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Q7L5Y9

- MAEA_HUMAN

UniProt

Q7L5Y9 - MAEA_HUMAN

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Protein

Macrophage erythroblast attacher

Gene
MAEA, EMP, HLC10, PIG5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA-mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events.2 Publications

GO - Molecular functioni

  1. actin binding Source: UniProtKB

GO - Biological processi

  1. cell adhesion Source: UniProtKB
  2. cell cycle Source: UniProtKB-KW
  3. cell division Source: UniProtKB-KW
  4. cytoskeleton organization Source: Ensembl
  5. enucleate erythrocyte development Source: Ensembl
  6. erythrocyte maturation Source: UniProtKB-KW
  7. negative regulation of myeloid cell apoptotic process Source: UniProtKB
  8. regulation of mitotic cell cycle Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Erythrocyte maturation

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Macrophage erythroblast attacher
Alternative name(s):
Cell proliferation-inducing gene 5 protein
Erythroblast macrophage protein
Human lung cancer oncogene 10 protein
Short name:
HLC-10
Gene namesi
Name:MAEA
Synonyms:EMP
ORF Names:HLC10, PIG5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:13731. MAEA.

Subcellular locationi

Nucleus matrix. Cell membrane. Cytoplasmcytoskeleton
Note: Localized as nuclear speckled-like pattern.1 Publication

GO - Cellular componenti

  1. actomyosin contractile ring Source: UniProtKB
  2. cytoskeleton Source: UniProtKB
  3. integral component of plasma membrane Source: UniProtKB
  4. nuclear matrix Source: UniProtKB
  5. nucleus Source: HPA
  6. spindle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30533.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396Macrophage erythroblast attacherPRO_0000284936Add
BLAST

Proteomic databases

MaxQBiQ7L5Y9.
PaxDbiQ7L5Y9.
PRIDEiQ7L5Y9.

PTM databases

PhosphoSiteiQ7L5Y9.

Expressioni

Tissue specificityi

Ubiquitous.2 Publications

Developmental stagei

Localized with condensed chromatin at prophase; Detected in nuclear spindle poles at metaphase and in the contractile ring during telophase and cytokinesis.1 Publication

Gene expression databases

ArrayExpressiQ7L5Y9.
BgeeiQ7L5Y9.
CleanExiHS_MAEA.
GenevestigatoriQ7L5Y9.

Organism-specific databases

HPAiHPA036886.

Interactioni

Subunit structurei

Forms a complex with F-actin.1 Publication

Protein-protein interaction databases

BioGridi115584. 12 interactions.
MINTiMINT-4725016.
STRINGi9606.ENSP00000302830.

Structurei

3D structure databases

ProteinModelPortaliQ7L5Y9.
SMRiQ7L5Y9. Positions 336-391.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini121 – 15333LisHAdd
BLAST
Domaini159 – 21658CTLHAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 124124Extracellular and involved in cell to cell contactAdd
BLAST

Sequence similaritiesi

Contains 1 CTLH domain.
Contains 1 LisH domain.

Phylogenomic databases

eggNOGiNOG241866.
HOVERGENiHBG053270.
InParanoidiQ7L5Y9.
OrthoDBiEOG722J8H.
PhylomeDBiQ7L5Y9.
TreeFamiTF314273.

Family and domain databases

InterProiIPR013144. CRA_dom.
IPR024964. CTLH/CRA.
IPR006595. CTLH_C.
IPR006594. LisH_dimerisation.
[Graphical view]
PfamiPF10607. CLTH. 1 hit.
[Graphical view]
SMARTiSM00757. CRA. 1 hit.
SM00668. CTLH. 1 hit.
SM00667. LisH. 1 hit.
[Graphical view]
PROSITEiPS50897. CTLH. 1 hit.
PS50896. LISH. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q7L5Y9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAVQESAAQL SMTLKVQEYP TLKVPYETLN KRFRAAQKNI DRETSHVTMV    50
VAELEKTLSG CPAVDSVVSL LDGVVEKLSV LKRKAVESIQ AEDESAKLCK 100
RRIEHLKEHS SDQPAAASVW KRKRMDRMMV EHLLRCGYYN TAVKLARQSG 150
IEDLVNIEMF LTAKEVEESL ERRETATCLA WCHDNKSRLR KMKSCLEFSL 200
RIQEFIELIR QNKRLDAVRH ARKHFSQAEG SQLDEVRQAM GMLAFPPDTH 250
ISPYKDLLDP ARWRMLIQQF RYDNYRLHQL GNNSVFTLTL QAGLSAIKTP 300
QCYKEDGSSK SPDCPVCSRS LNKLAQPLPM AHCANSRLVC KISGDVMNEN 350
NPPMMLPNGY VYGYNSLLSI RQDDKVVCPR TKEVFHFSQA EKVYIM 396
Length:396
Mass (Da):45,287
Last modified:July 5, 2005 - v1
Checksum:i361FB82BE0240C21
GO
Isoform 2 (identifier: Q7L5Y9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     153-193: Missing.
     265-265: M → TCTVAD

Show »
Length:360
Mass (Da):40,869
Checksum:i7EDD1E1771B311F0
GO
Isoform 3 (identifier: Q7L5Y9-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     153-193: Missing.

Show »
Length:355
Mass (Da):40,410
Checksum:iC949C3631DCD33E1
GO
Isoform 4 (identifier: Q7L5Y9-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     152-232: EDLVNIEMFL...KHFSQAEGSQ → GTCKKALQPS...PAGWPLSHQD
     233-300: Missing.

Note: No experimental confirmation available.

Show »
Length:328
Mass (Da):36,122
Checksum:iD7E3935AB82BE82D
GO
Isoform 5 (identifier: Q7L5Y9-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     153-245: DLVNIEMFLT...VRQAMGMLAF → TCKKALQPSR...LQGGRQLQEP
     246-396: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:245
Mass (Da):26,802
Checksum:i937AAE595F6C83BF
GO

Sequence cautioni

The sequence AAC67543.1 differs from that shown. Reason: Sequence differs at N-terminus.
The sequence AK128302 differs from that shown. Reason: Intron retention.
The sequence AAC67543.1 differs from that shown. Reason: Frameshift at positions 253 and 327.
The sequence AAO85220.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAC67543.1 differs from that shown. Reason: Erroneous termination at position 397. Translated as stop.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti34 – 341R → C.
Corresponds to variant rs34082974 [ dbSNP | Ensembl ].
VAR_051150

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei152 – 23281EDLVN…AEGSQ → GTCKKALQPSRREPAGRGAP GHGHAGLPARHAHLPVQGPS GPCTVADADPAVPVRQLPTT PAGKQFCVHPHPAGWPLSHQ D in isoform 4. VSP_024784Add
BLAST
Alternative sequencei153 – 24593DLVNI…GMLAF → TCKKALQPSRREPAGRGAPG HGHAGLPARHAHLPVQGPSG PCTVADADPAVPVRQLPTTP AGKQFCVHPHPAGRPLSHQD TTVLQGGRQLQEP in isoform 5. VSP_024785Add
BLAST
Alternative sequencei153 – 19341Missing in isoform 2 and isoform 3. VSP_024786Add
BLAST
Alternative sequencei233 – 30068Missing in isoform 4. VSP_024788Add
BLAST
Alternative sequencei246 – 396151Missing in isoform 5. VSP_024789Add
BLAST
Alternative sequencei265 – 2651M → TCTVAD in isoform 2. VSP_024790

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti32 – 321R → C in AAP74806. 1 Publication
Sequence conflicti56 – 561K → R in AAC67543. 1 Publication
Sequence conflicti101 – 1011R → L in AAC67543. 1 Publication
Sequence conflicti123 – 1231K → R in BAA91499. 1 Publication
Sequence conflicti313 – 3131D → V in AAC67543. 1 Publication
Sequence conflicti327 – 3271P → R in AAC67543. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY236486 mRNA. Translation: AAP74806.1.
AK001088 mRNA. Translation: BAA91499.1.
AK128302 mRNA. No translation available.
AK022515 mRNA. Translation: BAB14072.1.
AK022586 mRNA. Translation: BAB14113.1.
BC001225 mRNA. Translation: AAH01225.2.
BC006470 mRNA. Translation: AAH06470.2.
AF084928 mRNA. Translation: AAC67543.1. Sequence problems.
AY189687 mRNA. Translation: AAO85220.1. Different initiation.
BT006957 mRNA. Translation: AAP35603.1.
CCDSiCCDS33936.1. [Q7L5Y9-1]
CCDS33937.1. [Q7L5Y9-3]
RefSeqiNP_001017405.1. NM_001017405.1. [Q7L5Y9-1]
NP_005873.2. NM_005882.3. [Q7L5Y9-3]
UniGeneiHs.139896.

Genome annotation databases

EnsembliENST00000264750; ENSP00000264750; ENSG00000090316. [Q7L5Y9-3]
ENST00000303400; ENSP00000302830; ENSG00000090316. [Q7L5Y9-1]
GeneIDi10296.
KEGGihsa:10296.
UCSCiuc003gda.3. human. [Q7L5Y9-1]
uc003gdb.3. human. [Q7L5Y9-3]

Polymorphism databases

DMDMi74754297.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY236486 mRNA. Translation: AAP74806.1 .
AK001088 mRNA. Translation: BAA91499.1 .
AK128302 mRNA. No translation available.
AK022515 mRNA. Translation: BAB14072.1 .
AK022586 mRNA. Translation: BAB14113.1 .
BC001225 mRNA. Translation: AAH01225.2 .
BC006470 mRNA. Translation: AAH06470.2 .
AF084928 mRNA. Translation: AAC67543.1 . Sequence problems.
AY189687 mRNA. Translation: AAO85220.1 . Different initiation.
BT006957 mRNA. Translation: AAP35603.1 .
CCDSi CCDS33936.1. [Q7L5Y9-1 ]
CCDS33937.1. [Q7L5Y9-3 ]
RefSeqi NP_001017405.1. NM_001017405.1. [Q7L5Y9-1 ]
NP_005873.2. NM_005882.3. [Q7L5Y9-3 ]
UniGenei Hs.139896.

3D structure databases

ProteinModelPortali Q7L5Y9.
SMRi Q7L5Y9. Positions 336-391.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115584. 12 interactions.
MINTi MINT-4725016.
STRINGi 9606.ENSP00000302830.

PTM databases

PhosphoSitei Q7L5Y9.

Polymorphism databases

DMDMi 74754297.

Proteomic databases

MaxQBi Q7L5Y9.
PaxDbi Q7L5Y9.
PRIDEi Q7L5Y9.

Protocols and materials databases

DNASUi 10296.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000264750 ; ENSP00000264750 ; ENSG00000090316 . [Q7L5Y9-3 ]
ENST00000303400 ; ENSP00000302830 ; ENSG00000090316 . [Q7L5Y9-1 ]
GeneIDi 10296.
KEGGi hsa:10296.
UCSCi uc003gda.3. human. [Q7L5Y9-1 ]
uc003gdb.3. human. [Q7L5Y9-3 ]

Organism-specific databases

CTDi 10296.
GeneCardsi GC04P001273.
HGNCi HGNC:13731. MAEA.
HPAi HPA036886.
MIMi 606801. gene.
neXtProti NX_Q7L5Y9.
PharmGKBi PA30533.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG241866.
HOVERGENi HBG053270.
InParanoidi Q7L5Y9.
OrthoDBi EOG722J8H.
PhylomeDBi Q7L5Y9.
TreeFami TF314273.

Miscellaneous databases

ChiTaRSi MAEA. human.
GenomeRNAii 10296.
NextBioi 39018.
PROi Q7L5Y9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q7L5Y9.
Bgeei Q7L5Y9.
CleanExi HS_MAEA.
Genevestigatori Q7L5Y9.

Family and domain databases

InterProi IPR013144. CRA_dom.
IPR024964. CTLH/CRA.
IPR006595. CTLH_C.
IPR006594. LisH_dimerisation.
[Graphical view ]
Pfami PF10607. CLTH. 1 hit.
[Graphical view ]
SMARTi SM00757. CRA. 1 hit.
SM00668. CTLH. 1 hit.
SM00667. LisH. 1 hit.
[Graphical view ]
PROSITEi PS50897. CTLH. 1 hit.
PS50896. LISH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a human cell proliferation gene 5."
    Kim J.W.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
    Tissue: Embryo and Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  4. "Molecular identification and functional characterization of a novel protein that mediates the attachment of erythroblasts to macrophages."
    Hanspal M., Smockova Y., Uong Q.
    Blood 92:2940-2950(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-396 (ISOFORM 2), REGION, FUNCTION, TISSUE SPECIFICITY.
  5. "Identification of new human cancer-related gene (HLC-10)."
    Kim J.W.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-396 (ISOFORM 1).
  6. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 12-396 (ISOFORM 1).
  7. "Emp is a component of the nuclear matrix of mammalian cells and undergoes dynamic rearrangements during cell division."
    Bala S., Kumar A., Soni S., Sinha S., Hanspal M.
    Biochem. Biophys. Res. Commun. 342:1040-1048(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, SUBUNIT, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMAEA_HUMAN
AccessioniPrimary (citable) accession number: Q7L5Y9
Secondary accession number(s): O95285
, Q5JB54, Q6ZRD6, Q9BQ11, Q9H9V6, Q9H9Z4, Q9NW84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 5, 2005
Last modified: July 9, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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