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Q7L8C5 (SYT13_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Synaptotagmin-13
Alternative name(s):
Synaptotagmin XIII
Short name=SytXIII
Gene names
Name:SYT13
Synonyms:KIAA1427
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length426 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in transport vesicle docking to the plasma membrane By similarity.

Subunit structure

Interacts with NRXN1 By similarity.

Subcellular location

Membrane; Single-pass membrane protein By similarity.

Tissue specificity

Expressed in brain, pancreas and kidney. Ref.6

Domain

The first C2 domain/C2A does not mediate Ca2+-dependent phospholipid binding By similarity.

The second C2 domain/C2B domain binds phospholipids regardless of whether calcium is present By similarity.

Sequence similarities

Belongs to the synaptotagmin family.

Contains 2 C2 domains.

Sequence caution

The sequence BAA92665.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 426426Synaptotagmin-13
PRO_0000183975

Regions

Topological domain1 – 66Vesicular Potential
Transmembrane7 – 2923Helical; Potential
Topological domain30 – 426397Cytoplasmic Potential
Domain175 – 25985C2 1
Domain289 – 394106C2 2

Secondary structure

..................... 426
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q7L8C5 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 9BD0AD533E0CE886

FASTA42646,885
        10         20         30         40         50         60 
MVLSVPVIAL GATLGTATSI LALCGVTCLC RHMHPKKGLL PRDQDPDLEK AKPSLLGSAQ 

        70         80         90        100        110        120 
QFNVKKSTEP VQPRALLKFP DIYGPRPAVT APEVINYADY SLRSTEEPTA PASPQPPNDS 

       130        140        150        160        170        180 
RLKRQVTEEL FILPQNGVVE DVCVMETWNP EKAASWNQAP KLHYCLDYDC QKAELFVTRL 

       190        200        210        220        230        240 
EAVTSNHDGG CDCYVQGSVA NRTGSVEAQT ALKKRQLHTT WEEGLVLPLA EEELPTATLT 

       250        260        270        280        290        300 
LTLRTCDRFS RHSVAGELRL GLDGTSVPLG AAQWGELKTS AKEPSAGAGE VLLSISYLPA 

       310        320        330        340        350        360 
ANRLLVVLIK AKNLHSNQSK ELLGKDVSVK VTLKHQARKL KKKQTKRAKH KINPVWNEMI 

       370        380        390        400        410        420 
MFELPDDLLQ ASSVELEVLG QDDSGQSCAL GHCSLGLHTS GSERSHWEEM LKNPRRQIAM 


WHQLHL 

« Hide

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Fetal brain.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[6]"Genomic analysis of synaptotagmin genes."
Craxton M.A.
Genomics 77:43-49(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 150-322, TISSUE SPECIFICITY.
Tissue: Brain.
[7]"The first C2 domain of human synaptotagmin XIII."
RIKEN structural genomics initiative (RSGI)
Submitted (NOV-2004) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 155-280.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB037848 mRNA. Translation: BAA92665.1. Different initiation.
AK291009 mRNA. Translation: BAF83698.1.
AL512743 mRNA. Translation: CAC21669.1.
CH471064 Genomic DNA. Translation: EAW68043.1.
CH471064 Genomic DNA. Translation: EAW68044.1.
BC093830 mRNA. Translation: AAH93830.1.
BC093832 mRNA. Translation: AAH93832.1.
AJ303362 mRNA. Translation: CAC33884.1.
CCDSCCDS31470.1.
RefSeqNP_065877.1. NM_020826.2.
UniGeneHs.436643.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1WFMNMR-A155-279[»]
ProteinModelPortalQ7L8C5.
SMRQ7L8C5. Positions 156-426.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121638. 2 interactions.
MINTMINT-4723874.

PTM databases

PhosphoSiteQ7L8C5.

Polymorphism databases

DMDM74749900.

Proteomic databases

PaxDbQ7L8C5.
PRIDEQ7L8C5.

Protocols and materials databases

DNASU57586.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000020926; ENSP00000020926; ENSG00000019505.
GeneID57586.
KEGGhsa:57586.
UCSCuc001myq.2. human.

Organism-specific databases

CTD57586.
GeneCardsGC11M045261.
HGNCHGNC:14962. SYT13.
HPAHPA046224.
MIM607716. gene.
neXtProtNX_Q7L8C5.
PharmGKBPA37942.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG277582.
HOGENOMHOG000231448.
HOVERGENHBG098553.
InParanoidQ7L8C5.
OMADHDGGCD.
PhylomeDBQ7L8C5.
TreeFamTF315600.

Gene expression databases

BgeeQ7L8C5.
CleanExHS_SYT13.
GenevestigatorQ7L8C5.

Family and domain databases

Gene3D2.60.40.150. 2 hits.
InterProIPR000008. C2_dom.
IPR028692. SYT13.
[Graphical view]
PANTHERPTHR10024:SF211. PTHR10024:SF211. 1 hit.
PfamPF00168. C2. 2 hits.
[Graphical view]
SMARTSM00239. C2. 1 hit.
[Graphical view]
SUPFAMSSF49562. SSF49562. 2 hits.
PROSITEPS50004. C2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSYT13. human.
EvolutionaryTraceQ7L8C5.
GeneWikiSYT13.
GenomeRNAi57586.
NextBio64158.
PROQ7L8C5.
SOURCESearch...

Entry information

Entry nameSYT13_HUMAN
AccessionPrimary (citable) accession number: Q7L8C5
Secondary accession number(s): A8K4P4 expand/collapse secondary AC list , D3DQP1, Q9BQS3, Q9H041, Q9P2C0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM