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Protein

Activity-regulated cytoskeleton-associated protein

Gene

ARC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration.By similarity1 Publication

GO - Biological processi

  • anterior/posterior pattern specification Source: Ensembl
  • cell migration Source: UniProtKB
  • cytoskeleton organization Source: UniProtKB
  • endocytosis Source: UniProtKB-KW
  • endoderm development Source: Ensembl
  • learning Source: Ensembl
  • positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Source: Ensembl
  • regulation of cell morphogenesis Source: UniProtKB
  • regulation of neuronal synaptic plasticity Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Activity-regulated cytoskeleton-associated protein
Alternative name(s):
ARC/ARG3.1
Activity-regulated gene 3.1 protein homolog
Short name:
Arg3.1
Gene namesi
Name:ARCImported
Synonyms:KIAA0278Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:648. ARC.

Subcellular locationi

GO - Cellular componenti

  • acrosomal vesicle Source: UniProtKB-SubCell
  • actin cytoskeleton Source: Ensembl
  • cell junction Source: UniProtKB-KW
  • cytoplasm Source: UniProtKB
  • dendritic spine Source: UniProtKB-SubCell
  • endosome Source: UniProtKB-SubCell
  • plasma membrane Source: UniProtKB
  • postsynaptic density Source: UniProtKB-SubCell
  • postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endosome, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

MalaCardsiARC.
PharmGKBiPA24930.

Polymorphism and mutation databases

DMDMi74738627.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396Activity-regulated cytoskeleton-associated proteinPRO_0000273285Add
BLAST

Proteomic databases

PaxDbiQ7LC44.
PRIDEiQ7LC44.

PTM databases

iPTMnetiQ7LC44.
PhosphoSiteiQ7LC44.

Expressioni

Gene expression databases

BgeeiQ7LC44.
CleanExiHS_ARC.
GenevisibleiQ7LC44. HS.

Organism-specific databases

HPAiCAB009347.

Interactioni

Subunit structurei

Interacts with SH3GL1/endophilin-2, SH3GL3/endophilin-3 and DNM2/DYN2.By similarity

Protein-protein interaction databases

BioGridi116842. 7 interactions.
DIPiDIP-60107N.
IntActiQ7LC44. 1 interaction.
MINTiMINT-1440982.
STRINGi9606.ENSP00000349022.

Structurei

3D structure databases

ProteinModelPortaliQ7LC44.
SMRiQ7LC44. Positions 207-361.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni89 – 10012Binds SH3GL1 or SH3GL3By similarityAdd
BLAST
Regioni195 – 21420Required for binding DNM2By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili54 – 7825Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the ARC/ARG3.1 family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IIAZ. Eukaryota.
ENOG410YF34. LUCA.
GeneTreeiENSGT00390000003914.
HOGENOMiHOG000034037.
HOVERGENiHBG080862.
InParanoidiQ7LC44.
KOiK15867.
OMAiRCQETIA.
OrthoDBiEOG75B855.
PhylomeDBiQ7LC44.
TreeFamiTF335604.

Family and domain databases

InterProiIPR023263. Activity-reg_cytoskelet-assoc.
[Graphical view]
PANTHERiPTHR15962. PTHR15962. 1 hit.
PRINTSiPR02027. ARCARG31.

Sequencei

Sequence statusi: Complete.

Q7LC44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELDHRTSGG LHAYPGPRGG QVAKPNVILQ IGKCRAEMLE HVRRTHRHLL
60 70 80 90 100
AEVSKQVERE LKGLHRSVGK LESNLDGYVP TSDSQRWKKS IKACLCRCQE
110 120 130 140 150
TIANLERWVK REMHVWREVF YRLERWADRL ESTGGKYPVG SESARHTVSV
160 170 180 190 200
GVGGPESYCH EADGYDYTVS PYAITPPPAA GELPGQEPAE AQQYQPWVPG
210 220 230 240 250
EDGQPSPGVD TQIFEDPREF LSHLEEYLRQ VGGSEEYWLS QIQNHMNGPA
260 270 280 290 300
KKWWEFKQGS VKNWVEFKKE FLQYSEGTLS REAIQRELDL PQKQGEPLDQ
310 320 330 340 350
FLWRKRDLYQ TLYVDADEEE IIQYVVGTLQ PKLKRFLRHP LPKTLEQLIQ
360 370 380 390
RGMEVQDDLE QAAEPAGPHL PVEDEAETLT PAPNSESVAS DRTQPE
Length:396
Mass (Da):45,316
Last modified:July 5, 2004 - v1
Checksum:iD5C8A8A07FE9615D
GO

Sequence cautioni

The sequence BAA19667.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF193421 mRNA. Translation: AAF07185.1.
AF248637 Genomic DNA. Translation: AAG33705.1.
D87468 mRNA. Translation: BAA19667.1. Different initiation.
BC012321 mRNA. Translation: AAH12321.1.
BC075802 mRNA. Translation: AAH75802.1.
CCDSiCCDS34950.1.
RefSeqiNP_056008.1. NM_015193.4.
UniGeneiHs.40888.
Hs.743662.

Genome annotation databases

EnsembliENST00000356613; ENSP00000349022; ENSG00000198576.
GeneIDi23237.
KEGGihsa:23237.
UCSCiuc003ywn.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF193421 mRNA. Translation: AAF07185.1.
AF248637 Genomic DNA. Translation: AAG33705.1.
D87468 mRNA. Translation: BAA19667.1. Different initiation.
BC012321 mRNA. Translation: AAH12321.1.
BC075802 mRNA. Translation: AAH75802.1.
CCDSiCCDS34950.1.
RefSeqiNP_056008.1. NM_015193.4.
UniGeneiHs.40888.
Hs.743662.

3D structure databases

ProteinModelPortaliQ7LC44.
SMRiQ7LC44. Positions 207-361.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116842. 7 interactions.
DIPiDIP-60107N.
IntActiQ7LC44. 1 interaction.
MINTiMINT-1440982.
STRINGi9606.ENSP00000349022.

PTM databases

iPTMnetiQ7LC44.
PhosphoSiteiQ7LC44.

Polymorphism and mutation databases

DMDMi74738627.

Proteomic databases

PaxDbiQ7LC44.
PRIDEiQ7LC44.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356613; ENSP00000349022; ENSG00000198576.
GeneIDi23237.
KEGGihsa:23237.
UCSCiuc003ywn.2. human.

Organism-specific databases

CTDi23237.
GeneCardsiARC.
HGNCiHGNC:648. ARC.
HPAiCAB009347.
MalaCardsiARC.
MIMi612461. gene.
neXtProtiNX_Q7LC44.
PharmGKBiPA24930.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIAZ. Eukaryota.
ENOG410YF34. LUCA.
GeneTreeiENSGT00390000003914.
HOGENOMiHOG000034037.
HOVERGENiHBG080862.
InParanoidiQ7LC44.
KOiK15867.
OMAiRCQETIA.
OrthoDBiEOG75B855.
PhylomeDBiQ7LC44.
TreeFamiTF335604.

Miscellaneous databases

GenomeRNAii23237.
PROiQ7LC44.
SOURCEiSearch...

Gene expression databases

BgeeiQ7LC44.
CleanExiHS_ARC.
GenevisibleiQ7LC44. HS.

Family and domain databases

InterProiIPR023263. Activity-reg_cytoskelet-assoc.
[Graphical view]
PANTHERiPTHR15962. PTHR15962. 1 hit.
PRINTSiPR02027. ARCARG31.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mutation screening of the chromosome 8q24.3-human activity-regulated cytoskeleton-associated gene (ARC) in idiopathic generalized epilepsy."
    Haug K., Kremerskothen J., Hallmann K., Sander T., Dullinger J., Rau B., Beyenburg S., Lentze M.J., Barnekow A., Elger C.E., Propping P., Heils A.
    Mol. Cell. Probes 14:255-260(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: ForebrainImported.
  2. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
    Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
    DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported and UterusImported.
  4. "Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration."
    Bai S.W., Herrera-Abreu M.T., Rohn J.L., Racine V., Tajadura V., Suryavanshi N., Bechtel S., Wiemann S., Baum B., Ridley A.J.
    BMC Biol. 9:54-54(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiARC_HUMAN
AccessioniPrimary (citable) accession number: Q7LC44
Secondary accession number(s): Q9UJW6, Q9Y469
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.