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Protein

Solute carrier family 26 member 9

Gene

SLC26A9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Mediates chloride/bicarbonate exchange or chloride-independent bicarbonate extrusion thus assuring bicarbonate secretion. Inhibited by ammonium and thiosulfate.2 Publications

GO - Molecular functioni

GO - Biological processi

  • anion transport Source: UniProtKB
  • bicarbonate transport Source: UniProtKB
  • chloride transport Source: UniProtKB
  • ion transport Source: Reactome
  • positive regulation of gene expression Source: UniProtKB
  • regulation of intracellular pH Source: GO_Central
  • regulation of membrane potential Source: GO_Central
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-427601. Multifunctional anion exchangers.

Protein family/group databases

TCDBi2.A.53.2.15. the sulfate permease (sulp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 26 member 9
Alternative name(s):
Anion transporter/exchanger protein 9
Gene namesi
Name:SLC26A9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:14469. SLC26A9.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
Transmembranei92 – 112HelicalSequence analysisAdd BLAST21
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Transmembranei249 – 269HelicalSequence analysisAdd BLAST21
Transmembranei280 – 300HelicalSequence analysisAdd BLAST21
Transmembranei332 – 352HelicalSequence analysisAdd BLAST21
Transmembranei377 – 397HelicalSequence analysisAdd BLAST21
Transmembranei406 – 426HelicalSequence analysisAdd BLAST21
Transmembranei474 – 494HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • apical plasma membrane Source: UniProtKB
  • cell surface Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi115019.
OpenTargetsiENSG00000174502.
PharmGKBiPA37886.

Polymorphism and mutation databases

BioMutaiSLC26A9.
DMDMi74749908.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003244921 – 791Solute carrier family 26 member 9Add BLAST791

Proteomic databases

PaxDbiQ7LBE3.
PeptideAtlasiQ7LBE3.
PRIDEiQ7LBE3.

PTM databases

iPTMnetiQ7LBE3.
PhosphoSitePlusiQ7LBE3.

Expressioni

Tissue specificityi

Predominantly expressed in lung at the luminal side of the bronchiolar and alveolar epithelium of lung. To a lower extent, also expressed in pancreas and prostate.1 Publication

Gene expression databases

BgeeiENSG00000174502.
CleanExiHS_SLC26A9.
GenevisibleiQ7LBE3. HS.

Organism-specific databases

HPAiHPA051485.

Interactioni

GO - Molecular functioni

  • ATPase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi125409. 1 interactor.
STRINGi9606.ENSP00000341682.

Structurei

3D structure databases

ProteinModelPortaliQ7LBE3.
SMRiQ7LBE3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini519 – 737STASPROSITE-ProRule annotationAdd BLAST219

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi290 – 293Poly-Val4

Sequence similaritiesi

Contains 1 STAS domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0236. Eukaryota.
COG0659. LUCA.
GeneTreeiENSGT00760000119026.
HOGENOMiHOG000006546.
HOVERGENiHBG000639.
InParanoidiQ7LBE3.
KOiK14706.
OMAiFMQFGFV.
OrthoDBiEOG091G07RT.
PhylomeDBiQ7LBE3.
TreeFamiTF313784.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiIPR011547. SLC26A/SulP_dom.
IPR001902. SLC26A/SulP_fam.
IPR030306. SLC26A9.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 2 hits.
PTHR11814:SF17. PTHR11814:SF17. 2 hits.
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
TIGRFAMsiTIGR00815. sulP. 1 hit.
PROSITEiPS50801. STAS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7LBE3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSQPRPRYVV DRAAYSLTLF DDEFEKKDRT YPVGEKLRNA FRCSSAKIKA
60 70 80 90 100
VVFGLLPVLS WLPKYKIKDY IIPDLLGGLS GGSIQVPQGM AFALLANLPA
110 120 130 140 150
VNGLYSSFFP LLTYFFLGGV HQMVPGTFAV ISILVGNICL QLAPESKFQV
160 170 180 190 200
FNNATNESYV DTAAMEAERL HVSATLACLT AIIQMGLGFM QFGFVAIYLS
210 220 230 240 250
ESFIRGFMTA AGLQILISVL KYIFGLTIPS YTGPGSIVFT FIDICKNLPH
260 270 280 290 300
TNIASLIFAL ISGAFLVLVK ELNARYMHKI RFPIPTEMIV VVVATAISGG
310 320 330 340 350
CKMPKKYHMQ IVGEIQRGFP TPVSPVVSQW KDMIGTAFSL AIVSYVINLA
360 370 380 390 400
MGRTLANKHG YDVDSNQEMI ALGCSNFFGS FFKIHVICCA LSVTLAVDGA
410 420 430 440 450
GGKSQVASLC VSLVVMITML VLGIYLYPLP KSVLGALIAV NLKNSLKQLT
460 470 480 490 500
DPYYLWRKSK LDCCIWVVSF LSSFFLSLPY GVAVGVAFSV LVVVFQTQFR
510 520 530 540 550
NGYALAQVMD TDIYVNPKTY NRAQDIQGIK IITYCSPLYF ANSEIFRQKV
560 570 580 590 600
IAKTGMDPQK VLLAKQKYLK KQEKRRMRPT QQRRSLFMKT KTVSLQELQQ
610 620 630 640 650
DFENAPPTDP NNNQTPANGT SVSYITFSPD SSSPAQSEPP ASAEAPGEPS
660 670 680 690 700
DMLASVPPFV TFHTLILDMS GVSFVDLMGI KALAKLSSTY GKIGVKVFLV
710 720 730 740 750
NIHAQVYNDI SHGGVFEDGS LECKHVFPSI HDAVLFAQAN ARDVTPGHNF
760 770 780 790
QGAPGDAELS LYDSEEDIRS YWDLEQEMFG SMFHAETLTA L
Length:791
Mass (Da):86,988
Last modified:July 5, 2004 - v1
Checksum:iDC651F4E8DF2BF77
GO
Isoform 2 (identifier: Q7LBE3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     791-791: L → LESLSAAGGC...VSDGVRLSRT

Show »
Length:887
Mass (Da):97,288
Checksum:iFF83D3F708A6AD62
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64K → N in AAI51209 (PubMed:15489334).Curated1
Isoform 2 (identifier: Q7LBE3-2)
Sequence conflicti804R → G in AAL26867 (Ref. 2) Curated1
Sequence conflicti804R → G in EAW91587 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06868370Y → N Displays higher channel activity and enhanced chloride-bicarbonate ion exchange. 1 PublicationCorresponds to variant rs75021701dbSNPEnsembl.1
Natural variantiVAR_068684127T → N Results in smaller halide currents but not for thiocynate ion. 1 PublicationCorresponds to variant rs77497889dbSNPEnsembl.1
Natural variantiVAR_068685384I → T.1 PublicationCorresponds to variant rs112659452dbSNPEnsembl.1
Natural variantiVAR_068686575R → W.1 PublicationCorresponds to variant rs139697920dbSNPEnsembl.1
Natural variantiVAR_068687606P → L.1 PublicationCorresponds to variant rs74146719dbSNPEnsembl.1
Natural variantiVAR_068688622V → L Decreased plasma membrane expression which partially accounts for decreased whole cell currents; transport is reduced to about 50%. 1 PublicationCorresponds to variant rs34992672dbSNPEnsembl.1
Natural variantiVAR_039801744V → M Decreased plasma membrane expression which partially accounts for decreased whole cell currents. 1 PublicationCorresponds to variant rs3811428dbSNPEnsembl.1
Natural variantiVAR_039802748H → R.1 PublicationCorresponds to variant rs16856462dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054056791L → LESLSAAGGCYPYRSESLVS PLFTRQALAAMDKPPAHSTP PTSALSLAAEGHLDFQLLRV SQKQKDKYNCAGLLYKLQKV SQSPHGSVSDGVRLSRT in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF331525 mRNA. Translation: AAK95667.1.
AF314958 mRNA. Translation: AAL26867.1.
AL713965 Genomic DNA. Translation: CAI22384.1.
CH471067 Genomic DNA. Translation: EAW91587.1.
CH471067 Genomic DNA. Translation: EAW91588.1.
BC136538 mRNA. Translation: AAI36539.1.
BC151208 mRNA. Translation: AAI51209.1.
CCDSiCCDS30989.1. [Q7LBE3-2]
CCDS30990.1. [Q7LBE3-1]
RefSeqiNP_443166.1. NM_052934.3. [Q7LBE3-1]
NP_599152.2. NM_134325.2. [Q7LBE3-2]
UniGeneiHs.164073.

Genome annotation databases

EnsembliENST00000340781; ENSP00000341682; ENSG00000174502. [Q7LBE3-2]
ENST00000367134; ENSP00000356102; ENSG00000174502. [Q7LBE3-2]
ENST00000367135; ENSP00000356103; ENSG00000174502. [Q7LBE3-1]
GeneIDi115019.
KEGGihsa:115019.
UCSCiuc001hdp.5. human. [Q7LBE3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF331525 mRNA. Translation: AAK95667.1.
AF314958 mRNA. Translation: AAL26867.1.
AL713965 Genomic DNA. Translation: CAI22384.1.
CH471067 Genomic DNA. Translation: EAW91587.1.
CH471067 Genomic DNA. Translation: EAW91588.1.
BC136538 mRNA. Translation: AAI36539.1.
BC151208 mRNA. Translation: AAI51209.1.
CCDSiCCDS30989.1. [Q7LBE3-2]
CCDS30990.1. [Q7LBE3-1]
RefSeqiNP_443166.1. NM_052934.3. [Q7LBE3-1]
NP_599152.2. NM_134325.2. [Q7LBE3-2]
UniGeneiHs.164073.

3D structure databases

ProteinModelPortaliQ7LBE3.
SMRiQ7LBE3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125409. 1 interactor.
STRINGi9606.ENSP00000341682.

Protein family/group databases

TCDBi2.A.53.2.15. the sulfate permease (sulp) family.

PTM databases

iPTMnetiQ7LBE3.
PhosphoSitePlusiQ7LBE3.

Polymorphism and mutation databases

BioMutaiSLC26A9.
DMDMi74749908.

Proteomic databases

PaxDbiQ7LBE3.
PeptideAtlasiQ7LBE3.
PRIDEiQ7LBE3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340781; ENSP00000341682; ENSG00000174502. [Q7LBE3-2]
ENST00000367134; ENSP00000356102; ENSG00000174502. [Q7LBE3-2]
ENST00000367135; ENSP00000356103; ENSG00000174502. [Q7LBE3-1]
GeneIDi115019.
KEGGihsa:115019.
UCSCiuc001hdp.5. human. [Q7LBE3-1]

Organism-specific databases

CTDi115019.
DisGeNETi115019.
GeneCardsiSLC26A9.
HGNCiHGNC:14469. SLC26A9.
HPAiHPA051485.
MIMi608481. gene.
neXtProtiNX_Q7LBE3.
OpenTargetsiENSG00000174502.
PharmGKBiPA37886.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0236. Eukaryota.
COG0659. LUCA.
GeneTreeiENSGT00760000119026.
HOGENOMiHOG000006546.
HOVERGENiHBG000639.
InParanoidiQ7LBE3.
KOiK14706.
OMAiFMQFGFV.
OrthoDBiEOG091G07RT.
PhylomeDBiQ7LBE3.
TreeFamiTF313784.

Enzyme and pathway databases

ReactomeiR-HSA-427601. Multifunctional anion exchangers.

Miscellaneous databases

GenomeRNAii115019.
PROiQ7LBE3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000174502.
CleanExiHS_SLC26A9.
GenevisibleiQ7LBE3. HS.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiIPR011547. SLC26A/SulP_dom.
IPR001902. SLC26A/SulP_fam.
IPR030306. SLC26A9.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 2 hits.
PTHR11814:SF17. PTHR11814:SF17. 2 hits.
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
TIGRFAMsiTIGR00815. sulP. 1 hit.
PROSITEiPS50801. STAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS26A9_HUMAN
AccessioniPrimary (citable) accession number: Q7LBE3
Secondary accession number(s): A7E2V6
, B1AVM8, B1AVM9, B7ZKK2, Q96PK9, Q96RN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.