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Protein

Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2

Gene

LINGO2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2
Alternative name(s):
Leucine-rich repeat neuronal protein 3
Leucine-rich repeat neuronal protein 6C
Gene namesi
Name:LINGO2
Synonyms:LERN3, LRRN6C
ORF Names:UNQ9234/PRO31993
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000174482.10
HGNCiHGNC:21207 LINGO2
MIMi609793 gene
neXtProtiNX_Q7L985

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 545ExtracellularSequence analysisAdd BLAST518
Transmembranei546 – 566HelicalSequence analysisAdd BLAST21
Topological domaini567 – 606CytoplasmicSequence analysisAdd BLAST40

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi158038
OpenTargetsiENSG00000174482
PharmGKBiPA162394096

Polymorphism and mutation databases

BioMutaiLINGO2
DMDMi172046190

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000032438928 – 606Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2Add BLAST579

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi130N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi279N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi327N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi432 ↔ 483PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ7L985
PaxDbiQ7L985
PeptideAtlasiQ7L985
PRIDEiQ7L985

PTM databases

iPTMnetiQ7L985
PhosphoSitePlusiQ7L985

Expressioni

Gene expression databases

BgeeiENSG00000174482
CleanExiHS_LINGO2
GenevisibleiQ7L985 HS

Organism-specific databases

HPAiCAB025361
HPA016633

Interactioni

Protein-protein interaction databases

BioGridi127640, 12 interactors
STRINGi9606.ENSP00000310126

Structurei

3D structure databases

ProteinModelPortaliQ7L985
SMRiQ7L985
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 57LRRNTAdd BLAST30
Repeati58 – 79LRR 1Add BLAST22
Repeati82 – 103LRR 2Add BLAST22
Repeati106 – 127LRR 3Add BLAST22
Repeati130 – 151LRR 4Add BLAST22
Repeati154 – 175LRR 5Add BLAST22
Repeati178 – 199LRR 6Add BLAST22
Repeati202 – 223LRR 7Add BLAST22
Repeati226 – 247LRR 8Add BLAST22
Repeati250 – 271LRR 9Add BLAST22
Repeati274 – 295LRR 10Add BLAST22
Repeati298 – 319LRR 11Add BLAST22
Repeati322 – 343LRR 12Add BLAST22
Domaini355 – 409LRRCTAdd BLAST55
Domaini410 – 499Ig-like C2-typeAdd BLAST90

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000118831
HOGENOMiHOG000246971
HOVERGENiHBG057546
InParanoidiQ7L985
OMAiSYYVTCT
OrthoDBiEOG091G047N
PhylomeDBiQ7L985
TreeFamiTF334360

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF13855 LRR_8, 2 hits
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00369 LRR_TYP, 10 hits
SM00013 LRRNT, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 11 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7L985-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHTAISCWQ PFLGLAVVLI FMGSTIGCPA RCECSAQNKS VSCHRRRLIA
60 70 80 90 100
IPEGIPIETK ILDLSKNRLK SVNPEEFISY PLLEEIDLSD NIIANVEPGA
110 120 130 140 150
FNNLFNLRSL RLKGNRLKLV PLGVFTGLSN LTKLDISENK IVILLDYMFQ
160 170 180 190 200
DLHNLKSLEV GDNDLVYISH RAFSGLLSLE QLTLEKCNLT AVPTEALSHL
210 220 230 240 250
RSLISLHLKH LNINNMPVYA FKRLFHLKHL EIDYWPLLDM MPANSLYGLN
260 270 280 290 300
LTSLSVTNTN LSTVPFLAFK HLVYLTHLNL SYNPISTIEA GMFSDLIRLQ
310 320 330 340 350
ELHIVGAQLR TIEPHSFQGL RFLRVLNVSQ NLLETLEENV FSSPRALEVL
360 370 380 390 400
SINNNPLACD CRLLWILQRQ PTLQFGGQQP MCAGPDTIRE RSFKDFHSTA
410 420 430 440 450
LSFYFTCKKP KIREKKLQHL LVDEGQTVQL ECSADGDPQP VISWVTPRRR
460 470 480 490 500
FITTKSNGRA TVLGDGTLEI RFAQDQDSGM YVCIASNAAG NDTFTASLTV
510 520 530 540 550
KGFASDRFLY ANRTPMYMTD SNDTISNGTN ANTFSLDLKT ILVSTAMGCF
560 570 580 590 600
TFLGVVLFCF LLLFVWSRGK GKHKNSIDLE YVPRKNNGAV VEGEVAGPRR

FNMKMI
Length:606
Mass (Da):68,066
Last modified:February 5, 2008 - v1
Checksum:iCB608E281B066B9D
GO

Sequence cautioni

The sequence BAD18799 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti89S → G in BAF83661 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039798507R → H. Corresponds to variant dbSNP:rs17506843Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358114 mRNA Translation: AAQ88481.1
AK056372 mRNA Translation: BAB71167.1
AK172834 mRNA Translation: BAD18799.1 Different initiation.
AK290972 mRNA Translation: BAF83661.1
CH471071 Genomic DNA Translation: EAW58557.1
BC137514 mRNA Translation: AAI37515.1
CCDSiCCDS6524.1
RefSeqiNP_001245211.1, NM_001258282.1
NP_689783.1, NM_152570.2
XP_011516021.1, XM_011517719.1
XP_011516026.1, XM_011517724.2
XP_011516030.1, XM_011517728.2
XP_016869792.1, XM_017014303.1
XP_016869793.1, XM_017014304.1
XP_016869794.1, XM_017014305.1
XP_016869795.1, XM_017014306.1
XP_016869796.1, XM_017014307.1
UniGeneiHs.444665
Hs.662661
Hs.745029

Genome annotation databases

EnsembliENST00000308675; ENSP00000310126; ENSG00000174482
ENST00000379992; ENSP00000369328; ENSG00000174482
ENST00000613945; ENSP00000479634; ENSG00000174482
GeneIDi158038
KEGGihsa:158038
UCSCiuc064smp.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLIGO2_HUMAN
AccessioniPrimary (citable) accession number: Q7L985
Secondary accession number(s): A8K4K7, B2RPM5, Q6ZMD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: February 5, 2008
Last modified: March 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health