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Q7L8L6 (FAKD5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
FAST kinase domain-containing protein 5
Gene names
Name:FASTKD5
Synonyms:KIAA1792
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length764 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the FAST kinase family.

Contains 1 RAP domain.

Sequence caution

The sequence BAB15696.1 differs from that shown. Reason: Frameshift at position 662.

The sequence BAB47421.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular respiration

Inferred from sequence or structural similarity PubMed 20869947. Source: UniProtKB

   Cellular_componentmitochondrion

Inferred from direct assay PubMed 20869947. Source: UniProtKB

   Molecular_functionpoly(A) RNA binding

Inferred from direct assay PubMed 22681889. Source: UniProtKB

protein kinase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 764764FAST kinase domain-containing protein 5
PRO_0000284979

Regions

Domain697 – 75761RAP

Amino acid modifications

Modified residue951Phosphoserine Ref.5 Ref.6 Ref.7
Modified residue5071N6-acetyllysine Ref.8

Natural variations

Natural variant2561R → C.
Corresponds to variant rs3746700 [ dbSNP | Ensembl ].
VAR_053891
Natural variant2881I → T.
Corresponds to variant rs2422857 [ dbSNP | Ensembl ].
VAR_053892
Natural variant3771I → V.
Corresponds to variant rs3746699 [ dbSNP | Ensembl ].
VAR_053893

Sequences

Sequence LengthMass (Da)Tools
Q7L8L6 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 1064229F9B212405

FASTA76486,574
        10         20         30         40         50         60 
MAATLKSLKL VRYRAFCSPS AFGAVRSVSY WNVSSTQHGG QDPPEHISLC HSAKKVKNIC 

        70         80         90        100        110        120 
STFSSRRILT TSSAHPGLEF SKTSSSKAST LQLGSPRATG VDEEDVEVFD SFENMRVFLQ 

       130        140        150        160        170        180 
LRPEYRVHSY NASETSQLLS VSEGELILHK VRVNQNNLQA QVIVDYLCKL SSLPAEQHPV 

       190        200        210        220        230        240 
LLGSTSFALL CQLSVKKIQL FDTQDLINVL KAFVILGIPH SHSMLDVYET KCCHQVWEMN 

       250        260        270        280        290        300 
MDQLLLVADL WRYLGRKVPR FLNIFSSYLN LHWKDLSLSQ LVHLIYVIGE NRQVSQDLMQ 

       310        320        330        340        350        360 
KLESLILKYI DLINLEEVGT ICLGFFKSST NLSEFVMRKI GDLACANIQH LSSRSLVNIV 

       370        380        390        400        410        420 
KMFRFTHVDH INFMKQIGEI APQRIPSLGV QGVMHLTLYC SALRFLNEGV MNAVAASLPP 

       430        440        450        460        470        480 
RVAHCRSKDV AKILWSFGTL NYKPPNAEEF YSSLISEIHR KMPEFNQYPE HLPTCLLGLA 

       490        500        510        520        530        540 
FLEYFPVELI DFALSPGFVR LAQERTKFDL LKELYTLDGT VGIECPDYRG NRLSTHLQQE 

       550        560        570        580        590        600 
GSELLWYLAE KDMNSKPEFL ETVFLLETML GGPQYVKHHM ILPHTRSSDL EVQLDVNLKP 

       610        620        630        640        650        660 
LPFNREATPA ENVAKLRLEH VGVSLTDDLM NKLLKGKARG HFQGKTESEP GQQPMELENK 

       670        680        690        700        710        720 
AAVPLGGFLC NVADKSGAME MAGLCPAACM QTPRMKLAVQ FTNRNQYCYG SRDLLGLHNM 

       730        740        750        760 
KRRQLARLGY RVVELSYWEW LPLLKRTRLE KLAFLHEKVF TSAL 

« Hide

References

[1]"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[3]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Muscle and Skin.
[5]"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-95, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-95, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[7]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-95, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-507, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB058695 mRNA. Translation: BAB47421.1. Different initiation.
AK023211 mRNA. Translation: BAB14464.1.
AK027215 mRNA. Translation: BAB15696.1. Frameshift.
AL121891 Genomic DNA. Translation: CAC32460.1.
BC011856 mRNA. Translation: AAH11856.1.
BC007413 mRNA. Translation: AAH07413.1.
CCDSCCDS13048.1.
RefSeqNP_068598.1. NM_021826.4.
UniGeneHs.741168.

3D structure databases

ProteinModelPortalQ7L8L6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121924. 9 interactions.
IntActQ7L8L6. 5 interactions.
MINTMINT-1441258.
STRING9606.ENSP00000369618.

PTM databases

PhosphoSiteQ7L8L6.

Polymorphism databases

DMDM74749905.

Proteomic databases

MaxQBQ7L8L6.
PaxDbQ7L8L6.
PRIDEQ7L8L6.

Protocols and materials databases

DNASU60493.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000380266; ENSP00000369618; ENSG00000215251.
GeneID60493.
KEGGhsa:60493.
UCSCuc002whz.4. human.

Organism-specific databases

CTD60493.
GeneCardsGC20M003127.
HGNCHGNC:25790. FASTKD5.
HPAHPA043833.
neXtProtNX_Q7L8L6.
PharmGKBPA145148886.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG72287.
HOGENOMHOG000112492.
HOVERGENHBG103634.
InParanoidQ7L8L6.
OMAVPQDLMQ.
OrthoDBEOG7P2XS0.
PhylomeDBQ7L8L6.
TreeFamTF352874.

Gene expression databases

BgeeQ7L8L6.
GenevestigatorQ7L8L6.

Family and domain databases

InterProIPR013579. FAST_2.
IPR010622. FAST_Leu-rich.
IPR013584. RAP.
[Graphical view]
PfamPF06743. FAST_1. 1 hit.
PF08368. FAST_2. 1 hit.
PF08373. RAP. 1 hit.
[Graphical view]
SMARTSM00952. RAP. 1 hit.
[Graphical view]
PROSITEPS51286. RAP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi60493.
NextBio65391.
PROQ7L8L6.

Entry information

Entry nameFAKD5_HUMAN
AccessionPrimary (citable) accession number: Q7L8L6
Secondary accession number(s): Q96JN3, Q9H5D1, Q9H8Y3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM