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Q7LBC6

- KDM3B_HUMAN

UniProt

Q7LBC6 - KDM3B_HUMAN

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Protein

Lysine-specific demethylase 3B

Gene

KDM3B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity.1 Publication

Cofactori

Binds 1 Fe2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi1560 – 15601Iron; catalyticPROSITE-ProRule annotation
Metal bindingi1562 – 15621Iron; catalyticPROSITE-ProRule annotation
Metal bindingi1689 – 16891Iron; catalyticPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1031 – 105626C6-typeSequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. dioxygenase activity Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. chromatin modification Source: UniProtKB-KW
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Dioxygenase, Oxidoreductase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Iron, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine-specific demethylase 3B (EC:1.14.11.-)
Alternative name(s):
JmjC domain-containing histone demethylation protein 2B
Jumonji domain-containing protein 1B
Nuclear protein 5qNCA
Gene namesi
Name:KDM3B
Synonyms:C5orf7, JHDM2B, JMJD1B, KIAA1082
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:1337. KDM3B.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25918.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 17611760Lysine-specific demethylase 3BPRO_0000234373Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine2 Publications
Modified residuei361 – 3611N6-acetyllysine1 Publication
Modified residuei773 – 7731Phosphoserine2 Publications
Modified residuei779 – 7791Phosphoserine2 Publications
Modified residuei798 – 7981Phosphoserine2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ7LBC6.
PaxDbiQ7LBC6.
PRIDEiQ7LBC6.

PTM databases

PhosphoSiteiQ7LBC6.

Expressioni

Tissue specificityi

Ubiquitous. Highly expressed in placenta, skeletal muscle, kidney, heart and liver.2 Publications

Gene expression databases

BgeeiQ7LBC6.
CleanExiHS_JMJD1B.
ExpressionAtlasiQ7LBC6. baseline and differential.
GenevestigatoriQ7LBC6.

Organism-specific databases

HPAiHPA016610.

Interactioni

Protein-protein interaction databases

BioGridi119727. 16 interactions.
IntActiQ7LBC6. 3 interactions.
MINTiMINT-1195273.
STRINGi9606.ENSP00000326563.

Structurei

Secondary structure

1
1761
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1382 – 13854
Turni1386 – 13894
Beta strandi1390 – 13945
Helixi1401 – 141010
Beta strandi1415 – 14173
Helixi1420 – 14234
Helixi1426 – 14294
Helixi1431 – 14388
Beta strandi1441 – 14477
Turni1448 – 14503
Beta strandi1453 – 14586
Helixi1459 – 14646
Turni1465 – 14673
Helixi1469 – 14713
Beta strandi1483 – 14853
Helixi1493 – 14975
Helixi1499 – 150810
Helixi1512 – 15154
Turni1524 – 15263
Beta strandi1539 – 15435
Helixi1550 – 15534
Beta strandi1556 – 15605
Beta strandi1563 – 157412
Beta strandi1577 – 15793
Helixi1583 – 159210
Helixi1597 – 16048
Beta strandi1610 – 16167
Helixi1619 – 16213
Helixi1622 – 163413
Helixi1646 – 16494
Helixi1656 – 166611
Beta strandi1671 – 16766
Beta strandi1680 – 16834
Beta strandi1689 – 170416
Helixi1707 – 17093
Helixi1710 – 171910

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4C8DX-ray2.18A1380-1720[»]
ProteinModelPortaliQ7LBC6.
SMRiQ7LBC6. Positions 1380-1720.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1498 – 1721224JmjCPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1293 – 12975LXXLL motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi647 – 74498Ser-richAdd
BLAST

Domaini

Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.By similarity

Sequence similaritiesi

Belongs to the JHDM2 histone demethylase family.Curated
Contains 1 JmjC domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1031 – 105626C6-typeSequence AnalysisAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG305537.
GeneTreeiENSGT00530000063039.
InParanoidiQ7LBC6.
KOiK15601.
OMAiIICKRLR.
PhylomeDBiQ7LBC6.
TreeFamiTF324723.

Family and domain databases

InterProiIPR003347. JmjC_dom.
[Graphical view]
PfamiPF02373. JmjC. 1 hit.
[Graphical view]
SMARTiSM00558. JmjC. 1 hit.
[Graphical view]
PROSITEiPS51184. JMJC. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q7LBC6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADAAASPVG KRLLLLFADT AASASASAPA AAAASGDPGP ALRTRAWRAG
60 70 80 90 100
TVRAMSGAVP QDLAIFVEFD GCNWKQHSWV KVHAEEVIVL LLEGSLVWAP
110 120 130 140 150
REDPVLLQGI RVSIAQWPAL TFTPLVDKLG LGSVVPVEYL LDRELRFLSD
160 170 180 190 200
ANGLHLFQMG TDSQNQILLE HAALRETVNA LISDQKLQEI FSRGPYSVQG
210 220 230 240 250
HRVKIYQPEG EEGWLYGVVS HQDSITRLME VSVTESGEIK SVDPRLIHVM
260 270 280 290 300
LMDNSAPQSE GGTLKAVKSS KGKKKRESIE GKDGRRRKSA SDSGCDPASK
310 320 330 340 350
KLKGDRGEVD SNGSDGGEAS RGPWKGGNAS GEPGLDQRAK QPPSTFVPQI
360 370 380 390 400
NRNIRFATYT KENGRTLVVQ DEPVGGDTPA SFTPYSTATG QTPLAPEVGG
410 420 430 440 450
AENKEAGKTL EQVGQGIVAS AAVVTTASST PNTVRISDTG LAAGTVPEKQ
460 470 480 490 500
KGSRSQASGE NSRNSILASS GFGAPLPSSS QPLTFGSGRS QSNGVLATEN
510 520 530 540 550
KPLGFSFGCS SAQEAQKDTD LSKNLFFQCM SQTLPTSNYF TTVSESLADD
560 570 580 590 600
SSSRDSFKQS LESLSSGLCK GRSVLGTDTK PGSKAGSSVD RKVPAESMPT
610 620 630 640 650
LTPAFPRSLL NARTPENHEN LFLQPPKLSR EEPSNPFLAF VEKVEHSPFS
660 670 680 690 700
SFASQASGSS SSATTVTSKV APSWPESHSS ADSASLAKKK PLFITTDSSK
710 720 730 740 750
LVSGVLGSAL TSGGPSLSAM GNGRSSSPTS SLTQPIEMPT LSSSPTEERP
760 770 780 790 800
TVGPGQQDNP LLKTFSNVFG RHSGGFLSSP ADFSQENKAP FEAVKRFSLD
810 820 830 840 850
ERSLACRQDS DSSTNSDLSD LSDSEEQLQA KTGLKGIPEH LMGKLGPNGE
860 870 880 890 900
RSAELLLGKS KGKQAPKGRP RTAPLKVGQS VLKDVSKVKK LKQSGEPFLQ
910 920 930 940 950
DGSCINVAPH LHKCRECRLE RYRKFKEQEQ DDSTVACRFF HFRRLIFTRK
960 970 980 990 1000
GVLRVEGFLS PQQSDPDAMN LWIPSSSLAE GIDLETSKYI LANVGDQFCQ
1010 1020 1030 1040 1050
LVMSEKEAMM MVEPHQKVAW KRAVRGVREM CDVCETTLFN IHWVCRKCGF
1060 1070 1080 1090 1100
GVCLDCYRLR KSRPRSETEE MGDEEVFSWL KCAKGQSHEP ENLMPTQIIP
1110 1120 1130 1140 1150
GTALYNIGDM VHAARGKWGI KANCPCISRQ NKSVLRPAVT NGMSQLPSIN
1160 1170 1180 1190 1200
PSASSGNETT FSGGGGPAPV TTPEPDHVPK ADSTDIRSEE PLKTDSSASN
1210 1220 1230 1240 1250
SNSELKAIRP PCPDTAPPSS ALHWLADLAT QKAKEETKEA GSLRSVLNKE
1260 1270 1280 1290 1300
SHSPFGLDSF NSTAKVSPLT PKLFNSLLLG PTASNNKTEG SSLRDLLHSG
1310 1320 1330 1340 1350
PGKLPQTPLD TGIPFPPVFS TSSAGVKSKA SLPNFLDHII ASVVENKKTS
1360 1370 1380 1390 1400
DASKRACNLT DTQKEVKEMV MGLNVLDPHT SHSWLCDGRL LCLHDPSNKN
1410 1420 1430 1440 1450
NWKIFRECWK QGQPVLVSGV HKKLKSELWK PEAFSQEFGD QDVDLVNCRN
1460 1470 1480 1490 1500
CAIISDVKVR DFWDGFEIIC KRLRSEDGQP MVLKLKDWPP GEDFRDMMPT
1510 1520 1530 1540 1550
RFEDLMENLP LPEYTKRDGR LNLASRLPSY FVRPDLGPKM YNAYGLITAE
1560 1570 1580 1590 1600
DRRVGTTNLH LDVSDAVNVM VYVGIPIGEG AHDEEVLKTI DEGDADEVTK
1610 1620 1630 1640 1650
QRIHDGKEKP GALWHIYAAK DAEKIRELLR KVGEEQGQEN PPDHDPIHDQ
1660 1670 1680 1690 1700
SWYLDQTLRK RLYEEYGVQG WAIVQFLGDA VFIPAGAPHQ VHNLYSCIKV
1710 1720 1730 1740 1750
AEDFVSPEHV KHCFRLTQEF RHLSNTHTNH EDKLQVKNII YHAVKDAVGT
1760
LKAHESKLAR S
Length:1,761
Mass (Da):191,581
Last modified:October 5, 2010 - v2
Checksum:iFB900FCBF0675CD8
GO
Isoform 2 (identifier: Q7LBC6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-344: Missing.
     345-349: TFVPQ → MGAME

Show »
Length:1,417
Mass (Da):154,668
Checksum:iAF66C2E416D31F40
GO
Isoform 3 (identifier: Q7LBC6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1002: Missing.

Note: No experimental confirmation available.

Show »
Length:759
Mass (Da):84,712
Checksum:i5A13F19C0EE952EF
GO

Sequence cautioni

The sequence BAA83034.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti569 – 5691C → R in AAF63765. (PubMed:11087669)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti256 – 2561A → T.4 Publications
Corresponds to variant rs6865472 [ dbSNP | Ensembl ].
VAR_026221
Natural varianti1201 – 12011S → N.
Corresponds to variant rs7706614 [ dbSNP | Ensembl ].
VAR_026222

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 10021002Missing in isoform 3. 1 PublicationVSP_018298Add
BLAST
Alternative sequencei1 – 344344Missing in isoform 2. 1 PublicationVSP_018299Add
BLAST
Alternative sequencei345 – 3495TFVPQ → MGAME in isoform 2. 1 PublicationVSP_018300

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF251039 mRNA. Translation: AAF63765.1.
AF338242 mRNA. Translation: AAK13499.1.
AB029005 mRNA. Translation: BAA83034.2. Different initiation.
AC104116 Genomic DNA. No translation available.
AC113403 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW62141.1.
BC000539 mRNA. Translation: AAH00539.2.
BC001202 mRNA. Translation: AAH01202.1.
BC146788 mRNA. Translation: AAI46789.1.
CCDSiCCDS34242.1. [Q7LBC6-1]
RefSeqiNP_057688.2. NM_016604.3.
UniGeneiHs.483486.

Genome annotation databases

EnsembliENST00000314358; ENSP00000326563; ENSG00000120733. [Q7LBC6-1]
ENST00000542866; ENSP00000439462; ENSG00000120733. [Q7LBC6-3]
GeneIDi51780.
KEGGihsa:51780.
UCSCiuc003lcy.1. human. [Q7LBC6-1]
uc010jew.1. human. [Q7LBC6-2]

Polymorphism databases

DMDMi308153456.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF251039 mRNA. Translation: AAF63765.1 .
AF338242 mRNA. Translation: AAK13499.1 .
AB029005 mRNA. Translation: BAA83034.2 . Different initiation.
AC104116 Genomic DNA. No translation available.
AC113403 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW62141.1 .
BC000539 mRNA. Translation: AAH00539.2 .
BC001202 mRNA. Translation: AAH01202.1 .
BC146788 mRNA. Translation: AAI46789.1 .
CCDSi CCDS34242.1. [Q7LBC6-1 ]
RefSeqi NP_057688.2. NM_016604.3.
UniGenei Hs.483486.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4C8D X-ray 2.18 A 1380-1720 [» ]
ProteinModelPortali Q7LBC6.
SMRi Q7LBC6. Positions 1380-1720.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119727. 16 interactions.
IntActi Q7LBC6. 3 interactions.
MINTi MINT-1195273.
STRINGi 9606.ENSP00000326563.

PTM databases

PhosphoSitei Q7LBC6.

Polymorphism databases

DMDMi 308153456.

Proteomic databases

MaxQBi Q7LBC6.
PaxDbi Q7LBC6.
PRIDEi Q7LBC6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000314358 ; ENSP00000326563 ; ENSG00000120733 . [Q7LBC6-1 ]
ENST00000542866 ; ENSP00000439462 ; ENSG00000120733 . [Q7LBC6-3 ]
GeneIDi 51780.
KEGGi hsa:51780.
UCSCi uc003lcy.1. human. [Q7LBC6-1 ]
uc010jew.1. human. [Q7LBC6-2 ]

Organism-specific databases

CTDi 51780.
GeneCardsi GC05P137688.
HGNCi HGNC:1337. KDM3B.
HPAi HPA016610.
MIMi 609373. gene.
neXtProti NX_Q7LBC6.
PharmGKBi PA25918.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG305537.
GeneTreei ENSGT00530000063039.
InParanoidi Q7LBC6.
KOi K15601.
OMAi IICKRLR.
PhylomeDBi Q7LBC6.
TreeFami TF324723.

Miscellaneous databases

GeneWikii JMJD1B.
GenomeRNAii 51780.
NextBioi 55912.
PROi Q7LBC6.
SOURCEi Search...

Gene expression databases

Bgeei Q7LBC6.
CleanExi HS_JMJD1B.
ExpressionAtlasi Q7LBC6. baseline and differential.
Genevestigatori Q7LBC6.

Family and domain databases

InterProi IPR003347. JmjC_dom.
[Graphical view ]
Pfami PF02373. JmjC. 1 hit.
[Graphical view ]
SMARTi SM00558. JmjC. 1 hit.
[Graphical view ]
PROSITEi PS51184. JMJC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning and genomic structure of three genes localized to human chromosome band 5q31 encoding potential nuclear proteins."
    Lai F., Godley L.A., Fernald A.A., Orelli B.J., Pamintuan L., Zhao N., Le Beau M.M.
    Genomics 70:123-130(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
    Tissue: Bone marrow.
  2. "A novel nuclear protein, 5qNCA (LOC51780) is a candidate for the myeloid leukemia tumor suppressor gene on chromosome 5 band q31."
    Hu Z., Gomes I., Horrigan S.K., Kravarusic J., Mar B., Arbieva Z., Chyna B., Fulton N., Edassery S., Raza A., Westbrook C.A.
    Oncogene 20:6946-6954(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT THR-256.
  3. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-256.
    Tissue: Brain.
  4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  5. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT THR-256.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT THR-256.
    Tissue: Brain and Eye.
  8. "JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor."
    Yamane K., Toumazou C., Tsukada Y.I., Erdjument-Bromage H., Tempst P., Wong J., Zhang Y.
    Cell 125:483-495(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ENZYME ACTIVITY.
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-798, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-773 AND SER-779, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  13. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-361, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-773; SER-779 AND SER-798, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiKDM3B_HUMAN
AccessioniPrimary (citable) accession number: Q7LBC6
Secondary accession number(s): A6H8X7
, Q9BVH6, Q9BW93, Q9BZ52, Q9NYF4, Q9UPS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 5, 2010
Last modified: October 29, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Its gene is located in the 5q region of the genome which is deleted in del(5q) interstitial deletion, a frequent deletion found in myeloid leukemias and myelodysplasias, suggesting that it may be a good candidate for the del(5q) tumor suppressor gene.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3