ID   ARC_HUMAN               Reviewed;         396 AA.
AC   Q7LC44; Q9UJW6; Q9Y469;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-JAN-2012, entry version 61.
DE   RecName: Full=Activity-regulated cytoskeleton-associated protein;
DE   AltName: Full=ARC/ARG3.1;
DE   AltName: Full=Activity-regulated gene 3.1 protein homolog;
DE            Short=Arg3.1;
GN   Name=ARC; Synonyms=KIAA0278;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   TISSUE=Forebrain;
RX   MEDLINE=20429191; PubMed=10970730; DOI=10.1006/mcpr.2000.0314;
RA   Haug K., Kremerskothen J., Hallmann K., Sander T., Dullinger J.,
RA   Rau B., Beyenburg S., Lentze M.J., Barnekow A., Elger C.E.,
RA   Propping P., Heils A.;
RT   "Mutation screening of the chromosome 8q24.3-human activity-regulated
RT   cytoskeleton-associated gene (ARC) in idiopathic generalized
RT   epilepsy.";
RL   Mol. Cell. Probes 14:255-260(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   MEDLINE=97191544; PubMed=9039502; DOI=10.1093/dnares/3.5.321;
RA   Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O.,
RA   Tanaka A., Kotani H., Miyajima N., Nomura N.;
RT   "Prediction of the coding sequences of unidentified human genes. VI.
RT   The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by
RT   analysis of cDNA clones from cell line KG-1 and brain.";
RL   DNA Res. 3:321-329(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, and Uterus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=21834987; DOI=10.1186/1741-7007-9-54;
RA   Bai S.W., Herrera-Abreu M.T., Rohn J.L., Racine V., Tajadura V.,
RA   Suryavanshi N., Bechtel S., Wiemann S., Baum B., Ridley A.J.;
RT   "Identification and characterization of a set of conserved and new
RT   regulators of cytoskeletal organisation, cell morphology and
RT   migration.";
RL   BMC Biol. 9:54-54(2011).
CC   -!- FUNCTION: Required for consolidation of synaptic plasticity as
CC       well as formation of long-term memory. Regulates endocytosis of
CC       AMPA receptors in response to synaptic activity. Required for
CC       homeostatic synaptic scaling of AMPA receptors (By similarity).
CC       Plays a role in the regulation of cell morphology and cytoskeletal
CC       organization. Required in the stress fiber dynamics and cell
CC       migration.
CC   -!- SUBUNIT: Interacts with SH3GL1/endophilin-2, SH3GL3/endophilin-3
CC       and DNM2/DYN2 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity).
CC       Endosome (By similarity). Cytoplasmic vesicle, secretory vesicle,
CC       acrosome (By similarity). Cell junction, synapse, postsynaptic
CC       cell membrane, postsynaptic density (By similarity). Cell
CC       projection, dendrite (By similarity). Cell projection, dendritic
CC       spine (By similarity). Cell junction, synapse (By similarity).
CC       Note=Associated with the cell cortex of neuronal soma and
CC       dendrites. Enriched in postsynaptic density of dendritic spines.
CC       Associated with the sperm tail (By similarity). Enriched on the
CC       plasma membrane.
CC   -!- SIMILARITY: Belongs to the ARC/ARG3.1 family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA19667.1; Type=Erroneous initiation;
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DR   EMBL; AF193421; AAF07185.1; -; mRNA.
DR   EMBL; AF248637; AAG33705.1; -; Genomic_DNA.
DR   EMBL; D87468; BAA19667.1; ALT_INIT; mRNA.
DR   EMBL; BC012321; AAH12321.1; -; mRNA.
DR   EMBL; BC075802; AAH75802.1; -; mRNA.
DR   IPI; IPI00000357; -.
DR   RefSeq; NP_056008.1; NM_015193.3.
DR   UniGene; Hs.40888; -.
DR   ProteinModelPortal; Q7LC44; -.
DR   IntAct; Q7LC44; 1.
DR   MINT; MINT-1440982; -.
DR   STRING; Q7LC44; -.
DR   DMDM; 74738627; -.
DR   PRIDE; Q7LC44; -.
DR   Ensembl; ENST00000356613; ENSP00000349022; ENSG00000198576.
DR   GeneID; 23237; -.
DR   KEGG; hsa:23237; -.
DR   UCSC; uc003ywn.1; human.
DR   CTD; 23237; -.
DR   GeneCards; GC08M143690; -.
DR   H-InvDB; HIX0022720; -.
DR   HGNC; HGNC:648; ARC.
DR   HPA; CAB009347; -.
DR   MIM; 612461; gene.
DR   neXtProt; NX_Q7LC44; -.
DR   PharmGKB; PA24930; -.
DR   eggNOG; prNOG11715; -.
DR   GeneTree; ENSGT00390000003914; -.
DR   HOGENOM; HBG269748; -.
DR   HOVERGEN; HBG080862; -.
DR   InParanoid; Q7LC44; -.
DR   OMA; RCQETIA; -.
DR   OrthoDB; EOG49S66B; -.
DR   PhylomeDB; Q7LC44; -.
DR   NextBio; 44888; -.
DR   ArrayExpress; Q7LC44; -.
DR   Bgee; Q7LC44; -.
DR   CleanEx; HS_ARC; -.
DR   Genevestigator; Q7LC44; -.
DR   GO; GO:0001669; C:acrosomal vesicle; IEA:UniProtKB-SubCell.
DR   GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
DR   GO; GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR   GO; GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
DR   GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016477; P:cell migration; IMP:UniProtKB.
DR   GO; GO:0007010; P:cytoskeleton organization; IMP:UniProtKB.
DR   GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR   GO; GO:0022604; P:regulation of cell morphogenesis; IMP:UniProtKB.
DR   InterPro; IPR023263; Activity-reg_cytoskelet-assoc.
DR   PRINTS; PR02027; ARCARG31.
PE   1: Evidence at protein level;
KW   Cell junction; Cell membrane; Cell projection; Coiled coil;
KW   Complete proteome; Cytoplasm; Cytoplasmic vesicle; Cytoskeleton;
KW   Developmental protein; Endocytosis; Endosome; Membrane;
KW   Postsynaptic cell membrane; Reference proteome; Synapse.
FT   CHAIN         1    396       Activity-regulated cytoskeleton-
FT                                associated protein.
FT                                /FTId=PRO_0000273285.
FT   REGION       89    100       Binds SH3GL1 or SH3GL3 (By similarity).
FT   REGION      195    214       Required for binding DNM2 (By
FT                                similarity).
FT   COILED       54     78       Potential.
SQ   SEQUENCE   396 AA;  45316 MW;  D5C8A8A07FE9615D CRC64;
     MELDHRTSGG LHAYPGPRGG QVAKPNVILQ IGKCRAEMLE HVRRTHRHLL AEVSKQVERE
     LKGLHRSVGK LESNLDGYVP TSDSQRWKKS IKACLCRCQE TIANLERWVK REMHVWREVF
     YRLERWADRL ESTGGKYPVG SESARHTVSV GVGGPESYCH EADGYDYTVS PYAITPPPAA
     GELPGQEPAE AQQYQPWVPG EDGQPSPGVD TQIFEDPREF LSHLEEYLRQ VGGSEEYWLS
     QIQNHMNGPA KKWWEFKQGS VKNWVEFKKE FLQYSEGTLS REAIQRELDL PQKQGEPLDQ
     FLWRKRDLYQ TLYVDADEEE IIQYVVGTLQ PKLKRFLRHP LPKTLEQLIQ RGMEVQDDLE
     QAAEPAGPHL PVEDEAETLT PAPNSESVAS DRTQPE
//