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Protein

Protein FAM214B

Gene

FAM214B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM214B
Gene namesi
Name:FAM214B
Synonyms:KIAA1539
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:25666. FAM214B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134880815.

Polymorphism and mutation databases

BioMutaiFAM214B.
DMDMi74749892.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 538538Protein FAM214BPRO_0000313620Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei254 – 2541PhosphoserineBy similarity
Modified residuei255 – 2551PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ7L5A3.
PaxDbiQ7L5A3.
PeptideAtlasiQ7L5A3.
PRIDEiQ7L5A3.

PTM databases

iPTMnetiQ7L5A3.
PhosphoSiteiQ7L5A3.

Expressioni

Gene expression databases

BgeeiQ7L5A3.
CleanExiHS_KIAA1539.
GenevisibleiQ7L5A3. HS.

Organism-specific databases

HPAiHPA048831.
HPA055751.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CEP70Q8NHQ13EBI-745689,EBI-739624
DIP2AQ146893EBI-745689,EBI-2564275
DNAJA3Q96EY1-23EBI-745689,EBI-3952284
IKZF1Q134224EBI-745689,EBI-745305
KIF20AO952353EBI-745689,EBI-2551319
TRIM27P143733EBI-745689,EBI-719493

Protein-protein interaction databases

BioGridi123202. 10 interactions.
IntActiQ7L5A3. 9 interactions.
MINTiMINT-4719671.
STRINGi9606.ENSP00000319897.

Structurei

3D structure databases

ProteinModelPortaliQ7L5A3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM214 family.Curated

Phylogenomic databases

eggNOGiKOG2306. Eukaryota.
ENOG41115V6. LUCA.
GeneTreeiENSGT00530000063568.
HOGENOMiHOG000049081.
HOVERGENiHBG097397.
InParanoidiQ7L5A3.
OMAiGPRELKR.
OrthoDBiEOG7Z3F41.
PhylomeDBiQ7L5A3.
TreeFamiTF325496.

Family and domain databases

InterProiIPR025261. DUF4210.
IPR033473. FAM214/SPAC3H8.04_C.
[Graphical view]
PfamiPF13889. Chromosome_seg. 1 hit.
PF13915. DUF4210. 1 hit.
[Graphical view]
SMARTiSM01177. DUF4210. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7L5A3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRHVQAEPSP SSEPEAGPSQ PPVRQGALQG GLLMGYSPAG GATSPGVYQV
60 70 80 90 100
SIFSPPAGTS EPHRALKRQA PSTEGPRELK RGPGLGAREG LPPEEPSTVG
110 120 130 140 150
LLGPEGPGLG LGVASQHFSH RGLCVVEQRS SVTSSWTSGA WSPPCPPSNA
160 170 180 190 200
SCNTLHTRDW ASPDPGGQGS LGESPGPAPP GQLHTLDTDL HSLAQIGGKS
210 220 230 240 250
PVAGVGNGGS LWPRESPGTA NGHSPEHTPP GPGPPGPCPT KRRLLPAGEA
260 270 280 290 300
PDVSSEEEGP APRRRRGSLG HPTAANSSDA KATPFWSHLL PGPKEPVLDP
310 320 330 340 350
TDCGPMGRRL KGARRLKLSP LRSLRKGPGL LSPPSASPVP TPAVSRTLLG
360 370 380 390 400
NFEESLLRGR FAPSGHIEGF TAEIGASGSY CPQHVTLPVT VTFFDVSEQN
410 420 430 440 450
APAPFLGIVD LNPLGRKGYS VPKVGTVQVT LFNPNQTVVK MFLVTFDFSD
460 470 480 490 500
MPAAHMTFLR HRLFLVPVGE EGNANPTHRL LCYLLHLRFR SSRSGRLSLH
510 520 530
GDIRLLFSRR SLELDTGLPY ELQAVTEAPH NPRYSPLP
Length:538
Mass (Da):56,690
Last modified:July 5, 2004 - v1
Checksum:i7BF7E9EB38167BDC
GO
Isoform 2 (identifier: Q7L5A3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     435-538: NQTVVKMFLV...PHNPRYSPLP → NPFTSPTL

Show »
Length:442
Mass (Da):45,578
Checksum:i6124D4A4B8B10505
GO
Isoform 3 (identifier: Q7L5A3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-305: Missing.

Note: No experimental confirmation available.
Show »
Length:233
Mass (Da):25,691
Checksum:i295C286A5A5AAAD3
GO

Sequence cautioni

The sequence AAC07982.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence BAA96063.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Isoform 2 (identifier: Q7L5A3-2)
Sequence conflicti435 – 4351N → S in BAB13857 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 305305Missing in isoform 3. 1 PublicationVSP_042437Add
BLAST
Alternative sequencei435 – 538104NQTVV…YSPLP → NPFTSPTL in isoform 2. 1 PublicationVSP_030063Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040972 mRNA. Translation: BAA96063.1. Different initiation.
AK021622 mRNA. Translation: BAB13857.1.
AK022837 mRNA. Translation: BAG51123.1.
AL583909 mRNA. Translation: CAC29493.1.
AC004472 Genomic DNA. Translation: AAC07982.1. Sequence problems.
AL353795 Genomic DNA. Translation: CAH70999.1.
AL353795 Genomic DNA. Translation: CAH71000.1.
AL353795 Genomic DNA. Translation: CAH71001.1.
CH471071 Genomic DNA. Translation: EAW58387.1.
CH471071 Genomic DNA. Translation: EAW58388.1.
CH471071 Genomic DNA. Translation: EAW58389.1.
CH471071 Genomic DNA. Translation: EAW58391.1.
CH471071 Genomic DNA. Translation: EAW58392.1.
BC004406 mRNA. Translation: AAH04406.1.
CCDSiCCDS6578.1. [Q7L5A3-1]
PIRiT02247.
RefSeqiNP_001304920.1. NM_001317991.1. [Q7L5A3-1]
NP_079458.2. NM_025182.3. [Q7L5A3-1]
XP_005251645.1. XM_005251588.1. [Q7L5A3-1]
XP_005251647.1. XM_005251590.1. [Q7L5A3-1]
XP_005251648.1. XM_005251591.1. [Q7L5A3-1]
XP_011516339.1. XM_011518037.1. [Q7L5A3-1]
XP_011516340.1. XM_011518038.1. [Q7L5A3-1]
XP_011516345.1. XM_011518043.1. [Q7L5A3-3]
XP_011516346.1. XM_011518044.1. [Q7L5A3-3]
UniGeneiHs.301696.

Genome annotation databases

EnsembliENST00000322813; ENSP00000319897; ENSG00000005238. [Q7L5A3-1]
ENST00000378557; ENSP00000367819; ENSG00000005238. [Q7L5A3-1]
ENST00000378561; ENSP00000367823; ENSG00000005238. [Q7L5A3-1]
ENST00000378566; ENSP00000367829; ENSG00000005238. [Q7L5A3-3]
ENST00000488109; ENSP00000475120; ENSG00000005238. [Q7L5A3-1]
ENST00000603301; ENSP00000474335; ENSG00000005238. [Q7L5A3-1]
ENST00000605244; ENSP00000474833; ENSG00000005238. [Q7L5A3-1]
GeneIDi80256.
KEGGihsa:80256.
UCSCiuc003zwl.4. human. [Q7L5A3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040972 mRNA. Translation: BAA96063.1. Different initiation.
AK021622 mRNA. Translation: BAB13857.1.
AK022837 mRNA. Translation: BAG51123.1.
AL583909 mRNA. Translation: CAC29493.1.
AC004472 Genomic DNA. Translation: AAC07982.1. Sequence problems.
AL353795 Genomic DNA. Translation: CAH70999.1.
AL353795 Genomic DNA. Translation: CAH71000.1.
AL353795 Genomic DNA. Translation: CAH71001.1.
CH471071 Genomic DNA. Translation: EAW58387.1.
CH471071 Genomic DNA. Translation: EAW58388.1.
CH471071 Genomic DNA. Translation: EAW58389.1.
CH471071 Genomic DNA. Translation: EAW58391.1.
CH471071 Genomic DNA. Translation: EAW58392.1.
BC004406 mRNA. Translation: AAH04406.1.
CCDSiCCDS6578.1. [Q7L5A3-1]
PIRiT02247.
RefSeqiNP_001304920.1. NM_001317991.1. [Q7L5A3-1]
NP_079458.2. NM_025182.3. [Q7L5A3-1]
XP_005251645.1. XM_005251588.1. [Q7L5A3-1]
XP_005251647.1. XM_005251590.1. [Q7L5A3-1]
XP_005251648.1. XM_005251591.1. [Q7L5A3-1]
XP_011516339.1. XM_011518037.1. [Q7L5A3-1]
XP_011516340.1. XM_011518038.1. [Q7L5A3-1]
XP_011516345.1. XM_011518043.1. [Q7L5A3-3]
XP_011516346.1. XM_011518044.1. [Q7L5A3-3]
UniGeneiHs.301696.

3D structure databases

ProteinModelPortaliQ7L5A3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123202. 10 interactions.
IntActiQ7L5A3. 9 interactions.
MINTiMINT-4719671.
STRINGi9606.ENSP00000319897.

PTM databases

iPTMnetiQ7L5A3.
PhosphoSiteiQ7L5A3.

Polymorphism and mutation databases

BioMutaiFAM214B.
DMDMi74749892.

Proteomic databases

EPDiQ7L5A3.
PaxDbiQ7L5A3.
PeptideAtlasiQ7L5A3.
PRIDEiQ7L5A3.

Protocols and materials databases

DNASUi80256.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322813; ENSP00000319897; ENSG00000005238. [Q7L5A3-1]
ENST00000378557; ENSP00000367819; ENSG00000005238. [Q7L5A3-1]
ENST00000378561; ENSP00000367823; ENSG00000005238. [Q7L5A3-1]
ENST00000378566; ENSP00000367829; ENSG00000005238. [Q7L5A3-3]
ENST00000488109; ENSP00000475120; ENSG00000005238. [Q7L5A3-1]
ENST00000603301; ENSP00000474335; ENSG00000005238. [Q7L5A3-1]
ENST00000605244; ENSP00000474833; ENSG00000005238. [Q7L5A3-1]
GeneIDi80256.
KEGGihsa:80256.
UCSCiuc003zwl.4. human. [Q7L5A3-1]

Organism-specific databases

CTDi80256.
GeneCardsiFAM214B.
HGNCiHGNC:25666. FAM214B.
HPAiHPA048831.
HPA055751.
neXtProtiNX_Q7L5A3.
PharmGKBiPA134880815.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2306. Eukaryota.
ENOG41115V6. LUCA.
GeneTreeiENSGT00530000063568.
HOGENOMiHOG000049081.
HOVERGENiHBG097397.
InParanoidiQ7L5A3.
OMAiGPRELKR.
OrthoDBiEOG7Z3F41.
PhylomeDBiQ7L5A3.
TreeFamiTF325496.

Miscellaneous databases

ChiTaRSiFAM214B. human.
GeneWikiiKIAA1539.
GenomeRNAii80256.
PROiQ7L5A3.

Gene expression databases

BgeeiQ7L5A3.
CleanExiHS_KIAA1539.
GenevisibleiQ7L5A3. HS.

Family and domain databases

InterProiIPR025261. DUF4210.
IPR033473. FAM214/SPAC3H8.04_C.
[Graphical view]
PfamiPF13889. Chromosome_seg. 1 hit.
PF13915. DUF4210. 1 hit.
[Graphical view]
SMARTiSM01177. DUF4210. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Embryo and Teratocarcinoma.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Amygdala.
  4. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  7. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 299-538 (ISOFORM 1).

Entry informationi

Entry nameiF214B_HUMAN
AccessioniPrimary (citable) accession number: Q7L5A3
Secondary accession number(s): B1AML4
, B1AML5, D3DRN5, O60377, Q9BQ60, Q9HAI9, Q9P1Y9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.