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Q7LBC6

- KDM3B_HUMAN

UniProt

Q7LBC6 - KDM3B_HUMAN

Protein

Lysine-specific demethylase 3B

Gene

KDM3B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 2 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity.1 Publication

    Cofactori

    Binds 1 Fe2+ ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi1560 – 15601Iron; catalyticPROSITE-ProRule annotation
    Metal bindingi1562 – 15621Iron; catalyticPROSITE-ProRule annotation
    Metal bindingi1689 – 16891Iron; catalyticPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri1031 – 105626C6-typeSequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. dioxygenase activity Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. chromatin modification Source: UniProtKB-KW
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Dioxygenase, Oxidoreductase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Iron, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysine-specific demethylase 3B (EC:1.14.11.-)
    Alternative name(s):
    JmjC domain-containing histone demethylation protein 2B
    Jumonji domain-containing protein 1B
    Nuclear protein 5qNCA
    Gene namesi
    Name:KDM3B
    Synonyms:C5orf7, JHDM2B, JMJD1B, KIAA1082
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:1337. KDM3B.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25918.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 17611760Lysine-specific demethylase 3BPRO_0000234373Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine2 Publications
    Modified residuei361 – 3611N6-acetyllysine1 Publication
    Modified residuei773 – 7731Phosphoserine2 Publications
    Modified residuei779 – 7791Phosphoserine2 Publications
    Modified residuei798 – 7981Phosphoserine2 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ7LBC6.
    PaxDbiQ7LBC6.
    PRIDEiQ7LBC6.

    PTM databases

    PhosphoSiteiQ7LBC6.

    Expressioni

    Tissue specificityi

    Ubiquitous. Highly expressed in placenta, skeletal muscle, kidney, heart and liver.2 Publications

    Gene expression databases

    ArrayExpressiQ7LBC6.
    BgeeiQ7LBC6.
    CleanExiHS_JMJD1B.
    GenevestigatoriQ7LBC6.

    Organism-specific databases

    HPAiHPA016610.

    Interactioni

    Protein-protein interaction databases

    BioGridi119727. 14 interactions.
    IntActiQ7LBC6. 3 interactions.
    MINTiMINT-1195273.
    STRINGi9606.ENSP00000326563.

    Structurei

    Secondary structure

    1
    1761
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi1382 – 13854
    Turni1386 – 13894
    Beta strandi1390 – 13945
    Helixi1401 – 141010
    Beta strandi1415 – 14173
    Helixi1420 – 14234
    Helixi1426 – 14294
    Helixi1431 – 14388
    Beta strandi1441 – 14477
    Turni1448 – 14503
    Beta strandi1453 – 14586
    Helixi1459 – 14646
    Turni1465 – 14673
    Helixi1469 – 14713
    Beta strandi1483 – 14853
    Helixi1493 – 14975
    Helixi1499 – 150810
    Helixi1512 – 15154
    Turni1524 – 15263
    Beta strandi1539 – 15435
    Helixi1550 – 15534
    Beta strandi1556 – 15605
    Beta strandi1563 – 157412
    Beta strandi1577 – 15793
    Helixi1583 – 159210
    Helixi1597 – 16048
    Beta strandi1610 – 16167
    Helixi1619 – 16213
    Helixi1622 – 163413
    Helixi1646 – 16494
    Helixi1656 – 166611
    Beta strandi1671 – 16766
    Beta strandi1680 – 16834
    Beta strandi1689 – 170416
    Helixi1707 – 17093
    Helixi1710 – 171910

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4C8DX-ray2.18A1380-1720[»]
    ProteinModelPortaliQ7LBC6.
    SMRiQ7LBC6. Positions 1380-1720.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1498 – 1721224JmjCPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1293 – 12975LXXLL motif

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi647 – 74498Ser-richAdd
    BLAST

    Domaini

    Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.By similarity

    Sequence similaritiesi

    Belongs to the JHDM2 histone demethylase family.Curated
    Contains 1 JmjC domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri1031 – 105626C6-typeSequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG305537.
    InParanoidiQ7LBC6.
    KOiK15601.
    OMAiIICKRLR.
    PhylomeDBiQ7LBC6.
    TreeFamiTF324723.

    Family and domain databases

    InterProiIPR003347. JmjC_dom.
    [Graphical view]
    PfamiPF02373. JmjC. 1 hit.
    [Graphical view]
    SMARTiSM00558. JmjC. 1 hit.
    [Graphical view]
    PROSITEiPS51184. JMJC. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q7LBC6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MADAAASPVG KRLLLLFADT AASASASAPA AAAASGDPGP ALRTRAWRAG     50
    TVRAMSGAVP QDLAIFVEFD GCNWKQHSWV KVHAEEVIVL LLEGSLVWAP 100
    REDPVLLQGI RVSIAQWPAL TFTPLVDKLG LGSVVPVEYL LDRELRFLSD 150
    ANGLHLFQMG TDSQNQILLE HAALRETVNA LISDQKLQEI FSRGPYSVQG 200
    HRVKIYQPEG EEGWLYGVVS HQDSITRLME VSVTESGEIK SVDPRLIHVM 250
    LMDNSAPQSE GGTLKAVKSS KGKKKRESIE GKDGRRRKSA SDSGCDPASK 300
    KLKGDRGEVD SNGSDGGEAS RGPWKGGNAS GEPGLDQRAK QPPSTFVPQI 350
    NRNIRFATYT KENGRTLVVQ DEPVGGDTPA SFTPYSTATG QTPLAPEVGG 400
    AENKEAGKTL EQVGQGIVAS AAVVTTASST PNTVRISDTG LAAGTVPEKQ 450
    KGSRSQASGE NSRNSILASS GFGAPLPSSS QPLTFGSGRS QSNGVLATEN 500
    KPLGFSFGCS SAQEAQKDTD LSKNLFFQCM SQTLPTSNYF TTVSESLADD 550
    SSSRDSFKQS LESLSSGLCK GRSVLGTDTK PGSKAGSSVD RKVPAESMPT 600
    LTPAFPRSLL NARTPENHEN LFLQPPKLSR EEPSNPFLAF VEKVEHSPFS 650
    SFASQASGSS SSATTVTSKV APSWPESHSS ADSASLAKKK PLFITTDSSK 700
    LVSGVLGSAL TSGGPSLSAM GNGRSSSPTS SLTQPIEMPT LSSSPTEERP 750
    TVGPGQQDNP LLKTFSNVFG RHSGGFLSSP ADFSQENKAP FEAVKRFSLD 800
    ERSLACRQDS DSSTNSDLSD LSDSEEQLQA KTGLKGIPEH LMGKLGPNGE 850
    RSAELLLGKS KGKQAPKGRP RTAPLKVGQS VLKDVSKVKK LKQSGEPFLQ 900
    DGSCINVAPH LHKCRECRLE RYRKFKEQEQ DDSTVACRFF HFRRLIFTRK 950
    GVLRVEGFLS PQQSDPDAMN LWIPSSSLAE GIDLETSKYI LANVGDQFCQ 1000
    LVMSEKEAMM MVEPHQKVAW KRAVRGVREM CDVCETTLFN IHWVCRKCGF 1050
    GVCLDCYRLR KSRPRSETEE MGDEEVFSWL KCAKGQSHEP ENLMPTQIIP 1100
    GTALYNIGDM VHAARGKWGI KANCPCISRQ NKSVLRPAVT NGMSQLPSIN 1150
    PSASSGNETT FSGGGGPAPV TTPEPDHVPK ADSTDIRSEE PLKTDSSASN 1200
    SNSELKAIRP PCPDTAPPSS ALHWLADLAT QKAKEETKEA GSLRSVLNKE 1250
    SHSPFGLDSF NSTAKVSPLT PKLFNSLLLG PTASNNKTEG SSLRDLLHSG 1300
    PGKLPQTPLD TGIPFPPVFS TSSAGVKSKA SLPNFLDHII ASVVENKKTS 1350
    DASKRACNLT DTQKEVKEMV MGLNVLDPHT SHSWLCDGRL LCLHDPSNKN 1400
    NWKIFRECWK QGQPVLVSGV HKKLKSELWK PEAFSQEFGD QDVDLVNCRN 1450
    CAIISDVKVR DFWDGFEIIC KRLRSEDGQP MVLKLKDWPP GEDFRDMMPT 1500
    RFEDLMENLP LPEYTKRDGR LNLASRLPSY FVRPDLGPKM YNAYGLITAE 1550
    DRRVGTTNLH LDVSDAVNVM VYVGIPIGEG AHDEEVLKTI DEGDADEVTK 1600
    QRIHDGKEKP GALWHIYAAK DAEKIRELLR KVGEEQGQEN PPDHDPIHDQ 1650
    SWYLDQTLRK RLYEEYGVQG WAIVQFLGDA VFIPAGAPHQ VHNLYSCIKV 1700
    AEDFVSPEHV KHCFRLTQEF RHLSNTHTNH EDKLQVKNII YHAVKDAVGT 1750
    LKAHESKLAR S 1761
    Length:1,761
    Mass (Da):191,581
    Last modified:October 5, 2010 - v2
    Checksum:iFB900FCBF0675CD8
    GO
    Isoform 2 (identifier: Q7LBC6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-344: Missing.
         345-349: TFVPQ → MGAME

    Show »
    Length:1,417
    Mass (Da):154,668
    Checksum:iAF66C2E416D31F40
    GO
    Isoform 3 (identifier: Q7LBC6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1002: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:759
    Mass (Da):84,712
    Checksum:i5A13F19C0EE952EF
    GO

    Sequence cautioni

    The sequence BAA83034.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti569 – 5691C → R in AAF63765. (PubMed:11087669)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti256 – 2561A → T.4 Publications
    Corresponds to variant rs6865472 [ dbSNP | Ensembl ].
    VAR_026221
    Natural varianti1201 – 12011S → N.
    Corresponds to variant rs7706614 [ dbSNP | Ensembl ].
    VAR_026222

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 10021002Missing in isoform 3. 1 PublicationVSP_018298Add
    BLAST
    Alternative sequencei1 – 344344Missing in isoform 2. 1 PublicationVSP_018299Add
    BLAST
    Alternative sequencei345 – 3495TFVPQ → MGAME in isoform 2. 1 PublicationVSP_018300

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF251039 mRNA. Translation: AAF63765.1.
    AF338242 mRNA. Translation: AAK13499.1.
    AB029005 mRNA. Translation: BAA83034.2. Different initiation.
    AC104116 Genomic DNA. No translation available.
    AC113403 Genomic DNA. No translation available.
    CH471062 Genomic DNA. Translation: EAW62141.1.
    BC000539 mRNA. Translation: AAH00539.2.
    BC001202 mRNA. Translation: AAH01202.1.
    BC146788 mRNA. Translation: AAI46789.1.
    CCDSiCCDS34242.1. [Q7LBC6-1]
    RefSeqiNP_057688.2. NM_016604.3.
    UniGeneiHs.483486.

    Genome annotation databases

    EnsembliENST00000314358; ENSP00000326563; ENSG00000120733. [Q7LBC6-1]
    GeneIDi51780.
    KEGGihsa:51780.
    UCSCiuc003lcy.1. human. [Q7LBC6-1]
    uc010jew.1. human. [Q7LBC6-2]

    Polymorphism databases

    DMDMi308153456.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF251039 mRNA. Translation: AAF63765.1 .
    AF338242 mRNA. Translation: AAK13499.1 .
    AB029005 mRNA. Translation: BAA83034.2 . Different initiation.
    AC104116 Genomic DNA. No translation available.
    AC113403 Genomic DNA. No translation available.
    CH471062 Genomic DNA. Translation: EAW62141.1 .
    BC000539 mRNA. Translation: AAH00539.2 .
    BC001202 mRNA. Translation: AAH01202.1 .
    BC146788 mRNA. Translation: AAI46789.1 .
    CCDSi CCDS34242.1. [Q7LBC6-1 ]
    RefSeqi NP_057688.2. NM_016604.3.
    UniGenei Hs.483486.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4C8D X-ray 2.18 A 1380-1720 [» ]
    ProteinModelPortali Q7LBC6.
    SMRi Q7LBC6. Positions 1380-1720.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119727. 14 interactions.
    IntActi Q7LBC6. 3 interactions.
    MINTi MINT-1195273.
    STRINGi 9606.ENSP00000326563.

    PTM databases

    PhosphoSitei Q7LBC6.

    Polymorphism databases

    DMDMi 308153456.

    Proteomic databases

    MaxQBi Q7LBC6.
    PaxDbi Q7LBC6.
    PRIDEi Q7LBC6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000314358 ; ENSP00000326563 ; ENSG00000120733 . [Q7LBC6-1 ]
    GeneIDi 51780.
    KEGGi hsa:51780.
    UCSCi uc003lcy.1. human. [Q7LBC6-1 ]
    uc010jew.1. human. [Q7LBC6-2 ]

    Organism-specific databases

    CTDi 51780.
    GeneCardsi GC05P137688.
    HGNCi HGNC:1337. KDM3B.
    HPAi HPA016610.
    MIMi 609373. gene.
    neXtProti NX_Q7LBC6.
    PharmGKBi PA25918.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG305537.
    InParanoidi Q7LBC6.
    KOi K15601.
    OMAi IICKRLR.
    PhylomeDBi Q7LBC6.
    TreeFami TF324723.

    Miscellaneous databases

    GeneWikii JMJD1B.
    GenomeRNAii 51780.
    NextBioi 55912.
    PROi Q7LBC6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7LBC6.
    Bgeei Q7LBC6.
    CleanExi HS_JMJD1B.
    Genevestigatori Q7LBC6.

    Family and domain databases

    InterProi IPR003347. JmjC_dom.
    [Graphical view ]
    Pfami PF02373. JmjC. 1 hit.
    [Graphical view ]
    SMARTi SM00558. JmjC. 1 hit.
    [Graphical view ]
    PROSITEi PS51184. JMJC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning and genomic structure of three genes localized to human chromosome band 5q31 encoding potential nuclear proteins."
      Lai F., Godley L.A., Fernald A.A., Orelli B.J., Pamintuan L., Zhao N., Le Beau M.M.
      Genomics 70:123-130(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
      Tissue: Bone marrow.
    2. "A novel nuclear protein, 5qNCA (LOC51780) is a candidate for the myeloid leukemia tumor suppressor gene on chromosome 5 band q31."
      Hu Z., Gomes I., Horrigan S.K., Kravarusic J., Mar B., Arbieva Z., Chyna B., Fulton N., Edassery S., Raza A., Westbrook C.A.
      Oncogene 20:6946-6954(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT THR-256.
    3. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-256.
      Tissue: Brain.
    4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    5. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT THR-256.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT THR-256.
      Tissue: Brain and Eye.
    8. "JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor."
      Yamane K., Toumazou C., Tsukada Y.I., Erdjument-Bromage H., Tempst P., Wong J., Zhang Y.
      Cell 125:483-495(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, ENZYME ACTIVITY.
    9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-798, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-773 AND SER-779, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    13. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-361, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-773; SER-779 AND SER-798, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiKDM3B_HUMAN
    AccessioniPrimary (citable) accession number: Q7LBC6
    Secondary accession number(s): A6H8X7
    , Q9BVH6, Q9BW93, Q9BZ52, Q9NYF4, Q9UPS0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2006
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 92 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Its gene is located in the 5q region of the genome which is deleted in del(5q) interstitial deletion, a frequent deletion found in myeloid leukemias and myelodysplasias, suggesting that it may be a good candidate for the del(5q) tumor suppressor gene.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3