Q7L513 (FCRLA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fc receptor-like A

Alternative name(s):
Fc receptor homolog expressed in B-cells
Fc receptor-like and mucin-like protein 1
Fc receptor-like protein
Fc receptor-related protein X
Short name=FcRX

Gene names

Name:	FCRLA
Synonyms:	FCRL, FCRL1, FCRLM1, FCRX, FREB
ORF Names:	UNQ291/PRO329

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be implicated in B-cell differentiation and lymphomagenesis. Ref.1 Ref.2
Subunit structure	Monomer or homodimer; disulfide-linked.
Subcellular location	Secreted Probable. Cytoplasm Ref.1 Ref.2 Ref.4.
Tissue specificity	Expressed specifically in primary and secondary lymphoid tissues like lymph node, spleen and tonsil. Specifically expressed in B-cells with a high level in normal germinal center B-cells, centroblasts and in a subset of diffuse large B-cell lymphomas. Highly expressed in bone marrow B-cells and weakly in earlier B lineage cells. Expressed in pre-germinal and germinal center B-cells in secondary lymphoid tissues. Also expressed in melanoma and melanocytes. Ref.1 Ref.2 Ref.3 Ref.4
Sequence similarities	Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Caution	It is uncertain whether Met-1 or Met-8 is the initiator.

Ontologies

Keywords
Biological process	Differentiation
Cellular component	Cytoplasm Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Repeat Signal
PTM	Disulfide bond
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from direct assay PubMed 15815692. Source: MGI extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 9 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q7L513-1)

Also known as: FCRLa;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q7L513-2)

Also known as: FCRLa1;

The sequence of this isoform differs from the canonical sequence as follows:
     28-28: A → AGCHAAA

Isoform 3 (identifier: Q7L513-3)

Also known as: FCRLb;

The sequence of this isoform differs from the canonical sequence as follows:
     78-166: Missing.

Isoform 4 (identifier: Q7L513-4)

Also known as: FCRLc1;

The sequence of this isoform differs from the canonical sequence as follows:
     29-166: SFETLQCEGP...TASVVAITVQ → GCHA

Isoform 5 (identifier: Q7L513-5)

Also known as: FCRLc2;

The sequence of this isoform differs from the canonical sequence as follows:
     27-166: Missing.

Isoform 6 (identifier: Q7L513-6)

Also known as: FCRLd;

The sequence of this isoform differs from the canonical sequence as follows:
     78-261: Missing.

Isoform 7 (identifier: Q7L513-7)

Also known as: FCRLe;

The sequence of this isoform differs from the canonical sequence as follows:
     27-261: Missing.

Isoform 8 (identifier: Q7L513-8)

Also known as: FCRLf;

The sequence of this isoform differs from the canonical sequence as follows:
     167-261: Missing.

Isoform 9 (identifier: Q7L513-9)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLKKISVGVAGDLNTVTM

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 27

27

Ref.11

Chain

28 – 359

332

Fc receptor-like A

PRO_0000227935

Regions

Domain

70 – 159

90

Ig-like C2-type 1

Domain

170 – 257

88

Ig-like C2-type 2

Compositional bias

269 – 315

47

Pro-rich

Amino acid modifications

Disulfide bond

99 ↔ 143

By similarity

Disulfide bond

192 ↔ 240

By similarity

Natural variations

Alternative sequence

1

1

M → MLKKISVGVAGDLNTVTM in isoform 9.

VSP_038297

Alternative sequence

27 – 261

235

Missing in isoform 7.

VSP_017603

Alternative sequence

27 – 166

140

Missing in isoform 5.

VSP_017604

Alternative sequence

28

1

A → AGCHAAA in isoform 2.

VSP_017605

Alternative sequence

29 – 166

138

SFETL…AITVQ → GCHA in isoform 4.

VSP_017606

Alternative sequence

78 – 261

184

Missing in isoform 6.

VSP_017607

Alternative sequence

78 – 166

89

Missing in isoform 3.

VSP_017608

Alternative sequence

167 – 261

95

Missing in isoform 8.

VSP_017609

Natural variant

349

1

R → Q. Ref.1 Ref.2 Ref.3 Ref.5 Ref.7 Ref.10
Corresponds to variant rs11746 [ dbSNP | Ensembl ].

VAR_025646

Experimental info

Sequence conflict

265

1

S → N in AAL23904. Ref.1

Sequence conflict

308

1

S → P in AAL23903. Ref.1

Sequence conflict

317

1

L → P in AAL27307. Ref.1

Sequence conflict

343

1

R → G in AAL23905. Ref.1

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

359

Helix Strand Turn

Details...

Beta strand

173 – 178

6

Beta strand

188 – 193

6

Beta strand

206 – 211

6

Beta strand

214 – 221

8

Beta strand

224 – 229

6

Helix

232 – 234

3

Beta strand

236 – 243

8

Beta strand

247 – 252

6

Beta strand

256 – 258

3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (FCRLa) [UniParc]. Last modified March 21, 2006. Version 2. Checksum: 76821DADB121499F	FASTA	359	38,927
	10 20 30 40 50 60 MKLGCVLMAW ALYLSLGVLW VAQMLLAASF ETLQCEGPVC TEESSCHTED DLTDAREAGF 70 80 90 100 110 120 QVKAYTFSEP FHLIVSYDWL ILQGPAKPVF EGDLLVLRCQ AWQDWPLTQV TFYRDGSALG 130 140 150 160 170 180 PPGPNREFSI TVVQKADSGH YHCSGIFQSP GPGIPETASV VAITVQELFP APILRAVPSA 190 200 210 220 230 240 EPQAGSPMTL SCQTKLPLQR SAARLLFSFY KDGRIVQSRG LSSEFQIPTA SEDHSGSYWC 250 260 270 280 290 300 EAATEDNQVW KQSPQLEIRV QGASSSAAPP TLNPAPQKSA APGTAPEEAP GPLPPPPTPS 310 320 330 340 350 SEDPGFSSPL GMPDPHLYHQ MGLLLKHMQD VRVLLGHLLM ELRELSGHRK PGTTKATAE
	Isoform 2 (FCRLa1) [UniParc]. Checksum: CCE4864CD4C54490	FASTA	365	39,438
	10 20 30 40 50 60 MKLGCVLMAW ALYLSLGVLW VAQMLLAAGC HAAASFETLQ CEGPVCTEES SCHTEDDLTD 70 80 90 100 110 120 AREAGFQVKA YTFSEPFHLI VSYDWLILQG PAKPVFEGDL LVLRCQAWQD WPLTQVTFYR 130 140 150 160 170 180 DGSALGPPGP NREFSITVVQ KADSGHYHCS GIFQSPGPGI PETASVVAIT VQELFPAPIL 190 200 210 220 230 240 RAVPSAEPQA GSPMTLSCQT KLPLQRSAAR LLFSFYKDGR IVQSRGLSSE FQIPTASEDH 250 260 270 280 290 300 SGSYWCEAAT EDNQVWKQSP QLEIRVQGAS SSAAPPTLNP APQKSAAPGT APEEAPGPLP 310 320 330 340 350 360 PPPTPSSEDP GFSSPLGMPD PHLYHQMGLL LKHMQDVRVL LGHLLMELRE LSGHRKPGTT KATAE
	Isoform 3 (FCRLb) [UniParc]. Checksum: 5C8206F2AD581FEF	FASTA	270	29,281
	10 20 30 40 50 60 MKLGCVLMAW ALYLSLGVLW VAQMLLAASF ETLQCEGPVC TEESSCHTED DLTDAREAGF 70 80 90 100 110 120 QVKAYTFSEP FHLIVSYELF PAPILRAVPS AEPQAGSPMT LSCQTKLPLQ RSAARLLFSF 130 140 150 160 170 180 YKDGRIVQSR GLSSEFQIPT ASEDHSGSYW CEAATEDNQV WKQSPQLEIR VQGASSSAAP 190 200 210 220 230 240 PTLNPAPQKS AAPGTAPEEA PGPLPPPPTP SSEDPGFSSP LGMPDPHLYH QMGLLLKHMQ 250 260 270 DVRVLLGHLL MELRELSGHR KPGTTKATAE
	Isoform 4 (FCRLc1) [UniParc]. Checksum: 004B85CFCA2232C8	FASTA	225	24,149
	10 20 30 40 50 60 MKLGCVLMAW ALYLSLGVLW VAQMLLAAGC HAELFPAPIL RAVPSAEPQA GSPMTLSCQT 70 80 90 100 110 120 KLPLQRSAAR LLFSFYKDGR IVQSRGLSSE FQIPTASEDH SGSYWCEAAT EDNQVWKQSP 130 140 150 160 170 180 QLEIRVQGAS SSAAPPTLNP APQKSAAPGT APEEAPGPLP PPPTPSSEDP GFSSPLGMPD 190 200 210 220 PHLYHQMGLL LKHMQDVRVL LGHLLMELRE LSGHRKPGTT KATAE
	Isoform 5 (FCRLc2) [UniParc]. Checksum: 7221B95E05E01932	FASTA	219	23,638
	10 20 30 40 50 60 MKLGCVLMAW ALYLSLGVLW VAQMLLELFP APILRAVPSA EPQAGSPMTL SCQTKLPLQR 70 80 90 100 110 120 SAARLLFSFY KDGRIVQSRG LSSEFQIPTA SEDHSGSYWC EAATEDNQVW KQSPQLEIRV 130 140 150 160 170 180 QGASSSAAPP TLNPAPQKSA APGTAPEEAP GPLPPPPTPS SEDPGFSSPL GMPDPHLYHQ 190 200 210 MGLLLKHMQD VRVLLGHLLM ELRELSGHRK PGTTKATAE
	Isoform 6 (FCRLd) [UniParc]. Checksum: 1EB948BC1FD4EB45	FASTA	175	18,719
	10 20 30 40 50 60 MKLGCVLMAW ALYLSLGVLW VAQMLLAASF ETLQCEGPVC TEESSCHTED DLTDAREAGF 70 80 90 100 110 120 QVKAYTFSEP FHLIVSYGAS SSAAPPTLNP APQKSAAPGT APEEAPGPLP PPPTPSSEDP 130 140 150 160 170 GFSSPLGMPD PHLYHQMGLL LKHMQDVRVL LGHLLMELRE LSGHRKPGTT KATAE
	Isoform 7 (FCRLe) [UniParc]. Checksum: DA62850F76758F70	FASTA	124	13,076
	10 20 30 40 50 60 MKLGCVLMAW ALYLSLGVLW VAQMLLGASS SAAPPTLNPA PQKSAAPGTA PEEAPGPLPP 70 80 90 100 110 120 PPTPSSEDPG FSSPLGMPDP HLYHQMGLLL KHMQDVRVLL GHLLMELREL SGHRKPGTTK ATAE
	Isoform 8 (FCRLf) [UniParc]. Checksum: C3FC5FC795C82CD0	FASTA	264	28,365
	10 20 30 40 50 60 MKLGCVLMAW ALYLSLGVLW VAQMLLAASF ETLQCEGPVC TEESSCHTED DLTDAREAGF 70 80 90 100 110 120 QVKAYTFSEP FHLIVSYDWL ILQGPAKPVF EGDLLVLRCQ AWQDWPLTQV TFYRDGSALG 130 140 150 160 170 180 PPGPNREFSI TVVQKADSGH YHCSGIFQSP GPGIPETASV VAITVQGASS SAAPPTLNPA 190 200 210 220 230 240 PQKSAAPGTA PEEAPGPLPP PPTPSSEDPG FSSPLGMPDP HLYHQMGLLL KHMQDVRVLL 250 260 GHLLMELREL SGHRKPGTTK ATAE
	Isoform 9 [UniParc]. Checksum: A8EEAF71347126DE	FASTA	376	40,655
	10 20 30 40 50 60 MLKKISVGVA GDLNTVTMKL GCVLMAWALY LSLGVLWVAQ MLLAASFETL QCEGPVCTEE 70 80 90 100 110 120 SSCHTEDDLT DAREAGFQVK AYTFSEPFHL IVSYDWLILQ GPAKPVFEGD LLVLRCQAWQ 130 140 150 160 170 180 DWPLTQVTFY RDGSALGPPG PNREFSITVV QKADSGHYHC SGIFQSPGPG IPETASVVAI 190 200 210 220 230 240 TVQELFPAPI LRAVPSAEPQ AGSPMTLSCQ TKLPLQRSAA RLLFSFYKDG RIVQSRGLSS 250 260 270 280 290 300 EFQIPTASED HSGSYWCEAA TEDNQVWKQS PQLEIRVQGA SSSAAPPTLN PAPQKSAAPG 310 320 330 340 350 360 TAPEEAPGPL PPPPTPSSED PGFSSPLGMP DPHLYHQMGL LLKHMQDVRV LLGHLLMELR 370 ELSGHRKPGT TKATAE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"FCRL, a novel member of the leukocyte Fc receptor family possesses unique structural features." Mechetina L.V., Najakshin A.M., Volkova O.Y., Guselnikov S.V., Faizulin R.Z., Alabyev B.Y., Chikaev N.A., Vinogradova M.S., Taranin A.V. Eur. J. Immunol. 32:87-96(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 4; 5; 6 AND 7), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANT GLN-349. Tissue: Lymph, Melanocyte and Tonsil.
[2]	"An unusual Fc receptor-related protein expressed in human centroblasts." Facchetti F., Cella M., Festa S., Fremont D.H., Colonna M. Proc. Natl. Acad. Sci. U.S.A. 99:3776-3781(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 9), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANT GLN-349.
[3]	"Definition of an Fc receptor-related gene (FcRX) expressed in human and mouse B cells." Davis R.S., Li H., Chen C.-C., Wang Y.-H., Cooper M.D., Burrows P.D. Int. Immunol. 14:1075-1083(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 9), TISSUE SPECIFICITY, VARIANT GLN-349.
[4]	"Novel melanoma antigen, FCRL/FREB, identified by cDNA profile comparison using DNA chip are immunogenic in multiple melanoma patients." Inozume T., Matsuzaki Y., Kurihara S., Fujita T., Yamamoto A., Aburatani H., Shimada S., Kawakami Y. Int. J. Cancer 114:283-290(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 5; 6; 7 AND 8), TISSUE SPECIFICITY, SUBCELLULAR LOCATION. Tissue: Melanocyte.
[5]	Guselnikov S., Najakshin A.M. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT GLN-349. Tissue: Tonsil.
[6]	Livingston R.J., Shaffer T., McFarland I., Nguyen C.P., Stanaway I.B., Rajkumar N., Johnson E.J., da Ponte S.H., Willa H., Ahearn M.O., Bertucci C., Acklestad J., Carroll A., Swanson J., Gildersleeve H.I., Nickerson D.A. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[7]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 9), VARIANT GLN-349. Tissue: Lymph and Tonsil.
[8]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
[9]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLN-349. Tissue: Skin.
[11]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 28-42.
[12]	Bienvenut W.V. Submitted (JUN-2005) to UniProtKB Cited for: PROTEIN SEQUENCE OF 88-98; 252-259 AND 333-353, MASS SPECTROMETRY. Tissue: B-cell lymphoma.
[13]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF329489 mRNA. Translation: AAL23899.1.
AF329491 mRNA. Translation: AAL23901.1.
AF329493 mRNA. Translation: AAL23903.1.
AF329494 mRNA. Translation: AAL23904.1.
AF329495 mRNA. Translation: AAL23905.1.
AF390036 mRNA. Translation: AAL27307.1.
AF426461 mRNA. Translation: AAL58111.1.
AF531423 mRNA. Translation: AAM97591.1.
AY091642 mRNA. Translation: AAM13980.2.
EF064729 Genomic DNA. Translation: ABK41912.1.
AY358348 mRNA. Translation: AAQ88714.1.
AL359541 Genomic DNA. Translation: CAH74157.1.
AL359541 Genomic DNA. Translation: CAH74158.1.
AL359541 Genomic DNA. Translation: CAH74159.1.
AL359541 Genomic DNA. Translation: CAH74160.1.
AL359541 Genomic DNA. Translation: CAH74162.1.
CH471067 Genomic DNA. Translation: EAW90683.1.
BC006521 mRNA. Translation: AAH06521.2.

IPI

IPI00044501.
IPI00289766.
IPI00292096.
IPI00334123.
IPI00640728.
IPI00641296.
IPI00646535.
IPI00745500.
IPI00747979.

RefSeq

NP_001171795.1. NM_001184866.1.
NP_001171796.1. NM_001184867.1.
NP_001171799.1. NM_001184870.1.
NP_001171800.1. NM_001184871.1.
NP_001171801.1. NM_001184872.1.
NP_001171802.1. NM_001184873.1.
NP_116127.3. NM_032738.3.

UniGene

Hs.266331.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4HWN	X-ray	2.01	A	169-264	[»]

ProteinModelPortal

Q7L513.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q7L513. 4 interactions.

Protein family/group databases

MEROPS

I43.001.

PTM databases

PhosphoSite

Q7L513.

Polymorphism databases

DMDM

90101291.

Proteomic databases

PaxDb

Q7L513.

PRIDE

Q7L513.

Protocols and materials databases

DNASU

84824.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000236938; ENSP00000236938; ENSG00000132185.
ENST00000294796; ENSP00000294796; ENSG00000132185.
ENST00000309691; ENSP00000309596; ENSG00000132185.
ENST00000349527; ENSP00000294798; ENSG00000132185.
ENST00000367953; ENSP00000356930; ENSG00000132185.

GeneID

84824.

KEGG

hsa:84824.

UCSC

uc001gbd.3. human.
uc001gbf.3. human.

Organism-specific databases

CTD

84824.

GeneCards

GC01P161676.

H-InvDB

HIX0001250.

HGNC

HGNC:18504. FCRLA.

MIM

606891. gene.

neXtProt

NX_Q7L513.

PharmGKB

PA162388180.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG69552.

HOVERGEN

HBG059243.

InParanoid

Q7L513.

OrthoDB

EOG4R5038.

Gene expression databases

ArrayExpress

Q7L513.

Bgee

Q7L513.

CleanEx

HS_FCRL1.

Genevestigator

Q7L513.

GermOnline

ENSG00000132185. Homo sapiens.

Family and domain databases

Gene3D

2.60.40.10. 2 hits.

InterPro

IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]

SMART

SM00409. IG. 2 hits.
[Graphical view]

PROSITE

PS50835. IG_LIKE. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

GenomeRNAi

84824.

NextBio

75032.

SOURCE

Search...

Entry information

Entry name

FCRLA_HUMAN

Accession

Primary (citable) accession number: Q7L513
Secondary accession number(s): A0N0M1 , Q5VXA1, Q5VXA2, Q5VXA3, Q5VXA4, Q5VXB0, Q8NEW4, Q8WXH3, Q96PC6, Q96PJ0, Q96PJ1, Q96PJ2, Q96PJ4, Q9BR57

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	March 21, 2006
Last modified:	May 1, 2013
This is version 89 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.