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Protein

SH3 domain-binding protein 5-like

Gene

SH3BP5L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 domain-binding protein 5-like
Short name:
SH3BP-5-like
Gene namesi
Name:SH3BP5L
Synonyms:KIAA1720
ORF Names:UNQ2766/PRO7133
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:29360. SH3BP5L.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670923.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 393393SH3 domain-binding protein 5-likePRO_0000317508Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei343 – 3431Phosphoserine1 Publication
Modified residuei350 – 3501Phosphoserine1 Publication
Modified residuei358 – 3581Phosphoserine1 Publication
Modified residuei362 – 3621Phosphoserine3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ7L8J4.
PaxDbiQ7L8J4.
PRIDEiQ7L8J4.

PTM databases

PhosphoSiteiQ7L8J4.

Expressioni

Gene expression databases

BgeeiQ7L8J4.
CleanExiHS_SH3BP5L.
ExpressionAtlasiQ7L8J4. baseline and differential.
GenevestigatoriQ7L8J4.

Organism-specific databases

HPAiHPA038068.

Interactioni

Protein-protein interaction databases

BioGridi123329. 5 interactions.
IntActiQ7L8J4. 3 interactions.
MINTiMINT-1688351.

Structurei

3D structure databases

ProteinModelPortaliQ7L8J4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili59 – 14082Sequence AnalysisAdd
BLAST
Coiled coili169 – 272104Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi37 – 404Poly-Gly
Compositional biasi41 – 444Poly-Ser
Compositional biasi52 – 554Poly-Glu

Sequence similaritiesi

Belongs to the SH3BP5 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG263345.
GeneTreeiENSGT00390000018500.
HOGENOMiHOG000190360.
HOVERGENiHBG057307.
InParanoidiQ7L8J4.
OMAiGACIDKA.
OrthoDBiEOG7Z3F4J.
PhylomeDBiQ7L8J4.
TreeFamiTF105573.

Family and domain databases

InterProiIPR007940. SH3-bd_5.
[Graphical view]
PANTHERiPTHR19423. PTHR19423. 1 hit.
PfamiPF05276. SH3BP5. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q7L8J4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAELRQVPGG RETPQGELRP EVVEDEVPRS PVAEEPGGGG SSSSEAKLSP
60 70 80 90 100
REEEELDPRI QEELEHLNQA SEEINQVELQ LDEARTTYRR ILQESARKLN
110 120 130 140 150
TQGSHLGSCI EKARPYYEAR RLAKEAQQET QKAALRYERA VSMHNAAREM
160 170 180 190 200
VFVAEQGVMA DKNRLDPTWQ EMLNHATCKV NEAEEERLRG EREHQRVTRL
210 220 230 240 250
CQQAEARVQA LQKTLRRAIG KSRPYFELKA QFSQILEEHK AKVTELEQQV
260 270 280 290 300
AQAKTRYSVA LRNLEQISEQ IHARRRGGLP PHPLGPRRSS PVGAEAGPED
310 320 330 340 350
MEDGDSGIEG AEGAGLEEGS SLGPGPAPDT DTLSLLSLRT VASDLQKCDS
360 370 380 390
VEHLRGLSDH VSLDGQELGT RSGGRRGSDG GARGGRHQRS VSL
Length:393
Mass (Da):43,499
Last modified:July 5, 2004 - v1
Checksum:i3693431765F90FDC
GO
Isoform 2 (identifier: Q7L8J4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: MAELRQVPGG...EEEELDPRIQ → MYQVPDRQESFWQSPYLLSFPECLTSFPW

Note: No experimental confirmation available.

Show »
Length:361
Mass (Da):40,500
Checksum:i301F7348FD6B36A8
GO

Sequence cautioni

The sequence BAB21811.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6161MAELR…DPRIQ → MYQVPDRQESFWQSPYLLSF PECLTSFPW in isoform 2. 1 PublicationVSP_056075Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051507 mRNA. Translation: BAB21811.1. Different initiation.
AL136569 mRNA. Translation: CAB66504.1.
AY358453 mRNA. Translation: AAQ88818.1.
AK056382 mRNA. Translation: BAB71171.1.
AK298698 mRNA. Translation: BAG60856.1.
AL732583 Genomic DNA. Translation: CAI18798.1.
CH471257 Genomic DNA. Translation: EAW57534.1.
BC010871 mRNA. Translation: AAH10871.1.
BC017254 mRNA. Translation: AAH17254.1.
CCDSiCCDS31126.1. [Q7L8J4-1]
RefSeqiNP_085148.1. NM_030645.1. [Q7L8J4-1]
UniGeneiHs.298573.

Genome annotation databases

EnsembliENST00000366472; ENSP00000355428; ENSG00000175137. [Q7L8J4-1]
GeneIDi80851.
KEGGihsa:80851.
UCSCiuc001iev.1. human. [Q7L8J4-1]

Polymorphism databases

DMDMi74749902.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051507 mRNA. Translation: BAB21811.1. Different initiation.
AL136569 mRNA. Translation: CAB66504.1.
AY358453 mRNA. Translation: AAQ88818.1.
AK056382 mRNA. Translation: BAB71171.1.
AK298698 mRNA. Translation: BAG60856.1.
AL732583 Genomic DNA. Translation: CAI18798.1.
CH471257 Genomic DNA. Translation: EAW57534.1.
BC010871 mRNA. Translation: AAH10871.1.
BC017254 mRNA. Translation: AAH17254.1.
CCDSiCCDS31126.1. [Q7L8J4-1]
RefSeqiNP_085148.1. NM_030645.1. [Q7L8J4-1]
UniGeneiHs.298573.

3D structure databases

ProteinModelPortaliQ7L8J4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123329. 5 interactions.
IntActiQ7L8J4. 3 interactions.
MINTiMINT-1688351.

PTM databases

PhosphoSiteiQ7L8J4.

Polymorphism databases

DMDMi74749902.

Proteomic databases

MaxQBiQ7L8J4.
PaxDbiQ7L8J4.
PRIDEiQ7L8J4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366472; ENSP00000355428; ENSG00000175137. [Q7L8J4-1]
GeneIDi80851.
KEGGihsa:80851.
UCSCiuc001iev.1. human. [Q7L8J4-1]

Organism-specific databases

CTDi80851.
GeneCardsiGC01M249104.
H-InvDBHIX0160026.
HGNCiHGNC:29360. SH3BP5L.
HPAiHPA038068.
neXtProtiNX_Q7L8J4.
PharmGKBiPA142670923.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG263345.
GeneTreeiENSGT00390000018500.
HOGENOMiHOG000190360.
HOVERGENiHBG057307.
InParanoidiQ7L8J4.
OMAiGACIDKA.
OrthoDBiEOG7Z3F4J.
PhylomeDBiQ7L8J4.
TreeFamiTF105573.

Miscellaneous databases

GenomeRNAii80851.
NextBioi35474077.
PROiQ7L8J4.

Gene expression databases

BgeeiQ7L8J4.
CleanExiHS_SH3BP5L.
ExpressionAtlasiQ7L8J4. baseline and differential.
GenevestigatoriQ7L8J4.

Family and domain databases

InterProiIPR007940. SH3-bd_5.
[Graphical view]
PANTHERiPTHR19423. PTHR19423. 1 hit.
PfamiPF05276. SH3BP5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
    DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Amygdala.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon and Lung.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-343; SER-350 AND SER-362, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-362, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-358 AND SER-362, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry namei3BP5L_HUMAN
AccessioniPrimary (citable) accession number: Q7L8J4
Secondary accession number(s): B4DQ94
, Q96FI5, Q9BQH8, Q9C0E3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: January 7, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.