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Protein

BEN domain-containing protein 5

Gene

BEND5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a transcriptional repressor (PubMed:23468431).1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
BEN domain-containing protein 5
Gene namesi
Name:BEND5
Synonyms:C1orf165
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25668. BEND5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164716542.

Polymorphism and mutation databases

BioMutaiBEND5.
DMDMi74738577.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 421421BEN domain-containing protein 5PRO_0000274279Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei133 – 1331N6-acetyllysineCombined sources
Cross-linki258 – 258Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ7L4P6.
MaxQBiQ7L4P6.
PaxDbiQ7L4P6.
PeptideAtlasiQ7L4P6.
PRIDEiQ7L4P6.

PTM databases

iPTMnetiQ7L4P6.
PhosphoSiteiQ7L4P6.

Expressioni

Gene expression databases

BgeeiQ7L4P6.
CleanExiHS_BEND5.
GenevisibleiQ7L4P6. HS.

Organism-specific databases

HPAiHPA054347.
HPA058007.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BUD31P412233EBI-724373,EBI-3904603
EIF3DO153713EBI-724373,EBI-353818
FAM161AQ3B8203EBI-724373,EBI-719941
GORASP2Q9H8Y83EBI-724373,EBI-739467
LCE1BQ5T7P33EBI-724373,EBI-10245913
PRKAB2O437413EBI-724373,EBI-1053424
RTP5Q14D333EBI-724373,EBI-10217913
UBE2IQ7KZS03EBI-724373,EBI-10180829
USP20Q9Y2K63EBI-724373,EBI-2511991
VPS25Q9BRG13EBI-724373,EBI-741945
ZGPATQ8N5A53EBI-724373,EBI-3439227
ZNF417Q8TAU33EBI-724373,EBI-740727

Protein-protein interaction databases

BioGridi122782. 19 interactions.
IntActiQ7L4P6. 20 interactions.
MINTiMINT-2876342.
STRINGi9606.ENSP00000360899.

Structurei

3D structure databases

ProteinModelPortaliQ7L4P6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini302 – 408107BENPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili180 – 24364Sequence analysisAdd
BLAST

Domaini

The BEN domain mediates DNA-binding.1 Publication

Sequence similaritiesi

Contains 1 BEN domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410II6Q. Eukaryota.
ENOG4110WSD. LUCA.
GeneTreeiENSGT00390000001724.
HOGENOMiHOG000049159.
HOVERGENiHBG095938.
InParanoidiQ7L4P6.
OMAiSEGTHKS.
OrthoDBiEOG76T9TW.
PhylomeDBiQ7L4P6.
TreeFamiTF331898.

Family and domain databases

InterProiIPR018379. BEN_domain.
[Graphical view]
PfamiPF10523. BEN. 1 hit.
[Graphical view]
SMARTiSM01025. BEN. 1 hit.
[Graphical view]
PROSITEiPS51457. BEN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7L4P6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYAFVRFLED NVCYALPVSC VRDFSPRSRL DFDNQKVYAV YRGPEELGAG
60 70 80 90 100
PESPPRAPRD WGALLLHKAQ ILALAEDKSD LENSVMQKKI KIPKLSLNHV
110 120 130 140 150
EEDGEVKDYG EEDLQLRHIK RPEGRKPSEV AHKSIEAVVA RLEKQNGLSL
160 170 180 190 200
GHSTCPEEVF VEASPGTEDM DSLEDAVVPR ALYEELLRNY QQQQEEMRHL
210 220 230 240 250
QQELERTRRQ LVQQAKKLKE YGALVSEMKE LRDLNRRLQD VLLLRLGSGP
260 270 280 290 300
AIDLEKVKSE CLEPEPELRS TFSEEANTSS YYPAPAPVMD KYILDNGKVH
310 320 330 340 350
LGSGIWVDEE KWHQLQVTQG DSKYTKNLAV MIWGTDVLKN RSVTGVATKK
360 370 380 390 400
KKDAVPKPPL SPHKLSIVRE CLYDRIAQET VDETEIAQRL SKVNKYICEK
410 420
IMDINKSCKN EERREAKYNL Q
Length:421
Mass (Da):48,182
Last modified:July 5, 2004 - v1
Checksum:iC2C552B932F42AAC
GO
Isoform 2 (identifier: Q7L4P6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-169: Missing.

Show »
Length:252
Mass (Da):29,215
Checksum:i1305E13ECA76A7F3
GO

Sequence cautioni

The sequence AAH11804.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti363 – 3631H → R in BAB13864 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 169169Missing in isoform 2. 1 PublicationVSP_022695Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021650 mRNA. Translation: BAB13864.1.
CH471059 Genomic DNA. Translation: EAX06851.1.
BC007932 mRNA. Translation: AAH07932.2.
BC011804 mRNA. Translation: AAH11804.1. Different initiation.
CCDSiCCDS552.2. [Q7L4P6-1]
RefSeqiNP_001289011.1. NM_001302082.1. [Q7L4P6-2]
NP_078879.2. NM_024603.3. [Q7L4P6-1]
XP_006710960.1. XM_006710897.2. [Q7L4P6-2]
XP_011540444.1. XM_011542142.1. [Q7L4P6-2]
UniGeneiHs.475348.

Genome annotation databases

EnsembliENST00000371833; ENSP00000360899; ENSG00000162373. [Q7L4P6-1]
GeneIDi79656.
KEGGihsa:79656.
UCSCiuc001crx.5. human. [Q7L4P6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021650 mRNA. Translation: BAB13864.1.
CH471059 Genomic DNA. Translation: EAX06851.1.
BC007932 mRNA. Translation: AAH07932.2.
BC011804 mRNA. Translation: AAH11804.1. Different initiation.
CCDSiCCDS552.2. [Q7L4P6-1]
RefSeqiNP_001289011.1. NM_001302082.1. [Q7L4P6-2]
NP_078879.2. NM_024603.3. [Q7L4P6-1]
XP_006710960.1. XM_006710897.2. [Q7L4P6-2]
XP_011540444.1. XM_011542142.1. [Q7L4P6-2]
UniGeneiHs.475348.

3D structure databases

ProteinModelPortaliQ7L4P6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122782. 19 interactions.
IntActiQ7L4P6. 20 interactions.
MINTiMINT-2876342.
STRINGi9606.ENSP00000360899.

PTM databases

iPTMnetiQ7L4P6.
PhosphoSiteiQ7L4P6.

Polymorphism and mutation databases

BioMutaiBEND5.
DMDMi74738577.

Proteomic databases

EPDiQ7L4P6.
MaxQBiQ7L4P6.
PaxDbiQ7L4P6.
PeptideAtlasiQ7L4P6.
PRIDEiQ7L4P6.

Protocols and materials databases

DNASUi79656.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371833; ENSP00000360899; ENSG00000162373. [Q7L4P6-1]
GeneIDi79656.
KEGGihsa:79656.
UCSCiuc001crx.5. human. [Q7L4P6-1]

Organism-specific databases

CTDi79656.
GeneCardsiBEND5.
HGNCiHGNC:25668. BEND5.
HPAiHPA054347.
HPA058007.
neXtProtiNX_Q7L4P6.
PharmGKBiPA164716542.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II6Q. Eukaryota.
ENOG4110WSD. LUCA.
GeneTreeiENSGT00390000001724.
HOGENOMiHOG000049159.
HOVERGENiHBG095938.
InParanoidiQ7L4P6.
OMAiSEGTHKS.
OrthoDBiEOG76T9TW.
PhylomeDBiQ7L4P6.
TreeFamiTF331898.

Miscellaneous databases

GenomeRNAii79656.
PROiQ7L4P6.

Gene expression databases

BgeeiQ7L4P6.
CleanExiHS_BEND5.
GenevisibleiQ7L4P6. HS.

Family and domain databases

InterProiIPR018379. BEN_domain.
[Graphical view]
PfamiPF10523. BEN. 1 hit.
[Graphical view]
SMARTiSM01025. BEN. 1 hit.
[Graphical view]
PROSITEiPS51457. BEN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Embryo.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: B-cell and Muscle.
  4. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-133, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "The BEN domain is a novel sequence-specific DNA-binding domain conserved in neural transcriptional repressors."
    Dai Q., Ren A., Westholm J.O., Serganov A.A., Patel D.J., Lai E.C.
    Genes Dev. 27:602-614(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DOMAIN BEN, DNA-BINDING.
  6. "System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability."
    Xiao Z., Chang J.G., Hendriks I.A., Sigurdsson J.O., Olsen J.V., Vertegaal A.C.
    Mol. Cell. Proteomics 14:1419-1434(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-258, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiBEND5_HUMAN
AccessioniPrimary (citable) accession number: Q7L4P6
Secondary accession number(s): D3DQ27, Q96A62, Q9HAI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.