Q7L5Y6 (DET1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DET1 homolog

Alternative name(s):
De-etiolated-1 homolog

Gene names

Name:

DET1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	550 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation. Ref.3
Subunit structure	Component of the DCX DET1-COP1 ubiquitin ligase complex at least composed of RBX1, DET1, DDB1, CUL4A and COP1.
Subcellular location	Nucleus Probable.
Tissue specificity	Highly expressed in the ovary, some lymphoid organs and resting leukocytes. Ref.3
Sequence similarities	Belongs to the DET1 family.
Sequence caution	The sequence BAA91447.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Cellular component	Nucleus
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 550	550	DET1 homolog		PRO_0000129026

Sequences

	Sequence		Length	Mass (Da)
	Q7L5Y6 [UniParc]. Last modified November 23, 2004. Version 2. Checksum: A164AC844F897DF7	FASTA	550	63,848
	10 20 30 40 50 60 MDHHVSTIKP RRIQNQNVIH RLERRRISSG KAGTHWHQVR VFHQNVFPNF TVVNVEKPPC 70 80 90 100 110 120 FLRKFSPDGR YFIAFSSDQT SLEIYEYQGC QAAEDLLQGY EGEILSNGND QRSVNIRGRL 130 140 150 160 170 180 FERFFVLLHI TNVAANGEHL NRECSLFTDD CRCVIVGSAA YLPDEPHPPF FEVYRNSESV 190 200 210 220 230 240 TPNPRSPLED YSLHIIDLHT GRLCDTRTFK CDKVVLSHNQ GLYLYKNILA ILSVQQQTIH 250 260 270 280 290 300 VFQVTPEGTF IDVRTIGRFC YEDDLLTVSA VFPEVQRDSQ TGMANPFRDP FINSLKHRLL 310 320 330 340 350 360 VYLWRRAEQD GSAMAKRRFF QYFDQLRQLR MWKMQLLDEN HLFIKYTSED VVTLRVTDPS 370 380 390 400 410 420 QASFFVVYNM VTTEVIAVFE NTSDELLELF ENFCDLFRNA TLHSEVQFPC SASSNNFARQ 430 440 450 460 470 480 IQRRFKDTII NAKYGGHTEA VRRLLGQLPI SAQSYSGSPY LDLSLFSYDD KWVSVMERPK 490 500 510 520 530 540 TCGDHPIRFY ARDSGLLKFE IQAGLLGRPI NHTVRRLVAF TFHPFEPFAI SVQRTNAEYV 550 VNFHMRHCCT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo and Neuroblastoma.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[3]	"Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase." Wertz I.E., O'Rourke K.M., Zhang Z., Dornan D., Arnott D., Deshaies R.J., Dixit V.M. Science 303:1371-1374(2004) [PubMed: 14739464] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, IDENTIFICATION IN THE DCX DET1-COP1 COMPLEX WITH RBX1; CUL4A; COP1 AND DDB1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK000965 mRNA. Translation: BAA91447.1. Different initiation. AK054603 mRNA. No translation available. BC001242 mRNA. Translation: AAH01242.2. BC109060 mRNA. Translation: AAI09061.1. BC109061 mRNA. Translation: AAI09062.1.
IPI	IPI00921609.
RefSeq	NP_001137546.1. NM_001144074.1.
UniGene	Hs.690871.
3D structure databases
ProteinModelPortal	Q7L5Y6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7L5Y6.
Polymorphism databases
DMDM	55976471.
Proteomic databases
PRIDE	Q7L5Y6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000268148; ENSP00000268148; ENSG00000140543. ENST00000444300; ENSP00000408994; ENSG00000140543.
GeneID	55070.
KEGG	hsa:55070.
UCSC	uc002bmq.1. human.
Organism-specific databases
CTD	55070.
GeneCards	GC15M089055.
H-InvDB	HIX0012553.
HGNC	HGNC:25477. DET1.
MIM	608727. gene.
neXtProt	NX_Q7L5Y6.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG15470.
GeneTree	ENSGT00390000005224.
HOVERGEN	HBG051339.
InParanoid	Q7L5Y6.
OrthoDB	EOG4CC413.
PhylomeDB	Q7L5Y6.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
ArrayExpress	Q7L5Y6.
Bgee	Q7L5Y6.
Genevestigator	Q7L5Y6.
GermOnline	ENSG00000140543. Homo sapiens.
Family and domain databases
InterPro	IPR019138. De-etiolated_protein_1_Det1. [Graphical view]
KO	K10571.
Pfam	PF09737. Det1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

DET1_HUMAN

Accession

Primary (citable) accession number: Q7L5Y6
Secondary accession number(s): Q2VPC0, Q9NWD5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 23, 2004
Last sequence update:	November 23, 2004
Last modified:	January 25, 2012
This is version 65 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.