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Q7L8L6

- FAKD5_HUMAN

UniProt

Q7L8L6 - FAKD5_HUMAN

Protein

FAST kinase domain-containing protein 5

Gene

FASTKD5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. protein kinase activity Source: InterPro

    GO - Biological processi

    1. cellular respiration Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    FAST kinase domain-containing protein 5
    Gene namesi
    Name:FASTKD5
    Synonyms:KIAA1792
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:25790. FASTKD5.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA145148886.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 764764FAST kinase domain-containing protein 5PRO_0000284979Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei95 – 951Phosphoserine3 Publications
    Modified residuei507 – 5071N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ7L8L6.
    PaxDbiQ7L8L6.
    PRIDEiQ7L8L6.

    PTM databases

    PhosphoSiteiQ7L8L6.

    Expressioni

    Gene expression databases

    BgeeiQ7L8L6.
    GenevestigatoriQ7L8L6.

    Organism-specific databases

    HPAiHPA043833.

    Interactioni

    Protein-protein interaction databases

    BioGridi121924. 8 interactions.
    IntActiQ7L8L6. 5 interactions.
    MINTiMINT-1441258.
    STRINGi9606.ENSP00000369618.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7L8L6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini697 – 75761RAPPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the FAST kinase family.Curated
    Contains 1 RAP domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG72287.
    HOGENOMiHOG000112492.
    HOVERGENiHBG103634.
    InParanoidiQ7L8L6.
    OMAiVPQDLMQ.
    OrthoDBiEOG7P2XS0.
    PhylomeDBiQ7L8L6.
    TreeFamiTF352874.

    Family and domain databases

    InterProiIPR013579. FAST_2.
    IPR010622. FAST_Leu-rich.
    IPR013584. RAP.
    [Graphical view]
    PfamiPF06743. FAST_1. 1 hit.
    PF08368. FAST_2. 1 hit.
    PF08373. RAP. 1 hit.
    [Graphical view]
    SMARTiSM00952. RAP. 1 hit.
    [Graphical view]
    PROSITEiPS51286. RAP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7L8L6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAATLKSLKL VRYRAFCSPS AFGAVRSVSY WNVSSTQHGG QDPPEHISLC    50
    HSAKKVKNIC STFSSRRILT TSSAHPGLEF SKTSSSKAST LQLGSPRATG 100
    VDEEDVEVFD SFENMRVFLQ LRPEYRVHSY NASETSQLLS VSEGELILHK 150
    VRVNQNNLQA QVIVDYLCKL SSLPAEQHPV LLGSTSFALL CQLSVKKIQL 200
    FDTQDLINVL KAFVILGIPH SHSMLDVYET KCCHQVWEMN MDQLLLVADL 250
    WRYLGRKVPR FLNIFSSYLN LHWKDLSLSQ LVHLIYVIGE NRQVSQDLMQ 300
    KLESLILKYI DLINLEEVGT ICLGFFKSST NLSEFVMRKI GDLACANIQH 350
    LSSRSLVNIV KMFRFTHVDH INFMKQIGEI APQRIPSLGV QGVMHLTLYC 400
    SALRFLNEGV MNAVAASLPP RVAHCRSKDV AKILWSFGTL NYKPPNAEEF 450
    YSSLISEIHR KMPEFNQYPE HLPTCLLGLA FLEYFPVELI DFALSPGFVR 500
    LAQERTKFDL LKELYTLDGT VGIECPDYRG NRLSTHLQQE GSELLWYLAE 550
    KDMNSKPEFL ETVFLLETML GGPQYVKHHM ILPHTRSSDL EVQLDVNLKP 600
    LPFNREATPA ENVAKLRLEH VGVSLTDDLM NKLLKGKARG HFQGKTESEP 650
    GQQPMELENK AAVPLGGFLC NVADKSGAME MAGLCPAACM QTPRMKLAVQ 700
    FTNRNQYCYG SRDLLGLHNM KRRQLARLGY RVVELSYWEW LPLLKRTRLE 750
    KLAFLHEKVF TSAL 764
    Length:764
    Mass (Da):86,574
    Last modified:July 5, 2004 - v1
    Checksum:i1064229F9B212405
    GO

    Sequence cautioni

    The sequence BAB15696.1 differs from that shown. Reason: Frameshift at position 662.
    The sequence BAB47421.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti256 – 2561R → C.
    Corresponds to variant rs3746700 [ dbSNP | Ensembl ].
    VAR_053891
    Natural varianti288 – 2881I → T.
    Corresponds to variant rs2422857 [ dbSNP | Ensembl ].
    VAR_053892
    Natural varianti377 – 3771I → V.
    Corresponds to variant rs3746699 [ dbSNP | Ensembl ].
    VAR_053893

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB058695 mRNA. Translation: BAB47421.1. Different initiation.
    AK023211 mRNA. Translation: BAB14464.1.
    AK027215 mRNA. Translation: BAB15696.1. Frameshift.
    AL121891 Genomic DNA. Translation: CAC32460.1.
    BC011856 mRNA. Translation: AAH11856.1.
    BC007413 mRNA. Translation: AAH07413.1.
    CCDSiCCDS13048.1.
    RefSeqiNP_068598.1. NM_021826.4.
    UniGeneiHs.741168.

    Genome annotation databases

    EnsembliENST00000380266; ENSP00000369618; ENSG00000215251.
    GeneIDi60493.
    KEGGihsa:60493.
    UCSCiuc002whz.4. human.

    Polymorphism databases

    DMDMi74749905.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB058695 mRNA. Translation: BAB47421.1 . Different initiation.
    AK023211 mRNA. Translation: BAB14464.1 .
    AK027215 mRNA. Translation: BAB15696.1 . Frameshift.
    AL121891 Genomic DNA. Translation: CAC32460.1 .
    BC011856 mRNA. Translation: AAH11856.1 .
    BC007413 mRNA. Translation: AAH07413.1 .
    CCDSi CCDS13048.1.
    RefSeqi NP_068598.1. NM_021826.4.
    UniGenei Hs.741168.

    3D structure databases

    ProteinModelPortali Q7L8L6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121924. 8 interactions.
    IntActi Q7L8L6. 5 interactions.
    MINTi MINT-1441258.
    STRINGi 9606.ENSP00000369618.

    PTM databases

    PhosphoSitei Q7L8L6.

    Polymorphism databases

    DMDMi 74749905.

    Proteomic databases

    MaxQBi Q7L8L6.
    PaxDbi Q7L8L6.
    PRIDEi Q7L8L6.

    Protocols and materials databases

    DNASUi 60493.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000380266 ; ENSP00000369618 ; ENSG00000215251 .
    GeneIDi 60493.
    KEGGi hsa:60493.
    UCSCi uc002whz.4. human.

    Organism-specific databases

    CTDi 60493.
    GeneCardsi GC20M003127.
    HGNCi HGNC:25790. FASTKD5.
    HPAi HPA043833.
    neXtProti NX_Q7L8L6.
    PharmGKBi PA145148886.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG72287.
    HOGENOMi HOG000112492.
    HOVERGENi HBG103634.
    InParanoidi Q7L8L6.
    OMAi VPQDLMQ.
    OrthoDBi EOG7P2XS0.
    PhylomeDBi Q7L8L6.
    TreeFami TF352874.

    Miscellaneous databases

    GenomeRNAii 60493.
    NextBioi 65391.
    PROi Q7L8L6.

    Gene expression databases

    Bgeei Q7L8L6.
    Genevestigatori Q7L8L6.

    Family and domain databases

    InterProi IPR013579. FAST_2.
    IPR010622. FAST_Leu-rich.
    IPR013584. RAP.
    [Graphical view ]
    Pfami PF06743. FAST_1. 1 hit.
    PF08368. FAST_2. 1 hit.
    PF08373. RAP. 1 hit.
    [Graphical view ]
    SMARTi SM00952. RAP. 1 hit.
    [Graphical view ]
    PROSITEi PS51286. RAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
      DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    3. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Muscle and Skin.
    5. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-95, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-95, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-95, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-507, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiFAKD5_HUMAN
    AccessioniPrimary (citable) accession number: Q7L8L6
    Secondary accession number(s): Q96JN3, Q9H5D1, Q9H8Y3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3