Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein ARMCX6

Gene

ARMCX6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May regulate the dynamics and distribution of mitochondria in neural cells.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ARMCX6
Gene namesi
Name:ARMCX6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000198960.10.
HGNCiHGNC:26094. ARMCX6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6Mitochondrial intermembraneBy similarity6
Transmembranei7 – 27Helical; Signal-anchorSequence analysisAdd BLAST21
Topological domaini28 – 300CytoplasmicBy similarityAdd BLAST273

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198960.
PharmGKBiPA134869551.

Polymorphism and mutation databases

BioMutaiARMCX6.
DMDMi74749890.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001913741 – 300Protein ARMCX6Add BLAST300

Proteomic databases

EPDiQ7L4S7.
PaxDbiQ7L4S7.
PeptideAtlasiQ7L4S7.
PRIDEiQ7L4S7.

PTM databases

iPTMnetiQ7L4S7.
PhosphoSitePlusiQ7L4S7.

Expressioni

Gene expression databases

BgeeiENSG00000198960.
CleanExiHS_ARMCX6.
GenevisibleiQ7L4S7. HS.

Organism-specific databases

HPAiHPA043030.
HPA048125.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000354708.

Structurei

3D structure databases

ProteinModelPortaliQ7L4S7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 6Mitochondrion outer membrane (MOM)-targeting sequenceCurated6
Regioni26 – 36Mitochondrion outer membrane (MOM)-targeting sequenceCuratedAdd BLAST11

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II02. Eukaryota.
ENOG411142D. LUCA.
GeneTreeiENSGT00550000074488.
HOGENOMiHOG000231611.
HOVERGENiHBG097741.
InParanoidiQ7L4S7.
OMAiKANRAHP.
OrthoDBiEOG091G0PCU.
PhylomeDBiQ7L4S7.
TreeFamiTF335652.

Family and domain databases

InterProiView protein in InterPro
IPR006911. ARM-rpt_dom.
PfamiView protein in Pfam
PF04826. Arm_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7L4S7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRAREVGWM AAGLMIGAGA CYCVYKLTIG RDDSEKLEEE GEEEWDDDQE
60 70 80 90 100
LDEEEPDIWF DFETMARPWT EDGDWTEPGA PGGTEDRPSG GGKANRAHPI
110 120 130 140 150
KQRPFPYEHK NTWSAQNCKN GSCVLDLSKC LFIQGKLLFA EPKDAGFPFS
160 170 180 190 200
QDINSHLASL SMARNTSPTP DPTVREALCA PDNLNASIES QGQIKMYINE
210 220 230 240 250
VCRETVSRCC NSFLQQAGLN LLISMTVINN MLAKSASDLK FPLISEGSGC
260 270 280 290 300
AKVQVLKPLM GLSEKPVLAG ELVGAQMLFS FMSLFIRNGN REILLETPAP
Length:300
Mass (Da):33,019
Last modified:July 5, 2004 - v1
Checksum:i44393DA4160D88A1
GO

Sequence cautioni

The sequence BAA91387 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121883 Genomic DNA. Translation: CAI42938.1.
BC007677 mRNA. Translation: AAH07677.2.
AK000818 mRNA. Translation: BAA91387.1. Different initiation.
CCDSiCCDS14488.1.
RefSeqiNP_001009584.1. NM_001009584.1.
NP_001171697.1. NM_001184768.1.
NP_061880.2. NM_019007.3.
UniGeneiHs.83530.

Genome annotation databases

EnsembliENST00000361910; ENSP00000354708; ENSG00000198960.
ENST00000538627; ENSP00000440648; ENSG00000198960.
ENST00000539247; ENSP00000444537; ENSG00000198960.
GeneIDi54470.
KEGGihsa:54470.
UCSCiuc004ehx.4. human.

Similar proteinsi

Entry informationi

Entry nameiARMX6_HUMAN
AccessioniPrimary (citable) accession number: Q7L4S7
Secondary accession number(s): Q9NWJ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 5, 2004
Last modified: September 27, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families