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Protein

Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2

Gene

LINGO2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2
Alternative name(s):
Leucine-rich repeat neuronal protein 3
Leucine-rich repeat neuronal protein 6C
Gene namesi
Name:LINGO2
Synonyms:LERN3, LRRN6C
ORF Names:UNQ9234/PRO31993
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:21207. LINGO2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 545ExtracellularSequence analysisAdd BLAST518
Transmembranei546 – 566HelicalSequence analysisAdd BLAST21
Topological domaini567 – 606CytoplasmicSequence analysisAdd BLAST40

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi158038.
OpenTargetsiENSG00000174482.
PharmGKBiPA162394096.

Polymorphism and mutation databases

BioMutaiLINGO2.
DMDMi172046190.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000032438928 – 606Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2Add BLAST579

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...)Sequence analysis1
Glycosylationi130N-linked (GlcNAc...)Sequence analysis1
Glycosylationi188N-linked (GlcNAc...)Sequence analysis1
Glycosylationi279N-linked (GlcNAc...)Sequence analysis1
Glycosylationi327N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi432 ↔ 483PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ7L985.
PaxDbiQ7L985.
PeptideAtlasiQ7L985.
PRIDEiQ7L985.

PTM databases

iPTMnetiQ7L985.
PhosphoSitePlusiQ7L985.

Expressioni

Gene expression databases

BgeeiENSG00000174482.
CleanExiHS_LINGO2.
GenevisibleiQ7L985. HS.

Organism-specific databases

HPAiCAB025361.
HPA016633.

Interactioni

Protein-protein interaction databases

BioGridi127640. 12 interactors.
STRINGi9606.ENSP00000310126.

Structurei

3D structure databases

ProteinModelPortaliQ7L985.
SMRiQ7L985.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 57LRRNTAdd BLAST30
Repeati58 – 79LRR 1Add BLAST22
Repeati82 – 103LRR 2Add BLAST22
Repeati106 – 127LRR 3Add BLAST22
Repeati130 – 151LRR 4Add BLAST22
Repeati154 – 175LRR 5Add BLAST22
Repeati178 – 199LRR 6Add BLAST22
Repeati202 – 223LRR 7Add BLAST22
Repeati226 – 247LRR 8Add BLAST22
Repeati250 – 271LRR 9Add BLAST22
Repeati274 – 295LRR 10Add BLAST22
Repeati298 – 319LRR 11Add BLAST22
Repeati322 – 343LRR 12Add BLAST22
Domaini355 – 409LRRCTAdd BLAST55
Domaini410 – 499Ig-like C2-typeAdd BLAST90

Sequence similaritiesi

Contains 12 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118831.
HOGENOMiHOG000246971.
HOVERGENiHBG057546.
InParanoidiQ7L985.
OMAiGKHKNNI.
OrthoDBiEOG091G047N.
PhylomeDBiQ7L985.
TreeFamiTF334360.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 10 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7L985-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHTAISCWQ PFLGLAVVLI FMGSTIGCPA RCECSAQNKS VSCHRRRLIA
60 70 80 90 100
IPEGIPIETK ILDLSKNRLK SVNPEEFISY PLLEEIDLSD NIIANVEPGA
110 120 130 140 150
FNNLFNLRSL RLKGNRLKLV PLGVFTGLSN LTKLDISENK IVILLDYMFQ
160 170 180 190 200
DLHNLKSLEV GDNDLVYISH RAFSGLLSLE QLTLEKCNLT AVPTEALSHL
210 220 230 240 250
RSLISLHLKH LNINNMPVYA FKRLFHLKHL EIDYWPLLDM MPANSLYGLN
260 270 280 290 300
LTSLSVTNTN LSTVPFLAFK HLVYLTHLNL SYNPISTIEA GMFSDLIRLQ
310 320 330 340 350
ELHIVGAQLR TIEPHSFQGL RFLRVLNVSQ NLLETLEENV FSSPRALEVL
360 370 380 390 400
SINNNPLACD CRLLWILQRQ PTLQFGGQQP MCAGPDTIRE RSFKDFHSTA
410 420 430 440 450
LSFYFTCKKP KIREKKLQHL LVDEGQTVQL ECSADGDPQP VISWVTPRRR
460 470 480 490 500
FITTKSNGRA TVLGDGTLEI RFAQDQDSGM YVCIASNAAG NDTFTASLTV
510 520 530 540 550
KGFASDRFLY ANRTPMYMTD SNDTISNGTN ANTFSLDLKT ILVSTAMGCF
560 570 580 590 600
TFLGVVLFCF LLLFVWSRGK GKHKNSIDLE YVPRKNNGAV VEGEVAGPRR

FNMKMI
Length:606
Mass (Da):68,066
Last modified:February 5, 2008 - v1
Checksum:iCB608E281B066B9D
GO

Sequence cautioni

The sequence BAD18799 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti89S → G in BAF83661 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039798507R → H.Corresponds to variant rs17506843dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358114 mRNA. Translation: AAQ88481.1.
AK056372 mRNA. Translation: BAB71167.1.
AK172834 mRNA. Translation: BAD18799.1. Different initiation.
AK290972 mRNA. Translation: BAF83661.1.
CH471071 Genomic DNA. Translation: EAW58557.1.
BC137514 mRNA. Translation: AAI37515.1.
CCDSiCCDS6524.1.
RefSeqiNP_001245211.1. NM_001258282.1.
NP_689783.1. NM_152570.2.
XP_011516021.1. XM_011517719.1.
XP_011516026.1. XM_011517724.2.
XP_011516030.1. XM_011517728.2.
XP_016869792.1. XM_017014303.1.
XP_016869793.1. XM_017014304.1.
XP_016869794.1. XM_017014305.1.
XP_016869795.1. XM_017014306.1.
XP_016869796.1. XM_017014307.1.
UniGeneiHs.444665.
Hs.662661.
Hs.745029.

Genome annotation databases

EnsembliENST00000308675; ENSP00000310126; ENSG00000174482.
ENST00000379992; ENSP00000369328; ENSG00000174482.
ENST00000613945; ENSP00000479634; ENSG00000174482.
GeneIDi158038.
KEGGihsa:158038.
UCSCiuc064smp.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358114 mRNA. Translation: AAQ88481.1.
AK056372 mRNA. Translation: BAB71167.1.
AK172834 mRNA. Translation: BAD18799.1. Different initiation.
AK290972 mRNA. Translation: BAF83661.1.
CH471071 Genomic DNA. Translation: EAW58557.1.
BC137514 mRNA. Translation: AAI37515.1.
CCDSiCCDS6524.1.
RefSeqiNP_001245211.1. NM_001258282.1.
NP_689783.1. NM_152570.2.
XP_011516021.1. XM_011517719.1.
XP_011516026.1. XM_011517724.2.
XP_011516030.1. XM_011517728.2.
XP_016869792.1. XM_017014303.1.
XP_016869793.1. XM_017014304.1.
XP_016869794.1. XM_017014305.1.
XP_016869795.1. XM_017014306.1.
XP_016869796.1. XM_017014307.1.
UniGeneiHs.444665.
Hs.662661.
Hs.745029.

3D structure databases

ProteinModelPortaliQ7L985.
SMRiQ7L985.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127640. 12 interactors.
STRINGi9606.ENSP00000310126.

PTM databases

iPTMnetiQ7L985.
PhosphoSitePlusiQ7L985.

Polymorphism and mutation databases

BioMutaiLINGO2.
DMDMi172046190.

Proteomic databases

EPDiQ7L985.
PaxDbiQ7L985.
PeptideAtlasiQ7L985.
PRIDEiQ7L985.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308675; ENSP00000310126; ENSG00000174482.
ENST00000379992; ENSP00000369328; ENSG00000174482.
ENST00000613945; ENSP00000479634; ENSG00000174482.
GeneIDi158038.
KEGGihsa:158038.
UCSCiuc064smp.1. human.

Organism-specific databases

CTDi158038.
DisGeNETi158038.
GeneCardsiLINGO2.
HGNCiHGNC:21207. LINGO2.
HPAiCAB025361.
HPA016633.
MIMi609793. gene.
neXtProtiNX_Q7L985.
OpenTargetsiENSG00000174482.
PharmGKBiPA162394096.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118831.
HOGENOMiHOG000246971.
HOVERGENiHBG057546.
InParanoidiQ7L985.
OMAiGKHKNNI.
OrthoDBiEOG091G047N.
PhylomeDBiQ7L985.
TreeFamiTF334360.

Miscellaneous databases

GenomeRNAii158038.
PROiQ7L985.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000174482.
CleanExiHS_LINGO2.
GenevisibleiQ7L985. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 10 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 11 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLIGO2_HUMAN
AccessioniPrimary (citable) accession number: Q7L985
Secondary accession number(s): A8K4K7, B2RPM5, Q6ZMD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: February 5, 2008
Last modified: November 2, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.