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Protein

SH3 domain-binding protein 5-like

Gene

SH3BP5L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 domain-binding protein 5-like
Short name:
SH3BP-5-like
Gene namesi
Name:SH3BP5L
Synonyms:KIAA1720
ORF Names:UNQ2766/PRO7133
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000175137.10
HGNCiHGNC:29360 SH3BP5L
neXtProtiNX_Q7L8J4

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000175137
PharmGKBiPA142670923

Polymorphism and mutation databases

BioMutaiSH3BP5L
DMDMi74749902

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003175081 – 393SH3 domain-binding protein 5-likeAdd BLAST393

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphothreonineCombined sources1
Modified residuei30PhosphoserineCombined sources1
Modified residuei49PhosphoserineBy similarity1
Modified residuei343PhosphoserineCombined sources1
Modified residuei350PhosphoserineCombined sources1
Modified residuei358PhosphoserineCombined sources1
Modified residuei362PhosphoserineCombined sources1
Modified residuei378PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ7L8J4
MaxQBiQ7L8J4
PaxDbiQ7L8J4
PeptideAtlasiQ7L8J4
PRIDEiQ7L8J4

PTM databases

iPTMnetiQ7L8J4
PhosphoSitePlusiQ7L8J4

Expressioni

Gene expression databases

BgeeiENSG00000175137
CleanExiHS_SH3BP5L
ExpressionAtlasiQ7L8J4 baseline and differential
GenevisibleiQ7L8J4 HS

Organism-specific databases

HPAiHPA038067
HPA038068

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi123329, 17 interactors
IntActiQ7L8J4, 6 interactors
MINTiQ7L8J4
STRINGi9606.ENSP00000355428

Structurei

3D structure databases

SMRiQ7L8J4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili59 – 140Sequence analysisAdd BLAST82
Coiled coili169 – 272Sequence analysisAdd BLAST104

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi37 – 40Poly-Gly4
Compositional biasi41 – 44Poly-Ser4
Compositional biasi52 – 55Poly-Glu4

Sequence similaritiesi

Belongs to the SH3BP5 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2008 Eukaryota
ENOG410ZK48 LUCA
GeneTreeiENSGT00390000018500
HOGENOMiHOG000190360
HOVERGENiHBG057307
InParanoidiQ7L8J4
OMAiAEFRQVP
OrthoDBiEOG091G0BIF
PhylomeDBiQ7L8J4
TreeFamiTF105573

Family and domain databases

InterProiView protein in InterPro
IPR007940 SH3BP5
PANTHERiPTHR19423 PTHR19423, 1 hit
PfamiView protein in Pfam
PF05276 SH3BP5, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7L8J4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAELRQVPGG RETPQGELRP EVVEDEVPRS PVAEEPGGGG SSSSEAKLSP
60 70 80 90 100
REEEELDPRI QEELEHLNQA SEEINQVELQ LDEARTTYRR ILQESARKLN
110 120 130 140 150
TQGSHLGSCI EKARPYYEAR RLAKEAQQET QKAALRYERA VSMHNAAREM
160 170 180 190 200
VFVAEQGVMA DKNRLDPTWQ EMLNHATCKV NEAEEERLRG EREHQRVTRL
210 220 230 240 250
CQQAEARVQA LQKTLRRAIG KSRPYFELKA QFSQILEEHK AKVTELEQQV
260 270 280 290 300
AQAKTRYSVA LRNLEQISEQ IHARRRGGLP PHPLGPRRSS PVGAEAGPED
310 320 330 340 350
MEDGDSGIEG AEGAGLEEGS SLGPGPAPDT DTLSLLSLRT VASDLQKCDS
360 370 380 390
VEHLRGLSDH VSLDGQELGT RSGGRRGSDG GARGGRHQRS VSL
Length:393
Mass (Da):43,499
Last modified:July 5, 2004 - v1
Checksum:i3693431765F90FDC
GO
Isoform 2 (identifier: Q7L8J4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: MAELRQVPGG...EEEELDPRIQ → MYQVPDRQESFWQSPYLLSFPECLTSFPW

Note: No experimental confirmation available.
Show »
Length:361
Mass (Da):40,500
Checksum:i301F7348FD6B36A8
GO

Sequence cautioni

The sequence BAB21811 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0560751 – 61MAELR…DPRIQ → MYQVPDRQESFWQSPYLLSF PECLTSFPW in isoform 2. 1 PublicationAdd BLAST61

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051507 mRNA Translation: BAB21811.1 Different initiation.
AL136569 mRNA Translation: CAB66504.1
AY358453 mRNA Translation: AAQ88818.1
AK056382 mRNA Translation: BAB71171.1
AK298698 mRNA Translation: BAG60856.1
AL732583 Genomic DNA No translation available.
CH471257 Genomic DNA Translation: EAW57534.1
BC010871 mRNA Translation: AAH10871.1
BC017254 mRNA Translation: AAH17254.1
CCDSiCCDS31126.1 [Q7L8J4-1]
RefSeqiNP_001309391.1, NM_001322462.1
NP_085148.1, NM_030645.1 [Q7L8J4-1]
XP_016857896.1, XM_017002407.1 [Q7L8J4-2]
UniGeneiHs.298573

Genome annotation databases

EnsembliENST00000366472; ENSP00000355428; ENSG00000175137 [Q7L8J4-1]
GeneIDi80851
KEGGihsa:80851
UCSCiuc001iew.2 human [Q7L8J4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry namei3BP5L_HUMAN
AccessioniPrimary (citable) accession number: Q7L8J4
Secondary accession number(s): B4DQ94
, Q96FI5, Q9BQH8, Q9C0E3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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