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Protein

COP9 signalosome complex subunit 6

Gene

COPS6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity. Stabilizes RFWD2/COP1 through reducing RFWD2 auto-ubiquitination and decelerating RFWD2 turnover rate, hence regulates the ubiquitination of RFWD2 targets.6 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction

Enzyme and pathway databases

ReactomeiR-HSA-5696394. DNA Damage Recognition in GG-NER.
R-HSA-6781823. Formation of TC-NER Pre-Incision Complex.
R-HSA-8856825. Cargo recognition for clathrin-mediated endocytosis.
SIGNORiQ7L5N1.

Protein family/group databases

MEROPSiM67.972.

Names & Taxonomyi

Protein namesi
Recommended name:
COP9 signalosome complex subunit 6
Short name:
SGN6
Short name:
Signalosome subunit 6
Alternative name(s):
JAB1-containing signalosome subunit 6
MOV34 homolog
Vpr-interacting protein
Short name:
hVIP
Gene namesi
Name:COPS6
Synonyms:CSN6, HVIP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21749. COPS6.

Subcellular locationi

  • Nucleus
  • Cytoplasm

  • Note: The interaction with HIV-1 Vpr protein possibly leads its translocation to a perinuclear region.

GO - Cellular componenti

  • COP9 signalosome Source: UniProtKB
  • cytoplasm Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Signalosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi10980.
OpenTargetsiENSG00000168090.
PharmGKBiPA134919933.

Polymorphism and mutation databases

BioMutaiCOPS6.
DMDMi55976470.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001948601 – 327COP9 signalosome complex subunit 6Add BLAST327

Proteomic databases

EPDiQ7L5N1.
MaxQBiQ7L5N1.
PaxDbiQ7L5N1.
PeptideAtlasiQ7L5N1.
PRIDEiQ7L5N1.

PTM databases

iPTMnetiQ7L5N1.
PhosphoSitePlusiQ7L5N1.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000168090.
CleanExiHS_COPS6.
ExpressionAtlasiQ7L5N1. baseline and differential.
GenevisibleiQ7L5N1. HS.

Organism-specific databases

HPAiHPA044315.

Interactioni

Subunit structurei

Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 isoform 1 (PubMed:18850735, PubMed:26456823). In the complex, it probably interacts directly with COPS2, COPS4, COPS5, COPS7 (COPS7A or COPS7B) and COPS9 isoform 1 (PubMed:11337588, PubMed:26456823). Interacts with the translation initiation factor EIF3S6 (PubMed:12220626). Interacts weakly with RBX1 (PubMed:11337588). Directly interacts with RFWD2 and 14-3-3 protein sigma/SFN (PubMed:21625211).5 Publications
(Microbial infection) Interacts with the HIV-1 protein Vpr.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BTBD2Q9BX702EBI-486838,EBI-710091
COPS3Q9UNS28EBI-486838,EBI-350590
MAPK1P284822EBI-486838,EBI-959949
RFWD2Q8NHY23EBI-486838,EBI-1176214
SFNP319477EBI-486838,EBI-476295

Protein-protein interaction databases

BioGridi116176. 314 interactors.
DIPiDIP-32655N.
IntActiQ7L5N1. 134 interactors.
MINTiMINT-5005311.
STRINGi9606.ENSP00000304102.

Structurei

Secondary structure

1327
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi40 – 43Combined sources4
Helixi45 – 62Combined sources18
Beta strandi69 – 77Combined sources9
Beta strandi80 – 88Combined sources9
Beta strandi91 – 94Combined sources4
Beta strandi97 – 100Combined sources4
Helixi102 – 115Combined sources14
Beta strandi120 – 130Combined sources11
Helixi133 – 142Combined sources10
Turni143 – 145Combined sources3
Beta strandi146 – 148Combined sources3
Beta strandi150 – 154Combined sources5
Helixi160 – 162Combined sources3
Beta strandi165 – 186Combined sources22
Helixi200 – 207Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4D10X-ray3.80F/N1-327[»]
4D18X-ray4.08F/N1-327[»]
4QFTX-ray1.76A31-211[»]
4R14X-ray2.60A/B38-210[»]
4WSNX-ray5.50F/N/V/d/l/t1-327[»]
ProteinModelPortaliQ7L5N1.
SMRiQ7L5N1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 148MPNAdd BLAST110

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni211 – 327Interaction with VprAdd BLAST117

Sequence similaritiesi

Belongs to the peptidase M67A family. CSN6 subfamily.Curated
Contains 1 MPN (JAB/Mov34) domain.Curated

Phylogenomic databases

eggNOGiKOG3050. Eukaryota.
COG1310. LUCA.
GeneTreeiENSGT00530000063075.
HOGENOMiHOG000253002.
HOVERGENiHBG107770.
InParanoidiQ7L5N1.
KOiK12179.
OMAiDFLGWYT.
OrthoDBiEOG091G0AZ5.
PhylomeDBiQ7L5N1.
TreeFamiTF101148.

Family and domain databases

CDDicd08063. MPN_CSN6. 1 hit.
InterProiIPR000555. JAMM/MPN+_dom.
IPR033859. MPN_CSN6.
IPR024969. Rpn11/EIF3F_C.
[Graphical view]
PfamiPF01398. JAB. 1 hit.
PF13012. MitMem_reg. 1 hit.
[Graphical view]
SMARTiSM00232. JAB_MPN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7L5N1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAAAAAA TNGTGGSSGM EVDAAVVPSV MACGVTGSVS VALHPLVILN
60 70 80 90 100
ISDHWIRMRS QEGRPVQVIG ALIGKQEGRN IEVMNSFELL SHTVEEKIII
110 120 130 140 150
DKEYYYTKEE QFKQVFKELE FLGWYTTGGP PDPSDIHVHK QVCEIIESPL
160 170 180 190 200
FLKLNPMTKH TDLPVSVFES VIDIINGEAT MLFAELTYTL ATEEAERIGV
210 220 230 240 250
DHVARMTATG SGENSTVAEH LIAQHSAIKM LHSRVKLILE YVKASEAGEV
260 270 280 290 300
PFNHEILREA YALCHCLPVL STDKFKTDFY DQCNDVGLMA YLGTITKTCN
310 320
TMNQFVNKFN VLYDRQGIGR RMRGLFF
Length:327
Mass (Da):36,163
Last modified:July 5, 2004 - v1
Checksum:iE33CAC6ADF799A8D
GO

Sequence cautioni

The sequence AAD03469 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH236956 Genomic DNA. Translation: EAL23857.1.
CH471091 Genomic DNA. Translation: EAW76601.1.
BC002520 mRNA. Translation: AAH02520.2.
U70735 mRNA. Translation: AAD03469.1. Different initiation.
CCDSiCCDS5682.1.
RefSeqiNP_006824.2. NM_006833.4.
UniGeneiHs.15591.

Genome annotation databases

EnsembliENST00000303904; ENSP00000304102; ENSG00000168090.
GeneIDi10980.
KEGGihsa:10980.
UCSCiuc003usu.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH236956 Genomic DNA. Translation: EAL23857.1.
CH471091 Genomic DNA. Translation: EAW76601.1.
BC002520 mRNA. Translation: AAH02520.2.
U70735 mRNA. Translation: AAD03469.1. Different initiation.
CCDSiCCDS5682.1.
RefSeqiNP_006824.2. NM_006833.4.
UniGeneiHs.15591.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4D10X-ray3.80F/N1-327[»]
4D18X-ray4.08F/N1-327[»]
4QFTX-ray1.76A31-211[»]
4R14X-ray2.60A/B38-210[»]
4WSNX-ray5.50F/N/V/d/l/t1-327[»]
ProteinModelPortaliQ7L5N1.
SMRiQ7L5N1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116176. 314 interactors.
DIPiDIP-32655N.
IntActiQ7L5N1. 134 interactors.
MINTiMINT-5005311.
STRINGi9606.ENSP00000304102.

Protein family/group databases

MEROPSiM67.972.

PTM databases

iPTMnetiQ7L5N1.
PhosphoSitePlusiQ7L5N1.

Polymorphism and mutation databases

BioMutaiCOPS6.
DMDMi55976470.

Proteomic databases

EPDiQ7L5N1.
MaxQBiQ7L5N1.
PaxDbiQ7L5N1.
PeptideAtlasiQ7L5N1.
PRIDEiQ7L5N1.

Protocols and materials databases

DNASUi10980.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303904; ENSP00000304102; ENSG00000168090.
GeneIDi10980.
KEGGihsa:10980.
UCSCiuc003usu.4. human.

Organism-specific databases

CTDi10980.
DisGeNETi10980.
GeneCardsiCOPS6.
HGNCiHGNC:21749. COPS6.
HPAiHPA044315.
MIMi614729. gene.
neXtProtiNX_Q7L5N1.
OpenTargetsiENSG00000168090.
PharmGKBiPA134919933.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3050. Eukaryota.
COG1310. LUCA.
GeneTreeiENSGT00530000063075.
HOGENOMiHOG000253002.
HOVERGENiHBG107770.
InParanoidiQ7L5N1.
KOiK12179.
OMAiDFLGWYT.
OrthoDBiEOG091G0AZ5.
PhylomeDBiQ7L5N1.
TreeFamiTF101148.

Enzyme and pathway databases

ReactomeiR-HSA-5696394. DNA Damage Recognition in GG-NER.
R-HSA-6781823. Formation of TC-NER Pre-Incision Complex.
R-HSA-8856825. Cargo recognition for clathrin-mediated endocytosis.
SIGNORiQ7L5N1.

Miscellaneous databases

ChiTaRSiCOPS6. human.
GeneWikiiCOPS6.
GenomeRNAii10980.
PROiQ7L5N1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168090.
CleanExiHS_COPS6.
ExpressionAtlasiQ7L5N1. baseline and differential.
GenevisibleiQ7L5N1. HS.

Family and domain databases

CDDicd08063. MPN_CSN6. 1 hit.
InterProiIPR000555. JAMM/MPN+_dom.
IPR033859. MPN_CSN6.
IPR024969. Rpn11/EIF3F_C.
[Graphical view]
PfamiPF01398. JAB. 1 hit.
PF13012. MitMem_reg. 1 hit.
[Graphical view]
SMARTiSM00232. JAB_MPN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSN6_HUMAN
AccessioniPrimary (citable) accession number: Q7L5N1
Secondary accession number(s): A4D2A3, O15387
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Although related to the peptidase M67A family, it lacks the JAMM motif that probably constitutes the catalytic center and therefore it probably does not have a protease activity.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.