Reviewed, UniProtKB/Swiss-Prot Q7LC44 (ARC_HUMAN)

Names and origin

Protein names

Recommended name:
    Activity-regulated cytoskeleton-associated protein
Alternative name(s):
    Activity-regulated gene 3.1 protein homolog
      Short name=Arg3.1
    ARC/ARG3.1

Gene names

Name:	ARC
Synonyms:	KIAA0278

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	396 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors By similarity.
Subunit structure	Interacts with SH3GL1/endophilin-2, SH3GL3/endophilin-3 and DNM2/DYN2 By similarity.
Subcellular location	Cytoplasm › cytoskeletonBy similarity. EndosomeBy similarity. AcrosomeBy similarity. Cell junction › synapse › postsynaptic cell membrane › postsynaptic densityBy similarity. Cell projection › dendriteBy similarity. Cell projection › dendritic spineBy similarity. Cell junction › synapseBy similarity. Note= Associated with the cell cortex of neuronal soma and dendrites. Enriched in postsynaptic density of dendritic spines. Associated with the sperm tail By similarity.
Sequence similarities	Belongs to the ARC/ARG3.1 family.

Ontologies

Keywords
Biological process	Endocytosis
Cellular component	Cell junction Cell membrane Cell projection Cytoplasm Cytoskeleton Endosome Membrane Postsynaptic cell membrane Synapse
Domain	Coiled coil
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	endocytosis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	acrosome Inferred from electronic annotation. Source: UniProtKB-SubCell cell junction Inferred from electronic annotation. Source: UniProtKB-KW cell projection Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Inferred from electronic annotation. Source: UniProtKB-KW endosome Inferred from electronic annotation. Source: UniProtKB-KW postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 396	396	Activity-regulated cytoskeleton-associated protein		PRO_0000273285
Regions
	Region	89 – 100	12	Binds SH3GL1 or SH3GL3 By similarity
	Region	195 – 214	20	Required for binding DNM2 By similarity
	Coiled coil	54 – 78	25	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q7LC44-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: D5C8A8A07FE9615D	FASTA	396	45,316
	10 20 30 40 50 60 MELDHRTSGG LHAYPGPRGG QVAKPNVILQ IGKCRAEMLE HVRRTHRHLL AEVSKQVERE 70 80 90 100 110 120 LKGLHRSVGK LESNLDGYVP TSDSQRWKKS IKACLCRCQE TIANLERWVK REMHVWREVF 130 140 150 160 170 180 YRLERWADRL ESTGGKYPVG SESARHTVSV GVGGPESYCH EADGYDYTVS PYAITPPPAA 190 200 210 220 230 240 GELPGQEPAE AQQYQPWVPG EDGQPSPGVD TQIFEDPREF LSHLEEYLRQ VGGSEEYWLS 250 260 270 280 290 300 QIQNHMNGPA KKWWEFKQGS VKNWVEFKKE FLQYSEGTLS REAIQRELDL PQKQGEPLDQ 310 320 330 340 350 360 FLWRKRDLYQ TLYVDADEEE IIQYVVGTLQ PKLKRFLRHP LPKTLEQLIQ RGMEVQDDLE 370 380 390 QAAEPAGPHL PVEDEAETLT PAPNSESVAS DRTQPE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Mutation screening of the chromosome 8q24.3-human activity-regulated cytoskeleton-associated gene (ARC) in idiopathic generalized epilepsy." Haug K., Kremerskothen J., Hallmann K., Sander T., Dullinger J., Rau B., Beyenburg S., Lentze M.J., Barnekow A., Elger C.E., Propping P., Heils A. Mol. Cell. Probes 14:255-260(2000) [PubMed: 10970730] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Tissue: Forebrain.
[2]	"Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain." Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N. DNA Res. 3:321-329(1996) [PubMed: 9039502] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Uterus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF193421 mRNA. Translation: AAF07185.1. AF248637 Genomic DNA. Translation: AAG33705.1. D87468 mRNA. Translation: BAA19667.1. Different initiation. BC012321 mRNA. Translation: AAH12321.1. BC075802 mRNA. Translation: AAH75802.1.
RefSeq	NP_056008.1.
UniGene	Hs.40888
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q7LC44.
Genome annotation databases
Ensembl	ENSG00000198576. Homo sapiens. [Contig view]
GeneID	23237.
KEGG	hsa:23237.
Organism-specific databases
HGNC	HGNC:648. ARC.
HPA	CAB009347.
PharmGKB	PA24930.
HUGE	Search...
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q7LC44.
Gene expression databases
ArrayExpress	Q7LC44.
CleanEx	HS_ARC.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	44888.

Entry information

Entry name

ARC_HUMAN

Accession

Primary (citable) accession number: Q7LC44
Secondary accession number(s): Q9UJW6, Q9Y469

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	July 5, 2004
Last modified:	November 4, 2008
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)