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Protein

Mitochondrial enolase superfamily member 1

Gene

ENOSF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the catabolism of L-fucose, a sugar that is part of the carbohydrates that are attached to cellular glycoproteins. Catalyzes the dehydration of L-fuconate to 2-keto-3-deoxy-L-fuconate by the abstraction of the 2-proton to generate an enediolate intermediate that is stabilized by the magnesium ion (PubMed:24697329).1 Publication

Catalytic activityi

L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H2O.1 Publication

Cofactori

Mg2+1 PublicationNote: Binds 1 Mg2+ ion per subunit.1 Publication

Kineticsi

kcat is 0.5 sec(-1) for L-fuconate. kcat is 0.3 sec(-1) for L-galactonate. kcat is 0.3 sec(-1) for L-arabinonate. kcat is 0.04 sec(-1) for D-arabinonate. kcat is 0.002 sec(-1) for D-ribonate.

  1. KM=0.2 mM for L-fuconate1 Publication
  2. KM=3.0 mM for L-galactonate1 Publication
  3. KM=2.0 mM for D-arabinonate1 Publication
  4. KM=4.0 mM for L-arabinonate1 Publication
  5. KM=0.4 mM for D-ribonate1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Binding sitei34SubstrateBy similarity1
    Binding sitei220SubstrateBy similarity1
    Active sitei222Proton donor/acceptorBy similarity1
    Metal bindingi250Magnesium1 Publication1
    Binding sitei252SubstrateBy similarity1
    Metal bindingi276Magnesium1 Publication1
    Binding sitei276SubstrateBy similarity1
    Metal bindingi305Magnesium1 Publication1
    Binding sitei305SubstrateBy similarity1
    Active sitei355Sequence analysis1
    Binding sitei386SubstrateBy similarity1

    GO - Molecular functioni

    • isomerase activity Source: UniProtKB-KW
    • L-fuconate dehydratase activity Source: UniProtKB
    • magnesium ion binding Source: UniProtKB

    GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Isomerase, Lyase

    Keywords - Ligandi

    Magnesium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial enolase superfamily member 1 (EC:4.2.1.681 Publication)
    Alternative name(s):
    Antisense RNA to thymidylate synthase
    Short name:
    rTS
    L-fuconate dehydratase
    Gene namesi
    Name:ENOSF1
    Synonyms:RTS, TYMSAS
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:30365. ENOSF1.

    Subcellular locationi

    GO - Cellular componenti

    Complete GO annotation...

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Mutagenesisi1 – 27Missing : Impairs protein solubility. Abolishes catalytic activity. 1 PublicationAdd BLAST27

    Organism-specific databases

    DisGeNETi55556.
    OpenTargetsiENSG00000132199.
    PharmGKBiPA134897613.

    Polymorphism and mutation databases

    BioMutaiENOSF1.
    DMDMi74739173.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00003316521 – 443Mitochondrial enolase superfamily member 1Add BLAST443

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei148Phosphoserine1 Publication1

    Post-translational modificationi

    Could be sumoylated.1 Publication

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    EPDiQ7L5Y1.
    MaxQBiQ7L5Y1.
    PaxDbiQ7L5Y1.
    PeptideAtlasiQ7L5Y1.
    PRIDEiQ7L5Y1.

    PTM databases

    iPTMnetiQ7L5Y1.
    PhosphoSitePlusiQ7L5Y1.

    Expressioni

    Gene expression databases

    BgeeiENSG00000132199.
    CleanExiHS_ENOSF1.
    ExpressionAtlasiQ7L5Y1. baseline and differential.
    GenevisibleiQ7L5Y1. HS.

    Organism-specific databases

    HPAiHPA047829.

    Interactioni

    Protein-protein interaction databases

    BioGridi120716. 2 interactors.
    IntActiQ7L5Y1. 1 interactor.
    STRINGi9606.ENSP00000345974.

    Structurei

    Secondary structure

    1443
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Beta strandi5 – 15Combined sources11
    Helixi18 – 20Combined sources3
    Beta strandi35 – 45Combined sources11
    Beta strandi51 – 57Combined sources7
    Helixi62 – 72Combined sources11
    Helixi73 – 75Combined sources3
    Turni76 – 78Combined sources3
    Helixi81 – 85Combined sources5
    Helixi88 – 96Combined sources9
    Helixi101 – 104Combined sources4
    Beta strandi106 – 108Combined sources3
    Helixi109 – 130Combined sources22
    Helixi134 – 140Combined sources7
    Helixi143 – 147Combined sources5
    Turni153 – 158Combined sources6
    Helixi161 – 170Combined sources10
    Turni171 – 174Combined sources4
    Helixi175 – 185Combined sources11
    Beta strandi187 – 191Combined sources5
    Helixi201 – 213Combined sources13
    Beta strandi218 – 222Combined sources5
    Helixi227 – 241Combined sources15
    Beta strandi245 – 250Combined sources6
    Helixi257 – 267Combined sources11
    Helixi268 – 270Combined sources3
    Beta strandi273 – 276Combined sources4
    Helixi284 – 294Combined sources11
    Helixi295 – 297Combined sources3
    Beta strandi300 – 303Combined sources4
    Helixi310 – 318Combined sources9
    Beta strandi323 – 325Combined sources3
    Turni329 – 331Combined sources3
    Helixi334 – 347Combined sources14
    Turni358 – 360Combined sources3
    Helixi361 – 375Combined sources15
    Beta strandi385 – 387Combined sources3
    Helixi392 – 394Combined sources3
    Beta strandi395 – 397Combined sources3
    Beta strandi400 – 407Combined sources8
    Beta strandi411 – 413Combined sources3
    Helixi420 – 426Combined sources7
    Turni428 – 430Combined sources3
    Helixi432 – 437Combined sources6

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    4A35X-ray1.74A1-440[»]
    ProteinModelPortaliQ7L5Y1.
    SMRiQ7L5Y1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Regioni24 – 26Substrate bindingBy similarity3
    Regioni355 – 357Substrate bindingBy similarity3

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiENOG410IET8. Eukaryota.
    COG4948. LUCA.
    GeneTreeiENSGT00390000014290.
    HOGENOMiHOG000113757.
    HOVERGENiHBG053904.
    InParanoidiQ7L5Y1.
    KOiK18334.
    OMAiSAAYCIL.
    OrthoDBiEOG091G027L.
    PhylomeDBiQ7L5Y1.
    TreeFamiTF300529.

    Family and domain databases

    Gene3Di3.20.20.120. 1 hit.
    3.30.390.10. 1 hit.
    InterProiIPR029065. Enolase_C-like.
    IPR029017. Enolase_N-like.
    IPR018110. Mandel_Rmase/mucon_lact_enz_CS.
    IPR013342. Mandelate_racemase_C.
    IPR013341. Mandelate_racemase_N_dom.
    IPR001354. MR/MLE/MAL.
    [Graphical view]
    PANTHERiPTHR13794. PTHR13794. 2 hits.
    PfamiPF13378. MR_MLE_C. 1 hit.
    PF02746. MR_MLE_N. 1 hit.
    [Graphical view]
    SMARTiSM00922. MR_MLE. 1 hit.
    [Graphical view]
    SUPFAMiSSF51604. SSF51604. 1 hit.
    SSF54826. SSF54826. 1 hit.
    PROSITEiPS00909. MR_MLE_2. 1 hit.
    [Graphical view]

    Sequences (7)i

    Sequence statusi: Complete.

    This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

    Isoform 1 (identifier: Q7L5Y1-1) [UniParc]FASTAAdd to basket
    Also known as: rTSgamma

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

            10         20         30         40         50
    MVRGRISRLS VRDVRFPTSL GGHGADAMHT DPDYSAAYVV IETDAEDGIK
    60 70 80 90 100
    GCGITFTLGK GTEVVVCAVN ALAHHVLNKD LKDIVGDFRG FYRQLTSDGQ
    110 120 130 140 150
    LRWIGPEKGV VHLATAAVLN AVWDLWAKQE GKPVWKLLVD MDPRMLVSCI
    160 170 180 190 200
    DFRYITDVLT EEDALEILQK GQIGKKEREK QMLAQGYPAY TTSCAWLGYS
    210 220 230 240 250
    DDTLKQLCAQ ALKDGWTRFK VKVGADLQDD MRRCQIIRDM IGPEKTLMMD
    260 270 280 290 300
    ANQRWDVPEA VEWMSKLAKF KPLWIEEPTS PDDILGHATI SKALVPLGIG
    310 320 330 340 350
    IATGEQCHNR VIFKQLLQAK ALQFLQIDSC RLGSVNENLS VLLMAKKFEI
    360 370 380 390 400
    PVCPHAGGVG LCELVQHLII FDYISVSASL ENRVCEYVDH LHEHFKYPVM
    410 420 430 440
    IQRASYMPPK DPGYSTEMKE ESVKKHQYPD GEVWKKLLPA QEN
    Length:443
    Mass (Da):49,786
    Last modified:May 24, 2005 - v1
    Checksum:i82BEDAC229D1A729
    GO
    Isoform 2 (identifier: Q7L5Y1-2) [UniParc]FASTAAdd to basket
    Also known as: rTSalpha

    The sequence of this isoform differs from the canonical sequence as follows:
         1-102: Missing.
         103-103: W → MQKMESRGVELPSLWEKALKL

    Show »
    Length:361
    Mass (Da):41,024
    Checksum:i73B469F1C9C7E144
    GO
    Isoform 3 (identifier: Q7L5Y1-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         65-117: VVCAVNALAH...KGVVHLATAA → DWSRKGRGAP...GILHRFQVHH
         118-443: Missing.

    Show »
    Length:117
    Mass (Da):12,286
    Checksum:iB277BFA534E7DAF2
    GO
    Isoform 4 (identifier: Q7L5Y1-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-24: MVRGRISRLSVRDVRFPTSLGGHG → MVSADAMVSADAMVSADAMVSADAMVSADAMVSADAMVSADAMVS
         293-306: Missing.

    Note: Gene prediction based on EST data.
    Show »
    Length:450
    Mass (Da):50,170
    Checksum:i7D6BD13DF0F12AD0
    GO
    Isoform 5 (identifier: Q7L5Y1-5) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-24: MVRGRISRLSVRDVRFPTSLGGHG → MVSADAMVSA...AMVSADAMVS
         293-306: Missing.

    Show »
    Length:474
    Mass (Da):52,468
    Checksum:i97FA6018CAADF8CB
    GO
    Isoform 6 (identifier: Q7L5Y1-6) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-181: Missing.

    Show »
    Length:262
    Mass (Da):29,710
    Checksum:i5296CB2DCA806273
    GO
    Isoform 7 (identifier: Q7L5Y1-7) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-230: Missing.

    Show »
    Length:213
    Mass (Da):24,284
    Checksum:iF2CF0580E05E10BA
    GO

    Sequence cautioni

    The sequence AAG29537 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
    The sequence CAA47471 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_04293331D → E.Corresponds to variant rs34724061dbSNPEnsembl.1
    Natural variantiVAR_042934145M → T.4 PublicationsCorresponds to variant rs2612086dbSNPEnsembl.1
    Natural variantiVAR_042935428Y → S.Corresponds to variant rs2847620dbSNPEnsembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Alternative sequenceiVSP_0552411 – 230Missing in isoform 7. 1 PublicationAdd BLAST230
    Alternative sequenceiVSP_0552421 – 181Missing in isoform 6. 1 PublicationAdd BLAST181
    Alternative sequenceiVSP_0333111 – 102Missing in isoform 2. 1 PublicationAdd BLAST102
    Alternative sequenceiVSP_0471531 – 24MVRGR…LGGHG → MVSADAMVSADAMVSADAMV SADAMVSADAMVSADAMVSA DAMVS in isoform 4. CuratedAdd BLAST24
    Alternative sequenceiVSP_0552431 – 24MVRGR…LGGHG → MVSADAMVSADAMVSADAMV SADAMVSADAMVSADAMVSA DAMVSADAMVSADAMVSADA MVSADAMVS in isoform 5. 1 PublicationAdd BLAST24
    Alternative sequenceiVSP_03331265 – 117VVCAV…LATAA → DWSRKGRGAPGDSGRPKRGV GLVGQAGGKACLEVTCGHGS QDAGILHRFQVHH in isoform 3. 1 PublicationAdd BLAST53
    Alternative sequenceiVSP_033313103W → MQKMESRGVELPSLWEKALK L in isoform 2. 1 Publication1
    Alternative sequenceiVSP_033314118 – 443Missing in isoform 3. 1 PublicationAdd BLAST326
    Alternative sequenceiVSP_047154293 – 306Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST14

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF305057 Genomic DNA. Translation: AAG29536.1.
    X67098 mRNA. Translation: CAA47472.1.
    AF305057 Genomic DNA. Translation: AAG29537.1. Different initiation.
    X67098 mRNA. Translation: CAA47471.1. Different initiation.
    X89602 mRNA. Translation: CAA61761.1.
    AK127818 mRNA. Translation: BAC87148.1.
    AK093873 mRNA. Translation: BAG52778.1.
    AK127219 mRNA. Translation: BAG54456.1.
    AK292780 mRNA. Translation: BAF85469.1.
    AP001178 Genomic DNA. No translation available.
    CH471113 Genomic DNA. Translation: EAX01713.1.
    CH471113 Genomic DNA. Translation: EAX01714.1.
    CH471113 Genomic DNA. Translation: EAX01715.1.
    BC001285 mRNA. Translation: AAH01285.2.
    CCDSiCCDS11822.1. [Q7L5Y1-1]
    CCDS11823.1. [Q7L5Y1-4]
    CCDS45821.1. [Q7L5Y1-2]
    RefSeqiNP_001119595.1. NM_001126123.3. [Q7L5Y1-2]
    NP_001305688.1. NM_001318759.1. [Q7L5Y1-1]
    NP_001305689.1. NM_001318760.1. [Q7L5Y1-6]
    NP_059982.2. NM_017512.5. [Q7L5Y1-1]
    NP_974487.1. NM_202758.3. [Q7L5Y1-4]
    XP_016881324.1. XM_017025835.1. [Q7L5Y1-2]
    XP_016881325.1. XM_017025836.1. [Q7L5Y1-6]
    UniGeneiHs.658550.
    Hs.731510.
    Hs.732707.

    Genome annotation databases

    EnsembliENST00000251101; ENSP00000251101; ENSG00000132199. [Q7L5Y1-1]
    ENST00000340116; ENSP00000345974; ENSG00000132199. [Q7L5Y1-4]
    ENST00000383578; ENSP00000373072; ENSG00000132199. [Q7L5Y1-2]
    GeneIDi55556.
    KEGGihsa:55556.
    UCSCiuc002kkt.4. human. [Q7L5Y1-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF305057 Genomic DNA. Translation: AAG29536.1.
    X67098 mRNA. Translation: CAA47472.1.
    AF305057 Genomic DNA. Translation: AAG29537.1. Different initiation.
    X67098 mRNA. Translation: CAA47471.1. Different initiation.
    X89602 mRNA. Translation: CAA61761.1.
    AK127818 mRNA. Translation: BAC87148.1.
    AK093873 mRNA. Translation: BAG52778.1.
    AK127219 mRNA. Translation: BAG54456.1.
    AK292780 mRNA. Translation: BAF85469.1.
    AP001178 Genomic DNA. No translation available.
    CH471113 Genomic DNA. Translation: EAX01713.1.
    CH471113 Genomic DNA. Translation: EAX01714.1.
    CH471113 Genomic DNA. Translation: EAX01715.1.
    BC001285 mRNA. Translation: AAH01285.2.
    CCDSiCCDS11822.1. [Q7L5Y1-1]
    CCDS11823.1. [Q7L5Y1-4]
    CCDS45821.1. [Q7L5Y1-2]
    RefSeqiNP_001119595.1. NM_001126123.3. [Q7L5Y1-2]
    NP_001305688.1. NM_001318759.1. [Q7L5Y1-1]
    NP_001305689.1. NM_001318760.1. [Q7L5Y1-6]
    NP_059982.2. NM_017512.5. [Q7L5Y1-1]
    NP_974487.1. NM_202758.3. [Q7L5Y1-4]
    XP_016881324.1. XM_017025835.1. [Q7L5Y1-2]
    XP_016881325.1. XM_017025836.1. [Q7L5Y1-6]
    UniGeneiHs.658550.
    Hs.731510.
    Hs.732707.

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    4A35X-ray1.74A1-440[»]
    ProteinModelPortaliQ7L5Y1.
    SMRiQ7L5Y1.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi120716. 2 interactors.
    IntActiQ7L5Y1. 1 interactor.
    STRINGi9606.ENSP00000345974.

    PTM databases

    iPTMnetiQ7L5Y1.
    PhosphoSitePlusiQ7L5Y1.

    Polymorphism and mutation databases

    BioMutaiENOSF1.
    DMDMi74739173.

    Proteomic databases

    EPDiQ7L5Y1.
    MaxQBiQ7L5Y1.
    PaxDbiQ7L5Y1.
    PeptideAtlasiQ7L5Y1.
    PRIDEiQ7L5Y1.

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000251101; ENSP00000251101; ENSG00000132199. [Q7L5Y1-1]
    ENST00000340116; ENSP00000345974; ENSG00000132199. [Q7L5Y1-4]
    ENST00000383578; ENSP00000373072; ENSG00000132199. [Q7L5Y1-2]
    GeneIDi55556.
    KEGGihsa:55556.
    UCSCiuc002kkt.4. human. [Q7L5Y1-1]

    Organism-specific databases

    CTDi55556.
    DisGeNETi55556.
    GeneCardsiENOSF1.
    HGNCiHGNC:30365. ENOSF1.
    HPAiHPA047829.
    MIMi607427. gene.
    neXtProtiNX_Q7L5Y1.
    OpenTargetsiENSG00000132199.
    PharmGKBiPA134897613.
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiENOG410IET8. Eukaryota.
    COG4948. LUCA.
    GeneTreeiENSGT00390000014290.
    HOGENOMiHOG000113757.
    HOVERGENiHBG053904.
    InParanoidiQ7L5Y1.
    KOiK18334.
    OMAiSAAYCIL.
    OrthoDBiEOG091G027L.
    PhylomeDBiQ7L5Y1.
    TreeFamiTF300529.

    Miscellaneous databases

    ChiTaRSiENOSF1. human.
    GenomeRNAii55556.
    PROiQ7L5Y1.
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSG00000132199.
    CleanExiHS_ENOSF1.
    ExpressionAtlasiQ7L5Y1. baseline and differential.
    GenevisibleiQ7L5Y1. HS.

    Family and domain databases

    Gene3Di3.20.20.120. 1 hit.
    3.30.390.10. 1 hit.
    InterProiIPR029065. Enolase_C-like.
    IPR029017. Enolase_N-like.
    IPR018110. Mandel_Rmase/mucon_lact_enz_CS.
    IPR013342. Mandelate_racemase_C.
    IPR013341. Mandelate_racemase_N_dom.
    IPR001354. MR/MLE/MAL.
    [Graphical view]
    PANTHERiPTHR13794. PTHR13794. 2 hits.
    PfamiPF13378. MR_MLE_C. 1 hit.
    PF02746. MR_MLE_N. 1 hit.
    [Graphical view]
    SMARTiSM00922. MR_MLE. 1 hit.
    [Graphical view]
    SUPFAMiSSF51604. SSF51604. 1 hit.
    SSF54826. SSF54826. 1 hit.
    PROSITEiPS00909. MR_MLE_2. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Entry informationi

    Entry nameiENOF1_HUMAN
    AccessioniPrimary (citable) accession number: Q7L5Y1
    Secondary accession number(s): A6NMP3
    , A8K9R5, B3KSL6, B3KXE4, D3DUH0, Q15407, Q15594, Q15595, Q6ZS08, Q9HAS5, Q9HAS6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: May 24, 2005
    Last modified: November 2, 2016
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Was originally (PubMed:8493092) identified as a gene coding for an antisense RNA to thymidylate synthase, and was proposed to down-regulate TYMS activity (PubMed:8869746), possibly by promoting the degradation of TYMS mRNA via an antisense RNA-based mechanism (PubMed:12084460).3 Publications

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.