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Protein

Zinc finger protein 627

Gene

ZNF627

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri99 – 123C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri167 – 189C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri195 – 217C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri223 – 245C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri251 – 273C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri279 – 301C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri363 – 385C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri391 – 413C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri419 – 441C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 627
Gene namesi
Name:ZNF627
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:30570. ZNF627.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi199692.
OpenTargetsiENSG00000198551.
PharmGKBiPA134903355.

Polymorphism and mutation databases

BioMutaiZNF627.
DMDMi74759019.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002804251 – 461Zinc finger protein 627Add BLAST461

Proteomic databases

EPDiQ7L945.
MaxQBiQ7L945.
PaxDbiQ7L945.
PeptideAtlasiQ7L945.
PRIDEiQ7L945.

PTM databases

iPTMnetiQ7L945.
PhosphoSitePlusiQ7L945.

Expressioni

Gene expression databases

BgeeiENSG00000198551.
CleanExiHS_ZNF627.
ExpressionAtlasiQ7L945. baseline and differential.
GenevisibleiQ7L945. HS.

Organism-specific databases

HPAiHPA049770.
HPA073463.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCNDBP1O952733EBI-2797561,EBI-748961

Protein-protein interaction databases

BioGridi128262. 7 interactors.
IntActiQ7L945. 3 interactors.
STRINGi9606.ENSP00000354414.

Structurei

3D structure databases

ProteinModelPortaliQ7L945.
SMRiQ7L945.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 80KRABPROSITE-ProRule annotationAdd BLAST77

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri99 – 123C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri167 – 189C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri195 – 217C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri223 – 245C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri251 – 273C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri279 – 301C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri363 – 385C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri391 – 413C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri419 – 441C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ7L945.
KOiK09228.
OMAiKPCERSV.
OrthoDBiEOG091G02KC.
PhylomeDBiQ7L945.
TreeFamiTF338854.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR013087. Znf_C2H2_type.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 6 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.

Sequencei

Sequence statusi: Complete.

Q7L945-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSVAFEDVA VNFTLEEWAL LDPSQKNLYR DVMRETFRNL ASVGKQWEDQ
60 70 80 90 100
NIEDPFKIPR RNISHIPERL CESKEGGQGE ETFSQIPDGI LNKKTPGVKP
110 120 130 140 150
CESSVCGEVG MGPSSLNRHI RDHTGREPNE YQEYGKKSYT RNQCGRALSY
160 170 180 190 200
HRSFPVRERT HPGGKPYDCK ECGETFISLV SIRRHMLTHR GGVPYKCKVC
210 220 230 240 250
GKAFDYPSLF RIHERSHTGE KPYECKQCGK AFSCSSYIRI HERTHTGDKP
260 270 280 290 300
YECKQCGKAF SCSKYIRIHE RTHTGEKPYE CKQCGKAFRC ASSVRSHERT
310 320 330 340 350
HTGEKLFECK ECGKALTCLA SVRRHMIKHT GNGPYKCKVC GKAFDFPSSF
360 370 380 390 400
RIHERTHTGE KPYDCKQCGK AFSCSSSFRK HERIHTGEKP YKCTKCGKAF
410 420 430 440 450
SRSSYFRIHE RTHTGEKPYE CKQCGKAFSR STYFRVHEKI HTGEKPYENP
460
NPNASVVPVL S
Length:461
Mass (Da):52,853
Last modified:July 5, 2004 - v1
Checksum:i3440788DBB79A24A
GO

Sequence cautioni

The sequence AAH06279 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH98416 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti172C → V in AAB81084 (PubMed:12016960).Curated1
Sequence conflicti194P → T in AAB81084 (PubMed:12016960).Curated1
Sequence conflicti269H → R in AAH98416 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074846 mRNA. Translation: BAC11240.1.
BC006279 mRNA. Translation: AAH06279.2. Different initiation.
BC069232 mRNA. Translation: AAH69232.2.
BC098416 mRNA. Translation: AAH98416.1. Different initiation.
AF024694 mRNA. Translation: AAB81084.1.
CCDSiCCDS42502.1.
RefSeqiNP_001277012.1. NM_001290083.1.
NP_001277013.1. NM_001290084.1.
NP_001277014.1. NM_001290085.1.
NP_660338.1. NM_145295.3.
UniGeneiHs.526665.

Genome annotation databases

EnsembliENST00000361113; ENSP00000354414; ENSG00000198551.
GeneIDi199692.
KEGGihsa:199692.
UCSCiuc002msk.3. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiZN627_HUMAN
AccessioniPrimary (citable) accession number: Q7L945
Secondary accession number(s): O14846
, Q4KMP9, Q6NT81, Q9BRG4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 5, 2004
Last modified: May 10, 2017
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families