Reviewed,
UniProtKB/Swiss-Prot Q7L576 (CYFP1_HUMAN)
Last modified
November 25, 2008.
Version 37.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Cytoplasmic FMR1-interacting protein 1 Alternative name(s): Specifically Rac1-associated protein 1 Short name=Sra-1 p140sra-1 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 1253 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Involved in formation of membrane ruffles and lamellipodia protrusions and in axon outgrowth. Binds to F-actin but not to RNA. |
| Subunit structure | Interacts with the active GTP-bound form of RAC1. Interacts with FMR1/FMRP but does not bind to related proteins FXR1 or FXR2. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2 By similarity. Interacts through its C-terminus with the C-terminus of DPYSL2/CRMP2 which is necessary for DPYSL2-induced axon outgrowth. |
| Subcellular location | Cytoplasm › perinuclear regionBy similarity. Cell projection › lamellipodiumBy similarity. Cell projection › ruffleBy similarity. Cell junction › synapse › synaptosomeBy similarity. Note= Highly expressed in the perinuclear region. Enriched in synaptosomes, membrane ruffles and at the tips of lamellipodia By similarity. |
| Sequence similarities | Belongs to the CYFIP family. |
Ontologies
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| EIF4E | P06730 | 1 | EBI-1048143,EBI-73440 | |
| Eif4e | P63073 | 1 | EBI-1048143,EBI-2000006 | From a different organism. |
| NCKAP1 | Q9Y2A7 | 2 | EBI-1048143,EBI-389845 |
Alternative products
| This entry describes 3 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q7L576-1) Also known as: 3; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q7L576-2) Also known as: 4; The sequence of this isoform differs from the canonical sequence as follows: 1-431: Missing. 432-557: AEEYERATRY...PRRAVGPSST → MAESLGSAEL...SPPQMFPWII | ||||||
| Isoform 3 (identifier: Q7L576-3) Also known as: 5; The sequence of this isoform differs from the canonical sequence as follows: 1-806: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1253 | 1253 | Cytoplasmic FMR1-interacting protein 1 | PRO_0000279706 | |||||
Amino acid modifications | |||||||||
| Modified residue | 108 | 1 | Phosphotyrosine | ||||||
| Modified residue | 1068 | 1 | Phosphothreonine | ||||||
Natural variations | |||||||||
| Alternative sequence | 1 – 806 | 806 | Missing in isoform 3. | VSP_052345 | |||||
| Alternative sequence | 1 – 431 | 431 | Missing in isoform 2. | VSP_052346 | |||||
| Alternative sequence | 432 – 557 | 126 | AEEYE…GPSST → MAESLGSAELLRQLKSLGME RLLHAVNTFLRQSCTYLPLL TFGGKTSFVSLDVYGTEANC SATSCSFPKAAATWPRRQAP GPLGELVRGPPDQGVAEQSF SHGLFEFGITNVPCIFSPPQ MFPWII in isoform 2. | VSP_052347 | |||||
Experimental info | |||||||||
| Sequence conflict | 583 | 1 | S → N in AAW51478. Ref.1 | ||||||
| Sequence conflict | 583 | 1 | S → N in BAC86825. Ref.3 | ||||||
| Sequence conflict | 820 | 1 | G → S in AAW51478. Ref.1 | ||||||
| Sequence conflict | 820 | 1 | G → S in BAC86825. Ref.3 | ||||||
| Sequence conflict | 820 | 1 | G → S in AAH01306. Ref.4 | ||||||
| Sequence conflict | 898 | 1 | Y → H in AAW51478. Ref.1 | ||||||
| Sequence conflict | 898 | 1 | Y → H in BAC86825. Ref.3 | ||||||
| Sequence conflict | 930 | 1 | M → R in AAW51478. Ref.1 | ||||||
| Sequence conflict | 930 | 1 | M → R in BAC86825. Ref.3 | ||||||
| Sequence conflict | 1176 | 1 | V → A in AAW51479. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | Jiang Y.-H., Beaudet A.L. Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3). |
| [2] | "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1." Nomura N., Nagase T., Miyajima N., Sazuka T., Tanaka A., Sato S., Seki N., Kawarabayasi Y., Ishikawa K., Tabata S. DNA Res. 1:223-229(1994) [PubMed: 7584044] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Bone marrow. |
| [3] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain and Placenta. |
| [5] | Bienvenut W.V., Claeys D., Boldt K., von Kriegsheim A.F., Kolch W. Submitted (JUL-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 50-58; 111-130; 151-163; 366-377; 441-448; 505-515; 564-573; 754-760; 815-826; 867-877; 1054-1076; 1211-1224 AND 1228-1240, MASS SPECTROMETRY. Tissue: B-cell lymphoma and Hepatoma. |
| [6] | "p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase." Kobayashi K., Kuroda S., Fukata M., Nakamura T., Nagase T., Nomura N., Matsuura Y., Yoshida-Kubomura N., Iwamatsu A., Kaibuchi K. J. Biol. Chem. 273:291-295(1998) [PubMed: 9417078] [Abstract] Cited for: FUNCTION. |
| [7] | "CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation." Kawano Y., Yoshimura T., Tsuboi D., Kawabata S., Kaneko-Kawano T., Shirataki H., Takenawa T., Kaibuchi K. Mol. Cell. Biol. 25:9920-9935(2005) [PubMed: 16260607] [Abstract] Cited for: FUNCTION, INTERACTION WITH DPYSL2. |
| [8] | "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. Comb M.J.Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-108, MASS SPECTROMETRY. Tissue: Lung. |
| [9] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1068, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AY763577 mRNA. Translation: AAW51476.1. AY763578 mRNA. Translation: AAW51477.1. AY763579 mRNA. Translation: AAW51478.1. AY763580 mRNA. Translation: AAW51479.1. D38549 mRNA. Translation: BAA07552.1. Different initiation. AK127094 mRNA. Translation: BAC86825.1. BC001306 mRNA. Translation: AAH01306.2. BC005097 mRNA. Translation: AAH05097.1. | |
| RefSeq | NP_001028200.1. NP_055423.1. |
| UniGene | Hs.26704 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q7L576. |
PTM databases | |
| PhosphoSite | Q7L576. |
Genome annotation databases | |
| Ensembl | ENSG00000068793. Homo sapiens. [Contig view] |
| GeneID | 23191. |
| KEGG | hsa:23191. |
Organism-specific databases | |
| HGNC | HGNC:13759. CYFIP1. |
| MIM | 606322. gene. |
| Orphanet | 72. Angelman syndrome. |
| PharmGKB | PA38367. |
| HUGE | Search... |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOVERGEN | Q7L576. |
Gene expression databases | |
| ArrayExpress | Q7L576. |
| CleanEx | HS_CYFIP1. |
Family and domain databases | |
| InterPro | IPR008081. Cytoplasmic_FMR1-int. IPR016536. Cytoplasmic_FMR1-int_sub. [Graphical view] |
| PANTHER | PTHR12195. FragX_IP. 1 hit. |
| Pfam | PF05994. FragX_IP. 1 hit. [Graphical view] |
| PIRSF | PIRSF008153. FMR1_interacting. 1 hit. |
| PRINTS | PR01698. CYTOFMRPINTP. |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 44673. |
| SOURCE | Search... |
Entry information
| Entry name | CYFP1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q7L576 Secondary accession number(s): Q14467 Q9BVC7 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 15 Human chromosome 15: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


