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Protein

FAST kinase domain-containing protein 5, mitochondrial

Gene

FASTKD5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in the processing of non-canonical mitochondrial mRNA precursors (PubMed:25683715).1 Publication

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • protein kinase activity Source: InterPro
  • rRNA binding Source: UniProtKB

GO - Biological processi

  • cellular respiration Source: UniProtKB
  • mitochondrial RNA processing Source: UniProtKB
  • mRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

mRNA processing

Keywords - Ligandi

RNA-binding, rRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
FAST kinase domain-containing protein 5, mitochondrial
Gene namesi
Name:FASTKD5
Synonyms:KIAA1792
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:25790. FASTKD5.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial nucleoid Source: UniProtKB
  • mitochondrion Source: UniProtKB
  • ribonucleoprotein granule Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion, Mitochondrion nucleoid

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145148886.

Polymorphism and mutation databases

BioMutaiFASTKD5.
DMDMi74749905.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2727MitochondrionSequence analysisAdd
BLAST
Chaini28 – 764737FAST kinase domain-containing protein 5, mitochondrialPRO_0000284979Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei95 – 951PhosphoserineCombined sources
Modified residuei507 – 5071N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ7L8L6.
MaxQBiQ7L8L6.
PaxDbiQ7L8L6.
PeptideAtlasiQ7L8L6.
PRIDEiQ7L8L6.

PTM databases

iPTMnetiQ7L8L6.
PhosphoSiteiQ7L8L6.

Expressioni

Tissue specificityi

Expression detected in spleen, thymus, testis, ovary, colon, heart, smooth muscle, kidney, brain, lung, liver and white adipose tissue with highest expression in heart, smooth muscle, liver and thyroid.1 Publication

Gene expression databases

BgeeiENSG00000215251.
GenevisibleiQ7L8L6. HS.

Organism-specific databases

HPAiHPA043833.
HPA056951.

Interactioni

Subunit structurei

Found in a complex with GRSF1, DDX28, DHX30 and FASTKD2. Associates with the 12S mitochondrial rRNA (12S mt-rRNA).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
KCNH1O952593EBI-747570,EBI-2909270

Protein-protein interaction databases

BioGridi121924. 19 interactions.
IntActiQ7L8L6. 16 interactions.
MINTiMINT-1441258.
STRINGi9606.ENSP00000369618.

Structurei

3D structure databases

ProteinModelPortaliQ7L8L6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini697 – 75761RAPPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the FAST kinase family.Curated
Contains 1 RAP domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IF51. Eukaryota.
ENOG4111F08. LUCA.
GeneTreeiENSGT00510000049012.
HOGENOMiHOG000112492.
HOVERGENiHBG103634.
InParanoidiQ7L8L6.
OMAiVPQDLMQ.
OrthoDBiEOG091G0BFG.
PhylomeDBiQ7L8L6.
TreeFamiTF352874.

Family and domain databases

InterProiIPR013579. FAST_2.
IPR010622. FAST_Leu-rich.
IPR013584. RAP.
[Graphical view]
PfamiPF06743. FAST_1. 1 hit.
PF08368. FAST_2. 1 hit.
PF08373. RAP. 1 hit.
[Graphical view]
SMARTiSM00952. RAP. 1 hit.
[Graphical view]
PROSITEiPS51286. RAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7L8L6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATLKSLKL VRYRAFCSPS AFGAVRSVSY WNVSSTQHGG QDPPEHISLC
60 70 80 90 100
HSAKKVKNIC STFSSRRILT TSSAHPGLEF SKTSSSKAST LQLGSPRATG
110 120 130 140 150
VDEEDVEVFD SFENMRVFLQ LRPEYRVHSY NASETSQLLS VSEGELILHK
160 170 180 190 200
VRVNQNNLQA QVIVDYLCKL SSLPAEQHPV LLGSTSFALL CQLSVKKIQL
210 220 230 240 250
FDTQDLINVL KAFVILGIPH SHSMLDVYET KCCHQVWEMN MDQLLLVADL
260 270 280 290 300
WRYLGRKVPR FLNIFSSYLN LHWKDLSLSQ LVHLIYVIGE NRQVSQDLMQ
310 320 330 340 350
KLESLILKYI DLINLEEVGT ICLGFFKSST NLSEFVMRKI GDLACANIQH
360 370 380 390 400
LSSRSLVNIV KMFRFTHVDH INFMKQIGEI APQRIPSLGV QGVMHLTLYC
410 420 430 440 450
SALRFLNEGV MNAVAASLPP RVAHCRSKDV AKILWSFGTL NYKPPNAEEF
460 470 480 490 500
YSSLISEIHR KMPEFNQYPE HLPTCLLGLA FLEYFPVELI DFALSPGFVR
510 520 530 540 550
LAQERTKFDL LKELYTLDGT VGIECPDYRG NRLSTHLQQE GSELLWYLAE
560 570 580 590 600
KDMNSKPEFL ETVFLLETML GGPQYVKHHM ILPHTRSSDL EVQLDVNLKP
610 620 630 640 650
LPFNREATPA ENVAKLRLEH VGVSLTDDLM NKLLKGKARG HFQGKTESEP
660 670 680 690 700
GQQPMELENK AAVPLGGFLC NVADKSGAME MAGLCPAACM QTPRMKLAVQ
710 720 730 740 750
FTNRNQYCYG SRDLLGLHNM KRRQLARLGY RVVELSYWEW LPLLKRTRLE
760
KLAFLHEKVF TSAL
Length:764
Mass (Da):86,574
Last modified:July 5, 2004 - v1
Checksum:i1064229F9B212405
GO

Sequence cautioni

The sequence BAB15696 differs from that shown. Reason: Frameshift at position 662. Curated
The sequence BAB47421 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti256 – 2561R → C.
Corresponds to variant rs3746700 [ dbSNP | Ensembl ].
VAR_053891
Natural varianti288 – 2881I → T.
Corresponds to variant rs2422857 [ dbSNP | Ensembl ].
VAR_053892
Natural varianti377 – 3771I → V.
Corresponds to variant rs3746699 [ dbSNP | Ensembl ].
VAR_053893

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058695 mRNA. Translation: BAB47421.1. Different initiation.
AK023211 mRNA. Translation: BAB14464.1.
AK027215 mRNA. Translation: BAB15696.1. Frameshift.
AL121891 Genomic DNA. Translation: CAC32460.1.
BC011856 mRNA. Translation: AAH11856.1.
BC007413 mRNA. Translation: AAH07413.1.
CCDSiCCDS13048.1.
RefSeqiNP_068598.1. NM_021826.4.
UniGeneiHs.741168.

Genome annotation databases

EnsembliENST00000380266; ENSP00000369618; ENSG00000215251.
GeneIDi60493.
KEGGihsa:60493.
UCSCiuc002whz.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058695 mRNA. Translation: BAB47421.1. Different initiation.
AK023211 mRNA. Translation: BAB14464.1.
AK027215 mRNA. Translation: BAB15696.1. Frameshift.
AL121891 Genomic DNA. Translation: CAC32460.1.
BC011856 mRNA. Translation: AAH11856.1.
BC007413 mRNA. Translation: AAH07413.1.
CCDSiCCDS13048.1.
RefSeqiNP_068598.1. NM_021826.4.
UniGeneiHs.741168.

3D structure databases

ProteinModelPortaliQ7L8L6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121924. 19 interactions.
IntActiQ7L8L6. 16 interactions.
MINTiMINT-1441258.
STRINGi9606.ENSP00000369618.

PTM databases

iPTMnetiQ7L8L6.
PhosphoSiteiQ7L8L6.

Polymorphism and mutation databases

BioMutaiFASTKD5.
DMDMi74749905.

Proteomic databases

EPDiQ7L8L6.
MaxQBiQ7L8L6.
PaxDbiQ7L8L6.
PeptideAtlasiQ7L8L6.
PRIDEiQ7L8L6.

Protocols and materials databases

DNASUi60493.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380266; ENSP00000369618; ENSG00000215251.
GeneIDi60493.
KEGGihsa:60493.
UCSCiuc002whz.5. human.

Organism-specific databases

CTDi60493.
GeneCardsiFASTKD5.
HGNCiHGNC:25790. FASTKD5.
HPAiHPA043833.
HPA056951.
neXtProtiNX_Q7L8L6.
PharmGKBiPA145148886.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF51. Eukaryota.
ENOG4111F08. LUCA.
GeneTreeiENSGT00510000049012.
HOGENOMiHOG000112492.
HOVERGENiHBG103634.
InParanoidiQ7L8L6.
OMAiVPQDLMQ.
OrthoDBiEOG091G0BFG.
PhylomeDBiQ7L8L6.
TreeFamiTF352874.

Miscellaneous databases

GenomeRNAii60493.
PROiQ7L8L6.

Gene expression databases

BgeeiENSG00000215251.
GenevisibleiQ7L8L6. HS.

Family and domain databases

InterProiIPR013579. FAST_2.
IPR010622. FAST_Leu-rich.
IPR013584. RAP.
[Graphical view]
PfamiPF06743. FAST_1. 1 hit.
PF08368. FAST_2. 1 hit.
PF08373. RAP. 1 hit.
[Graphical view]
SMARTiSM00952. RAP. 1 hit.
[Graphical view]
PROSITEiPS51286. RAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFAKD5_HUMAN
AccessioniPrimary (citable) accession number: Q7L8L6
Secondary accession number(s): Q96JN3, Q9H5D1, Q9H8Y3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.