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Protein

OTU domain-containing protein 6A

Gene

OTUD6A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Deubiquitinating enzyme that hydrolyzes 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains.1 Publication

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei149By similarity1
Active sitei152NucleophileBy similarity1
Active sitei268By similarity1

GO - Molecular functioni

  • thiol-dependent ubiquitin-specific protease activity Source: UniProtKB

GO - Biological processi

  • protein K11-linked deubiquitination Source: UniProtKB
  • protein K27-linked deubiquitination Source: UniProtKB
  • protein K29-linked deubiquitination Source: UniProtKB
  • protein K33-linked deubiquitination Source: UniProtKB

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Protein family/group databases

MEROPSiC85.008.

Names & Taxonomyi

Protein namesi
Recommended name:
OTU domain-containing protein 6A (EC:3.4.19.12)
Alternative name(s):
DUBA-2
Gene namesi
Name:OTUD6A
Synonyms:DUBA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000189401.2.
HGNCiHGNC:32312. OTUD6A.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000189401.
PharmGKBiPA142671218.

Polymorphism and mutation databases

BioMutaiOTUD6A.
DMDMi74713135.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000762771 – 288OTU domain-containing protein 6AAdd BLAST288

Proteomic databases

PaxDbiQ7L8S5.
PeptideAtlasiQ7L8S5.
PRIDEiQ7L8S5.

PTM databases

iPTMnetiQ7L8S5.
PhosphoSitePlusiQ7L8S5.

Expressioni

Gene expression databases

BgeeiENSG00000189401.
CleanExiHS_OTUD6A.

Organism-specific databases

HPAiHPA053304.

Interactioni

Protein-protein interaction databases

BioGridi126574. 9 interactors.
IntActiQ7L8S5. 10 interactors.
STRINGi9606.ENSP00000339389.

Structurei

3D structure databases

ProteinModelPortaliQ7L8S5.
SMRiQ7L8S5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini141 – 275OTUPROSITE-ProRule annotationAdd BLAST135

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni146 – 152Cys-loopBy similarity7
Regioni210 – 220Variable-loopBy similarityAdd BLAST11
Regioni258 – 268His-loopBy similarityAdd BLAST11

Phylogenomic databases

eggNOGiKOG2606. Eukaryota.
COG5539. LUCA.
GeneTreeiENSGT00390000012840.
HOGENOMiHOG000192906.
HOVERGENiHBG080227.
InParanoidiQ7L8S5.
KOiK18342.
OMAiQDQLVFS.
OrthoDBiEOG091G0VVZ.
PhylomeDBiQ7L8S5.
TreeFamiTF315010.

Family and domain databases

InterProiView protein in InterPro
IPR003323. OTU_dom.
PfamiView protein in Pfam
PF02338. OTU. 1 hit.
PROSITEiView protein in PROSITE
PS50802. OTU. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7L8S5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDPKSEQQR ILRRHQRERQ ELQAQIRSLK NSVPKTDKTK RKQLLQDVAR
60 70 80 90 100
MEAEMAQKHR QELEKFQDDS SIESVVEDLA KMNLENRPPR SSKAHRKRER
110 120 130 140 150
MESEERERQE SIFQAEMSEH LAGFKREEEE KLAAILGARG LEMKAIPADG
160 170 180 190 200
HCMYRAIQDQ LVFSVSVEML RCRTASYMKK HVDEFLPFFS NPETSDSFGY
210 220 230 240 250
DDFMIYCDNI VRTTAWGGQL ELRALSHVLK TPIEVIQADS PTLIIGEEYV
260 270 280
KKPIILVYLR YAYSLGEHYN SVTPLEAGAA GGVLPRLL
Length:288
Mass (Da):33,300
Last modified:February 15, 2005 - v1
Checksum:i78DCB2729A729C31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098697 mRNA. Translation: BAC05384.1.
CH471132 Genomic DNA. Translation: EAX05357.1.
BC137355 mRNA. Translation: AAI37356.1.
BC137356 mRNA. Translation: AAI37357.1.
CCDSiCCDS14395.1.
RefSeqiNP_997203.1. NM_207320.2.
UniGeneiHs.447381.

Genome annotation databases

EnsembliENST00000338352; ENSP00000339389; ENSG00000189401.
GeneIDi139562.
KEGGihsa:139562.
UCSCiuc004dxu.1. human.

Similar proteinsi

Entry informationi

Entry nameiOTU6A_HUMAN
AccessioniPrimary (citable) accession number: Q7L8S5
Secondary accession number(s): B2RPB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: February 15, 2005
Last modified: September 27, 2017
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot