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Q7L9L4

- MOB1B_HUMAN

UniProt

Q7L9L4 - MOB1B_HUMAN

Protein

MOB kinase activator 1B

Gene

MOB1B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.2 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi79 – 791ZincBy similarity
    Metal bindingi84 – 841ZincBy similarity
    Metal bindingi161 – 1611ZincBy similarity
    Metal bindingi166 – 1661ZincBy similarity

    GO - Molecular functioni

    1. kinase activator activity Source: UniProtKB
    2. kinase binding Source: UniProtKB
    3. metal ion binding Source: UniProtKB-KW
    4. protein binding Source: UniProtKB

    GO - Biological processi

    1. hippo signaling Source: UniProtKB
    2. positive regulation of phosphorylation Source: GOC
    3. protein autophosphorylation Source: UniProtKB

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_118607. Signaling by Hippo.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    MOB kinase activator 1B
    Alternative name(s):
    Mob1 homolog 1A
    Short name:
    Mob1A
    Mob1B
    Mps one binder kinase activator-like 1A
    Gene namesi
    Name:MOB1B
    Synonyms:MOB4A, MOBKL1A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:29801. MOB1B.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytosol Source: Reactome
    3. extracellular vesicular exosome Source: UniProt
    4. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134871841.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 216215MOB kinase activator 1BPRO_0000193564Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication
    Modified residuei12 – 121Phosphothreonine; by STK4/MST11 Publication
    Modified residuei35 – 351Phosphothreonine; by STK4/MST11 Publication
    Modified residuei74 – 741PhosphothreonineBy similarity
    Modified residuei181 – 1811PhosphothreonineBy similarity

    Post-translational modificationi

    Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1.1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ7L9L4.
    PaxDbiQ7L9L4.
    PRIDEiQ7L9L4.

    PTM databases

    PhosphoSiteiQ7L9L4.

    Expressioni

    Tissue specificityi

    Adrenal gland, bone marrow, brain, lung, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, uterus, colon with mucosa, fetal brain and fetal liver.1 Publication

    Gene expression databases

    ArrayExpressiQ7L9L4.
    BgeeiQ7L9L4.
    CleanExiHS_MOBKL1A.
    GenevestigatoriQ7L9L4.

    Organism-specific databases

    HPAiHPA047088.

    Interactioni

    Subunit structurei

    Binds STK38L. Interacts with LATS1 and LATS2.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    LATS1O958356EBI-2558745,EBI-444209
    LATS2Q9NRM73EBI-2558745,EBI-3506895
    STK4Q130434EBI-2558745,EBI-367376

    Protein-protein interaction databases

    BioGridi124960. 31 interactions.
    IntActiQ7L9L4. 31 interactions.
    MINTiMINT-5003307.
    STRINGi9606.ENSP00000310189.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7L9L4.
    SMRiQ7L9L4. Positions 33-216.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MOB1/phocein family.Curated

    Phylogenomic databases

    eggNOGiNOG287143.
    HOGENOMiHOG000164685.
    HOVERGENiHBG052489.
    InParanoidiQ7L9L4.
    KOiK06685.
    OMAiYHQHFSE.
    PhylomeDBiQ7L9L4.
    TreeFamiTF300789.

    Family and domain databases

    Gene3Di1.20.140.30. 1 hit.
    InterProiIPR005301. Mob1_phocein.
    [Graphical view]
    PANTHERiPTHR22599. PTHR22599. 1 hit.
    PfamiPF03637. Mob1_phocein. 1 hit.
    [Graphical view]
    SUPFAMiSSF101152. SSF101152. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q7L9L4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSFLFGSRSS KTFKPKKNIP EGSHQYELLK HAEATLGSGN LRMAVMLPEG    50
    EDLNEWVAVN TVDFFNQINM LYGTITDFCT EESCPVMSAG PKYEYHWADG 100
    TNIKKPIKCS APKYIDYLMT WVQDQLDDET LFPSKIGVPF PKNFMSVAKT 150
    ILKRLFRVYA HIYHQHFDPV IQLQEEAHLN TSFKHFIFFV QEFNLIDRRE 200
    LAPLQELIEK LTSKDR 216
    Length:216
    Mass (Da):25,091
    Last modified:January 23, 2007 - v3
    Checksum:i29EBA287B0CDAF90
    GO
    Isoform 2 (identifier: Q7L9L4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-5: MSFLF → MEGATDVNES

    Show »
    Length:221
    Mass (Da):25,499
    Checksum:i4DF1286311C0BC5F
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 55MSFLF → MEGATDVNES in isoform 2. 1 PublicationVSP_045097

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ577473 mRNA. Translation: CAE12091.1.
    AK299481 mRNA. Translation: BAG61445.1.
    AK313513 mRNA. Translation: BAG36293.1.
    AC021989 Genomic DNA. No translation available.
    AC093851 Genomic DNA. No translation available.
    AC108014 Genomic DNA. No translation available.
    CH471057 Genomic DNA. Translation: EAX05636.1.
    BC038112 mRNA. Translation: AAH38112.1.
    CCDSiCCDS34002.1. [Q7L9L4-1]
    CCDS58903.1. [Q7L9L4-2]
    RefSeqiNP_001231695.1. NM_001244766.1. [Q7L9L4-2]
    NP_775739.1. NM_173468.3. [Q7L9L4-1]
    XP_005265766.1. XM_005265709.1. [Q7L9L4-2]
    UniGeneiHs.691454.
    Hs.744715.

    Genome annotation databases

    EnsembliENST00000309395; ENSP00000310189; ENSG00000173542. [Q7L9L4-1]
    ENST00000396051; ENSP00000379366; ENSG00000173542. [Q7L9L4-2]
    GeneIDi92597.
    KEGGihsa:92597.
    UCSCiuc003hfw.3. human. [Q7L9L4-1]
    uc011cba.2. human.

    Polymorphism databases

    DMDMi56749324.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ577473 mRNA. Translation: CAE12091.1 .
    AK299481 mRNA. Translation: BAG61445.1 .
    AK313513 mRNA. Translation: BAG36293.1 .
    AC021989 Genomic DNA. No translation available.
    AC093851 Genomic DNA. No translation available.
    AC108014 Genomic DNA. No translation available.
    CH471057 Genomic DNA. Translation: EAX05636.1 .
    BC038112 mRNA. Translation: AAH38112.1 .
    CCDSi CCDS34002.1. [Q7L9L4-1 ]
    CCDS58903.1. [Q7L9L4-2 ]
    RefSeqi NP_001231695.1. NM_001244766.1. [Q7L9L4-2 ]
    NP_775739.1. NM_173468.3. [Q7L9L4-1 ]
    XP_005265766.1. XM_005265709.1. [Q7L9L4-2 ]
    UniGenei Hs.691454.
    Hs.744715.

    3D structure databases

    ProteinModelPortali Q7L9L4.
    SMRi Q7L9L4. Positions 33-216.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124960. 31 interactions.
    IntActi Q7L9L4. 31 interactions.
    MINTi MINT-5003307.
    STRINGi 9606.ENSP00000310189.

    PTM databases

    PhosphoSitei Q7L9L4.

    Polymorphism databases

    DMDMi 56749324.

    Proteomic databases

    MaxQBi Q7L9L4.
    PaxDbi Q7L9L4.
    PRIDEi Q7L9L4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000309395 ; ENSP00000310189 ; ENSG00000173542 . [Q7L9L4-1 ]
    ENST00000396051 ; ENSP00000379366 ; ENSG00000173542 . [Q7L9L4-2 ]
    GeneIDi 92597.
    KEGGi hsa:92597.
    UCSCi uc003hfw.3. human. [Q7L9L4-1 ]
    uc011cba.2. human.

    Organism-specific databases

    CTDi 92597.
    GeneCardsi GC04P071769.
    HGNCi HGNC:29801. MOB1B.
    HPAi HPA047088.
    MIMi 609282. gene.
    neXtProti NX_Q7L9L4.
    PharmGKBi PA134871841.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG287143.
    HOGENOMi HOG000164685.
    HOVERGENi HBG052489.
    InParanoidi Q7L9L4.
    KOi K06685.
    OMAi YHQHFSE.
    PhylomeDBi Q7L9L4.
    TreeFami TF300789.

    Enzyme and pathway databases

    Reactomei REACT_118607. Signaling by Hippo.

    Miscellaneous databases

    GeneWikii MOBKL1A.
    GenomeRNAii 92597.
    NextBioi 77815.
    PROi Q7L9L4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7L9L4.
    Bgeei Q7L9L4.
    CleanExi HS_MOBKL1A.
    Genevestigatori Q7L9L4.

    Family and domain databases

    Gene3Di 1.20.140.30. 1 hit.
    InterProi IPR005301. Mob1_phocein.
    [Graphical view ]
    PANTHERi PTHR22599. PTHR22599. 1 hit.
    Pfami PF03637. Mob1_phocein. 1 hit.
    [Graphical view ]
    SUPFAMi SSF101152. SSF101152. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the human Mob-1 like proteins."
      Florindo C.S., Tavares A.A.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    5. "Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases."
      Devroe E., Erdjument-Bromage H., Tempst P., Silver P.A.
      J. Biol. Chem. 279:24444-24451(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH STK38L, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
    6. "MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation."
      Praskova M., Xia F., Avruch J.
      Curr. Biol. 18:311-321(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT THR-12 AND THR-35.
    7. "Molecular characterization of human homologs of yeast MOB1."
      Chow A., Hao Y., Yang X.
      Int. J. Cancer 126:2079-2089(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH LATS1 AND LATS2, TISSUE SPECIFICITY.
    8. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMOB1B_HUMAN
    AccessioniPrimary (citable) accession number: Q7L9L4
    Secondary accession number(s): B2R8U6, B4DRY3, Q8IY23
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 21, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 102 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3