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Q7L8J4

- 3BP5L_HUMAN

UniProt

Q7L8J4 - 3BP5L_HUMAN

Protein

SH3 domain-binding protein 5-like

Gene

SH3BP5L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SH3 domain-binding protein 5-like
    Short name:
    SH3BP-5-like
    Gene namesi
    Name:SH3BP5L
    Synonyms:KIAA1720
    ORF Names:UNQ2766/PRO7133
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:29360. SH3BP5L.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670923.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 393393SH3 domain-binding protein 5-likePRO_0000317508Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei343 – 3431Phosphoserine1 Publication
    Modified residuei350 – 3501Phosphoserine1 Publication
    Modified residuei358 – 3581Phosphoserine1 Publication
    Modified residuei362 – 3621Phosphoserine3 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ7L8J4.
    PaxDbiQ7L8J4.
    PRIDEiQ7L8J4.

    PTM databases

    PhosphoSiteiQ7L8J4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ7L8J4.
    BgeeiQ7L8J4.
    CleanExiHS_SH3BP5L.
    GenevestigatoriQ7L8J4.

    Organism-specific databases

    HPAiHPA038068.

    Interactioni

    Protein-protein interaction databases

    BioGridi123329. 4 interactions.
    IntActiQ7L8J4. 3 interactions.
    MINTiMINT-1688351.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7L8J4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili59 – 14082Sequence AnalysisAdd
    BLAST
    Coiled coili169 – 272104Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi37 – 404Poly-Gly
    Compositional biasi41 – 444Poly-Ser
    Compositional biasi52 – 554Poly-Glu

    Sequence similaritiesi

    Belongs to the SH3BP5 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG263345.
    HOGENOMiHOG000190360.
    HOVERGENiHBG057307.
    InParanoidiQ7L8J4.
    OMAiNTMDPTW.
    OrthoDBiEOG7Z3F4J.
    PhylomeDBiQ7L8J4.
    TreeFamiTF105573.

    Family and domain databases

    InterProiIPR007940. SH3-bd_5.
    [Graphical view]
    PANTHERiPTHR19423. PTHR19423. 1 hit.
    PfamiPF05276. SH3BP5. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q7L8J4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAELRQVPGG RETPQGELRP EVVEDEVPRS PVAEEPGGGG SSSSEAKLSP    50
    REEEELDPRI QEELEHLNQA SEEINQVELQ LDEARTTYRR ILQESARKLN 100
    TQGSHLGSCI EKARPYYEAR RLAKEAQQET QKAALRYERA VSMHNAAREM 150
    VFVAEQGVMA DKNRLDPTWQ EMLNHATCKV NEAEEERLRG EREHQRVTRL 200
    CQQAEARVQA LQKTLRRAIG KSRPYFELKA QFSQILEEHK AKVTELEQQV 250
    AQAKTRYSVA LRNLEQISEQ IHARRRGGLP PHPLGPRRSS PVGAEAGPED 300
    MEDGDSGIEG AEGAGLEEGS SLGPGPAPDT DTLSLLSLRT VASDLQKCDS 350
    VEHLRGLSDH VSLDGQELGT RSGGRRGSDG GARGGRHQRS VSL 393
    Length:393
    Mass (Da):43,499
    Last modified:July 5, 2004 - v1
    Checksum:i3693431765F90FDC
    GO
    Isoform 2 (identifier: Q7L8J4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-61: MAELRQVPGG...EEEELDPRIQ → MYQVPDRQESFWQSPYLLSFPECLTSFPW

    Note: No experimental confirmation available.

    Show »
    Length:361
    Mass (Da):40,500
    Checksum:i301F7348FD6B36A8
    GO

    Sequence cautioni

    The sequence BAB21811.1 differs from that shown. Reason: Erroneous initiation.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6161MAELR…DPRIQ → MYQVPDRQESFWQSPYLLSF PECLTSFPW in isoform 2. 1 PublicationVSP_056075Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB051507 mRNA. Translation: BAB21811.1. Different initiation.
    AL136569 mRNA. Translation: CAB66504.1.
    AY358453 mRNA. Translation: AAQ88818.1.
    AK056382 mRNA. Translation: BAB71171.1.
    AK298698 mRNA. Translation: BAG60856.1.
    AL732583 Genomic DNA. Translation: CAI18798.1.
    CH471257 Genomic DNA. Translation: EAW57534.1.
    BC010871 mRNA. Translation: AAH10871.1.
    BC017254 mRNA. Translation: AAH17254.1.
    CCDSiCCDS31126.1.
    RefSeqiNP_085148.1. NM_030645.1.
    UniGeneiHs.298573.

    Genome annotation databases

    EnsembliENST00000366472; ENSP00000355428; ENSG00000175137.
    ENST00000411742; ENSP00000412203; ENSG00000175137.
    GeneIDi80851.
    KEGGihsa:80851.
    UCSCiuc001iev.1. human.

    Polymorphism databases

    DMDMi74749902.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB051507 mRNA. Translation: BAB21811.1 . Different initiation.
    AL136569 mRNA. Translation: CAB66504.1 .
    AY358453 mRNA. Translation: AAQ88818.1 .
    AK056382 mRNA. Translation: BAB71171.1 .
    AK298698 mRNA. Translation: BAG60856.1 .
    AL732583 Genomic DNA. Translation: CAI18798.1 .
    CH471257 Genomic DNA. Translation: EAW57534.1 .
    BC010871 mRNA. Translation: AAH10871.1 .
    BC017254 mRNA. Translation: AAH17254.1 .
    CCDSi CCDS31126.1.
    RefSeqi NP_085148.1. NM_030645.1.
    UniGenei Hs.298573.

    3D structure databases

    ProteinModelPortali Q7L8J4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123329. 4 interactions.
    IntActi Q7L8J4. 3 interactions.
    MINTi MINT-1688351.

    PTM databases

    PhosphoSitei Q7L8J4.

    Polymorphism databases

    DMDMi 74749902.

    Proteomic databases

    MaxQBi Q7L8J4.
    PaxDbi Q7L8J4.
    PRIDEi Q7L8J4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000366472 ; ENSP00000355428 ; ENSG00000175137 .
    ENST00000411742 ; ENSP00000412203 ; ENSG00000175137 .
    GeneIDi 80851.
    KEGGi hsa:80851.
    UCSCi uc001iev.1. human.

    Organism-specific databases

    CTDi 80851.
    GeneCardsi GC01M249104.
    H-InvDB HIX0160026.
    HGNCi HGNC:29360. SH3BP5L.
    HPAi HPA038068.
    neXtProti NX_Q7L8J4.
    PharmGKBi PA142670923.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG263345.
    HOGENOMi HOG000190360.
    HOVERGENi HBG057307.
    InParanoidi Q7L8J4.
    OMAi NTMDPTW.
    OrthoDBi EOG7Z3F4J.
    PhylomeDBi Q7L8J4.
    TreeFami TF105573.

    Miscellaneous databases

    GenomeRNAii 80851.
    NextBioi 71284.
    PROi Q7L8J4.

    Gene expression databases

    ArrayExpressi Q7L8J4.
    Bgeei Q7L8J4.
    CleanExi HS_SH3BP5L.
    Genevestigatori Q7L8J4.

    Family and domain databases

    InterProi IPR007940. SH3-bd_5.
    [Graphical view ]
    PANTHERi PTHR19423. PTHR19423. 1 hit.
    Pfami PF05276. SH3BP5. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
      DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Amygdala.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    5. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Colon and Lung.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-343; SER-350 AND SER-362, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-362, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-358 AND SER-362, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry namei3BP5L_HUMAN
    AccessioniPrimary (citable) accession number: Q7L8J4
    Secondary accession number(s): B4DQ94
    , Q96FI5, Q9BQH8, Q9C0E3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3