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Protein

Synaptotagmin-13

Gene

SYT13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transport vesicle docking to the plasma membrane.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-13
Alternative name(s):
Synaptotagmin XIII
Short name:
SytXIII
Gene namesi
Name:SYT13
Synonyms:KIAA1427
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14962. SYT13.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6VesicularSequence analysis6
Transmembranei7 – 29HelicalSequence analysisAdd BLAST23
Topological domaini30 – 426CytoplasmicSequence analysisAdd BLAST397

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57586.
OpenTargetsiENSG00000019505.
PharmGKBiPA37942.

Polymorphism and mutation databases

BioMutaiSYT13.
DMDMi74749900.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001839751 – 426Synaptotagmin-13Add BLAST426

Proteomic databases

PaxDbiQ7L8C5.
PeptideAtlasiQ7L8C5.
PRIDEiQ7L8C5.

PTM databases

iPTMnetiQ7L8C5.
PhosphoSitePlusiQ7L8C5.

Expressioni

Tissue specificityi

Expressed in brain, pancreas and kidney.1 Publication

Gene expression databases

BgeeiENSG00000019505.
CleanExiHS_SYT13.
ExpressionAtlasiQ7L8C5. baseline and differential.
GenevisibleiQ7L8C5. HS.

Organism-specific databases

HPAiHPA046224.
HPA056602.

Interactioni

Subunit structurei

Interacts with NRXN1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121638. 2 interactors.
MINTiMINT-4723874.
STRINGi9606.ENSP00000020926.

Structurei

Secondary structure

1426
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi161 – 168Combined sources8
Turni170 – 172Combined sources3
Beta strandi174 – 183Combined sources10
Beta strandi193 – 201Combined sources9
Beta strandi204 – 209Combined sources6
Beta strandi217 – 220Combined sources4
Beta strandi225 – 228Combined sources4
Beta strandi238 – 245Combined sources8
Beta strandi255 – 267Combined sources13
Beta strandi273 – 276Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WFMNMR-A155-279[»]
ProteinModelPortaliQ7L8C5.
SMRiQ7L8C5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7L8C5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini175 – 259C2 1PROSITE-ProRule annotationAdd BLAST85
Domaini289 – 394C2 2PROSITE-ProRule annotationAdd BLAST106

Domaini

The first C2 domain/C2A does not mediate Ca2+-dependent phospholipid binding.By similarity
The second C2 domain/C2B domain binds phospholipids regardless of whether calcium is present.By similarity

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated
Contains 2 C2 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IT3H. Eukaryota.
ENOG4110ZXG. LUCA.
GeneTreeiENSGT00830000128339.
HOGENOMiHOG000231448.
HOVERGENiHBG098553.
InParanoidiQ7L8C5.
KOiK19913.
OMAiCSLGLHT.
OrthoDBiEOG091G0DPW.
PhylomeDBiQ7L8C5.
TreeFamiTF315600.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR028692. SYT13.
[Graphical view]
PANTHERiPTHR10024:SF250. PTHR10024:SF250. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7L8C5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLSVPVIAL GATLGTATSI LALCGVTCLC RHMHPKKGLL PRDQDPDLEK
60 70 80 90 100
AKPSLLGSAQ QFNVKKSTEP VQPRALLKFP DIYGPRPAVT APEVINYADY
110 120 130 140 150
SLRSTEEPTA PASPQPPNDS RLKRQVTEEL FILPQNGVVE DVCVMETWNP
160 170 180 190 200
EKAASWNQAP KLHYCLDYDC QKAELFVTRL EAVTSNHDGG CDCYVQGSVA
210 220 230 240 250
NRTGSVEAQT ALKKRQLHTT WEEGLVLPLA EEELPTATLT LTLRTCDRFS
260 270 280 290 300
RHSVAGELRL GLDGTSVPLG AAQWGELKTS AKEPSAGAGE VLLSISYLPA
310 320 330 340 350
ANRLLVVLIK AKNLHSNQSK ELLGKDVSVK VTLKHQARKL KKKQTKRAKH
360 370 380 390 400
KINPVWNEMI MFELPDDLLQ ASSVELEVLG QDDSGQSCAL GHCSLGLHTS
410 420
GSERSHWEEM LKNPRRQIAM WHQLHL
Length:426
Mass (Da):46,885
Last modified:July 5, 2004 - v1
Checksum:i9BD0AD533E0CE886
GO

Sequence cautioni

The sequence BAA92665 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037848 mRNA. Translation: BAA92665.1. Different initiation.
AK291009 mRNA. Translation: BAF83698.1.
AL512743 mRNA. Translation: CAC21669.1.
CH471064 Genomic DNA. Translation: EAW68043.1.
CH471064 Genomic DNA. Translation: EAW68044.1.
BC093830 mRNA. Translation: AAH93830.1.
BC093832 mRNA. Translation: AAH93832.1.
AJ303362 mRNA. Translation: CAC33884.1.
CCDSiCCDS31470.1.
RefSeqiNP_065877.1. NM_020826.2.
UniGeneiHs.436643.

Genome annotation databases

EnsembliENST00000020926; ENSP00000020926; ENSG00000019505.
GeneIDi57586.
KEGGihsa:57586.
UCSCiuc001myq.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037848 mRNA. Translation: BAA92665.1. Different initiation.
AK291009 mRNA. Translation: BAF83698.1.
AL512743 mRNA. Translation: CAC21669.1.
CH471064 Genomic DNA. Translation: EAW68043.1.
CH471064 Genomic DNA. Translation: EAW68044.1.
BC093830 mRNA. Translation: AAH93830.1.
BC093832 mRNA. Translation: AAH93832.1.
AJ303362 mRNA. Translation: CAC33884.1.
CCDSiCCDS31470.1.
RefSeqiNP_065877.1. NM_020826.2.
UniGeneiHs.436643.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WFMNMR-A155-279[»]
ProteinModelPortaliQ7L8C5.
SMRiQ7L8C5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121638. 2 interactors.
MINTiMINT-4723874.
STRINGi9606.ENSP00000020926.

PTM databases

iPTMnetiQ7L8C5.
PhosphoSitePlusiQ7L8C5.

Polymorphism and mutation databases

BioMutaiSYT13.
DMDMi74749900.

Proteomic databases

PaxDbiQ7L8C5.
PeptideAtlasiQ7L8C5.
PRIDEiQ7L8C5.

Protocols and materials databases

DNASUi57586.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000020926; ENSP00000020926; ENSG00000019505.
GeneIDi57586.
KEGGihsa:57586.
UCSCiuc001myq.3. human.

Organism-specific databases

CTDi57586.
DisGeNETi57586.
GeneCardsiSYT13.
HGNCiHGNC:14962. SYT13.
HPAiHPA046224.
HPA056602.
MIMi607716. gene.
neXtProtiNX_Q7L8C5.
OpenTargetsiENSG00000019505.
PharmGKBiPA37942.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IT3H. Eukaryota.
ENOG4110ZXG. LUCA.
GeneTreeiENSGT00830000128339.
HOGENOMiHOG000231448.
HOVERGENiHBG098553.
InParanoidiQ7L8C5.
KOiK19913.
OMAiCSLGLHT.
OrthoDBiEOG091G0DPW.
PhylomeDBiQ7L8C5.
TreeFamiTF315600.

Miscellaneous databases

ChiTaRSiSYT13. human.
EvolutionaryTraceiQ7L8C5.
GeneWikiiSYT13.
GenomeRNAii57586.
PROiQ7L8C5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000019505.
CleanExiHS_SYT13.
ExpressionAtlasiQ7L8C5. baseline and differential.
GenevisibleiQ7L8C5. HS.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR028692. SYT13.
[Graphical view]
PANTHERiPTHR10024:SF250. PTHR10024:SF250. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYT13_HUMAN
AccessioniPrimary (citable) accession number: Q7L8C5
Secondary accession number(s): A8K4P4
, D3DQP1, Q9BQS3, Q9H041, Q9P2C0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.