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Protein

CXXC-type zinc finger protein 5

Gene

CXXC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788).By similarity3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri256 – 29742CXXC-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • sequence-specific DNA binding Source: UniProtKB
  • signal transducer activity Source: UniProtKB
  • transcription factor binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  • signal transduction Source: GOC
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
CXXC-type zinc finger protein 5
Short name:
CF5
Alternative name(s):
Putative MAPK-activating protein PM08
Putative NF-kappa-B-activating protein 102
Retinoid-inducible nuclear factor
Short name:
RINF
Gene namesi
Name:CXXC5
ORF Names:HSPC195, TCCCIA00297
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:26943. CXXC5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394661.

Polymorphism and mutation databases

BioMutaiCXXC5.
DMDMi167011303.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322CXXC-type zinc finger protein 5PRO_0000317548Add
BLAST

Proteomic databases

MaxQBiQ7LFL8.
PaxDbiQ7LFL8.
PRIDEiQ7LFL8.

PTM databases

iPTMnetiQ7LFL8.

Expressioni

Inductioni

By retinoic acid.1 Publication

Gene expression databases

BgeeiQ7LFL8.
CleanExiHS_CXXC5.
ExpressionAtlasiQ7LFL8. baseline and differential.
GenevisibleiQ7LFL8. HS.

Organism-specific databases

HPAiHPA036508.
HPA058148.

Interactioni

Subunit structurei

Interacts with DVL1. Interacts with RBPJ (PubMed:23303788).By similarity1 Publication

GO - Molecular functioni

  • transcription factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi119586. 7 interactions.
IntActiQ7LFL8. 6 interactions.
MINTiMINT-1191647.
STRINGi9606.ENSP00000302543.

Structurei

3D structure databases

ProteinModelPortaliQ7LFL8.
SMRiQ7LFL8. Positions 259-302.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi257 – 2626Nuclear localization signalSequence analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi14 – 185Poly-Ser

Sequence similaritiesi

Contains 1 CXXC-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri256 – 29742CXXC-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IGNJ. Eukaryota.
ENOG4110UND. LUCA.
GeneTreeiENSGT00510000046972.
HOGENOMiHOG000112118.
HOVERGENiHBG095668.
InParanoidiQ7LFL8.
OMAiRAGMEHM.
PhylomeDBiQ7LFL8.
TreeFamiTF326617.

Family and domain databases

InterProiIPR002857. Znf_CXXC.
[Graphical view]
PfamiPF02008. zf-CXXC. 1 hit.
[Graphical view]
PROSITEiPS51058. ZF_CXXC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7LFL8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSLGGGSQD AGGSSSSSTN GSGGSGSSGP KAGAADKSAV VAAAAPASVA
60 70 80 90 100
DDTPPPERRN KSGIISEPLN KSLRRSRPLS HYSSFGSSGG SGGGSMMGGE
110 120 130 140 150
SADKATAAAA AASLLANGHD LAAAMAVDKS NPTSKHKSGA VASLLSKAER
160 170 180 190 200
ATELAAEGQL TLQQFAQSTE MLKRVVQEHL PLMSEAGAGL PDMEAVAGAE
210 220 230 240 250
ALNGQSDFPY LGAFPINPGL FIMTPAGVFL AESALHMAGL AEYPMQGELA
260 270 280 290 300
SAISSGKKKR KRCGMCAPCR RRINCEQCSS CRNRKTGHQI CKFRKCEELK
310 320
KKPSAALEKV MLPTGAAFRW FQ
Length:322
Mass (Da):32,977
Last modified:April 17, 2007 - v1
Checksum:iECC19B4DE9872BC5
GO
Isoform 2 (identifier: Q7LFL8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-95: Missing.

Show »
Length:227
Mass (Da):24,072
Checksum:i03146D66E6FC4E30
GO

Sequence cautioni

The sequence AAF36115.1 differs from that shown. Reason: Frameshift at positions 32, 102, 119, 250 and 265. Curated
The sequence AAH02490.3 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH06428.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH17439.2 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH24040.2 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH41013.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti111 – 1122AA → WP in AAF36115 (PubMed:11042152).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9595Missing in isoform 2. 2 PublicationsVSP_031013Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ379202 mRNA. Translation: ACU80469.1.
AB097005 mRNA. Translation: BAC77358.1.
AB097032 mRNA. Translation: BAC77385.1.
AK001782 mRNA. Translation: BAA91907.1.
AK024338 mRNA. Translation: BAG51292.1.
AY007103 mRNA. Translation: AAG01986.1.
AC113361 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW62090.1.
CH471062 Genomic DNA. Translation: EAW62091.1.
CH471062 Genomic DNA. Translation: EAW62092.1.
CH471062 Genomic DNA. Translation: EAW62093.1.
BC002490 mRNA. Translation: AAH02490.3. Different initiation.
BC006428 mRNA. Translation: AAH06428.1. Different initiation.
BC017439 mRNA. Translation: AAH17439.2. Different initiation.
BC024040 mRNA. Translation: AAH24040.2. Different initiation.
BC041013 mRNA. Translation: AAH41013.2. Different initiation.
AF151029 mRNA. Translation: AAF36115.1. Frameshift.
CCDSiCCDS43370.1. [Q7LFL8-1]
RefSeqiNP_001304128.1. NM_001317199.1. [Q7LFL8-1]
NP_001304129.1. NM_001317200.1. [Q7LFL8-1]
NP_001304130.1. NM_001317201.1. [Q7LFL8-1]
NP_001304131.1. NM_001317202.1. [Q7LFL8-1]
NP_001304132.1. NM_001317203.1. [Q7LFL8-1]
NP_001304133.1. NM_001317204.1. [Q7LFL8-1]
NP_001304134.1. NM_001317205.1. [Q7LFL8-1]
NP_001304135.1. NM_001317206.1. [Q7LFL8-1]
NP_001304136.1. NM_001317207.1. [Q7LFL8-1]
NP_001304137.1. NM_001317208.1. [Q7LFL8-1]
NP_001304138.1. NM_001317209.1. [Q7LFL8-1]
NP_001304139.1. NM_001317210.1. [Q7LFL8-1]
NP_001304140.1. NM_001317211.1. [Q7LFL8-1]
NP_057547.5. NM_016463.8. [Q7LFL8-1]
UniGeneiHs.189119.
Hs.744933.

Genome annotation databases

EnsembliENST00000302517; ENSP00000302543; ENSG00000171604. [Q7LFL8-1]
ENST00000511048; ENSP00000427379; ENSG00000171604. [Q7LFL8-1]
GeneIDi51523.
KEGGihsa:51523.
UCSCiuc003let.3. human. [Q7LFL8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ379202 mRNA. Translation: ACU80469.1.
AB097005 mRNA. Translation: BAC77358.1.
AB097032 mRNA. Translation: BAC77385.1.
AK001782 mRNA. Translation: BAA91907.1.
AK024338 mRNA. Translation: BAG51292.1.
AY007103 mRNA. Translation: AAG01986.1.
AC113361 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW62090.1.
CH471062 Genomic DNA. Translation: EAW62091.1.
CH471062 Genomic DNA. Translation: EAW62092.1.
CH471062 Genomic DNA. Translation: EAW62093.1.
BC002490 mRNA. Translation: AAH02490.3. Different initiation.
BC006428 mRNA. Translation: AAH06428.1. Different initiation.
BC017439 mRNA. Translation: AAH17439.2. Different initiation.
BC024040 mRNA. Translation: AAH24040.2. Different initiation.
BC041013 mRNA. Translation: AAH41013.2. Different initiation.
AF151029 mRNA. Translation: AAF36115.1. Frameshift.
CCDSiCCDS43370.1. [Q7LFL8-1]
RefSeqiNP_001304128.1. NM_001317199.1. [Q7LFL8-1]
NP_001304129.1. NM_001317200.1. [Q7LFL8-1]
NP_001304130.1. NM_001317201.1. [Q7LFL8-1]
NP_001304131.1. NM_001317202.1. [Q7LFL8-1]
NP_001304132.1. NM_001317203.1. [Q7LFL8-1]
NP_001304133.1. NM_001317204.1. [Q7LFL8-1]
NP_001304134.1. NM_001317205.1. [Q7LFL8-1]
NP_001304135.1. NM_001317206.1. [Q7LFL8-1]
NP_001304136.1. NM_001317207.1. [Q7LFL8-1]
NP_001304137.1. NM_001317208.1. [Q7LFL8-1]
NP_001304138.1. NM_001317209.1. [Q7LFL8-1]
NP_001304139.1. NM_001317210.1. [Q7LFL8-1]
NP_001304140.1. NM_001317211.1. [Q7LFL8-1]
NP_057547.5. NM_016463.8. [Q7LFL8-1]
UniGeneiHs.189119.
Hs.744933.

3D structure databases

ProteinModelPortaliQ7LFL8.
SMRiQ7LFL8. Positions 259-302.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119586. 7 interactions.
IntActiQ7LFL8. 6 interactions.
MINTiMINT-1191647.
STRINGi9606.ENSP00000302543.

PTM databases

iPTMnetiQ7LFL8.

Polymorphism and mutation databases

BioMutaiCXXC5.
DMDMi167011303.

Proteomic databases

MaxQBiQ7LFL8.
PaxDbiQ7LFL8.
PRIDEiQ7LFL8.

Protocols and materials databases

DNASUi51523.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302517; ENSP00000302543; ENSG00000171604. [Q7LFL8-1]
ENST00000511048; ENSP00000427379; ENSG00000171604. [Q7LFL8-1]
GeneIDi51523.
KEGGihsa:51523.
UCSCiuc003let.3. human. [Q7LFL8-1]

Organism-specific databases

CTDi51523.
GeneCardsiCXXC5.
HGNCiHGNC:26943. CXXC5.
HPAiHPA036508.
HPA058148.
MIMi612752. gene.
neXtProtiNX_Q7LFL8.
PharmGKBiPA128394661.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGNJ. Eukaryota.
ENOG4110UND. LUCA.
GeneTreeiENSGT00510000046972.
HOGENOMiHOG000112118.
HOVERGENiHBG095668.
InParanoidiQ7LFL8.
OMAiRAGMEHM.
PhylomeDBiQ7LFL8.
TreeFamiTF326617.

Miscellaneous databases

ChiTaRSiCXXC5. human.
GeneWikiiCXXC5.
GenomeRNAii51523.
PROiQ7LFL8.
SOURCEiSearch...

Gene expression databases

BgeeiQ7LFL8.
CleanExiHS_CXXC5.
ExpressionAtlasiQ7LFL8. baseline and differential.
GenevisibleiQ7LFL8. HS.

Family and domain databases

InterProiIPR002857. Znf_CXXC.
[Graphical view]
PfamiPF02008. zf-CXXC. 1 hit.
[Graphical view]
PROSITEiPS51058. ZF_CXXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The CXXC finger 5 protein is required for DNA damage-induced p53 activation."
    Zhang M., Wang R.-P., Wang Y.-Y., Diao F., Gao D., Chen D.-Y., Zhai Z., Shu H.-B.
    Sci. China, Ser. C, Life Sci. 52:528-538(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION.
  2. "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways."
    Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O., Nagano Y., Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H., Sugano S.
    Oncogene 22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), POSSIBLE FUNCTION.
    Tissue: Lung.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Ovarian carcinoma and Placenta.
  4. "Pediatric leukemia cDNA sequencing project."
    Zhou J., Yu W., Tang H., Mei G., Tsang Y.T.M., Bouck J., Gibbs R.A., Margolin J.F.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Leukemia.
  5. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Eye, Lymph, Muscle, Placenta and Skin.
  8. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 33-322 (ISOFORM 1).
    Tissue: Umbilical cord blood.
  9. "Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis."
    Pendino F., Nguyen E., Jonassen I., Dysvik B., Azouz A., Lanotte M., Segal-Bendirdjian E., Lillehaug J.R.
    Blood 113:3172-3181(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION BY RETINOIDS, SUBCELLULAR LOCATION.
  10. "Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2."
    Aras S., Pak O., Sommer N., Finley R. Jr., Huttemann M., Weissmann N., Grossman L.I.
    Nucleic Acids Res. 41:2255-2266(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN COX4I2 TRANSCRIPTION, INTERACTION WITH RBPJ.

Entry informationi

Entry nameiCXXC5_HUMAN
AccessioniPrimary (citable) accession number: Q7LFL8
Secondary accession number(s): B3KND0
, C8CBA8, Q8TB79, Q9NV51, Q9P0S8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: April 17, 2007
Last modified: June 8, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.