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Reviewed, UniProtKB/Swiss-Prot Q7L9L4 (MOL1A_HUMAN)

Last modified January 19, 2010. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Mps one binder kinase activator-like 1A
Alternative name(s):
    Mob1 homolog 1A
      Short name=Mob1A
    Mob1B
    Protein Mob4A
Gene names
Name: MOBKL1A
Synonyms: MOB4A
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length216 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Stimulates the kinase activity of STK38L. Ref.5

Subunit structure

Binds STK38L.

Subcellular location

Cytoplasm. Nucleus Ref.5.

Sequence similarities

Belongs to the MOB1/phocein family.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   LigandMetal-binding
Zinc
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processprotein amino acid autophosphorylation

Inferred from direct assay. Source: UniProtKB

   Cellular componentcytoplasm Ref.5

Inferred from direct assay. Source: UniProtKB

nucleus Ref.5

Inferred from direct assay. Source: UniProtKB

   Molecular functionkinase activator activity

Inferred from direct assay. Source: UniProtKB

kinase binding

Inferred from physical interaction. Source: UniProtKB

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 216215Mps one binder kinase activator-like 1A
PRO_0000193564

Sites

Metal binding791Zinc By similarity
Metal binding841Zinc By similarity
Metal binding1611Zinc By similarity
Metal binding1661Zinc By similarity

Amino acid modifications

Modified residue21N-acetylserine By similarity
Modified residue351Phosphothreonine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7L9L4-1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 29EBA287B0CDAF90

FASTA21625,091
        10         20         30         40         50         60 
MSFLFGSRSS KTFKPKKNIP EGSHQYELLK HAEATLGSGN LRMAVMLPEG EDLNEWVAVN 

        70         80         90        100        110        120 
TVDFFNQINM LYGTITDFCT EESCPVMSAG PKYEYHWADG TNIKKPIKCS APKYIDYLMT 

       130        140        150        160        170        180 
WVQDQLDDET LFPSKIGVPF PKNFMSVAKT ILKRLFRVYA HIYHQHFDPV IQLQEEAHLN 

       190        200        210 
TSFKHFIFFV QEFNLIDRRE LAPLQELIEK LTSKDR 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of the human Mob-1 like proteins."
Florindo C.S., Tavares A.A.
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[5]"Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases."
Devroe E., Erdjument-Bromage H., Tempst P., Silver P.A.
J. Biol. Chem. 279:24444-24451(2004) [PubMed: 15067004] [Abstract]
Cited for: FUNCTION, INTERACTION WITH STK38L, MASS SPECTROMETRY, SUBCELLULAR LOCATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ577473 mRNA. Translation: CAE12091.1.
AK313513 mRNA. Translation: BAG36293.1.
CH471057 Genomic DNA. Translation: EAX05636.1.
BC038112 mRNA. Translation: AAH38112.1.
IPIIPI00514212.
RefSeqNP_775739.1.
UniGeneHs.700445
Hs.719746

3D structure databases

SMRQ7L9L4. Positions 33-216.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ7L9L4.

PTM databases

PhosphoSiteQ7L9L4.

Proteomic databases

PRIDEQ7L9L4.

Genome annotation databases

EnsemblENST00000309395; ENSP00000310189; ENSG00000173542; Homo sapiens. [Genome view]
GeneID92597.
KEGGhsa:92597.
UCSCuc003hfw.1. human.

Organism-specific databases

CTD92597.
GeneCardsGC04P071986.
H-InvDBHIX0004271.
HGNCHGNC:29801. MOBKL1A.
MIM609282. gene.
PharmGKBPA134871841.
GenAtlasSearch...

Phylogenomic databases

HOVERGENQ7L9L4.
InParanoidQ7L9L4.
OrthoDBEOG9RZ1JW.
PhylomeDBQ7L9L4.

Gene expression databases

ArrayExpressQ7L9L4.
BgeeQ7L9L4.
CleanExHS_MOBKL1A.
GenevestigatorQ7L9L4.
GermOnlineENSG00000173542. Homo sapiens.

Family and domain databases

InterProIPR005301. Mob1_phocein.
[Graphical view]
Gene3DG3DSA:1.20.140.30. Mob1_phocein. 1 hit.
PANTHERPTHR22599. Mob1_phocein. 1 hit.
PfamPF03637. Mob1_phocein. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio77815.
SOURCESearch...

Entry information

Entry nameMOL1A_HUMAN
AccessionPrimary (citable) accession number: Q7L9L4
Secondary accession number(s): B2R8U6, Q8IY23
Entry history
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: January 23, 2007
Last modified: January 19, 2010
This is version 54 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents