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Protein

CXXC-type zinc finger protein 5

Gene

CXXC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788).By similarity3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri256 – 297CXXC-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

  • sequence-specific DNA binding Source: UniProtKB
  • signal transducer activity Source: UniProtKB
  • transcription factor binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-9018519 Estrogen-dependent gene expression

Names & Taxonomyi

Protein namesi
Recommended name:
CXXC-type zinc finger protein 5
Short name:
CF5
Alternative name(s):
Putative MAPK-activating protein PM08
Putative NF-kappa-B-activating protein 102
Retinoid-inducible nuclear factor
Short name:
RINF
Gene namesi
Name:CXXC5
ORF Names:HSPC195, TCCCIA00297
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000171604.11
HGNCiHGNC:26943 CXXC5
MIMi612752 gene
neXtProtiNX_Q7LFL8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi51523
OpenTargetsiENSG00000171604
PharmGKBiPA128394661

Polymorphism and mutation databases

BioMutaiCXXC5
DMDMi167011303

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003175481 – 322CXXC-type zinc finger protein 5Add BLAST322

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei53PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ7LFL8
MaxQBiQ7LFL8
PaxDbiQ7LFL8
PeptideAtlasiQ7LFL8
PRIDEiQ7LFL8

PTM databases

iPTMnetiQ7LFL8
PhosphoSitePlusiQ7LFL8

Expressioni

Inductioni

By retinoic acid.1 Publication

Gene expression databases

BgeeiENSG00000171604
CleanExiHS_CXXC5
ExpressionAtlasiQ7LFL8 baseline and differential
GenevisibleiQ7LFL8 HS

Organism-specific databases

HPAiHPA036508
HPA058148

Interactioni

Subunit structurei

Interacts with DVL1. Interacts with RBPJ (PubMed:23303788).By similarity1 Publication

GO - Molecular functioni

  • transcription factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi119586, 8 interactors
IntActiQ7LFL8, 6 interactors
MINTiQ7LFL8
STRINGi9606.ENSP00000302543

Structurei

Secondary structure

1322
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi267 – 270Combined sources4
Beta strandi276 – 278Combined sources3
Helixi279 – 282Combined sources4
Helixi284 – 287Combined sources4
Turni292 – 294Combined sources3
Helixi297 – 299Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5W9SX-ray2.10C254-306[»]
ProteinModelPortaliQ7LFL8
SMRiQ7LFL8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi257 – 262Nuclear localization signalSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi14 – 18Poly-Ser5

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri256 – 297CXXC-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IGNJ Eukaryota
ENOG4110UND LUCA
GeneTreeiENSGT00910000144072
HOGENOMiHOG000112118
HOVERGENiHBG095668
InParanoidiQ7LFL8
OMAiRCGMCPP
OrthoDBiEOG091G0FYR
PhylomeDBiQ7LFL8
TreeFamiTF326617

Family and domain databases

InterProiView protein in InterPro
IPR002857 Znf_CXXC
PfamiView protein in Pfam
PF02008 zf-CXXC, 1 hit
PROSITEiView protein in PROSITE
PS51058 ZF_CXXC, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7LFL8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSLGGGSQD AGGSSSSSTN GSGGSGSSGP KAGAADKSAV VAAAAPASVA
60 70 80 90 100
DDTPPPERRN KSGIISEPLN KSLRRSRPLS HYSSFGSSGG SGGGSMMGGE
110 120 130 140 150
SADKATAAAA AASLLANGHD LAAAMAVDKS NPTSKHKSGA VASLLSKAER
160 170 180 190 200
ATELAAEGQL TLQQFAQSTE MLKRVVQEHL PLMSEAGAGL PDMEAVAGAE
210 220 230 240 250
ALNGQSDFPY LGAFPINPGL FIMTPAGVFL AESALHMAGL AEYPMQGELA
260 270 280 290 300
SAISSGKKKR KRCGMCAPCR RRINCEQCSS CRNRKTGHQI CKFRKCEELK
310 320
KKPSAALEKV MLPTGAAFRW FQ
Length:322
Mass (Da):32,977
Last modified:April 17, 2007 - v1
Checksum:iECC19B4DE9872BC5
GO
Isoform 2 (identifier: Q7LFL8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-95: Missing.

Show »
Length:227
Mass (Da):24,072
Checksum:i03146D66E6FC4E30
GO

Sequence cautioni

The sequence AAF36115 differs from that shown. Reason: Frameshift at positions 32, 102, 119, 250 and 265.Curated
The sequence AAH02490 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH06428 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH17439 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH24040 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH41013 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti111 – 112AA → WP in AAF36115 (PubMed:11042152).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0310131 – 95Missing in isoform 2. 2 PublicationsAdd BLAST95

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ379202 mRNA Translation: ACU80469.1
AB097005 mRNA Translation: BAC77358.1
AB097032 mRNA Translation: BAC77385.1
AK001782 mRNA Translation: BAA91907.1
AK024338 mRNA Translation: BAG51292.1
AY007103 mRNA Translation: AAG01986.1
AC113361 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW62090.1
CH471062 Genomic DNA Translation: EAW62091.1
CH471062 Genomic DNA Translation: EAW62092.1
CH471062 Genomic DNA Translation: EAW62093.1
BC002490 mRNA Translation: AAH02490.3 Different initiation.
BC006428 mRNA Translation: AAH06428.1 Different initiation.
BC017439 mRNA Translation: AAH17439.2 Different initiation.
BC024040 mRNA Translation: AAH24040.2 Different initiation.
BC041013 mRNA Translation: AAH41013.2 Different initiation.
AF151029 mRNA Translation: AAF36115.1 Frameshift.
CCDSiCCDS43370.1 [Q7LFL8-1]
RefSeqiNP_001304128.1, NM_001317199.1 [Q7LFL8-1]
NP_001304129.1, NM_001317200.1 [Q7LFL8-1]
NP_001304130.1, NM_001317201.1 [Q7LFL8-1]
NP_001304131.1, NM_001317202.1 [Q7LFL8-1]
NP_001304132.1, NM_001317203.1 [Q7LFL8-1]
NP_001304133.1, NM_001317204.1 [Q7LFL8-1]
NP_001304134.1, NM_001317205.1 [Q7LFL8-1]
NP_001304135.1, NM_001317206.1 [Q7LFL8-1]
NP_001304136.1, NM_001317207.1 [Q7LFL8-1]
NP_001304137.1, NM_001317208.1 [Q7LFL8-1]
NP_001304138.1, NM_001317209.1 [Q7LFL8-1]
NP_001304139.1, NM_001317210.1 [Q7LFL8-1]
NP_001304140.1, NM_001317211.1 [Q7LFL8-1]
NP_057547.5, NM_016463.8 [Q7LFL8-1]
XP_016865062.1, XM_017009573.1 [Q7LFL8-1]
UniGeneiHs.189119
Hs.744933

Genome annotation databases

EnsembliENST00000302517; ENSP00000302543; ENSG00000171604 [Q7LFL8-1]
ENST00000511048; ENSP00000427379; ENSG00000171604 [Q7LFL8-1]
GeneIDi51523
KEGGihsa:51523
UCSCiuc003let.3 human [Q7LFL8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCXXC5_HUMAN
AccessioniPrimary (citable) accession number: Q7LFL8
Secondary accession number(s): B3KND0
, C8CBA8, Q8TB79, Q9NV51, Q9P0S8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: April 17, 2007
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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