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Q7L8S5

- OTU6A_HUMAN

UniProt

Q7L8S5 - OTU6A_HUMAN

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Protein
OTU domain-containing protein 6A
Gene
OTUD6A, DUBA2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Deubiquitinating enzyme that hydrolyzes 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains.1 Publication

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei149 – 1491 By similarity
Active sitei152 – 1521Nucleophile By similarity
Active sitei268 – 2681 By similarity

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: UniProtKB

GO - Biological processi

  1. protein K11-linked deubiquitination Source: UniProtKB
  2. protein K27-linked deubiquitination Source: UniProtKB
  3. protein K29-linked deubiquitination Source: UniProtKB
  4. protein K33-linked deubiquitination Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
OTU domain-containing protein 6A (EC:3.4.19.12)
Alternative name(s):
DUBA-2
Gene namesi
Name:OTUD6A
Synonyms:DUBA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:32312. OTUD6A.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671218.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288OTU domain-containing protein 6A
PRO_0000076277Add
BLAST

Proteomic databases

PaxDbiQ7L8S5.
PRIDEiQ7L8S5.

PTM databases

PhosphoSiteiQ7L8S5.

Expressioni

Gene expression databases

BgeeiQ7L8S5.
CleanExiHS_OTUD6A.
GenevestigatoriQ7L8S5.

Organism-specific databases

HPAiHPA053304.

Interactioni

Protein-protein interaction databases

BioGridi126574. 6 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ7L8S5.
SMRiQ7L8S5. Positions 122-272.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini141 – 275135OTU
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni146 – 1527Cys-loop By similarity
Regioni210 – 22011Variable-loop By similarity
Add
BLAST
Regioni258 – 26811His-loop By similarity
Add
BLAST

Sequence similaritiesi

Contains 1 OTU domain.

Phylogenomic databases

eggNOGiCOG5539.
HOGENOMiHOG000192906.
HOVERGENiHBG080227.
InParanoidiQ7L8S5.
KOiK18342.
OMAiKHVDDFL.
OrthoDBiEOG7WT42W.
PhylomeDBiQ7L8S5.
TreeFamiTF315010.

Family and domain databases

InterProiIPR003323. OTU.
[Graphical view]
PfamiPF02338. OTU. 1 hit.
[Graphical view]
PROSITEiPS50802. OTU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7L8S5-1 [UniParc]FASTAAdd to Basket

« Hide

MDDPKSEQQR ILRRHQRERQ ELQAQIRSLK NSVPKTDKTK RKQLLQDVAR    50
MEAEMAQKHR QELEKFQDDS SIESVVEDLA KMNLENRPPR SSKAHRKRER 100
MESEERERQE SIFQAEMSEH LAGFKREEEE KLAAILGARG LEMKAIPADG 150
HCMYRAIQDQ LVFSVSVEML RCRTASYMKK HVDEFLPFFS NPETSDSFGY 200
DDFMIYCDNI VRTTAWGGQL ELRALSHVLK TPIEVIQADS PTLIIGEEYV 250
KKPIILVYLR YAYSLGEHYN SVTPLEAGAA GGVLPRLL 288
Length:288
Mass (Da):33,300
Last modified:February 15, 2005 - v1
Checksum:i78DCB2729A729C31
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK098697 mRNA. Translation: BAC05384.1.
CH471132 Genomic DNA. Translation: EAX05357.1.
BC137355 mRNA. Translation: AAI37356.1.
BC137356 mRNA. Translation: AAI37357.1.
CCDSiCCDS14395.1.
RefSeqiNP_997203.1. NM_207320.1.
UniGeneiHs.447381.

Genome annotation databases

EnsembliENST00000338352; ENSP00000339389; ENSG00000189401.
GeneIDi139562.
KEGGihsa:139562.
UCSCiuc004dxu.1. human.

Polymorphism databases

DMDMi74713135.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK098697 mRNA. Translation: BAC05384.1 .
CH471132 Genomic DNA. Translation: EAX05357.1 .
BC137355 mRNA. Translation: AAI37356.1 .
BC137356 mRNA. Translation: AAI37357.1 .
CCDSi CCDS14395.1.
RefSeqi NP_997203.1. NM_207320.1.
UniGenei Hs.447381.

3D structure databases

ProteinModelPortali Q7L8S5.
SMRi Q7L8S5. Positions 122-272.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126574. 6 interactions.

PTM databases

PhosphoSitei Q7L8S5.

Polymorphism databases

DMDMi 74713135.

Proteomic databases

PaxDbi Q7L8S5.
PRIDEi Q7L8S5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000338352 ; ENSP00000339389 ; ENSG00000189401 .
GeneIDi 139562.
KEGGi hsa:139562.
UCSCi uc004dxu.1. human.

Organism-specific databases

CTDi 139562.
GeneCardsi GC0XP069282.
HGNCi HGNC:32312. OTUD6A.
HPAi HPA053304.
MIMi 300714. gene.
neXtProti NX_Q7L8S5.
PharmGKBi PA142671218.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5539.
HOGENOMi HOG000192906.
HOVERGENi HBG080227.
InParanoidi Q7L8S5.
KOi K18342.
OMAi KHVDDFL.
OrthoDBi EOG7WT42W.
PhylomeDBi Q7L8S5.
TreeFami TF315010.

Miscellaneous databases

GenomeRNAii 139562.
NextBioi 83989.
PROi Q7L8S5.
SOURCEi Search...

Gene expression databases

Bgeei Q7L8S5.
CleanExi HS_OTUD6A.
Genevestigatori Q7L8S5.

Family and domain databases

InterProi IPR003323. OTU.
[Graphical view ]
Pfami PF02338. OTU. 1 hit.
[Graphical view ]
PROSITEi PS50802. OTU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis."
    Mevissen T.E., Hospenthal M.K., Geurink P.P., Elliott P.R., Akutsu M., Arnaudo N., Ekkebus R., Kulathu Y., Wauer T., El Oualid F., Freund S.M., Ovaa H., Komander D.
    Cell 154:169-184(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY.

Entry informationi

Entry nameiOTU6A_HUMAN
AccessioniPrimary (citable) accession number: Q7L8S5
Secondary accession number(s): B2RPB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: February 15, 2005
Last modified: September 3, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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