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Protein

Fc receptor-like A

Gene

FCRLA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be implicated in B-cell differentiation and lymphomagenesis.2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Fc receptor-like A
Alternative name(s):
Fc receptor homolog expressed in B-cells
Fc receptor-like and mucin-like protein 1
Fc receptor-like protein
Fc receptor-related protein X
Short name:
FcRX
Gene namesi
Name:FCRLA
Synonyms:FCRL, FCRL1, FCRLM1, FCRX, FREB
ORF Names:UNQ291/PRO329
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:18504. FCRLA.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi84824.
OpenTargetsiENSG00000132185.
PharmGKBiPA162388180.

Polymorphism and mutation databases

BioMutaiFCRLA.
DMDMi90101291.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 271 PublicationAdd BLAST27
ChainiPRO_000022793528 – 359Fc receptor-like AAdd BLAST332

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi99 ↔ 143PROSITE-ProRule annotation
Disulfide bondi192 ↔ 240PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ7L513.
PaxDbiQ7L513.
PeptideAtlasiQ7L513.
PRIDEiQ7L513.

PTM databases

PhosphoSitePlusiQ7L513.

Expressioni

Tissue specificityi

Expressed specifically in primary and secondary lymphoid tissues like lymph node, spleen and tonsil. Specifically expressed in B-cells with a high level in normal germinal center B-cells, centroblasts and in a subset of diffuse large B-cell lymphomas. Highly expressed in bone marrow B-cells and weakly in earlier B lineage cells. Expressed in pre-germinal and germinal center B-cells in secondary lymphoid tissues. Also expressed in melanoma and melanocytes.4 Publications

Gene expression databases

BgeeiENSG00000132185.
CleanExiHS_FCRL1.
ExpressionAtlasiQ7L513. baseline and differential.
GenevisibleiQ7L513. HS.

Organism-specific databases

HPAiCAB016545.

Interactioni

Subunit structurei

Monomer or homodimer; disulfide-linked.

Protein-protein interaction databases

IntActiQ7L513. 4 interactors.
STRINGi9606.ENSP00000356936.

Structurei

Secondary structure

1359
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi173 – 178Combined sources6
Beta strandi188 – 193Combined sources6
Beta strandi206 – 211Combined sources6
Beta strandi214 – 221Combined sources8
Beta strandi224 – 229Combined sources6
Helixi232 – 234Combined sources3
Beta strandi236 – 243Combined sources8
Beta strandi247 – 252Combined sources6
Beta strandi256 – 258Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4HWNX-ray2.01A169-264[»]
ProteinModelPortaliQ7L513.
SMRiQ7L513.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini70 – 159Ig-like C2-type 1Add BLAST90
Domaini170 – 257Ig-like C2-type 2Add BLAST88

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi269 – 315Pro-richAdd BLAST47

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IHSR. Eukaryota.
ENOG4111EGY. LUCA.
GeneTreeiENSGT00760000119130.
HOGENOMiHOG000036934.
HOVERGENiHBG059243.
InParanoidiQ7L513.
OMAiTLSCQTK.
OrthoDBiEOG091G0ETN.
PhylomeDBiQ7L513.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequences (15)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 15 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7L513-1) [UniParc]FASTAAdd to basket
Also known as: FCRLa

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLGCVLMAW ALYLSLGVLW VAQMLLAASF ETLQCEGPVC TEESSCHTED
60 70 80 90 100
DLTDAREAGF QVKAYTFSEP FHLIVSYDWL ILQGPAKPVF EGDLLVLRCQ
110 120 130 140 150
AWQDWPLTQV TFYRDGSALG PPGPNREFSI TVVQKADSGH YHCSGIFQSP
160 170 180 190 200
GPGIPETASV VAITVQELFP APILRAVPSA EPQAGSPMTL SCQTKLPLQR
210 220 230 240 250
SAARLLFSFY KDGRIVQSRG LSSEFQIPTA SEDHSGSYWC EAATEDNQVW
260 270 280 290 300
KQSPQLEIRV QGASSSAAPP TLNPAPQKSA APGTAPEEAP GPLPPPPTPS
310 320 330 340 350
SEDPGFSSPL GMPDPHLYHQ MGLLLKHMQD VRVLLGHLLM ELRELSGHRK

PGTTKATAE
Length:359
Mass (Da):38,927
Last modified:March 21, 2006 - v2
Checksum:i76821DADB121499F
GO
Isoform 2 (identifier: Q7L513-2) [UniParc]FASTAAdd to basket
Also known as: FCRLa1

The sequence of this isoform differs from the canonical sequence as follows:
     28-28: A → AGCHAAA

Show »
Length:365
Mass (Da):39,438
Checksum:iCCE4864CD4C54490
GO
Isoform 3 (identifier: Q7L513-3) [UniParc]FASTAAdd to basket
Also known as: FCRLb

The sequence of this isoform differs from the canonical sequence as follows:
     78-166: Missing.

Show »
Length:270
Mass (Da):29,281
Checksum:i5C8206F2AD581FEF
GO
Isoform 4 (identifier: Q7L513-4) [UniParc]FASTAAdd to basket
Also known as: FCRLc1

The sequence of this isoform differs from the canonical sequence as follows:
     29-166: SFETLQCEGP...TASVVAITVQ → GCHA

Show »
Length:225
Mass (Da):24,149
Checksum:i004B85CFCA2232C8
GO
Isoform 5 (identifier: Q7L513-5) [UniParc]FASTAAdd to basket
Also known as: FCRLc2

The sequence of this isoform differs from the canonical sequence as follows:
     27-166: Missing.

Show »
Length:219
Mass (Da):23,638
Checksum:i7221B95E05E01932
GO
Isoform 6 (identifier: Q7L513-6) [UniParc]FASTAAdd to basket
Also known as: FCRLd

The sequence of this isoform differs from the canonical sequence as follows:
     78-261: Missing.

Show »
Length:175
Mass (Da):18,719
Checksum:i1EB948BC1FD4EB45
GO
Isoform 7 (identifier: Q7L513-7) [UniParc]FASTAAdd to basket
Also known as: FCRLe

The sequence of this isoform differs from the canonical sequence as follows:
     27-261: Missing.

Show »
Length:124
Mass (Da):13,076
Checksum:iDA62850F76758F70
GO
Isoform 8 (identifier: Q7L513-8) [UniParc]FASTAAdd to basket
Also known as: FCRLf

The sequence of this isoform differs from the canonical sequence as follows:
     167-261: Missing.

Show »
Length:264
Mass (Da):28,365
Checksum:iC3FC5FC795C82CD0
GO
Isoform 9 (identifier: Q7L513-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLKKISVGVAGDLNTVTM

Show »
Length:376
Mass (Da):40,655
Checksum:iA8EEAF71347126DE
GO
Isoform 10 (identifier: Q7L513-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLKKISVGVAGDLNTVTM
     28-28: A → AGCHAAA

Note: No experimental confirmation available.
Show »
Length:382
Mass (Da):41,166
Checksum:i3A20194B87382AFC
GO
Isoform 11 (identifier: Q7L513-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLKKISVGVAGDLNTVTM
     29-166: SFETLQCEGP...TASVVAITVQ → GCHA

Note: No experimental confirmation available.
Show »
Length:242
Mass (Da):25,877
Checksum:iFCFE2BFCD6328F00
GO
Isoform 12 (identifier: Q7L513-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLKKISVGVAGDLNTVTM
     78-166: Missing.

Note: No experimental confirmation available.
Show »
Length:287
Mass (Da):31,009
Checksum:iC3F802DDA6EAF181
GO
Isoform 13 (identifier: Q7L513-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLKKISVGVAGDLNTVTM
     78-261: Missing.

Note: No experimental confirmation available.
Show »
Length:192
Mass (Da):20,448
Checksum:iB0CDC702FB3B4F09
GO
Isoform 14 (identifier: Q7L513-14) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLKKISVGVAGDLNTVTM
     27-166: Missing.

Note: No experimental confirmation available.
Show »
Length:236
Mass (Da):25,366
Checksum:i3FE90660ECE2455F
GO
Isoform 15 (identifier: Q7L513-15) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLKKISVGVAGDLNTVTM
     27-261: Missing.

Note: No experimental confirmation available.
Show »
Length:141
Mass (Da):14,804
Checksum:iA481C1809EA0F67F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti265S → N in AAL23904 (PubMed:11754007).Curated1
Sequence conflicti308S → P in AAL23903 (PubMed:11754007).Curated1
Sequence conflicti317L → P in AAL27307 (PubMed:11754007).Curated1
Sequence conflicti343R → G in AAL23905 (PubMed:11754007).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_025646349R → Q.6 PublicationsCorresponds to variant rs11746dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0382971M → MLKKISVGVAGDLNTVTM in isoform 9, isoform 10, isoform 11, isoform 12, isoform 13, isoform 14 and isoform 15. 3 Publications1
Alternative sequenceiVSP_01760327 – 261Missing in isoform 7 and isoform 15. 2 PublicationsAdd BLAST235
Alternative sequenceiVSP_01760427 – 166Missing in isoform 5 and isoform 14. 2 PublicationsAdd BLAST140
Alternative sequenceiVSP_01760528A → AGCHAAA in isoform 2 and isoform 10. 1 Publication1
Alternative sequenceiVSP_01760629 – 166SFETL…AITVQ → GCHA in isoform 4 and isoform 11. 1 PublicationAdd BLAST138
Alternative sequenceiVSP_01760778 – 261Missing in isoform 6 and isoform 13. 2 PublicationsAdd BLAST184
Alternative sequenceiVSP_01760878 – 166Missing in isoform 3 and isoform 12. 2 PublicationsAdd BLAST89
Alternative sequenceiVSP_017609167 – 261Missing in isoform 8. 1 PublicationAdd BLAST95

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329489 mRNA. Translation: AAL23899.1.
AF329491 mRNA. Translation: AAL23901.1.
AF329493 mRNA. Translation: AAL23903.1.
AF329494 mRNA. Translation: AAL23904.1.
AF329495 mRNA. Translation: AAL23905.1.
AF390036 mRNA. Translation: AAL27307.1.
AF426461 mRNA. Translation: AAL58111.1.
AF531423 mRNA. Translation: AAM97591.1.
AY091642 mRNA. Translation: AAM13980.2.
EF064729 Genomic DNA. Translation: ABK41912.1.
AY358348 mRNA. Translation: AAQ88714.1.
AL359541 Genomic DNA. No translation available.
CH471067 Genomic DNA. Translation: EAW90683.1.
CH471067 Genomic DNA. Translation: EAW90684.1.
CH471067 Genomic DNA. Translation: EAW90685.1.
BC006521 mRNA. Translation: AAH06521.2.
CCDSiCCDS30926.1. [Q7L513-9]
CCDS53415.1. [Q7L513-10]
CCDS53416.1. [Q7L513-11]
CCDS53417.1. [Q7L513-12]
CCDS53418.1. [Q7L513-13]
CCDS53419.1. [Q7L513-14]
CCDS53420.1. [Q7L513-15]
RefSeqiNP_001171795.1. NM_001184866.1. [Q7L513-10]
NP_001171796.1. NM_001184867.1. [Q7L513-12]
NP_001171799.1. NM_001184870.1. [Q7L513-11]
NP_001171800.1. NM_001184871.1. [Q7L513-15]
NP_001171801.1. NM_001184872.1. [Q7L513-14]
NP_001171802.1. NM_001184873.1. [Q7L513-13]
NP_116127.3. NM_032738.3. [Q7L513-9]
UniGeneiHs.266331.

Genome annotation databases

EnsembliENST00000236938; ENSP00000236938; ENSG00000132185. [Q7L513-9]
ENST00000294796; ENSP00000294796; ENSG00000132185. [Q7L513-4]
ENST00000309691; ENSP00000309596; ENSG00000132185. [Q7L513-3]
ENST00000349527; ENSP00000294798; ENSG00000132185. [Q7L513-8]
ENST00000350710; ENSP00000344808; ENSG00000132185. [Q7L513-15]
ENST00000367949; ENSP00000356926; ENSG00000132185. [Q7L513-13]
ENST00000367953; ENSP00000356930; ENSG00000132185. [Q7L513-2]
ENST00000367957; ENSP00000356934; ENSG00000132185. [Q7L513-14]
ENST00000367959; ENSP00000356936; ENSG00000132185. [Q7L513-10]
ENST00000540521; ENSP00000442870; ENSG00000132185. [Q7L513-11]
ENST00000546024; ENSP00000439838; ENSG00000132185. [Q7L513-12]
GeneIDi84824.
KEGGihsa:84824.
UCSCiuc001gbd.4. human. [Q7L513-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329489 mRNA. Translation: AAL23899.1.
AF329491 mRNA. Translation: AAL23901.1.
AF329493 mRNA. Translation: AAL23903.1.
AF329494 mRNA. Translation: AAL23904.1.
AF329495 mRNA. Translation: AAL23905.1.
AF390036 mRNA. Translation: AAL27307.1.
AF426461 mRNA. Translation: AAL58111.1.
AF531423 mRNA. Translation: AAM97591.1.
AY091642 mRNA. Translation: AAM13980.2.
EF064729 Genomic DNA. Translation: ABK41912.1.
AY358348 mRNA. Translation: AAQ88714.1.
AL359541 Genomic DNA. No translation available.
CH471067 Genomic DNA. Translation: EAW90683.1.
CH471067 Genomic DNA. Translation: EAW90684.1.
CH471067 Genomic DNA. Translation: EAW90685.1.
BC006521 mRNA. Translation: AAH06521.2.
CCDSiCCDS30926.1. [Q7L513-9]
CCDS53415.1. [Q7L513-10]
CCDS53416.1. [Q7L513-11]
CCDS53417.1. [Q7L513-12]
CCDS53418.1. [Q7L513-13]
CCDS53419.1. [Q7L513-14]
CCDS53420.1. [Q7L513-15]
RefSeqiNP_001171795.1. NM_001184866.1. [Q7L513-10]
NP_001171796.1. NM_001184867.1. [Q7L513-12]
NP_001171799.1. NM_001184870.1. [Q7L513-11]
NP_001171800.1. NM_001184871.1. [Q7L513-15]
NP_001171801.1. NM_001184872.1. [Q7L513-14]
NP_001171802.1. NM_001184873.1. [Q7L513-13]
NP_116127.3. NM_032738.3. [Q7L513-9]
UniGeneiHs.266331.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4HWNX-ray2.01A169-264[»]
ProteinModelPortaliQ7L513.
SMRiQ7L513.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ7L513. 4 interactors.
STRINGi9606.ENSP00000356936.

PTM databases

PhosphoSitePlusiQ7L513.

Polymorphism and mutation databases

BioMutaiFCRLA.
DMDMi90101291.

Proteomic databases

MaxQBiQ7L513.
PaxDbiQ7L513.
PeptideAtlasiQ7L513.
PRIDEiQ7L513.

Protocols and materials databases

DNASUi84824.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000236938; ENSP00000236938; ENSG00000132185. [Q7L513-9]
ENST00000294796; ENSP00000294796; ENSG00000132185. [Q7L513-4]
ENST00000309691; ENSP00000309596; ENSG00000132185. [Q7L513-3]
ENST00000349527; ENSP00000294798; ENSG00000132185. [Q7L513-8]
ENST00000350710; ENSP00000344808; ENSG00000132185. [Q7L513-15]
ENST00000367949; ENSP00000356926; ENSG00000132185. [Q7L513-13]
ENST00000367953; ENSP00000356930; ENSG00000132185. [Q7L513-2]
ENST00000367957; ENSP00000356934; ENSG00000132185. [Q7L513-14]
ENST00000367959; ENSP00000356936; ENSG00000132185. [Q7L513-10]
ENST00000540521; ENSP00000442870; ENSG00000132185. [Q7L513-11]
ENST00000546024; ENSP00000439838; ENSG00000132185. [Q7L513-12]
GeneIDi84824.
KEGGihsa:84824.
UCSCiuc001gbd.4. human. [Q7L513-1]

Organism-specific databases

CTDi84824.
DisGeNETi84824.
GeneCardsiFCRLA.
H-InvDBHIX0001250.
HGNCiHGNC:18504. FCRLA.
HPAiCAB016545.
MIMi606891. gene.
neXtProtiNX_Q7L513.
OpenTargetsiENSG00000132185.
PharmGKBiPA162388180.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHSR. Eukaryota.
ENOG4111EGY. LUCA.
GeneTreeiENSGT00760000119130.
HOGENOMiHOG000036934.
HOVERGENiHBG059243.
InParanoidiQ7L513.
OMAiTLSCQTK.
OrthoDBiEOG091G0ETN.
PhylomeDBiQ7L513.

Miscellaneous databases

ChiTaRSiFCRLA. human.
GeneWikiiFCRLA.
GenomeRNAii84824.
PROiQ7L513.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132185.
CleanExiHS_FCRL1.
ExpressionAtlasiQ7L513. baseline and differential.
GenevisibleiQ7L513. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFCRLA_HUMAN
AccessioniPrimary (citable) accession number: Q7L513
Secondary accession number(s): A0N0M1
, A6NC03, A6NL20, F5H720, F8W743, G3V1J2, Q5VXA1, Q5VXA2, Q5VXA3, Q5VXA4, Q5VXB0, Q5VXB1, Q8NEW4, Q8WXH3, Q96PC6, Q96PJ0, Q96PJ1, Q96PJ2, Q96PJ4, Q9BR57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: November 2, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-8 is the initiator.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.