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Q7L513

- FCRLA_HUMAN

UniProt

Q7L513 - FCRLA_HUMAN

Protein

Fc receptor-like A

Gene

FCRLA

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 2 (21 Mar 2006)
      Previous versions | rss
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    Functioni

    May be implicated in B-cell differentiation and lymphomagenesis.2 Publications

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW

    Keywords - Biological processi

    Differentiation

    Protein family/group databases

    MEROPSiI43.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fc receptor-like A
    Alternative name(s):
    Fc receptor homolog expressed in B-cells
    Fc receptor-like and mucin-like protein 1
    Fc receptor-like protein
    Fc receptor-related protein X
    Short name:
    FcRX
    Gene namesi
    Name:FCRLA
    Synonyms:FCRL, FCRL1, FCRLM1, FCRX, FREB
    ORF Names:UNQ291/PRO329
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:18504. FCRLA.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162388180.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 27271 PublicationAdd
    BLAST
    Chaini28 – 359332Fc receptor-like APRO_0000227935Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi99 ↔ 143PROSITE-ProRule annotation
    Disulfide bondi192 ↔ 240PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    MaxQBiQ7L513.
    PaxDbiQ7L513.
    PRIDEiQ7L513.

    PTM databases

    PhosphoSiteiQ7L513.

    Expressioni

    Tissue specificityi

    Expressed specifically in primary and secondary lymphoid tissues like lymph node, spleen and tonsil. Specifically expressed in B-cells with a high level in normal germinal center B-cells, centroblasts and in a subset of diffuse large B-cell lymphomas. Highly expressed in bone marrow B-cells and weakly in earlier B lineage cells. Expressed in pre-germinal and germinal center B-cells in secondary lymphoid tissues. Also expressed in melanoma and melanocytes.4 Publications

    Gene expression databases

    ArrayExpressiQ7L513.
    BgeeiQ7L513.
    CleanExiHS_FCRL1.
    GenevestigatoriQ7L513.

    Organism-specific databases

    HPAiCAB016545.

    Interactioni

    Subunit structurei

    Monomer or homodimer; disulfide-linked.

    Protein-protein interaction databases

    IntActiQ7L513. 4 interactions.

    Structurei

    Secondary structure

    1
    359
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi173 – 1786
    Beta strandi188 – 1936
    Beta strandi206 – 2116
    Beta strandi214 – 2218
    Beta strandi224 – 2296
    Helixi232 – 2343
    Beta strandi236 – 2438
    Beta strandi247 – 2526
    Beta strandi256 – 2583

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4HWNX-ray2.01A169-264[»]
    ProteinModelPortaliQ7L513.
    SMRiQ7L513. Positions 32-262.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini70 – 15990Ig-like C2-type 1Add
    BLAST
    Domaini170 – 25788Ig-like C2-type 2Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi269 – 31547Pro-richAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG69552.
    HOVERGENiHBG059243.
    InParanoidiQ7L513.
    OrthoDBiEOG7H1JM6.
    PhylomeDBiQ7L513.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view]
    SMARTiSM00409. IG. 2 hits.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 2 hits.
    [Graphical view]

    Sequences (15)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 15 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q7L513-1) [UniParc]FASTAAdd to Basket

    Also known as: FCRLa

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKLGCVLMAW ALYLSLGVLW VAQMLLAASF ETLQCEGPVC TEESSCHTED    50
    DLTDAREAGF QVKAYTFSEP FHLIVSYDWL ILQGPAKPVF EGDLLVLRCQ 100
    AWQDWPLTQV TFYRDGSALG PPGPNREFSI TVVQKADSGH YHCSGIFQSP 150
    GPGIPETASV VAITVQELFP APILRAVPSA EPQAGSPMTL SCQTKLPLQR 200
    SAARLLFSFY KDGRIVQSRG LSSEFQIPTA SEDHSGSYWC EAATEDNQVW 250
    KQSPQLEIRV QGASSSAAPP TLNPAPQKSA APGTAPEEAP GPLPPPPTPS 300
    SEDPGFSSPL GMPDPHLYHQ MGLLLKHMQD VRVLLGHLLM ELRELSGHRK 350
    PGTTKATAE 359
    Length:359
    Mass (Da):38,927
    Last modified:March 21, 2006 - v2
    Checksum:i76821DADB121499F
    GO
    Isoform 2 (identifier: Q7L513-2) [UniParc]FASTAAdd to Basket

    Also known as: FCRLa1

    The sequence of this isoform differs from the canonical sequence as follows:
         28-28: A → AGCHAAA

    Show »
    Length:365
    Mass (Da):39,438
    Checksum:iCCE4864CD4C54490
    GO
    Isoform 3 (identifier: Q7L513-3) [UniParc]FASTAAdd to Basket

    Also known as: FCRLb

    The sequence of this isoform differs from the canonical sequence as follows:
         78-166: Missing.

    Show »
    Length:270
    Mass (Da):29,281
    Checksum:i5C8206F2AD581FEF
    GO
    Isoform 4 (identifier: Q7L513-4) [UniParc]FASTAAdd to Basket

    Also known as: FCRLc1

    The sequence of this isoform differs from the canonical sequence as follows:
         29-166: SFETLQCEGP...TASVVAITVQ → GCHA

    Show »
    Length:225
    Mass (Da):24,149
    Checksum:i004B85CFCA2232C8
    GO
    Isoform 5 (identifier: Q7L513-5) [UniParc]FASTAAdd to Basket

    Also known as: FCRLc2

    The sequence of this isoform differs from the canonical sequence as follows:
         27-166: Missing.

    Show »
    Length:219
    Mass (Da):23,638
    Checksum:i7221B95E05E01932
    GO
    Isoform 6 (identifier: Q7L513-6) [UniParc]FASTAAdd to Basket

    Also known as: FCRLd

    The sequence of this isoform differs from the canonical sequence as follows:
         78-261: Missing.

    Show »
    Length:175
    Mass (Da):18,719
    Checksum:i1EB948BC1FD4EB45
    GO
    Isoform 7 (identifier: Q7L513-7) [UniParc]FASTAAdd to Basket

    Also known as: FCRLe

    The sequence of this isoform differs from the canonical sequence as follows:
         27-261: Missing.

    Show »
    Length:124
    Mass (Da):13,076
    Checksum:iDA62850F76758F70
    GO
    Isoform 8 (identifier: Q7L513-8) [UniParc]FASTAAdd to Basket

    Also known as: FCRLf

    The sequence of this isoform differs from the canonical sequence as follows:
         167-261: Missing.

    Show »
    Length:264
    Mass (Da):28,365
    Checksum:iC3FC5FC795C82CD0
    GO
    Isoform 9 (identifier: Q7L513-9) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MLKKISVGVAGDLNTVTM

    Show »
    Length:376
    Mass (Da):40,655
    Checksum:iA8EEAF71347126DE
    GO
    Isoform 10 (identifier: Q7L513-10) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MLKKISVGVAGDLNTVTM
         28-28: A → AGCHAAA

    Note: No experimental confirmation available.

    Show »
    Length:382
    Mass (Da):41,166
    Checksum:i3A20194B87382AFC
    GO
    Isoform 11 (identifier: Q7L513-11) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MLKKISVGVAGDLNTVTM
         29-166: SFETLQCEGP...TASVVAITVQ → GCHA

    Note: No experimental confirmation available.

    Show »
    Length:242
    Mass (Da):25,877
    Checksum:iFCFE2BFCD6328F00
    GO
    Isoform 12 (identifier: Q7L513-12) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MLKKISVGVAGDLNTVTM
         78-166: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:287
    Mass (Da):31,009
    Checksum:iC3F802DDA6EAF181
    GO
    Isoform 13 (identifier: Q7L513-13) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MLKKISVGVAGDLNTVTM
         78-261: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:192
    Mass (Da):20,448
    Checksum:iB0CDC702FB3B4F09
    GO
    Isoform 14 (identifier: Q7L513-14) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MLKKISVGVAGDLNTVTM
         27-166: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:236
    Mass (Da):25,366
    Checksum:i3FE90660ECE2455F
    GO
    Isoform 15 (identifier: Q7L513-15) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MLKKISVGVAGDLNTVTM
         27-261: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:141
    Mass (Da):14,804
    Checksum:iA481C1809EA0F67F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti265 – 2651S → N in AAL23904. (PubMed:11754007)Curated
    Sequence conflicti308 – 3081S → P in AAL23903. (PubMed:11754007)Curated
    Sequence conflicti317 – 3171L → P in AAL27307. (PubMed:11754007)Curated
    Sequence conflicti343 – 3431R → G in AAL23905. (PubMed:11754007)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti349 – 3491R → Q.6 Publications
    Corresponds to variant rs11746 [ dbSNP | Ensembl ].
    VAR_025646

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MLKKISVGVAGDLNTVTM in isoform 9, isoform 10, isoform 11, isoform 12, isoform 13, isoform 14 and isoform 15. 3 PublicationsVSP_038297
    Alternative sequencei27 – 261235Missing in isoform 7 and isoform 15. 2 PublicationsVSP_017603Add
    BLAST
    Alternative sequencei27 – 166140Missing in isoform 5 and isoform 14. 2 PublicationsVSP_017604Add
    BLAST
    Alternative sequencei28 – 281A → AGCHAAA in isoform 2 and isoform 10. 1 PublicationVSP_017605
    Alternative sequencei29 – 166138SFETL…AITVQ → GCHA in isoform 4 and isoform 11. 1 PublicationVSP_017606Add
    BLAST
    Alternative sequencei78 – 261184Missing in isoform 6 and isoform 13. 2 PublicationsVSP_017607Add
    BLAST
    Alternative sequencei78 – 16689Missing in isoform 3 and isoform 12. 2 PublicationsVSP_017608Add
    BLAST
    Alternative sequencei167 – 26195Missing in isoform 8. 1 PublicationVSP_017609Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF329489 mRNA. Translation: AAL23899.1.
    AF329491 mRNA. Translation: AAL23901.1.
    AF329493 mRNA. Translation: AAL23903.1.
    AF329494 mRNA. Translation: AAL23904.1.
    AF329495 mRNA. Translation: AAL23905.1.
    AF390036 mRNA. Translation: AAL27307.1.
    AF426461 mRNA. Translation: AAL58111.1.
    AF531423 mRNA. Translation: AAM97591.1.
    AY091642 mRNA. Translation: AAM13980.2.
    EF064729 Genomic DNA. Translation: ABK41912.1.
    AY358348 mRNA. Translation: AAQ88714.1.
    AL359541 Genomic DNA. No translation available.
    CH471067 Genomic DNA. Translation: EAW90683.1.
    CH471067 Genomic DNA. Translation: EAW90684.1.
    CH471067 Genomic DNA. Translation: EAW90685.1.
    BC006521 mRNA. Translation: AAH06521.2.
    CCDSiCCDS30926.1. [Q7L513-9]
    RefSeqiNP_001171795.1. NM_001184866.1.
    NP_001171796.1. NM_001184867.1.
    NP_001171799.1. NM_001184870.1.
    NP_001171800.1. NM_001184871.1.
    NP_001171801.1. NM_001184872.1.
    NP_001171802.1. NM_001184873.1.
    NP_116127.3. NM_032738.3. [Q7L513-9]
    UniGeneiHs.266331.

    Genome annotation databases

    EnsembliENST00000236938; ENSP00000236938; ENSG00000132185. [Q7L513-9]
    ENST00000294796; ENSP00000294796; ENSG00000132185. [Q7L513-4]
    ENST00000309691; ENSP00000309596; ENSG00000132185. [Q7L513-3]
    ENST00000349527; ENSP00000294798; ENSG00000132185. [Q7L513-8]
    ENST00000350710; ENSP00000344808; ENSG00000132185. [Q7L513-15]
    ENST00000367949; ENSP00000356926; ENSG00000132185. [Q7L513-13]
    ENST00000367953; ENSP00000356930; ENSG00000132185. [Q7L513-2]
    ENST00000367957; ENSP00000356934; ENSG00000132185. [Q7L513-14]
    ENST00000367959; ENSP00000356936; ENSG00000132185. [Q7L513-10]
    ENST00000540521; ENSP00000442870; ENSG00000132185. [Q7L513-11]
    ENST00000546024; ENSP00000439838; ENSG00000132185. [Q7L513-12]
    GeneIDi84824.
    KEGGihsa:84824.
    UCSCiuc001gbd.3. human. [Q7L513-9]
    uc031prb.1. human. [Q7L513-1]

    Polymorphism databases

    DMDMi90101291.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF329489 mRNA. Translation: AAL23899.1 .
    AF329491 mRNA. Translation: AAL23901.1 .
    AF329493 mRNA. Translation: AAL23903.1 .
    AF329494 mRNA. Translation: AAL23904.1 .
    AF329495 mRNA. Translation: AAL23905.1 .
    AF390036 mRNA. Translation: AAL27307.1 .
    AF426461 mRNA. Translation: AAL58111.1 .
    AF531423 mRNA. Translation: AAM97591.1 .
    AY091642 mRNA. Translation: AAM13980.2 .
    EF064729 Genomic DNA. Translation: ABK41912.1 .
    AY358348 mRNA. Translation: AAQ88714.1 .
    AL359541 Genomic DNA. No translation available.
    CH471067 Genomic DNA. Translation: EAW90683.1 .
    CH471067 Genomic DNA. Translation: EAW90684.1 .
    CH471067 Genomic DNA. Translation: EAW90685.1 .
    BC006521 mRNA. Translation: AAH06521.2 .
    CCDSi CCDS30926.1. [Q7L513-9 ]
    RefSeqi NP_001171795.1. NM_001184866.1.
    NP_001171796.1. NM_001184867.1.
    NP_001171799.1. NM_001184870.1.
    NP_001171800.1. NM_001184871.1.
    NP_001171801.1. NM_001184872.1.
    NP_001171802.1. NM_001184873.1.
    NP_116127.3. NM_032738.3. [Q7L513-9 ]
    UniGenei Hs.266331.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4HWN X-ray 2.01 A 169-264 [» ]
    ProteinModelPortali Q7L513.
    SMRi Q7L513. Positions 32-262.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q7L513. 4 interactions.

    Protein family/group databases

    MEROPSi I43.001.

    PTM databases

    PhosphoSitei Q7L513.

    Polymorphism databases

    DMDMi 90101291.

    Proteomic databases

    MaxQBi Q7L513.
    PaxDbi Q7L513.
    PRIDEi Q7L513.

    Protocols and materials databases

    DNASUi 84824.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000236938 ; ENSP00000236938 ; ENSG00000132185 . [Q7L513-9 ]
    ENST00000294796 ; ENSP00000294796 ; ENSG00000132185 . [Q7L513-4 ]
    ENST00000309691 ; ENSP00000309596 ; ENSG00000132185 . [Q7L513-3 ]
    ENST00000349527 ; ENSP00000294798 ; ENSG00000132185 . [Q7L513-8 ]
    ENST00000350710 ; ENSP00000344808 ; ENSG00000132185 . [Q7L513-15 ]
    ENST00000367949 ; ENSP00000356926 ; ENSG00000132185 . [Q7L513-13 ]
    ENST00000367953 ; ENSP00000356930 ; ENSG00000132185 . [Q7L513-2 ]
    ENST00000367957 ; ENSP00000356934 ; ENSG00000132185 . [Q7L513-14 ]
    ENST00000367959 ; ENSP00000356936 ; ENSG00000132185 . [Q7L513-10 ]
    ENST00000540521 ; ENSP00000442870 ; ENSG00000132185 . [Q7L513-11 ]
    ENST00000546024 ; ENSP00000439838 ; ENSG00000132185 . [Q7L513-12 ]
    GeneIDi 84824.
    KEGGi hsa:84824.
    UCSCi uc001gbd.3. human. [Q7L513-9 ]
    uc031prb.1. human. [Q7L513-1 ]

    Organism-specific databases

    CTDi 84824.
    GeneCardsi GC01P161676.
    H-InvDB HIX0001250.
    HGNCi HGNC:18504. FCRLA.
    HPAi CAB016545.
    MIMi 606891. gene.
    neXtProti NX_Q7L513.
    PharmGKBi PA162388180.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG69552.
    HOVERGENi HBG059243.
    InParanoidi Q7L513.
    OrthoDBi EOG7H1JM6.
    PhylomeDBi Q7L513.

    Miscellaneous databases

    GeneWikii FCRLA.
    GenomeRNAii 84824.
    NextBioi 75032.
    PROi Q7L513.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7L513.
    Bgeei Q7L513.
    CleanExi HS_FCRL1.
    Genevestigatori Q7L513.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view ]
    SMARTi SM00409. IG. 2 hits.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "FCRL, a novel member of the leukocyte Fc receptor family possesses unique structural features."
      Mechetina L.V., Najakshin A.M., Volkova O.Y., Guselnikov S.V., Faizulin R.Z., Alabyev B.Y., Chikaev N.A., Vinogradova M.S., Taranin A.V.
      Eur. J. Immunol. 32:87-96(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 4; 5; 6 AND 7), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANT GLN-349.
      Tissue: Lymph, Melanocyte and Tonsil.
    2. "An unusual Fc receptor-related protein expressed in human centroblasts."
      Facchetti F., Cella M., Festa S., Fremont D.H., Colonna M.
      Proc. Natl. Acad. Sci. U.S.A. 99:3776-3781(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 9), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANT GLN-349.
    3. "Definition of an Fc receptor-related gene (FcRX) expressed in human and mouse B cells."
      Davis R.S., Li H., Chen C.-C., Wang Y.-H., Cooper M.D., Burrows P.D.
      Int. Immunol. 14:1075-1083(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 9), TISSUE SPECIFICITY, VARIANT GLN-349.
    4. "Novel melanoma antigen, FCRL/FREB, identified by cDNA profile comparison using DNA chip are immunogenic in multiple melanoma patients."
      Inozume T., Matsuzaki Y., Kurihara S., Fujita T., Yamamoto A., Aburatani H., Shimada S., Kawakami Y.
      Int. J. Cancer 114:283-290(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 5; 6; 7 AND 8), TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
      Tissue: Melanocyte.
    5. Guselnikov S., Najakshin A.M.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT GLN-349.
      Tissue: Tonsil.
    6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 9), VARIANT GLN-349.
      Tissue: Lymph and Tonsil.
    8. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLN-349.
      Tissue: Skin.
    11. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 28-42.
    12. Bienvenut W.V.
      Submitted (JUN-2005) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 88-98; 252-259 AND 333-353, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: B-cell lymphoma.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiFCRLA_HUMAN
    AccessioniPrimary (citable) accession number: Q7L513
    Secondary accession number(s): A0N0M1
    , A6NC03, A6NL20, F5H720, F8W743, G3V1J2, Q5VXA1, Q5VXA2, Q5VXA3, Q5VXA4, Q5VXB0, Q5VXB1, Q8NEW4, Q8WXH3, Q96PC6, Q96PJ0, Q96PJ1, Q96PJ2, Q96PJ4, Q9BR57
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: March 21, 2006
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3