Reviewed, UniProtKB/Swiss-Prot Q7L9L4 (MOL1A_HUMAN)

Names and origin

Protein names

Recommended name:
    Mps one binder kinase activator-like 1A
Alternative name(s):
    Mob1 homolog 1A
      Short name=Mob1A
    Mob1B
    Protein Mob4A

Gene names

Name:	MOBKL1A
Synonyms:	MOB4A

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	216 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Stimulates the kinase activity of STK38L. Ref.5
Subunit structure	Binds STK38L.
Subcellular location	Cytoplasm. Nucleus Ref.5.
Sequence similarities	Belongs to the MOB1/phocein family.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Ligand	Metal-binding Zinc
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein amino acid autophosphorylation Inferred from direct assay. Source: UniProtKB
Cellular component	cytoplasm Ref.5 Inferred from direct assay. Source: UniProtKB nucleus Ref.5 Inferred from direct assay. Source: UniProtKB
Molecular function	kinase activator activity Inferred from direct assay. Source: UniProtKB kinase binding Inferred from physical interaction. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 216	215	Mps one binder kinase activator-like 1A		PRO_0000193564
Sites
	Metal binding	79	1	Zinc By similarity
	Metal binding	84	1	Zinc By similarity
	Metal binding	161	1	Zinc By similarity
	Metal binding	166	1	Zinc By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylserine By similarity
	Modified residue	35	1	Phosphothreonine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7L9L4-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 29EBA287B0CDAF90	FASTA	216	25,091
	10 20 30 40 50 60 MSFLFGSRSS KTFKPKKNIP EGSHQYELLK HAEATLGSGN LRMAVMLPEG EDLNEWVAVN 70 80 90 100 110 120 TVDFFNQINM LYGTITDFCT EESCPVMSAG PKYEYHWADG TNIKKPIKCS APKYIDYLMT 130 140 150 160 170 180 WVQDQLDDET LFPSKIGVPF PKNFMSVAKT ILKRLFRVYA HIYHQHFDPV IQLQEEAHLN 190 200 210 TSFKHFIFFV QEFNLIDRRE LAPLQELIEK LTSKDR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the human Mob-1 like proteins." Florindo C.S., Tavares A.A. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[5]	"Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases." Devroe E., Erdjument-Bromage H., Tempst P., Silver P.A. J. Biol. Chem. 279:24444-24451(2004) [PubMed: 15067004] [Abstract] Cited for: FUNCTION, INTERACTION WITH STK38L, MASS SPECTROMETRY, SUBCELLULAR LOCATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ577473 mRNA. Translation: CAE12091.1. AK313513 mRNA. Translation: BAG36293.1. CH471057 Genomic DNA. Translation: EAX05636.1. BC038112 mRNA. Translation: AAH38112.1.
IPI	IPI00514212.
RefSeq	NP_775739.1.
UniGene	Hs.700445 Hs.719746
3D structure databases
SMR	Q7L9L4. Positions 33-216.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7L9L4.
PTM databases
PhosphoSite	Q7L9L4.
Proteomic databases
PRIDE	Q7L9L4.
Genome annotation databases
Ensembl	ENST00000309395; ENSP00000310189; ENSG00000173542; Homo sapiens. [Genome view]
GeneID	92597.
KEGG	hsa:92597.
UCSC	uc003hfw.1. human.
Organism-specific databases
CTD	92597.
GeneCards	GC04P071986.
H-InvDB	HIX0004271.
HGNC	HGNC:29801. MOBKL1A.
MIM	609282. gene.
PharmGKB	PA134871841.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q7L9L4.
InParanoid	Q7L9L4.
OrthoDB	EOG9RZ1JW.
PhylomeDB	Q7L9L4.
Gene expression databases
ArrayExpress	Q7L9L4.
Bgee	Q7L9L4.
CleanEx	HS_MOBKL1A.
Genevestigator	Q7L9L4.
GermOnline	ENSG00000173542. Homo sapiens.
Family and domain databases
InterPro	IPR005301. Mob1_phocein. [Graphical view]
Gene3D	G3DSA:1.20.140.30. Mob1_phocein. 1 hit.
PANTHER	PTHR22599. Mob1_phocein. 1 hit.
Pfam	PF03637. Mob1_phocein. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	77815.
SOURCE	Search...

Entry information

Entry name

MOL1A_HUMAN

Accession

Primary (citable) accession number: Q7L9L4
Secondary accession number(s): B2R8U6, Q8IY23

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 21, 2004
Last sequence update:	January 23, 2007
Last modified:	January 19, 2010
This is version 54 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.