASLKRVLYG HRYRITCVTV
2360 2370 2380 2390 2400
CKAFSIIVSG DAGGNLIIWD LNRAEFVSSL SVYKLPIQTI AVNARNAEIA
2410 2420 2430 2440 2450
FSTGFYCCVV NVNGKILVKD KLSRIYNENS DENILCSCFY TGANSEWLHK
2460 2470 2480 2490 2500
NLFITGHPDG IIRIWEKRLQ SNAKLEAEKN NADRPKWRFH LLRQLQHTKG
2510 2520 2530 2540 2550
LGRNRVATRQ NIITITPNGQ ARGIFAGDDK GQVFSWMLPD TTSNVHLEKD
2560 2570 2580 2590 2600
NTSELCSLCD SRFSLMEWRS QCRACGNSNV CSDCVSMLKD TNIKTCYECY

RQMPLCYKN
Length:2,609
Mass (Da):295,658
Last modified:August 21, 2007 - v2
Checksum:i9E9624F739DB9227
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA20653.2.
RefSeqiNP_595759.2. NM_001021659.3.

Genome annotation databases

EnsemblFungiiSPBC28E12.06c.1; SPBC28E12.06c.1:pep; SPBC28E12.06c.
GeneIDi2540571.
KEGGispo:SPBC28E12.06c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA20653.2.
RefSeqiNP_595759.2. NM_001021659.3.

3D structure databases

ProteinModelPortaliQ7LKZ7.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiQ7LKZ7.
PRIDEiQ7LKZ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC28E12.06c.1; SPBC28E12.06c.1:pep; SPBC28E12.06c.
GeneIDi2540571.
KEGGispo:SPBC28E12.06c.

Organism-specific databases

EuPathDBiFungiDB:SPBC28E12.06c.
PomBaseiSPBC28E12.06c. lvs1.

Phylogenomic databases

InParanoidiQ7LKZ7.
OMAiEIVNVWQ.
OrthoDBiEOG7CK3G4.
PhylomeDBiQ7LKZ7.

Miscellaneous databases

NextBioi20801697.
PROiQ7LKZ7.

Family and domain databases

Gene3Di1.10.1540.10. 1 hit.
2.130.10.10. 1 hit.
2.30.29.40. 1 hit.
2.60.120.200. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR000409. BEACH_dom.
IPR013320. ConA-like_dom.
IPR023362. PH-BEACH_dom.
IPR011993. PH_dom-like.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
IPR000306. Znf_FYVE.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF02138. Beach. 1 hit.
PF14844. PH_BEACH. 1 hit.
[Graphical view]
SMARTiSM01026. Beach. 1 hit.
SM00064. FYVE. 1 hit.
SM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF50729. SSF50729. 2 hits.
SSF50978. SSF50978. 1 hit.
SSF57903. SSF57903. 1 hit.
SSF81837. SSF81837. 1 hit.
PROSITEiPS50197. BEACH. 1 hit.
PS51783. PH_BEACH. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiBPH1_SCHPO
AccessioniPrimary (citable) accession number: Q7LKZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: August 21, 2007
Last modified: April 13, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.