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Protein

Protein Bop

Gene

BOP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation BOP intrinsic apoptotic signaling activity.1 Publication

GO - Biological processi

  • mitochondrial outer membrane permeabilization Source: UniProtKB
  • regulation of mitochondrial membrane potential Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Bop
Alternative name(s):
BH3-only protein
Gene namesi
Name:BOP
Synonyms:C22orf29
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:26112. C22orf29.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi118 – 1181L → A: Reduces the pro-apoptotic activity and interaction with VDAC1. 1 Publication
Mutagenesisi120 – 1201Q → A: No effect on interaction with VDAC1. 1 Publication
Mutagenesisi122 – 1221G → A: No effect on interaction with VDAC1. 1 Publication
Mutagenesisi123 – 1231D → A: Reduces the pro-apoptotic activity, no effect on interaction with VDAC1. 1 Publication

Organism-specific databases

PharmGKBiPA145149415.

Polymorphism and mutation databases

BioMutaiBOP.
DMDMi74739166.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 364364Protein BopPRO_0000295910Add
BLAST

Proteomic databases

MaxQBiQ7L3V2.
PaxDbiQ7L3V2.
PeptideAtlasiQ7L3V2.
PRIDEiQ7L3V2.

PTM databases

iPTMnetiQ7L3V2.
PhosphoSiteiQ7L3V2.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000215012.
ExpressionAtlasiQ7L3V2. baseline and differential.
GenevisibleiQ7L3V2. HS.

Organism-specific databases

HPAiHPA000721.
HPA001419.

Interactioni

Subunit structurei

Interacts (via BH3 domain) with VDAC1. Interacts with pro-survival Bcl-2 family members, BCL2, BCL2L1 isoform Bcl-X(L), MCL1, BCL2A1 and BCL2L2. Interacts with BAX and BAK.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
BAK1Q166112EBI-10697720,EBI-519866
BAXQ078122EBI-10697720,EBI-516580
BCL2L1Q07817-13EBI-10697720,EBI-287195
BCL2L2Q928435EBI-10697720,EBI-707714
MCL1Q078202EBI-10697720,EBI-1003422
VDAC1P217962EBI-10697720,EBI-354158

Protein-protein interaction databases

BioGridi122804. 2 interactions.
IntActiQ7L3V2. 10 interactions.
STRINGi9606.ENSP00000330596.

Structurei

3D structure databases

ProteinModelPortaliQ7L3V2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi114 – 12815BH3Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi265 – 32460Pro-richAdd
BLAST

Domaini

The BH3 motif is required for pro-apoptotic activity and for interaction with pro-survival Bcl-2 family members.1 Publication

Phylogenomic databases

eggNOGiENOG410JAJ3. Eukaryota.
ENOG41117AG. LUCA.
GeneTreeiENSGT00510000050172.
HOGENOMiHOG000112084.
HOVERGENiHBG099854.
InParanoidiQ7L3V2.
OMAiLSRVCEI.
OrthoDBiEOG091G02TH.
PhylomeDBiQ7L3V2.
TreeFamiTF342426.

Family and domain databases

InterProiIPR031298. Bop.
IPR032549. DUF4939.
IPR032567. LDOC1-rel.
[Graphical view]
PANTHERiPTHR15503. PTHR15503. 1 hit.
PTHR15503:SF4. PTHR15503:SF4. 1 hit.
PfamiPF16297. DUF4939. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7L3V2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRGRCRQQG PRIPIWAAAN YANAHPWQQM DKASPGVAYT PLVDPWIERP
60 70 80 90 100
CCGDTVCVRT TMEQKSTASG TCGGKPAERG PLAGHMPSSR PHRVDFCWVP
110 120 130 140 150
GSDPGTFDGS PWLLDRFLAQ LGDYMSFHFE HYQDNISRVC EILRRLTGRA
160 170 180 190 200
QAWAAPYLDG DLPLPDDYEL FCQDLKEVVQ DPNSFAEYHA VVTCPLPLAS
210 220 230 240 250
SQLPVAPQLP VVRQYLARFL EGLALDMGTA PRSLPAAMAT PAVSGSNSVS
260 270 280 290 300
RSALFEQQLT KESTPGPKEP PVLPSSTCSS KPGPVEPASS QPEEAAPTPV
310 320 330 340 350
PRLSESANPP AQRPDPAHPG GPKPQKTEEE VLETEGDQEV SLGTPQEVVE
360
APETPGEPPL SPGF
Length:364
Mass (Da):39,299
Last modified:May 24, 2005 - v1
Checksum:i28FD406757BE082A
GO

Sequence cautioni

The sequence BAB14998 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti124 – 1241Y → H in BAF83951 (PubMed:14702039).Curated
Sequence conflicti206 – 2061A → V in CAE45984 (PubMed:17974005).Curated
Sequence conflicti206 – 2061A → V in CAE46001 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti116 – 1161R → H.
Corresponds to variant rs17745302 [ dbSNP | Ensembl ].
VAR_034590
Natural varianti123 – 1231D → Y.1 Publication
Corresponds to variant rs34027839 [ dbSNP | Ensembl ].
VAR_034591

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291262 mRNA. Translation: BAF83951.1.
BX640785 mRNA. Translation: CAE45875.1.
BX640969 mRNA. Translation: CAE45984.1.
BX640998 mRNA. Translation: CAE46001.1.
AC000076 Genomic DNA. No translation available.
CH471176 Genomic DNA. Translation: EAX03018.1.
CH471176 Genomic DNA. Translation: EAX03019.1.
BC011679 mRNA. Translation: AAH11679.2.
AK024778 mRNA. Translation: BAB14998.1. Different initiation.
CCDSiCCDS13769.1.
RefSeqiNP_078903.3. NM_024627.5.
UniGeneiHs.105642.

Genome annotation databases

EnsembliENST00000328554; ENSP00000330596; ENSG00000215012.
ENST00000405640; ENSP00000384924; ENSG00000215012.
ENST00000407472; ENSP00000386111; ENSG00000215012.
GeneIDi79680.
KEGGihsa:79680.
UCSCiuc002zqg.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291262 mRNA. Translation: BAF83951.1.
BX640785 mRNA. Translation: CAE45875.1.
BX640969 mRNA. Translation: CAE45984.1.
BX640998 mRNA. Translation: CAE46001.1.
AC000076 Genomic DNA. No translation available.
CH471176 Genomic DNA. Translation: EAX03018.1.
CH471176 Genomic DNA. Translation: EAX03019.1.
BC011679 mRNA. Translation: AAH11679.2.
AK024778 mRNA. Translation: BAB14998.1. Different initiation.
CCDSiCCDS13769.1.
RefSeqiNP_078903.3. NM_024627.5.
UniGeneiHs.105642.

3D structure databases

ProteinModelPortaliQ7L3V2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122804. 2 interactions.
IntActiQ7L3V2. 10 interactions.
STRINGi9606.ENSP00000330596.

PTM databases

iPTMnetiQ7L3V2.
PhosphoSiteiQ7L3V2.

Polymorphism and mutation databases

BioMutaiBOP.
DMDMi74739166.

Proteomic databases

MaxQBiQ7L3V2.
PaxDbiQ7L3V2.
PeptideAtlasiQ7L3V2.
PRIDEiQ7L3V2.

Protocols and materials databases

DNASUi79680.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328554; ENSP00000330596; ENSG00000215012.
ENST00000405640; ENSP00000384924; ENSG00000215012.
ENST00000407472; ENSP00000386111; ENSG00000215012.
GeneIDi79680.
KEGGihsa:79680.
UCSCiuc002zqg.4. human.

Organism-specific databases

CTDi79680.
GeneCardsiBOP.
C22orf29.
HGNCiHGNC:26112. C22orf29.
HPAiHPA000721.
HPA001419.
neXtProtiNX_Q7L3V2.
PharmGKBiPA145149415.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JAJ3. Eukaryota.
ENOG41117AG. LUCA.
GeneTreeiENSGT00510000050172.
HOGENOMiHOG000112084.
HOVERGENiHBG099854.
InParanoidiQ7L3V2.
OMAiLSRVCEI.
OrthoDBiEOG091G02TH.
PhylomeDBiQ7L3V2.
TreeFamiTF342426.

Miscellaneous databases

GenomeRNAii79680.
PROiQ7L3V2.

Gene expression databases

BgeeiENSG00000215012.
ExpressionAtlasiQ7L3V2. baseline and differential.
GenevisibleiQ7L3V2. HS.

Family and domain databases

InterProiIPR031298. Bop.
IPR032549. DUF4939.
IPR032567. LDOC1-rel.
[Graphical view]
PANTHERiPTHR15503. PTHR15503. 1 hit.
PTHR15503:SF4. PTHR15503:SF4. 1 hit.
PfamiPF16297. DUF4939. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBOP_HUMAN
AccessioniPrimary (citable) accession number: Q7L3V2
Secondary accession number(s): A8K5E7
, D3DX21, Q6MZM8, Q6N000, Q9H7A0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: May 24, 2005
Last modified: September 7, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.