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Protein

Solute carrier family 26 member 9

Gene

SLC26A9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Mediates chloride/bicarbonate exchange or chloride-independent bicarbonate extrusion thus assuring bicarbonate secretion. Inhibited by ammonium and thiosulfate.2 Publications

GO - Molecular functioni

GO - Biological processi

  • anion transmembrane transport Source: GOC
  • anion transport Source: UniProtKB
  • bicarbonate transport Source: UniProtKB
  • chloride transmembrane transport Source: GOC
  • chloride transport Source: UniProtKB
  • ion transport Source: Reactome
  • oxalate transport Source: GOC
  • positive regulation of gene expression Source: UniProtKB
  • regulation of intracellular pH Source: GO_Central
  • regulation of membrane potential Source: GO_Central
  • sulfate transmembrane transport Source: GOC
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-427601. Multifunctional anion exchangers.

Protein family/group databases

TCDBi2.A.53.2.15. the sulfate permease (sulp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 26 member 9
Alternative name(s):
Anion transporter/exchanger protein 9
Gene namesi
Name:SLC26A9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:14469. SLC26A9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei43 – 6321HelicalSequence analysisAdd
BLAST
Transmembranei71 – 9121HelicalSequence analysisAdd
BLAST
Transmembranei92 – 11221HelicalSequence analysisAdd
BLAST
Transmembranei115 – 13521HelicalSequence analysisAdd
BLAST
Transmembranei179 – 19921HelicalSequence analysisAdd
BLAST
Transmembranei200 – 22021HelicalSequence analysisAdd
BLAST
Transmembranei222 – 24221HelicalSequence analysisAdd
BLAST
Transmembranei249 – 26921HelicalSequence analysisAdd
BLAST
Transmembranei280 – 30021HelicalSequence analysisAdd
BLAST
Transmembranei332 – 35221HelicalSequence analysisAdd
BLAST
Transmembranei377 – 39721HelicalSequence analysisAdd
BLAST
Transmembranei406 – 42621HelicalSequence analysisAdd
BLAST
Transmembranei474 – 49421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • apical plasma membrane Source: UniProtKB
  • cell surface Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37886.

Polymorphism and mutation databases

BioMutaiSLC26A9.
DMDMi74749908.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 791791Solute carrier family 26 member 9PRO_0000324492Add
BLAST

Proteomic databases

PaxDbiQ7LBE3.
PRIDEiQ7LBE3.

PTM databases

iPTMnetiQ7LBE3.
PhosphoSiteiQ7LBE3.

Expressioni

Tissue specificityi

Predominantly expressed in lung at the luminal side of the bronchiolar and alveolar epithelium of lung. To a lower extent, also expressed in pancreas and prostate.1 Publication

Gene expression databases

BgeeiQ7LBE3.
CleanExiHS_SLC26A9.
GenevisibleiQ7LBE3. HS.

Organism-specific databases

HPAiHPA051485.

Interactioni

GO - Molecular functioni

  • ATPase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi125409. 1 interaction.
STRINGi9606.ENSP00000341682.

Structurei

3D structure databases

ProteinModelPortaliQ7LBE3.
SMRiQ7LBE3. Positions 650-738.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini519 – 737219STASPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi290 – 2934Poly-Val

Sequence similaritiesi

Contains 1 STAS domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0236. Eukaryota.
COG0659. LUCA.
GeneTreeiENSGT00760000119026.
HOGENOMiHOG000006546.
HOVERGENiHBG000639.
InParanoidiQ7LBE3.
KOiK14706.
OMAiMQFGFVA.
OrthoDBiEOG76T9QT.
PhylomeDBiQ7LBE3.
TreeFamiTF313784.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiIPR011547. SLC26A/SulP_dom.
IPR001902. SLC26A/SulP_fam.
IPR030306. SLC26A9.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 2 hits.
PTHR11814:SF17. PTHR11814:SF17. 2 hits.
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
TIGRFAMsiTIGR00815. sulP. 1 hit.
PROSITEiPS50801. STAS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7LBE3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSQPRPRYVV DRAAYSLTLF DDEFEKKDRT YPVGEKLRNA FRCSSAKIKA
60 70 80 90 100
VVFGLLPVLS WLPKYKIKDY IIPDLLGGLS GGSIQVPQGM AFALLANLPA
110 120 130 140 150
VNGLYSSFFP LLTYFFLGGV HQMVPGTFAV ISILVGNICL QLAPESKFQV
160 170 180 190 200
FNNATNESYV DTAAMEAERL HVSATLACLT AIIQMGLGFM QFGFVAIYLS
210 220 230 240 250
ESFIRGFMTA AGLQILISVL KYIFGLTIPS YTGPGSIVFT FIDICKNLPH
260 270 280 290 300
TNIASLIFAL ISGAFLVLVK ELNARYMHKI RFPIPTEMIV VVVATAISGG
310 320 330 340 350
CKMPKKYHMQ IVGEIQRGFP TPVSPVVSQW KDMIGTAFSL AIVSYVINLA
360 370 380 390 400
MGRTLANKHG YDVDSNQEMI ALGCSNFFGS FFKIHVICCA LSVTLAVDGA
410 420 430 440 450
GGKSQVASLC VSLVVMITML VLGIYLYPLP KSVLGALIAV NLKNSLKQLT
460 470 480 490 500
DPYYLWRKSK LDCCIWVVSF LSSFFLSLPY GVAVGVAFSV LVVVFQTQFR
510 520 530 540 550
NGYALAQVMD TDIYVNPKTY NRAQDIQGIK IITYCSPLYF ANSEIFRQKV
560 570 580 590 600
IAKTGMDPQK VLLAKQKYLK KQEKRRMRPT QQRRSLFMKT KTVSLQELQQ
610 620 630 640 650
DFENAPPTDP NNNQTPANGT SVSYITFSPD SSSPAQSEPP ASAEAPGEPS
660 670 680 690 700
DMLASVPPFV TFHTLILDMS GVSFVDLMGI KALAKLSSTY GKIGVKVFLV
710 720 730 740 750
NIHAQVYNDI SHGGVFEDGS LECKHVFPSI HDAVLFAQAN ARDVTPGHNF
760 770 780 790
QGAPGDAELS LYDSEEDIRS YWDLEQEMFG SMFHAETLTA L
Length:791
Mass (Da):86,988
Last modified:July 5, 2004 - v1
Checksum:iDC651F4E8DF2BF77
GO
Isoform 2 (identifier: Q7LBE3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     791-791: L → LESLSAAGGC...VSDGVRLSRT

Show »
Length:887
Mass (Da):97,288
Checksum:iFF83D3F708A6AD62
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti64 – 641K → N in AAI51209 (PubMed:15489334).Curated
Isoform 2 (identifier: Q7LBE3-2)
Sequence conflicti804 – 8041R → G in AAL26867 (Ref. 2) Curated
Sequence conflicti804 – 8041R → G in EAW91587 (Ref. 4) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti70 – 701Y → N Displays higher channel activity and enhanced chloride-bicarbonate ion exchange. 1 Publication
Corresponds to variant rs75021701 [ dbSNP | Ensembl ].
VAR_068683
Natural varianti127 – 1271T → N Results in smaller halide currents but not for thiocynate ion. 1 Publication
Corresponds to variant rs77497889 [ dbSNP | Ensembl ].
VAR_068684
Natural varianti384 – 3841I → T.1 Publication
Corresponds to variant rs112659452 [ dbSNP | Ensembl ].
VAR_068685
Natural varianti575 – 5751R → W.1 Publication
Corresponds to variant rs139697920 [ dbSNP | Ensembl ].
VAR_068686
Natural varianti606 – 6061P → L.1 Publication
Corresponds to variant rs74146719 [ dbSNP | Ensembl ].
VAR_068687
Natural varianti622 – 6221V → L Decreased plasma membrane expression which partially accounts for decreased whole cell currents; transport is reduced to about 50%. 1 Publication
Corresponds to variant rs34992672 [ dbSNP | Ensembl ].
VAR_068688
Natural varianti744 – 7441V → M Decreased plasma membrane expression which partially accounts for decreased whole cell currents. 1 Publication
Corresponds to variant rs3811428 [ dbSNP | Ensembl ].
VAR_039801
Natural varianti748 – 7481H → R.1 Publication
Corresponds to variant rs16856462 [ dbSNP | Ensembl ].
VAR_039802

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei791 – 7911L → LESLSAAGGCYPYRSESLVS PLFTRQALAAMDKPPAHSTP PTSALSLAAEGHLDFQLLRV SQKQKDKYNCAGLLYKLQKV SQSPHGSVSDGVRLSRT in isoform 2. 1 PublicationVSP_054056

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF331525 mRNA. Translation: AAK95667.1.
AF314958 mRNA. Translation: AAL26867.1.
AL713965 Genomic DNA. Translation: CAI22384.1.
CH471067 Genomic DNA. Translation: EAW91587.1.
CH471067 Genomic DNA. Translation: EAW91588.1.
BC136538 mRNA. Translation: AAI36539.1.
BC151208 mRNA. Translation: AAI51209.1.
CCDSiCCDS30989.1. [Q7LBE3-2]
CCDS30990.1. [Q7LBE3-1]
RefSeqiNP_443166.1. NM_052934.3. [Q7LBE3-1]
NP_599152.2. NM_134325.2. [Q7LBE3-2]
UniGeneiHs.164073.

Genome annotation databases

EnsembliENST00000340781; ENSP00000341682; ENSG00000174502. [Q7LBE3-2]
ENST00000367134; ENSP00000356102; ENSG00000174502. [Q7LBE3-2]
ENST00000367135; ENSP00000356103; ENSG00000174502. [Q7LBE3-1]
GeneIDi115019.
KEGGihsa:115019.
UCSCiuc001hdp.5. human. [Q7LBE3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF331525 mRNA. Translation: AAK95667.1.
AF314958 mRNA. Translation: AAL26867.1.
AL713965 Genomic DNA. Translation: CAI22384.1.
CH471067 Genomic DNA. Translation: EAW91587.1.
CH471067 Genomic DNA. Translation: EAW91588.1.
BC136538 mRNA. Translation: AAI36539.1.
BC151208 mRNA. Translation: AAI51209.1.
CCDSiCCDS30989.1. [Q7LBE3-2]
CCDS30990.1. [Q7LBE3-1]
RefSeqiNP_443166.1. NM_052934.3. [Q7LBE3-1]
NP_599152.2. NM_134325.2. [Q7LBE3-2]
UniGeneiHs.164073.

3D structure databases

ProteinModelPortaliQ7LBE3.
SMRiQ7LBE3. Positions 650-738.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125409. 1 interaction.
STRINGi9606.ENSP00000341682.

Protein family/group databases

TCDBi2.A.53.2.15. the sulfate permease (sulp) family.

PTM databases

iPTMnetiQ7LBE3.
PhosphoSiteiQ7LBE3.

Polymorphism and mutation databases

BioMutaiSLC26A9.
DMDMi74749908.

Proteomic databases

PaxDbiQ7LBE3.
PRIDEiQ7LBE3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340781; ENSP00000341682; ENSG00000174502. [Q7LBE3-2]
ENST00000367134; ENSP00000356102; ENSG00000174502. [Q7LBE3-2]
ENST00000367135; ENSP00000356103; ENSG00000174502. [Q7LBE3-1]
GeneIDi115019.
KEGGihsa:115019.
UCSCiuc001hdp.5. human. [Q7LBE3-1]

Organism-specific databases

CTDi115019.
GeneCardsiSLC26A9.
HGNCiHGNC:14469. SLC26A9.
HPAiHPA051485.
MIMi608481. gene.
neXtProtiNX_Q7LBE3.
PharmGKBiPA37886.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0236. Eukaryota.
COG0659. LUCA.
GeneTreeiENSGT00760000119026.
HOGENOMiHOG000006546.
HOVERGENiHBG000639.
InParanoidiQ7LBE3.
KOiK14706.
OMAiMQFGFVA.
OrthoDBiEOG76T9QT.
PhylomeDBiQ7LBE3.
TreeFamiTF313784.

Enzyme and pathway databases

ReactomeiR-HSA-427601. Multifunctional anion exchangers.

Miscellaneous databases

GenomeRNAii115019.
PROiQ7LBE3.
SOURCEiSearch...

Gene expression databases

BgeeiQ7LBE3.
CleanExiHS_SLC26A9.
GenevisibleiQ7LBE3. HS.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiIPR011547. SLC26A/SulP_dom.
IPR001902. SLC26A/SulP_fam.
IPR030306. SLC26A9.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 2 hits.
PTHR11814:SF17. PTHR11814:SF17. 2 hits.
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
TIGRFAMsiTIGR00815. sulP. 1 hit.
PROSITEiPS50801. STAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9."
    Lohi H., Kujala M., Maekelae S., Lehtonen E., Kestilae M., Saarialho-Kere U., Markovich D., Kere J.
    J. Biol. Chem. 277:14246-14254(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, FUNCTION.
  2. "Cloning of human SLC26A9, a new member of the sulphate transporter gene family of anion transporter/exchangers."
    Mount D.B.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  6. "SLC26A9 is expressed in gastric surface epithelial cells, mediates Cl-/HCO3- exchange, and is inhibited by NH4+."
    Xu J., Henriksnas J., Barone S., Witte D., Shull G.E., Forte J.G., Holm L., Soleimani M.
    Am. J. Physiol. 289:C493-C505(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Functional analysis of nonsynonymous single nucleotide polymorphisms in human SLC26A9."
    Chen A.P., Chang M.H., Romero M.F.
    Hum. Mutat. 33:1275-1284(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS ASN-70; ASN-127; THR-384; TRP-575; LEU-606; LEU-622; MET-744 AND ARG-748, CHARACTERIZATION OF VARIANTS ASN-70; ASN-127; LEU-622 AND MET-744.

Entry informationi

Entry nameiS26A9_HUMAN
AccessioniPrimary (citable) accession number: Q7LBE3
Secondary accession number(s): A7E2V6
, B1AVM8, B1AVM9, B7ZKK2, Q96PK9, Q96RN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.