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Q7L9L4 (MOB1B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
MOB kinase activator 1B
Alternative name(s):
Mob1 homolog 1A
Short name=Mob1A
Mob1B
Mps one binder kinase activator-like 1A
Gene names
Name:MOB1B
Synonyms:MOB4A, MOBKL1A
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length216 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L. Ref.5 Ref.7

Subunit structure

Binds STK38L. Interacts with LATS1 and LATS2. Ref.5 Ref.7

Subcellular location

Cytoplasm. Nucleus Ref.5.

Tissue specificity

Adrenal gland, bone marrow, brain, lung, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, uterus, colon with mucosa, fetal brain and fetal liver. Ref.7

Post-translational modification

Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1. Ref.6

Sequence similarities

Belongs to the MOB1/phocein family.

Binary interactions

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q7L9L4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q7L9L4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: MSFLF → MEGATDVNES

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.8
Chain2 – 216215MOB kinase activator 1B
PRO_0000193564

Sites

Metal binding791Zinc By similarity
Metal binding841Zinc By similarity
Metal binding1611Zinc By similarity
Metal binding1661Zinc By similarity

Amino acid modifications

Modified residue21N-acetylserine Ref.8
Modified residue121Phosphothreonine; by STK4/MST1 Ref.6
Modified residue351Phosphothreonine; by STK4/MST1 Ref.6
Modified residue741Phosphothreonine By similarity
Modified residue1811Phosphothreonine By similarity

Natural variations

Alternative sequence1 – 55MSFLF → MEGATDVNES in isoform 2.
VSP_045097

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 29EBA287B0CDAF90

FASTA21625,091
        10         20         30         40         50         60 
MSFLFGSRSS KTFKPKKNIP EGSHQYELLK HAEATLGSGN LRMAVMLPEG EDLNEWVAVN 

        70         80         90        100        110        120 
TVDFFNQINM LYGTITDFCT EESCPVMSAG PKYEYHWADG TNIKKPIKCS APKYIDYLMT 

       130        140        150        160        170        180 
WVQDQLDDET LFPSKIGVPF PKNFMSVAKT ILKRLFRVYA HIYHQHFDPV IQLQEEAHLN 

       190        200        210 
TSFKHFIFFV QEFNLIDRRE LAPLQELIEK LTSKDR 

« Hide

Isoform 2 [UniParc].

Checksum: 4DF1286311C0BC5F
Show »

FASTA22125,499

References

« Hide 'large scale' references
[1]"Characterization of the human Mob-1 like proteins."
Florindo C.S., Tavares A.A.
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[5]"Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases."
Devroe E., Erdjument-Bromage H., Tempst P., Silver P.A.
J. Biol. Chem. 279:24444-24451(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH STK38L, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
[6]"MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation."
Praskova M., Xia F., Avruch J.
Curr. Biol. 18:311-321(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT THR-12 AND THR-35.
[7]"Molecular characterization of human homologs of yeast MOB1."
Chow A., Hao Y., Yang X.
Int. J. Cancer 126:2079-2089(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH LATS1 AND LATS2, TISSUE SPECIFICITY.
[8]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ577473 mRNA. Translation: CAE12091.1.
AK299481 mRNA. Translation: BAG61445.1.
AK313513 mRNA. Translation: BAG36293.1.
AC021989 Genomic DNA. No translation available.
AC093851 Genomic DNA. No translation available.
AC108014 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX05636.1.
BC038112 mRNA. Translation: AAH38112.1.
RefSeqNP_001231695.1. NM_001244766.1.
NP_775739.1. NM_173468.3.
XP_005265766.1. XM_005265709.1.
UniGeneHs.691454.
Hs.744715.

3D structure databases

ProteinModelPortalQ7L9L4.
SMRQ7L9L4. Positions 33-216.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124960. 31 interactions.
IntActQ7L9L4. 31 interactions.
MINTMINT-5003307.
STRING9606.ENSP00000310189.

PTM databases

PhosphoSiteQ7L9L4.

Polymorphism databases

DMDM56749324.

Proteomic databases

PaxDbQ7L9L4.
PRIDEQ7L9L4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000309395; ENSP00000310189; ENSG00000173542. [Q7L9L4-1]
ENST00000396051; ENSP00000379366; ENSG00000173542. [Q7L9L4-2]
GeneID92597.
KEGGhsa:92597.
UCSCuc003hfw.3. human. [Q7L9L4-1]
uc011cba.2. human.

Organism-specific databases

CTD92597.
GeneCardsGC04P071769.
HGNCHGNC:29801. MOB1B.
HPAHPA047088.
MIM609282. gene.
neXtProtNX_Q7L9L4.
PharmGKBPA134871841.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG287143.
HOGENOMHOG000164685.
HOVERGENHBG052489.
InParanoidQ7L9L4.
KOK06685.
OMAYHQHFSE.
PhylomeDBQ7L9L4.
TreeFamTF300789.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressQ7L9L4.
BgeeQ7L9L4.
CleanExHS_MOBKL1A.
GenevestigatorQ7L9L4.

Family and domain databases

Gene3D1.20.140.30. 1 hit.
InterProIPR005301. Mob1_phocein.
[Graphical view]
PANTHERPTHR22599. PTHR22599. 1 hit.
PfamPF03637. Mob1_phocein. 1 hit.
[Graphical view]
SUPFAMSSF101152. SSF101152. 1 hit.
ProtoNetSearch...

Other

GeneWikiMOBKL1A.
GenomeRNAi92597.
NextBio77815.
PROQ7L9L4.
SOURCESearch...

Entry information

Entry nameMOB1B_HUMAN
AccessionPrimary (citable) accession number: Q7L9L4
Secondary accession number(s): B2R8U6, B4DRY3, Q8IY23
Entry history
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM