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Q7L513 (FCRLA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fc receptor-like A
Alternative name(s):
Fc receptor homolog expressed in B-cells
Fc receptor-like and mucin-like protein 1
Fc receptor-like protein
Fc receptor-related protein X
Short name=FcRX
Gene names
Name:FCRLA
Synonyms:FCRL, FCRL1, FCRLM1, FCRX, FREB
ORF Names:UNQ291/PRO329
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be implicated in B-cell differentiation and lymphomagenesis. Ref.1 Ref.2

Subunit structure

Monomer or homodimer; disulfide-linked.

Subcellular location

Secreted Probable. Cytoplasm Ref.1 Ref.2 Ref.4.

Tissue specificity

Expressed specifically in primary and secondary lymphoid tissues like lymph node, spleen and tonsil. Specifically expressed in B-cells with a high level in normal germinal center B-cells, centroblasts and in a subset of diffuse large B-cell lymphomas. Highly expressed in bone marrow B-cells and weakly in earlier B lineage cells. Expressed in pre-germinal and germinal center B-cells in secondary lymphoid tissues. Also expressed in melanoma and melanocytes. Ref.1 Ref.2 Ref.3 Ref.4

Sequence similarities

Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Caution

It is uncertain whether Met-1 or Met-8 is the initiator.

Ontologies

Keywords
   Biological processDifferentiation
   Cellular componentCytoplasm
Secreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainImmunoglobulin domain
Repeat
Signal
   PTMDisulfide bond
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processcell differentiation

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 15815692. Source: MGI

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 9 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q7L513-1)

Also known as: FCRLa;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q7L513-2)

Also known as: FCRLa1;

The sequence of this isoform differs from the canonical sequence as follows:
     28-28: A → AGCHAAA
Isoform 3 (identifier: Q7L513-3)

Also known as: FCRLb;

The sequence of this isoform differs from the canonical sequence as follows:
     78-166: Missing.
Isoform 4 (identifier: Q7L513-4)

Also known as: FCRLc1;

The sequence of this isoform differs from the canonical sequence as follows:
     29-166: SFETLQCEGP...TASVVAITVQ → GCHA
Isoform 5 (identifier: Q7L513-5)

Also known as: FCRLc2;

The sequence of this isoform differs from the canonical sequence as follows:
     27-166: Missing.
Isoform 6 (identifier: Q7L513-6)

Also known as: FCRLd;

The sequence of this isoform differs from the canonical sequence as follows:
     78-261: Missing.
Isoform 7 (identifier: Q7L513-7)

Also known as: FCRLe;

The sequence of this isoform differs from the canonical sequence as follows:
     27-261: Missing.
Isoform 8 (identifier: Q7L513-8)

Also known as: FCRLf;

The sequence of this isoform differs from the canonical sequence as follows:
     167-261: Missing.
Isoform 9 (identifier: Q7L513-9)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLKKISVGVAGDLNTVTM

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Ref.11
Chain28 – 359332Fc receptor-like A
PRO_0000227935

Regions

Domain70 – 15990Ig-like C2-type 1
Domain170 – 25788Ig-like C2-type 2
Compositional bias269 – 31547Pro-rich

Amino acid modifications

Disulfide bond99 ↔ 143 By similarity
Disulfide bond192 ↔ 240 By similarity

Natural variations

Alternative sequence11M → MLKKISVGVAGDLNTVTM in isoform 9.
VSP_038297
Alternative sequence27 – 261235Missing in isoform 7.
VSP_017603
Alternative sequence27 – 166140Missing in isoform 5.
VSP_017604
Alternative sequence281A → AGCHAAA in isoform 2.
VSP_017605
Alternative sequence29 – 166138SFETL…AITVQ → GCHA in isoform 4.
VSP_017606
Alternative sequence78 – 261184Missing in isoform 6.
VSP_017607
Alternative sequence78 – 16689Missing in isoform 3.
VSP_017608
Alternative sequence167 – 26195Missing in isoform 8.
VSP_017609
Natural variant3491R → Q. Ref.1 Ref.2 Ref.3 Ref.5 Ref.7 Ref.10
Corresponds to variant rs11746 [ dbSNP | Ensembl ].
VAR_025646

Experimental info

Sequence conflict2651S → N in AAL23904. Ref.1
Sequence conflict3081S → P in AAL23903. Ref.1
Sequence conflict3171L → P in AAL27307. Ref.1
Sequence conflict3431R → G in AAL23905. Ref.1

Secondary structure

................... 359
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (FCRLa) [UniParc].

Last modified March 21, 2006. Version 2.
Checksum: 76821DADB121499F

FASTA35938,927
        10         20         30         40         50         60 
MKLGCVLMAW ALYLSLGVLW VAQMLLAASF ETLQCEGPVC TEESSCHTED DLTDAREAGF 

        70         80         90        100        110        120 
QVKAYTFSEP FHLIVSYDWL ILQGPAKPVF EGDLLVLRCQ AWQDWPLTQV TFYRDGSALG 

       130        140        150        160        170        180 
PPGPNREFSI TVVQKADSGH YHCSGIFQSP GPGIPETASV VAITVQELFP APILRAVPSA 

       190        200        210        220        230        240 
EPQAGSPMTL SCQTKLPLQR SAARLLFSFY KDGRIVQSRG LSSEFQIPTA SEDHSGSYWC 

       250        260        270        280        290        300 
EAATEDNQVW KQSPQLEIRV QGASSSAAPP TLNPAPQKSA APGTAPEEAP GPLPPPPTPS 

       310        320        330        340        350 
SEDPGFSSPL GMPDPHLYHQ MGLLLKHMQD VRVLLGHLLM ELRELSGHRK PGTTKATAE 

« Hide

Isoform 2 (FCRLa1) [UniParc].

Checksum: CCE4864CD4C54490
Show »

FASTA36539,438
Isoform 3 (FCRLb) [UniParc].

Checksum: 5C8206F2AD581FEF
Show »

FASTA27029,281
Isoform 4 (FCRLc1) [UniParc].

Checksum: 004B85CFCA2232C8
Show »

FASTA22524,149
Isoform 5 (FCRLc2) [UniParc].

Checksum: 7221B95E05E01932
Show »

FASTA21923,638
Isoform 6 (FCRLd) [UniParc].

Checksum: 1EB948BC1FD4EB45
Show »

FASTA17518,719
Isoform 7 (FCRLe) [UniParc].

Checksum: DA62850F76758F70
Show »

FASTA12413,076
Isoform 8 (FCRLf) [UniParc].

Checksum: C3FC5FC795C82CD0
Show »

FASTA26428,365
Isoform 9 [UniParc].

Checksum: A8EEAF71347126DE
Show »

FASTA37640,655

References

« Hide 'large scale' references
[1]"FCRL, a novel member of the leukocyte Fc receptor family possesses unique structural features."
Mechetina L.V., Najakshin A.M., Volkova O.Y., Guselnikov S.V., Faizulin R.Z., Alabyev B.Y., Chikaev N.A., Vinogradova M.S., Taranin A.V.
Eur. J. Immunol. 32:87-96(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 4; 5; 6 AND 7), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANT GLN-349.
Tissue: Lymph, Melanocyte and Tonsil.
[2]"An unusual Fc receptor-related protein expressed in human centroblasts."
Facchetti F., Cella M., Festa S., Fremont D.H., Colonna M.
Proc. Natl. Acad. Sci. U.S.A. 99:3776-3781(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 9), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANT GLN-349.
[3]"Definition of an Fc receptor-related gene (FcRX) expressed in human and mouse B cells."
Davis R.S., Li H., Chen C.-C., Wang Y.-H., Cooper M.D., Burrows P.D.
Int. Immunol. 14:1075-1083(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 9), TISSUE SPECIFICITY, VARIANT GLN-349.
[4]"Novel melanoma antigen, FCRL/FREB, identified by cDNA profile comparison using DNA chip are immunogenic in multiple melanoma patients."
Inozume T., Matsuzaki Y., Kurihara S., Fujita T., Yamamoto A., Aburatani H., Shimada S., Kawakami Y.
Int. J. Cancer 114:283-290(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 5; 6; 7 AND 8), TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
Tissue: Melanocyte.
[5]Guselnikov S., Najakshin A.M.
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT GLN-349.
Tissue: Tonsil.
[6]Livingston R.J., Shaffer T., McFarland I., Nguyen C.P., Stanaway I.B., Rajkumar N., Johnson E.J., da Ponte S.H., Willa H., Ahearn M.O., Bertucci C., Acklestad J., Carroll A., Swanson J., Gildersleeve H.I., Nickerson D.A.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[7]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 9), VARIANT GLN-349.
Tissue: Lymph and Tonsil.
[8]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
[9]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLN-349.
Tissue: Skin.
[11]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 28-42.
[12]Bienvenut W.V.
Submitted (JUN-2005) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 88-98; 252-259 AND 333-353, MASS SPECTROMETRY.
Tissue: B-cell lymphoma.
[13]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF329489 mRNA. Translation: AAL23899.1.
AF329491 mRNA. Translation: AAL23901.1.
AF329493 mRNA. Translation: AAL23903.1.
AF329494 mRNA. Translation: AAL23904.1.
AF329495 mRNA. Translation: AAL23905.1.
AF390036 mRNA. Translation: AAL27307.1.
AF426461 mRNA. Translation: AAL58111.1.
AF531423 mRNA. Translation: AAM97591.1.
AY091642 mRNA. Translation: AAM13980.2.
EF064729 Genomic DNA. Translation: ABK41912.1.
AY358348 mRNA. Translation: AAQ88714.1.
AL359541 Genomic DNA. Translation: CAH74157.1.
AL359541 Genomic DNA. Translation: CAH74158.1.
AL359541 Genomic DNA. Translation: CAH74159.1.
AL359541 Genomic DNA. Translation: CAH74160.1.
AL359541 Genomic DNA. Translation: CAH74162.1.
CH471067 Genomic DNA. Translation: EAW90683.1.
BC006521 mRNA. Translation: AAH06521.2.
RefSeqNP_001171795.1. NM_001184866.1.
NP_001171796.1. NM_001184867.1.
NP_001171799.1. NM_001184870.1.
NP_001171800.1. NM_001184871.1.
NP_001171801.1. NM_001184872.1.
NP_001171802.1. NM_001184873.1.
NP_116127.3. NM_032738.3.
UniGeneHs.266331.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4HWNX-ray2.01A169-264[»]
ProteinModelPortalQ7L513.
SMRQ7L513. Positions 50-262.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ7L513. 4 interactions.

Protein family/group databases

MEROPSI43.001.

PTM databases

PhosphoSiteQ7L513.

Polymorphism databases

DMDM90101291.

Proteomic databases

PaxDbQ7L513.
PRIDEQ7L513.

Protocols and materials databases

DNASU84824.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000236938; ENSP00000236938; ENSG00000132185. [Q7L513-9]
ENST00000294796; ENSP00000294796; ENSG00000132185. [Q7L513-4]
ENST00000309691; ENSP00000309596; ENSG00000132185. [Q7L513-3]
ENST00000349527; ENSP00000294798; ENSG00000132185. [Q7L513-8]
ENST00000367953; ENSP00000356930; ENSG00000132185. [Q7L513-2]
GeneID84824.
KEGGhsa:84824.
UCSCuc001gbd.3. human. [Q7L513-9]
uc031prb.1. human. [Q7L513-1]

Organism-specific databases

CTD84824.
GeneCardsGC01P161676.
H-InvDBHIX0001250.
HGNCHGNC:18504. FCRLA.
HPACAB016545.
MIM606891. gene.
neXtProtNX_Q7L513.
PharmGKBPA162388180.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG69552.
HOVERGENHBG059243.
InParanoidQ7L513.
OrthoDBEOG7H1JM6.

Gene expression databases

ArrayExpressQ7L513.
BgeeQ7L513.
CleanExHS_FCRL1.
GenevestigatorQ7L513.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTSM00409. IG. 2 hits.
[Graphical view]
PROSITEPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiFCRLA.
GenomeRNAi84824.
NextBio75032.
PROQ7L513.
SOURCESearch...

Entry information

Entry nameFCRLA_HUMAN
AccessionPrimary (citable) accession number: Q7L513
Secondary accession number(s): A0N0M1 expand/collapse secondary AC list , Q5VXA1, Q5VXA2, Q5VXA3, Q5VXA4, Q5VXB0, Q8NEW4, Q8WXH3, Q96PC6, Q96PJ0, Q96PJ1, Q96PJ2, Q96PJ4, Q9BR57
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: March 19, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM