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Protein

FAST kinase domain-containing protein 5, mitochondrial

Gene

FASTKD5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in the processing of non-canonical mitochondrial mRNA precursors (PubMed:25683715).1 Publication

GO - Molecular functioni

  • protein kinase activity Source: InterPro
  • RNA binding Source: UniProtKB
  • rRNA binding Source: UniProtKB

GO - Biological processi

  • cellular respiration Source: UniProtKB
  • mitochondrial RNA processing Source: UniProtKB
  • mRNA processing Source: UniProtKB-KW

Keywordsi

Molecular functionRNA-binding, rRNA-binding
Biological processmRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
FAST kinase domain-containing protein 5, mitochondrial
Gene namesi
Name:FASTKD5
Synonyms:KIAA1792
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000215251.3
HGNCiHGNC:25790 FASTKD5
neXtProtiNX_Q7L8L6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion, Mitochondrion nucleoid

Pathology & Biotechi

Organism-specific databases

DisGeNETi60493
OpenTargetsiENSG00000215251
PharmGKBiPA145148886

Polymorphism and mutation databases

BioMutaiFASTKD5
DMDMi74749905

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 27MitochondrionSequence analysisAdd BLAST27
ChainiPRO_000028497928 – 764FAST kinase domain-containing protein 5, mitochondrialAdd BLAST737

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei95PhosphoserineCombined sources1
Modified residuei507N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ7L8L6
MaxQBiQ7L8L6
PaxDbiQ7L8L6
PeptideAtlasiQ7L8L6
PRIDEiQ7L8L6

PTM databases

iPTMnetiQ7L8L6
PhosphoSitePlusiQ7L8L6

Expressioni

Tissue specificityi

Expression detected in spleen, thymus, testis, ovary, colon, heart, smooth muscle, kidney, brain, lung, liver and white adipose tissue with highest expression in heart, smooth muscle, liver and thyroid.1 Publication

Gene expression databases

BgeeiENSG00000215251
GenevisibleiQ7L8L6 HS

Organism-specific databases

HPAiHPA043833

Interactioni

Subunit structurei

Found in a complex with GRSF1, DDX28, DHX30 and FASTKD2. Associates with the 12S mitochondrial rRNA (12S mt-rRNA).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
KCNH1O952593EBI-747570,EBI-2909270

Protein-protein interaction databases

BioGridi121924, 22 interactors
CORUMiQ7L8L6
IntActiQ7L8L6, 20 interactors
STRINGi9606.ENSP00000369618

Structurei

3D structure databases

ProteinModelPortaliQ7L8L6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini697 – 757RAPPROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Belongs to the FAST kinase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IF51 Eukaryota
ENOG4111F08 LUCA
GeneTreeiENSGT00510000049012
HOGENOMiHOG000112492
HOVERGENiHBG103634
InParanoidiQ7L8L6
OMAiIKHHMIL
OrthoDBiEOG091G0BFG
PhylomeDBiQ7L8L6
TreeFamiTF352874

Family and domain databases

InterProiView protein in InterPro
IPR013579 FAST_2
IPR010622 FAST_Leu-rich
IPR013584 RAP
PfamiView protein in Pfam
PF06743 FAST_1, 1 hit
PF08368 FAST_2, 1 hit
PF08373 RAP, 1 hit
SMARTiView protein in SMART
SM00952 RAP, 1 hit
PROSITEiView protein in PROSITE
PS51286 RAP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7L8L6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATLKSLKL VRYRAFCSPS AFGAVRSVSY WNVSSTQHGG QDPPEHISLC
60 70 80 90 100
HSAKKVKNIC STFSSRRILT TSSAHPGLEF SKTSSSKAST LQLGSPRATG
110 120 130 140 150
VDEEDVEVFD SFENMRVFLQ LRPEYRVHSY NASETSQLLS VSEGELILHK
160 170 180 190 200
VRVNQNNLQA QVIVDYLCKL SSLPAEQHPV LLGSTSFALL CQLSVKKIQL
210 220 230 240 250
FDTQDLINVL KAFVILGIPH SHSMLDVYET KCCHQVWEMN MDQLLLVADL
260 270 280 290 300
WRYLGRKVPR FLNIFSSYLN LHWKDLSLSQ LVHLIYVIGE NRQVSQDLMQ
310 320 330 340 350
KLESLILKYI DLINLEEVGT ICLGFFKSST NLSEFVMRKI GDLACANIQH
360 370 380 390 400
LSSRSLVNIV KMFRFTHVDH INFMKQIGEI APQRIPSLGV QGVMHLTLYC
410 420 430 440 450
SALRFLNEGV MNAVAASLPP RVAHCRSKDV AKILWSFGTL NYKPPNAEEF
460 470 480 490 500
YSSLISEIHR KMPEFNQYPE HLPTCLLGLA FLEYFPVELI DFALSPGFVR
510 520 530 540 550
LAQERTKFDL LKELYTLDGT VGIECPDYRG NRLSTHLQQE GSELLWYLAE
560 570 580 590 600
KDMNSKPEFL ETVFLLETML GGPQYVKHHM ILPHTRSSDL EVQLDVNLKP
610 620 630 640 650
LPFNREATPA ENVAKLRLEH VGVSLTDDLM NKLLKGKARG HFQGKTESEP
660 670 680 690 700
GQQPMELENK AAVPLGGFLC NVADKSGAME MAGLCPAACM QTPRMKLAVQ
710 720 730 740 750
FTNRNQYCYG SRDLLGLHNM KRRQLARLGY RVVELSYWEW LPLLKRTRLE
760
KLAFLHEKVF TSAL
Length:764
Mass (Da):86,574
Last modified:July 5, 2004 - v1
Checksum:i1064229F9B212405
GO

Sequence cautioni

The sequence BAB15696 differs from that shown. Reason: Frameshift at position 662.Curated
The sequence BAB47421 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053891256R → C. Corresponds to variant dbSNP:rs3746700Ensembl.1
Natural variantiVAR_053892288I → T. Corresponds to variant dbSNP:rs2422857Ensembl.1
Natural variantiVAR_053893377I → V. Corresponds to variant dbSNP:rs3746699Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058695 mRNA Translation: BAB47421.1 Different initiation.
AK023211 mRNA Translation: BAB14464.1
AK027215 mRNA Translation: BAB15696.1 Frameshift.
AL121891 Genomic DNA No translation available.
BC011856 mRNA Translation: AAH11856.1
BC007413 mRNA Translation: AAH07413.1
CCDSiCCDS13048.1
RefSeqiNP_068598.1, NM_021826.4
UniGeneiHs.741168

Genome annotation databases

EnsembliENST00000380266; ENSP00000369618; ENSG00000215251
GeneIDi60493
KEGGihsa:60493
UCSCiuc002whz.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFAKD5_HUMAN
AccessioniPrimary (citable) accession number: Q7L8L6
Secondary accession number(s): Q96JN3, Q9H5D1, Q9H8Y3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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