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Protein

Arginine/serine-rich coiled-coil protein 2

Gene

RSRC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine/serine-rich coiled-coil protein 2
Gene namesi
Name:RSRC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:30559. RSRC2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162402249.

Polymorphism and mutation databases

BioMutaiRSRC2.
DMDMi74739167.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 434433Arginine/serine-rich coiled-coil protein 2PRO_0000314937Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources
Modified residuei4 – 41PhosphoserineCombined sources
Modified residuei6 – 61PhosphothreonineCombined sources
Modified residuei16 – 161PhosphothreonineCombined sources
Modified residuei17 – 171PhosphoserineCombined sources
Modified residuei30 – 301PhosphoserineCombined sources
Modified residuei32 – 321PhosphoserineCombined sources
Modified residuei104 – 1041PhosphoserineCombined sources
Cross-linki375 – 375Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Modified residuei376 – 3761PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ7L4I2.
MaxQBiQ7L4I2.
PaxDbiQ7L4I2.
PeptideAtlasiQ7L4I2.
PRIDEiQ7L4I2.

PTM databases

iPTMnetiQ7L4I2.
PhosphoSiteiQ7L4I2.

Expressioni

Gene expression databases

BgeeiENSG00000111011.
CleanExiHS_RSRC2.
ExpressionAtlasiQ7L4I2. baseline and differential.
GenevisibleiQ7L4I2. HS.

Organism-specific databases

HPAiHPA040070.
HPA048183.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC155Q8N6L03EBI-10256202,EBI-749265
CMTM5Q96DZ93EBI-10256202,EBI-2548702
GOLGA2Q083793EBI-10256202,EBI-618309
PNMA1Q8ND903EBI-10256202,EBI-302345
RINT1Q6NUQ13EBI-10256202,EBI-726876
TRIM23P364063EBI-10256202,EBI-740098
TRIM54Q9BYV23EBI-10256202,EBI-2130429
UBQLN1Q9UMX03EBI-10256202,EBI-741480

Protein-protein interaction databases

BioGridi122398. 24 interactions.
IntActiQ7L4I2. 17 interactions.
MINTiMINT-2876118.
STRINGi9606.ENSP00000330188.

Structurei

3D structure databases

ProteinModelPortaliQ7L4I2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili230 – 27041Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi27 – 200174Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the RSRC2 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IIT5. Eukaryota.
ENOG4111VFY. LUCA.
GeneTreeiENSGT00730000111142.
HOGENOMiHOG000154211.
HOVERGENiHBG061992.
InParanoidiQ7L4I2.
OMAiSHRKTDE.
OrthoDBiEOG091G0YUO.
PhylomeDBiQ7L4I2.
TreeFamiTF325523.

Family and domain databases

InterProiIPR028124. SMAP_dom.
[Graphical view]
PfamiPF15477. SMAP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7L4I2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASDTERDG LAPEKTSPDR DKKKEQSEVS VSPRASKHHY SRSRSRSRER
60 70 80 90 100
KRKSDNEGRK HRSRSRSKEG RRHESKDKSS KKHKSEEHND KEHSSDKGRE
110 120 130 140 150
RLNSSENGED RHKRKERKSS RGRSHSRSRS RERRHRSRSR ERKKSRSRSR
160 170 180 190 200
ERKKSRSRSR ERKKSRSRSR ERKRRIRSRS RSRSRHRHRT RSRSRTRSRS
210 220 230 240 250
RDRKKRIEKP RRFSRSLSRT PSPPPFRGRN TAMDAQEALA RRLERAKKLQ
260 270 280 290 300
EQREKEMVEK QKQQEIAAAA ATGGSVLNVA ALLASGTQVT PQIAMAAQMA
310 320 330 340 350
ALQAKALAET GIAVPSYYNP AAVNPMKFAE QEKKRKMLWQ GKKEGDKSQS
360 370 380 390 400
AEIWEKLNFG NKDQNVKFRK LMGIKSEDEA GCSSVDEESY KTLKQQEEVF
410 420 430
RNLDAQYEMA RSQTHTQRGM GLGFTSSMRG MDAV
Length:434
Mass (Da):50,560
Last modified:May 24, 2005 - v1
Checksum:iD744ADEFF395E888
GO
Isoform 2 (identifier: Q7L4I2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: MAASDTERDG...KHRSRSRSKE → MKEENTGAGAEAKRTNFFLKQ

Show »
Length:386
Mass (Da):44,879
Checksum:iACEEDC35C56029E2
GO

Sequence cautioni

The sequence BAB14755 differs from that shown. Reason: Erroneous initiation. Curated
The sequence EAW98327 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti224 – 2241P → R in AAH67773 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti88 – 881H → R.
Corresponds to variant rs17886684 [ dbSNP | Ensembl ].
VAR_038133

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6969MAASD…SRSKE → MKEENTGAGAEAKRTNFFLK Q in isoform 2. 1 PublicationVSP_030440Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB212664 mRNA. Translation: BAE93762.1.
BX640711 mRNA. Translation: CAE45830.1.
CH471054 Genomic DNA. Translation: EAW98327.1. Sequence problems.
CH471054 Genomic DNA. Translation: EAW98330.1.
BC008684 mRNA. Translation: AAH08684.2.
BC067773 mRNA. Translation: AAH67773.1.
AK023985 mRNA. Translation: BAB14755.1. Different initiation.
CCDSiCCDS31920.1. [Q7L4I2-1]
RefSeqiNP_075388.2. NM_023012.5. [Q7L4I2-1]
UniGeneiHs.432996.

Genome annotation databases

EnsembliENST00000331738; ENSP00000330188; ENSG00000111011. [Q7L4I2-1]
GeneIDi65117.
KEGGihsa:65117.
UCSCiuc001ucr.4. human. [Q7L4I2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB212664 mRNA. Translation: BAE93762.1.
BX640711 mRNA. Translation: CAE45830.1.
CH471054 Genomic DNA. Translation: EAW98327.1. Sequence problems.
CH471054 Genomic DNA. Translation: EAW98330.1.
BC008684 mRNA. Translation: AAH08684.2.
BC067773 mRNA. Translation: AAH67773.1.
AK023985 mRNA. Translation: BAB14755.1. Different initiation.
CCDSiCCDS31920.1. [Q7L4I2-1]
RefSeqiNP_075388.2. NM_023012.5. [Q7L4I2-1]
UniGeneiHs.432996.

3D structure databases

ProteinModelPortaliQ7L4I2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122398. 24 interactions.
IntActiQ7L4I2. 17 interactions.
MINTiMINT-2876118.
STRINGi9606.ENSP00000330188.

PTM databases

iPTMnetiQ7L4I2.
PhosphoSiteiQ7L4I2.

Polymorphism and mutation databases

BioMutaiRSRC2.
DMDMi74739167.

Proteomic databases

EPDiQ7L4I2.
MaxQBiQ7L4I2.
PaxDbiQ7L4I2.
PeptideAtlasiQ7L4I2.
PRIDEiQ7L4I2.

Protocols and materials databases

DNASUi65117.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331738; ENSP00000330188; ENSG00000111011. [Q7L4I2-1]
GeneIDi65117.
KEGGihsa:65117.
UCSCiuc001ucr.4. human. [Q7L4I2-1]

Organism-specific databases

CTDi65117.
GeneCardsiRSRC2.
H-InvDBHIX0021325.
HGNCiHGNC:30559. RSRC2.
HPAiHPA040070.
HPA048183.
neXtProtiNX_Q7L4I2.
PharmGKBiPA162402249.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIT5. Eukaryota.
ENOG4111VFY. LUCA.
GeneTreeiENSGT00730000111142.
HOGENOMiHOG000154211.
HOVERGENiHBG061992.
InParanoidiQ7L4I2.
OMAiSHRKTDE.
OrthoDBiEOG091G0YUO.
PhylomeDBiQ7L4I2.
TreeFamiTF325523.

Miscellaneous databases

ChiTaRSiRSRC2. human.
GenomeRNAii65117.
PROiQ7L4I2.

Gene expression databases

BgeeiENSG00000111011.
CleanExiHS_RSRC2.
ExpressionAtlasiQ7L4I2. baseline and differential.
GenevisibleiQ7L4I2. HS.

Family and domain databases

InterProiIPR028124. SMAP_dom.
[Graphical view]
PfamiPF15477. SMAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRSRC2_HUMAN
AccessioniPrimary (citable) accession number: Q7L4I2
Secondary accession number(s): Q6N040, Q6NW16, Q9H864
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 24, 2005
Last modified: September 7, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.