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Q7L8L6

- FAKD5_HUMAN

UniProt

Q7L8L6 - FAKD5_HUMAN

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Protein

FAST kinase domain-containing protein 5

Gene

FASTKD5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. protein kinase activity Source: InterPro

GO - Biological processi

  1. cellular respiration Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
FAST kinase domain-containing protein 5
Gene namesi
Name:FASTKD5
Synonyms:KIAA1792
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:25790. FASTKD5.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145148886.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 764764FAST kinase domain-containing protein 5PRO_0000284979Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei95 – 951Phosphoserine3 Publications
Modified residuei507 – 5071N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ7L8L6.
PaxDbiQ7L8L6.
PRIDEiQ7L8L6.

PTM databases

PhosphoSiteiQ7L8L6.

Expressioni

Gene expression databases

BgeeiQ7L8L6.
GenevestigatoriQ7L8L6.

Organism-specific databases

HPAiHPA043833.

Interactioni

Protein-protein interaction databases

BioGridi121924. 8 interactions.
IntActiQ7L8L6. 5 interactions.
MINTiMINT-1441258.
STRINGi9606.ENSP00000369618.

Structurei

3D structure databases

ProteinModelPortaliQ7L8L6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini697 – 75761RAPPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the FAST kinase family.Curated
Contains 1 RAP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG72287.
GeneTreeiENSGT00510000049012.
HOGENOMiHOG000112492.
HOVERGENiHBG103634.
InParanoidiQ7L8L6.
OMAiVPQDLMQ.
OrthoDBiEOG7P2XS0.
PhylomeDBiQ7L8L6.
TreeFamiTF352874.

Family and domain databases

InterProiIPR013579. FAST_2.
IPR010622. FAST_Leu-rich.
IPR013584. RAP.
[Graphical view]
PfamiPF06743. FAST_1. 1 hit.
PF08368. FAST_2. 1 hit.
PF08373. RAP. 1 hit.
[Graphical view]
SMARTiSM00952. RAP. 1 hit.
[Graphical view]
PROSITEiPS51286. RAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7L8L6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAATLKSLKL VRYRAFCSPS AFGAVRSVSY WNVSSTQHGG QDPPEHISLC
60 70 80 90 100
HSAKKVKNIC STFSSRRILT TSSAHPGLEF SKTSSSKAST LQLGSPRATG
110 120 130 140 150
VDEEDVEVFD SFENMRVFLQ LRPEYRVHSY NASETSQLLS VSEGELILHK
160 170 180 190 200
VRVNQNNLQA QVIVDYLCKL SSLPAEQHPV LLGSTSFALL CQLSVKKIQL
210 220 230 240 250
FDTQDLINVL KAFVILGIPH SHSMLDVYET KCCHQVWEMN MDQLLLVADL
260 270 280 290 300
WRYLGRKVPR FLNIFSSYLN LHWKDLSLSQ LVHLIYVIGE NRQVSQDLMQ
310 320 330 340 350
KLESLILKYI DLINLEEVGT ICLGFFKSST NLSEFVMRKI GDLACANIQH
360 370 380 390 400
LSSRSLVNIV KMFRFTHVDH INFMKQIGEI APQRIPSLGV QGVMHLTLYC
410 420 430 440 450
SALRFLNEGV MNAVAASLPP RVAHCRSKDV AKILWSFGTL NYKPPNAEEF
460 470 480 490 500
YSSLISEIHR KMPEFNQYPE HLPTCLLGLA FLEYFPVELI DFALSPGFVR
510 520 530 540 550
LAQERTKFDL LKELYTLDGT VGIECPDYRG NRLSTHLQQE GSELLWYLAE
560 570 580 590 600
KDMNSKPEFL ETVFLLETML GGPQYVKHHM ILPHTRSSDL EVQLDVNLKP
610 620 630 640 650
LPFNREATPA ENVAKLRLEH VGVSLTDDLM NKLLKGKARG HFQGKTESEP
660 670 680 690 700
GQQPMELENK AAVPLGGFLC NVADKSGAME MAGLCPAACM QTPRMKLAVQ
710 720 730 740 750
FTNRNQYCYG SRDLLGLHNM KRRQLARLGY RVVELSYWEW LPLLKRTRLE
760
KLAFLHEKVF TSAL
Length:764
Mass (Da):86,574
Last modified:July 5, 2004 - v1
Checksum:i1064229F9B212405
GO

Sequence cautioni

The sequence BAB15696.1 differs from that shown. Reason: Frameshift at position 662.
The sequence BAB47421.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti256 – 2561R → C.
Corresponds to variant rs3746700 [ dbSNP | Ensembl ].
VAR_053891
Natural varianti288 – 2881I → T.
Corresponds to variant rs2422857 [ dbSNP | Ensembl ].
VAR_053892
Natural varianti377 – 3771I → V.
Corresponds to variant rs3746699 [ dbSNP | Ensembl ].
VAR_053893

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB058695 mRNA. Translation: BAB47421.1. Different initiation.
AK023211 mRNA. Translation: BAB14464.1.
AK027215 mRNA. Translation: BAB15696.1. Frameshift.
AL121891 Genomic DNA. Translation: CAC32460.1.
BC011856 mRNA. Translation: AAH11856.1.
BC007413 mRNA. Translation: AAH07413.1.
CCDSiCCDS13048.1.
RefSeqiNP_068598.1. NM_021826.4.
UniGeneiHs.741168.

Genome annotation databases

EnsembliENST00000380266; ENSP00000369618; ENSG00000215251.
GeneIDi60493.
KEGGihsa:60493.
UCSCiuc002whz.4. human.

Polymorphism databases

DMDMi74749905.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB058695 mRNA. Translation: BAB47421.1 . Different initiation.
AK023211 mRNA. Translation: BAB14464.1 .
AK027215 mRNA. Translation: BAB15696.1 . Frameshift.
AL121891 Genomic DNA. Translation: CAC32460.1 .
BC011856 mRNA. Translation: AAH11856.1 .
BC007413 mRNA. Translation: AAH07413.1 .
CCDSi CCDS13048.1.
RefSeqi NP_068598.1. NM_021826.4.
UniGenei Hs.741168.

3D structure databases

ProteinModelPortali Q7L8L6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121924. 8 interactions.
IntActi Q7L8L6. 5 interactions.
MINTi MINT-1441258.
STRINGi 9606.ENSP00000369618.

PTM databases

PhosphoSitei Q7L8L6.

Polymorphism databases

DMDMi 74749905.

Proteomic databases

MaxQBi Q7L8L6.
PaxDbi Q7L8L6.
PRIDEi Q7L8L6.

Protocols and materials databases

DNASUi 60493.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000380266 ; ENSP00000369618 ; ENSG00000215251 .
GeneIDi 60493.
KEGGi hsa:60493.
UCSCi uc002whz.4. human.

Organism-specific databases

CTDi 60493.
GeneCardsi GC20M003127.
HGNCi HGNC:25790. FASTKD5.
HPAi HPA043833.
neXtProti NX_Q7L8L6.
PharmGKBi PA145148886.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG72287.
GeneTreei ENSGT00510000049012.
HOGENOMi HOG000112492.
HOVERGENi HBG103634.
InParanoidi Q7L8L6.
OMAi VPQDLMQ.
OrthoDBi EOG7P2XS0.
PhylomeDBi Q7L8L6.
TreeFami TF352874.

Miscellaneous databases

GenomeRNAii 60493.
NextBioi 65391.
PROi Q7L8L6.

Gene expression databases

Bgeei Q7L8L6.
Genevestigatori Q7L8L6.

Family and domain databases

InterProi IPR013579. FAST_2.
IPR010622. FAST_Leu-rich.
IPR013584. RAP.
[Graphical view ]
Pfami PF06743. FAST_1. 1 hit.
PF08368. FAST_2. 1 hit.
PF08373. RAP. 1 hit.
[Graphical view ]
SMARTi SM00952. RAP. 1 hit.
[Graphical view ]
PROSITEi PS51286. RAP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
    DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  3. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle and Skin.
  5. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-95, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-95, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-95, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-507, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFAKD5_HUMAN
AccessioniPrimary (citable) accession number: Q7L8L6
Secondary accession number(s): Q96JN3, Q9H5D1, Q9H8Y3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3