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Protein

Endonuclease/exonuclease/phosphatase family domain-containing protein 1

Gene

EEPD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Endonuclease/exonuclease/phosphatase family domain-containing protein 1
Gene namesi
Name:EEPD1
Synonyms:KIAA1706
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:22223. EEPD1.

Pathology & Biotechi

Organism-specific databases

DisGeNETi80820.
OpenTargetsiENSG00000122547.
PharmGKBiPA162384303.

Polymorphism and mutation databases

BioMutaiEEPD1.
DMDMi296434489.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00003172612 – 569Endonuclease/exonuclease/phosphatase family domain-containing protein 1Add BLAST568

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1
Modified residuei16PhosphoserineCombined sources1
Modified residuei21PhosphoserineBy similarity1
Modified residuei25PhosphoserineCombined sources1
Modified residuei106PhosphoserineBy similarity1
Modified residuei110PhosphoserineCombined sources1
Modified residuei160PhosphoserineCombined sources1
Modified residuei173PhosphoserineCombined sources1
Modified residuei265PhosphothreonineBy similarity1
Modified residuei428PhosphoserineCombined sources1

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ7L9B9.
MaxQBiQ7L9B9.
PaxDbiQ7L9B9.
PeptideAtlasiQ7L9B9.
PRIDEiQ7L9B9.

PTM databases

iPTMnetiQ7L9B9.
PhosphoSitePlusiQ7L9B9.
SwissPalmiQ7L9B9.

Expressioni

Gene expression databases

BgeeiENSG00000122547.
CleanExiHS_EEPD1.
ExpressionAtlasiQ7L9B9. baseline and differential.
GenevisibleiQ7L9B9. HS.

Organism-specific databases

HPAiHPA053668.

Interactioni

Protein-protein interaction databases

BioGridi123317. 13 interactors.
IntActiQ7L9B9. 1 interactor.
STRINGi9606.ENSP00000242108.

Structurei

3D structure databases

ProteinModelPortaliQ7L9B9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 67HhHAdd BLAST30

Sequence similaritiesi

Contains 1 HhH domain.Curated

Phylogenomic databases

eggNOGiENOG410IUAK. Eukaryota.
COG1555. LUCA.
GeneTreeiENSGT00390000009677.
HOGENOMiHOG000112330.
HOVERGENiHBG100313.
InParanoidiQ7L9B9.
OMAiAQLMSIR.
OrthoDBiEOG091G0FFB.
PhylomeDBiQ7L9B9.
TreeFamiTF328735.

Family and domain databases

Gene3Di3.60.10.10. 1 hit.
InterProiIPR004509. Competence_ComEA_HhH.
IPR005135. Endo/exonuclease/phosphatase.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
[Graphical view]
SMARTiSM00278. HhH1. 3 hits.
[Graphical view]
SUPFAMiSSF47781. SSF47781. 2 hits.
SSF56219. SSF56219. 1 hit.
TIGRFAMsiTIGR00426. TIGR00426. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7L9B9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSTLGCHRS IPRDPSDLSH SRKFSAACNF SNILVNQERL NINTATEEEL
60 70 80 90 100
MTLPGVTRAV ARSIVEYREY IGGFKKVEDL ALVSGVGATK LEQVKFEICV
110 120 130 140 150
SSKGSSAQHS PSSLRRDLLA EQQPHHLATA VPLTPRVNIN TATPAQLMSV
160 170 180 190 200
RGLSEKMALS IVDFRREHGP FRSVEDLVRM DGINAAFLDR IRHQVFAERS
210 220 230 240 250
RPPSTHTNGG LTFTAKPHPS PTSLSLQSED LDLPPGGPTQ IISTRPSVEA
260 270 280 290 300
FGGTRDGRPV LRLATWNLQG CSVEKANNPG VREVVCMTLL ENSIKLLAVQ
310 320 330 340 350
ELLDREALEK FCTELNQPTL PNIRKWKGPR GCWKAVVAEK PSSQLQKGAG
360 370 380 390 400
YAGFLWDAAA GMELRDAGSQ ESSPSNGHGK LAGPSPYLGR FKVGSHDLTL
410 420 430 440 450
VNLHLAALTL LGSENPSKNH SDGHRLASFA QTLQETLKGE KDVIILGDFG
460 470 480 490 500
QGPDSNDYDI LRKEKFHHLI PAHTFTNIST KNPQGSKSLD NIWISKSLKK
510 520 530 540 550
VFTGHWAVVR EGLTNPWIPD NWSWGGVASE HCPVLAEFYT EKDWSKKDAP
560
RNGSGVALER SEANIKHER
Length:569
Mass (Da):62,403
Last modified:May 18, 2010 - v2
Checksum:i6A1C1D106583E670
GO

Sequence cautioni

The sequence BAB21797 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060374343S → N.5 PublicationsCorresponds to variant rs196586dbSNPEnsembl.1
Natural variantiVAR_056867358A → S.Corresponds to variant rs3815682dbSNPEnsembl.1
Natural variantiVAR_056868416P → S.Corresponds to variant rs196594dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051493 mRNA. Translation: BAB21797.1. Different initiation.
AK027386 mRNA. Translation: BAB55076.1.
AC007327 Genomic DNA. No translation available.
AC078841 Genomic DNA. No translation available.
CH236951 Genomic DNA. Translation: EAL23976.1.
CH471073 Genomic DNA. Translation: EAW94063.1.
BC065518 mRNA. Translation: AAH65518.1.
CCDSiCCDS34619.1.
RefSeqiNP_085139.2. NM_030636.2.
UniGeneiHs.487994.
Hs.670591.

Genome annotation databases

EnsembliENST00000242108; ENSP00000242108; ENSG00000122547.
ENST00000534978; ENSP00000442692; ENSG00000122547.
GeneIDi80820.
KEGGihsa:80820.
UCSCiuc003tfa.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051493 mRNA. Translation: BAB21797.1. Different initiation.
AK027386 mRNA. Translation: BAB55076.1.
AC007327 Genomic DNA. No translation available.
AC078841 Genomic DNA. No translation available.
CH236951 Genomic DNA. Translation: EAL23976.1.
CH471073 Genomic DNA. Translation: EAW94063.1.
BC065518 mRNA. Translation: AAH65518.1.
CCDSiCCDS34619.1.
RefSeqiNP_085139.2. NM_030636.2.
UniGeneiHs.487994.
Hs.670591.

3D structure databases

ProteinModelPortaliQ7L9B9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123317. 13 interactors.
IntActiQ7L9B9. 1 interactor.
STRINGi9606.ENSP00000242108.

PTM databases

iPTMnetiQ7L9B9.
PhosphoSitePlusiQ7L9B9.
SwissPalmiQ7L9B9.

Polymorphism and mutation databases

BioMutaiEEPD1.
DMDMi296434489.

Proteomic databases

EPDiQ7L9B9.
MaxQBiQ7L9B9.
PaxDbiQ7L9B9.
PeptideAtlasiQ7L9B9.
PRIDEiQ7L9B9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000242108; ENSP00000242108; ENSG00000122547.
ENST00000534978; ENSP00000442692; ENSG00000122547.
GeneIDi80820.
KEGGihsa:80820.
UCSCiuc003tfa.4. human.

Organism-specific databases

CTDi80820.
DisGeNETi80820.
GeneCardsiEEPD1.
H-InvDBHIX0006600.
HGNCiHGNC:22223. EEPD1.
HPAiHPA053668.
neXtProtiNX_Q7L9B9.
OpenTargetsiENSG00000122547.
PharmGKBiPA162384303.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IUAK. Eukaryota.
COG1555. LUCA.
GeneTreeiENSGT00390000009677.
HOGENOMiHOG000112330.
HOVERGENiHBG100313.
InParanoidiQ7L9B9.
OMAiAQLMSIR.
OrthoDBiEOG091G0FFB.
PhylomeDBiQ7L9B9.
TreeFamiTF328735.

Miscellaneous databases

GenomeRNAii80820.
PROiQ7L9B9.

Gene expression databases

BgeeiENSG00000122547.
CleanExiHS_EEPD1.
ExpressionAtlasiQ7L9B9. baseline and differential.
GenevisibleiQ7L9B9. HS.

Family and domain databases

Gene3Di3.60.10.10. 1 hit.
InterProiIPR004509. Competence_ComEA_HhH.
IPR005135. Endo/exonuclease/phosphatase.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
[Graphical view]
SMARTiSM00278. HhH1. 3 hits.
[Graphical view]
SUPFAMiSSF47781. SSF47781. 2 hits.
SSF56219. SSF56219. 1 hit.
TIGRFAMsiTIGR00426. TIGR00426. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEEPD1_HUMAN
AccessioniPrimary (citable) accession number: Q7L9B9
Secondary accession number(s): Q96K64, Q9C0F7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.