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Q7L8C5

- SYT13_HUMAN

UniProt

Q7L8C5 - SYT13_HUMAN

Protein

Synaptotagmin-13

Gene

SYT13

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    May be involved in transport vesicle docking to the plasma membrane.By similarity

    GO - Biological processi

    1. vesicle-mediated transport Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Synaptotagmin-13
    Alternative name(s):
    Synaptotagmin XIII
    Short name:
    SytXIII
    Gene namesi
    Name:SYT13
    Synonyms:KIAA1427
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:14962. SYT13.

    Subcellular locationi

    Membrane By similarity; Single-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of plasma membrane Source: Ensembl
    2. transport vesicle Source: LIFEdb

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37942.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 426426Synaptotagmin-13PRO_0000183975Add
    BLAST

    Proteomic databases

    PaxDbiQ7L8C5.
    PRIDEiQ7L8C5.

    PTM databases

    PhosphoSiteiQ7L8C5.

    Expressioni

    Tissue specificityi

    Expressed in brain, pancreas and kidney.1 Publication

    Gene expression databases

    BgeeiQ7L8C5.
    CleanExiHS_SYT13.
    GenevestigatoriQ7L8C5.

    Organism-specific databases

    HPAiHPA046224.

    Interactioni

    Subunit structurei

    Interacts with NRXN1.By similarity

    Protein-protein interaction databases

    BioGridi121638. 2 interactions.
    MINTiMINT-4723874.

    Structurei

    Secondary structure

    1
    426
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi161 – 1688
    Turni170 – 1723
    Beta strandi174 – 18310
    Beta strandi193 – 2019
    Beta strandi204 – 2096
    Beta strandi217 – 2204
    Beta strandi225 – 2284
    Beta strandi238 – 2458
    Beta strandi255 – 26713
    Beta strandi273 – 2764

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1WFMNMR-A155-279[»]
    ProteinModelPortaliQ7L8C5.
    SMRiQ7L8C5. Positions 156-426.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ7L8C5.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 66VesicularSequence Analysis
    Topological domaini30 – 426397CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2923HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini175 – 25985C2 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini289 – 394106C2 2PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The first C2 domain/C2A does not mediate Ca2+-dependent phospholipid binding.By similarity
    The second C2 domain/C2B domain binds phospholipids regardless of whether calcium is present.By similarity

    Sequence similaritiesi

    Belongs to the synaptotagmin family.Curated
    Contains 2 C2 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG277582.
    HOGENOMiHOG000231448.
    HOVERGENiHBG098553.
    InParanoidiQ7L8C5.
    OMAiDHDGGCD.
    PhylomeDBiQ7L8C5.
    TreeFamiTF315600.

    Family and domain databases

    Gene3Di2.60.40.150. 2 hits.
    InterProiIPR000008. C2_dom.
    IPR028692. SYT13.
    [Graphical view]
    PANTHERiPTHR10024:SF211. PTHR10024:SF211. 1 hit.
    PfamiPF00168. C2. 2 hits.
    [Graphical view]
    SMARTiSM00239. C2. 1 hit.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 2 hits.
    PROSITEiPS50004. C2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7L8C5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVLSVPVIAL GATLGTATSI LALCGVTCLC RHMHPKKGLL PRDQDPDLEK    50
    AKPSLLGSAQ QFNVKKSTEP VQPRALLKFP DIYGPRPAVT APEVINYADY 100
    SLRSTEEPTA PASPQPPNDS RLKRQVTEEL FILPQNGVVE DVCVMETWNP 150
    EKAASWNQAP KLHYCLDYDC QKAELFVTRL EAVTSNHDGG CDCYVQGSVA 200
    NRTGSVEAQT ALKKRQLHTT WEEGLVLPLA EEELPTATLT LTLRTCDRFS 250
    RHSVAGELRL GLDGTSVPLG AAQWGELKTS AKEPSAGAGE VLLSISYLPA 300
    ANRLLVVLIK AKNLHSNQSK ELLGKDVSVK VTLKHQARKL KKKQTKRAKH 350
    KINPVWNEMI MFELPDDLLQ ASSVELEVLG QDDSGQSCAL GHCSLGLHTS 400
    GSERSHWEEM LKNPRRQIAM WHQLHL 426
    Length:426
    Mass (Da):46,885
    Last modified:July 5, 2004 - v1
    Checksum:i9BD0AD533E0CE886
    GO

    Sequence cautioni

    The sequence BAA92665.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB037848 mRNA. Translation: BAA92665.1. Different initiation.
    AK291009 mRNA. Translation: BAF83698.1.
    AL512743 mRNA. Translation: CAC21669.1.
    CH471064 Genomic DNA. Translation: EAW68043.1.
    CH471064 Genomic DNA. Translation: EAW68044.1.
    BC093830 mRNA. Translation: AAH93830.1.
    BC093832 mRNA. Translation: AAH93832.1.
    AJ303362 mRNA. Translation: CAC33884.1.
    CCDSiCCDS31470.1.
    RefSeqiNP_065877.1. NM_020826.2.
    UniGeneiHs.436643.

    Genome annotation databases

    EnsembliENST00000020926; ENSP00000020926; ENSG00000019505.
    GeneIDi57586.
    KEGGihsa:57586.
    UCSCiuc001myq.2. human.

    Polymorphism databases

    DMDMi74749900.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB037848 mRNA. Translation: BAA92665.1 . Different initiation.
    AK291009 mRNA. Translation: BAF83698.1 .
    AL512743 mRNA. Translation: CAC21669.1 .
    CH471064 Genomic DNA. Translation: EAW68043.1 .
    CH471064 Genomic DNA. Translation: EAW68044.1 .
    BC093830 mRNA. Translation: AAH93830.1 .
    BC093832 mRNA. Translation: AAH93832.1 .
    AJ303362 mRNA. Translation: CAC33884.1 .
    CCDSi CCDS31470.1.
    RefSeqi NP_065877.1. NM_020826.2.
    UniGenei Hs.436643.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1WFM NMR - A 155-279 [» ]
    ProteinModelPortali Q7L8C5.
    SMRi Q7L8C5. Positions 156-426.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121638. 2 interactions.
    MINTi MINT-4723874.

    PTM databases

    PhosphoSitei Q7L8C5.

    Polymorphism databases

    DMDMi 74749900.

    Proteomic databases

    PaxDbi Q7L8C5.
    PRIDEi Q7L8C5.

    Protocols and materials databases

    DNASUi 57586.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000020926 ; ENSP00000020926 ; ENSG00000019505 .
    GeneIDi 57586.
    KEGGi hsa:57586.
    UCSCi uc001myq.2. human.

    Organism-specific databases

    CTDi 57586.
    GeneCardsi GC11M045261.
    HGNCi HGNC:14962. SYT13.
    HPAi HPA046224.
    MIMi 607716. gene.
    neXtProti NX_Q7L8C5.
    PharmGKBi PA37942.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG277582.
    HOGENOMi HOG000231448.
    HOVERGENi HBG098553.
    InParanoidi Q7L8C5.
    OMAi DHDGGCD.
    PhylomeDBi Q7L8C5.
    TreeFami TF315600.

    Miscellaneous databases

    ChiTaRSi SYT13. human.
    EvolutionaryTracei Q7L8C5.
    GeneWikii SYT13.
    GenomeRNAii 57586.
    NextBioi 64158.
    PROi Q7L8C5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q7L8C5.
    CleanExi HS_SYT13.
    Genevestigatori Q7L8C5.

    Family and domain databases

    Gene3Di 2.60.40.150. 2 hits.
    InterProi IPR000008. C2_dom.
    IPR028692. SYT13.
    [Graphical view ]
    PANTHERi PTHR10024:SF211. PTHR10024:SF211. 1 hit.
    Pfami PF00168. C2. 2 hits.
    [Graphical view ]
    SMARTi SM00239. C2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 2 hits.
    PROSITEi PS50004. C2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
      DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Fetal brain.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. "Genomic analysis of synaptotagmin genes."
      Craxton M.A.
      Genomics 77:43-49(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 150-322, TISSUE SPECIFICITY.
      Tissue: Brain.
    7. "The first C2 domain of human synaptotagmin XIII."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2004) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 155-280.

    Entry informationi

    Entry nameiSYT13_HUMAN
    AccessioniPrimary (citable) accession number: Q7L8C5
    Secondary accession number(s): A8K4P4
    , D3DQP1, Q9BQS3, Q9H041, Q9P2C0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3