Q7LC44 (ARC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Activity-regulated cytoskeleton-associated protein

Alternative name(s):
ARC/ARG3.1
Activity-regulated gene 3.1 protein homolog
Short name=Arg3.1

Gene names

Name:	ARC
Synonyms:	KIAA0278

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	396 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors By similarity. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. Ref.4 UniProtKB Q9WV31 UniProtKB Q63053
Subunit structure	Interacts with SH3GL1/endophilin-2, SH3GL3/endophilin-3 and DNM2/DYN2 By similarity. UniProtKB Q63053
Subcellular location	Cytoplasm › cytoskeleton By similarity. Endosome By similarity. Cytoplasmic vesicle › secretory vesicle › acrosome By similarity. Cell junction › synapse › postsynaptic cell membrane › postsynaptic density By similarity. Cell projection › dendrite By similarity. Cell projection › dendritic spine By similarity. Cell junction › synapse By similarity. Note: Associated with the cell cortex of neuronal soma and dendrites. Enriched in postsynaptic density of dendritic spines. Associated with the sperm tail By similarity. Enriched on the plasma membrane. Ref.4
Sequence similarities	Belongs to the ARC/ARG3.1 family.
Sequence caution	The sequence BAA19667.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Endocytosis
Cellular component	Cell junction Cell membrane Cell projection Cytoplasm Cytoplasmic vesicle Cytoskeleton Endosome Membrane Postsynaptic cell membrane Synapse
Domain	Coiled coil
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell migration Inferred from mutant phenotype Ref.4. Source: UniProtKB cytoskeleton organization Inferred from mutant phenotype Ref.4. Source: UniProtKB endocytosis Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell morphogenesis Inferred from mutant phenotype Ref.4. Source: UniProtKB
Cellular component	acrosomal vesicle Inferred from electronic annotation. Source: UniProtKB-SubCell cell junction Inferred from electronic annotation. Source: UniProtKB-KW endosome Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from direct assay Ref.4. Source: UniProtKB postsynaptic density Inferred from electronic annotation. Source: UniProtKB-SubCell postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 396	396	Activity-regulated cytoskeleton-associated protein		PRO_0000273285
Regions
	Region	89 – 100	12	Binds SH3GL1 or SH3GL3 By similarity UniProtKB Q63053
	Region	195 – 214	20	Required for binding DNM2 By similarity UniProtKB Q63053
	Coiled coil	54 – 78	25	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q7LC44 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: D5C8A8A07FE9615D	FASTA	396	45,316
	10 20 30 40 50 60 MELDHRTSGG LHAYPGPRGG QVAKPNVILQ IGKCRAEMLE HVRRTHRHLL AEVSKQVERE 70 80 90 100 110 120 LKGLHRSVGK LESNLDGYVP TSDSQRWKKS IKACLCRCQE TIANLERWVK REMHVWREVF 130 140 150 160 170 180 YRLERWADRL ESTGGKYPVG SESARHTVSV GVGGPESYCH EADGYDYTVS PYAITPPPAA 190 200 210 220 230 240 GELPGQEPAE AQQYQPWVPG EDGQPSPGVD TQIFEDPREF LSHLEEYLRQ VGGSEEYWLS 250 260 270 280 290 300 QIQNHMNGPA KKWWEFKQGS VKNWVEFKKE FLQYSEGTLS REAIQRELDL PQKQGEPLDQ 310 320 330 340 350 360 FLWRKRDLYQ TLYVDADEEE IIQYVVGTLQ PKLKRFLRHP LPKTLEQLIQ RGMEVQDDLE 370 380 390 QAAEPAGPHL PVEDEAETLT PAPNSESVAS DRTQPE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Mutation screening of the chromosome 8q24.3-human activity-regulated cytoskeleton-associated gene (ARC) in idiopathic generalized epilepsy." Haug K., Kremerskothen J., Hallmann K., Sander T., Dullinger J., Rau B., Beyenburg S., Lentze M.J., Barnekow A., Elger C.E., Propping P., Heils A. Mol. Cell. Probes 14:255-260(2000) [PubMed: 10970730] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Tissue: Forebrain.
[2]	"Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain." Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N. DNA Res. 3:321-329(1996) [PubMed: 9039502] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Uterus.
[4]	"Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration." Bai S.W., Herrera-Abreu M.T., Rohn J.L., Racine V., Tajadura V., Suryavanshi N., Bechtel S., Wiemann S., Baum B., Ridley A.J. BMC Biol. 9:54-54(2011) [PubMed: 21834987] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF193421 mRNA. Translation: AAF07185.1. AF248637 Genomic DNA. Translation: AAG33705.1. D87468 mRNA. Translation: BAA19667.1. Different initiation. BC012321 mRNA. Translation: AAH12321.1. BC075802 mRNA. Translation: AAH75802.1.
IPI	IPI00000357.
RefSeq	NP_056008.1. NM_015193.3.
UniGene	Hs.40888.
3D structure databases
ProteinModelPortal	Q7LC44.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q7LC44. 1 interaction.
MINT	MINT-1440982.
STRING	Q7LC44.
Polymorphism databases
DMDM	74738627.
Proteomic databases
PRIDE	Q7LC44.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000356613; ENSP00000349022; ENSG00000198576.
GeneID	23237.
KEGG	hsa:23237.
UCSC	uc003ywn.1. human.
Organism-specific databases
CTD	23237.
GeneCards	GC08M143690.
H-InvDB	HIX0022720.
HGNC	HGNC:648. ARC.
HPA	CAB009347.
MIM	612461. gene.
neXtProt	NX_Q7LC44.
PharmGKB	PA24930.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG11715.
GeneTree	ENSGT00390000003914.
HOGENOM	HBG269748.
HOVERGEN	HBG080862.
InParanoid	Q7LC44.
OMA	RCQETIA.
OrthoDB	EOG49S66B.
PhylomeDB	Q7LC44.
Gene expression databases
ArrayExpress	Q7LC44.
Bgee	Q7LC44.
CleanEx	HS_ARC.
Genevestigator	Q7LC44.
Family and domain databases
InterPro	IPR023263. Activity-reg_cytoskelet-assoc. [Graphical view]
PRINTS	PR02027. ARCARG31.
ProtoNet	Search...
Other
NextBio	44888.
SOURCE	Search...

Entry information

Entry name

ARC_HUMAN

Accession

Primary (citable) accession number: Q7LC44
Secondary accession number(s): Q9UJW6, Q9Y469

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.