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Q7L8C5

- SYT13_HUMAN

UniProt

Q7L8C5 - SYT13_HUMAN

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Protein

Synaptotagmin-13

Gene
SYT13, KIAA1427
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in transport vesicle docking to the plasma membrane By similarity.

GO - Biological processi

  1. vesicle-mediated transport Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-13
Alternative name(s):
Synaptotagmin XIII
Short name:
SytXIII
Gene namesi
Name:SYT13
Synonyms:KIAA1427
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:14962. SYT13.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66Vesicular Reviewed prediction
Transmembranei7 – 2923Helical; Reviewed predictionAdd
BLAST
Topological domaini30 – 426397Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: Ensembl
  2. transport vesicle Source: LIFEdb
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37942.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 426426Synaptotagmin-13PRO_0000183975Add
BLAST

Proteomic databases

PaxDbiQ7L8C5.
PRIDEiQ7L8C5.

PTM databases

PhosphoSiteiQ7L8C5.

Expressioni

Tissue specificityi

Expressed in brain, pancreas and kidney.1 Publication

Gene expression databases

BgeeiQ7L8C5.
CleanExiHS_SYT13.
GenevestigatoriQ7L8C5.

Organism-specific databases

HPAiHPA046224.

Interactioni

Subunit structurei

Interacts with NRXN1 By similarity.

Protein-protein interaction databases

BioGridi121638. 2 interactions.
MINTiMINT-4723874.

Structurei

Secondary structure

1
426
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi161 – 1688
Turni170 – 1723
Beta strandi174 – 18310
Beta strandi193 – 2019
Beta strandi204 – 2096
Beta strandi217 – 2204
Beta strandi225 – 2284
Beta strandi238 – 2458
Beta strandi255 – 26713
Beta strandi273 – 2764

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WFMNMR-A155-279[»]
ProteinModelPortaliQ7L8C5.
SMRiQ7L8C5. Positions 156-426.

Miscellaneous databases

EvolutionaryTraceiQ7L8C5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini175 – 25985C2 1Add
BLAST
Domaini289 – 394106C2 2Add
BLAST

Domaini

The first C2 domain/C2A does not mediate Ca2+-dependent phospholipid binding By similarity.
The second C2 domain/C2B domain binds phospholipids regardless of whether calcium is present By similarity.

Sequence similaritiesi

Belongs to the synaptotagmin family.
Contains 2 C2 domains.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG277582.
HOGENOMiHOG000231448.
HOVERGENiHBG098553.
InParanoidiQ7L8C5.
OMAiDHDGGCD.
PhylomeDBiQ7L8C5.
TreeFamiTF315600.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR028692. SYT13.
[Graphical view]
PANTHERiPTHR10024:SF211. PTHR10024:SF211. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7L8C5-1 [UniParc]FASTAAdd to Basket

« Hide

MVLSVPVIAL GATLGTATSI LALCGVTCLC RHMHPKKGLL PRDQDPDLEK    50
AKPSLLGSAQ QFNVKKSTEP VQPRALLKFP DIYGPRPAVT APEVINYADY 100
SLRSTEEPTA PASPQPPNDS RLKRQVTEEL FILPQNGVVE DVCVMETWNP 150
EKAASWNQAP KLHYCLDYDC QKAELFVTRL EAVTSNHDGG CDCYVQGSVA 200
NRTGSVEAQT ALKKRQLHTT WEEGLVLPLA EEELPTATLT LTLRTCDRFS 250
RHSVAGELRL GLDGTSVPLG AAQWGELKTS AKEPSAGAGE VLLSISYLPA 300
ANRLLVVLIK AKNLHSNQSK ELLGKDVSVK VTLKHQARKL KKKQTKRAKH 350
KINPVWNEMI MFELPDDLLQ ASSVELEVLG QDDSGQSCAL GHCSLGLHTS 400
GSERSHWEEM LKNPRRQIAM WHQLHL 426
Length:426
Mass (Da):46,885
Last modified:July 5, 2004 - v1
Checksum:i9BD0AD533E0CE886
GO

Sequence cautioni

The sequence BAA92665.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB037848 mRNA. Translation: BAA92665.1. Different initiation.
AK291009 mRNA. Translation: BAF83698.1.
AL512743 mRNA. Translation: CAC21669.1.
CH471064 Genomic DNA. Translation: EAW68043.1.
CH471064 Genomic DNA. Translation: EAW68044.1.
BC093830 mRNA. Translation: AAH93830.1.
BC093832 mRNA. Translation: AAH93832.1.
AJ303362 mRNA. Translation: CAC33884.1.
CCDSiCCDS31470.1.
RefSeqiNP_065877.1. NM_020826.2.
UniGeneiHs.436643.

Genome annotation databases

EnsembliENST00000020926; ENSP00000020926; ENSG00000019505.
GeneIDi57586.
KEGGihsa:57586.
UCSCiuc001myq.2. human.

Polymorphism databases

DMDMi74749900.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB037848 mRNA. Translation: BAA92665.1 . Different initiation.
AK291009 mRNA. Translation: BAF83698.1 .
AL512743 mRNA. Translation: CAC21669.1 .
CH471064 Genomic DNA. Translation: EAW68043.1 .
CH471064 Genomic DNA. Translation: EAW68044.1 .
BC093830 mRNA. Translation: AAH93830.1 .
BC093832 mRNA. Translation: AAH93832.1 .
AJ303362 mRNA. Translation: CAC33884.1 .
CCDSi CCDS31470.1.
RefSeqi NP_065877.1. NM_020826.2.
UniGenei Hs.436643.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1WFM NMR - A 155-279 [» ]
ProteinModelPortali Q7L8C5.
SMRi Q7L8C5. Positions 156-426.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121638. 2 interactions.
MINTi MINT-4723874.

PTM databases

PhosphoSitei Q7L8C5.

Polymorphism databases

DMDMi 74749900.

Proteomic databases

PaxDbi Q7L8C5.
PRIDEi Q7L8C5.

Protocols and materials databases

DNASUi 57586.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000020926 ; ENSP00000020926 ; ENSG00000019505 .
GeneIDi 57586.
KEGGi hsa:57586.
UCSCi uc001myq.2. human.

Organism-specific databases

CTDi 57586.
GeneCardsi GC11M045261.
HGNCi HGNC:14962. SYT13.
HPAi HPA046224.
MIMi 607716. gene.
neXtProti NX_Q7L8C5.
PharmGKBi PA37942.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG277582.
HOGENOMi HOG000231448.
HOVERGENi HBG098553.
InParanoidi Q7L8C5.
OMAi DHDGGCD.
PhylomeDBi Q7L8C5.
TreeFami TF315600.

Miscellaneous databases

ChiTaRSi SYT13. human.
EvolutionaryTracei Q7L8C5.
GeneWikii SYT13.
GenomeRNAii 57586.
NextBioi 64158.
PROi Q7L8C5.
SOURCEi Search...

Gene expression databases

Bgeei Q7L8C5.
CleanExi HS_SYT13.
Genevestigatori Q7L8C5.

Family and domain databases

Gene3Di 2.60.40.150. 2 hits.
InterProi IPR000008. C2_dom.
IPR028692. SYT13.
[Graphical view ]
PANTHERi PTHR10024:SF211. PTHR10024:SF211. 1 hit.
Pfami PF00168. C2. 2 hits.
[Graphical view ]
SMARTi SM00239. C2. 1 hit.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 2 hits.
PROSITEi PS50004. C2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. "Genomic analysis of synaptotagmin genes."
    Craxton M.A.
    Genomics 77:43-49(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 150-322, TISSUE SPECIFICITY.
    Tissue: Brain.
  7. "The first C2 domain of human synaptotagmin XIII."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2004) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 155-280.

Entry informationi

Entry nameiSYT13_HUMAN
AccessioniPrimary (citable) accession number: Q7L8C5
Secondary accession number(s): A8K4P4
, D3DQP1, Q9BQS3, Q9H041, Q9P2C0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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