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Q7L8S5

- OTU6A_HUMAN

UniProt

Q7L8S5 - OTU6A_HUMAN

Protein

OTU domain-containing protein 6A

Gene

OTUD6A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    Deubiquitinating enzyme that hydrolyzes 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains.1 Publication

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei149 – 1491By similarity
    Active sitei152 – 1521NucleophileBy similarity
    Active sitei268 – 2681By similarity

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: UniProtKB

    GO - Biological processi

    1. protein K11-linked deubiquitination Source: UniProtKB
    2. protein K27-linked deubiquitination Source: UniProtKB
    3. protein K29-linked deubiquitination Source: UniProtKB
    4. protein K33-linked deubiquitination Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    OTU domain-containing protein 6A (EC:3.4.19.12)
    Alternative name(s):
    DUBA-2
    Gene namesi
    Name:OTUD6A
    Synonyms:DUBA2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:32312. OTUD6A.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671218.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 288288OTU domain-containing protein 6APRO_0000076277Add
    BLAST

    Proteomic databases

    PaxDbiQ7L8S5.
    PRIDEiQ7L8S5.

    PTM databases

    PhosphoSiteiQ7L8S5.

    Expressioni

    Gene expression databases

    BgeeiQ7L8S5.
    CleanExiHS_OTUD6A.
    GenevestigatoriQ7L8S5.

    Organism-specific databases

    HPAiHPA053304.

    Interactioni

    Protein-protein interaction databases

    BioGridi126574. 6 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7L8S5.
    SMRiQ7L8S5. Positions 122-272.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini141 – 275135OTUPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni146 – 1527Cys-loopBy similarity
    Regioni210 – 22011Variable-loopBy similarityAdd
    BLAST
    Regioni258 – 26811His-loopBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 1 OTU domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5539.
    HOGENOMiHOG000192906.
    HOVERGENiHBG080227.
    InParanoidiQ7L8S5.
    KOiK18342.
    OMAiKHVDDFL.
    OrthoDBiEOG7WT42W.
    PhylomeDBiQ7L8S5.
    TreeFamiTF315010.

    Family and domain databases

    InterProiIPR003323. OTU.
    [Graphical view]
    PfamiPF02338. OTU. 1 hit.
    [Graphical view]
    PROSITEiPS50802. OTU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7L8S5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDDPKSEQQR ILRRHQRERQ ELQAQIRSLK NSVPKTDKTK RKQLLQDVAR    50
    MEAEMAQKHR QELEKFQDDS SIESVVEDLA KMNLENRPPR SSKAHRKRER 100
    MESEERERQE SIFQAEMSEH LAGFKREEEE KLAAILGARG LEMKAIPADG 150
    HCMYRAIQDQ LVFSVSVEML RCRTASYMKK HVDEFLPFFS NPETSDSFGY 200
    DDFMIYCDNI VRTTAWGGQL ELRALSHVLK TPIEVIQADS PTLIIGEEYV 250
    KKPIILVYLR YAYSLGEHYN SVTPLEAGAA GGVLPRLL 288
    Length:288
    Mass (Da):33,300
    Last modified:February 15, 2005 - v1
    Checksum:i78DCB2729A729C31
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK098697 mRNA. Translation: BAC05384.1.
    CH471132 Genomic DNA. Translation: EAX05357.1.
    BC137355 mRNA. Translation: AAI37356.1.
    BC137356 mRNA. Translation: AAI37357.1.
    CCDSiCCDS14395.1.
    RefSeqiNP_997203.1. NM_207320.1.
    UniGeneiHs.447381.

    Genome annotation databases

    GeneIDi139562.
    KEGGihsa:139562.
    UCSCiuc004dxu.1. human.

    Polymorphism databases

    DMDMi74713135.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK098697 mRNA. Translation: BAC05384.1 .
    CH471132 Genomic DNA. Translation: EAX05357.1 .
    BC137355 mRNA. Translation: AAI37356.1 .
    BC137356 mRNA. Translation: AAI37357.1 .
    CCDSi CCDS14395.1.
    RefSeqi NP_997203.1. NM_207320.1.
    UniGenei Hs.447381.

    3D structure databases

    ProteinModelPortali Q7L8S5.
    SMRi Q7L8S5. Positions 122-272.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126574. 6 interactions.

    PTM databases

    PhosphoSitei Q7L8S5.

    Polymorphism databases

    DMDMi 74713135.

    Proteomic databases

    PaxDbi Q7L8S5.
    PRIDEi Q7L8S5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 139562.
    KEGGi hsa:139562.
    UCSCi uc004dxu.1. human.

    Organism-specific databases

    CTDi 139562.
    GeneCardsi GC0XP069282.
    HGNCi HGNC:32312. OTUD6A.
    HPAi HPA053304.
    MIMi 300714. gene.
    neXtProti NX_Q7L8S5.
    PharmGKBi PA142671218.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5539.
    HOGENOMi HOG000192906.
    HOVERGENi HBG080227.
    InParanoidi Q7L8S5.
    KOi K18342.
    OMAi KHVDDFL.
    OrthoDBi EOG7WT42W.
    PhylomeDBi Q7L8S5.
    TreeFami TF315010.

    Miscellaneous databases

    GenomeRNAii 139562.
    NextBioi 83989.
    PROi Q7L8S5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q7L8S5.
    CleanExi HS_OTUD6A.
    Genevestigatori Q7L8S5.

    Family and domain databases

    InterProi IPR003323. OTU.
    [Graphical view ]
    Pfami PF02338. OTU. 1 hit.
    [Graphical view ]
    PROSITEi PS50802. OTU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. "OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis."
      Mevissen T.E., Hospenthal M.K., Geurink P.P., Elliott P.R., Akutsu M., Arnaudo N., Ekkebus R., Kulathu Y., Wauer T., El Oualid F., Freund S.M., Ovaa H., Komander D.
      Cell 154:169-184(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CATALYTIC ACTIVITY.

    Entry informationi

    Entry nameiOTU6A_HUMAN
    AccessioniPrimary (citable) accession number: Q7L8S5
    Secondary accession number(s): B2RPB7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3