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Protein

Protein Bop

Gene

RTL10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation RTL10/BOP intrinsic apoptotic signaling activity.1 Publication

GO - Biological processi

  • mitochondrial outer membrane permeabilization Source: UniProtKB
  • regulation of mitochondrial membrane potential Source: UniProtKB

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Bop1 Publication
Alternative name(s):
BH3-only protein
Retrotransposon Gag-like protein 10Imported
Gene namesi
Name:RTL10Imported
Synonyms:BOP, C22orf29
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000215012.8
HGNCiHGNC:26112 RTL10
neXtProtiNX_Q7L3V2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi118L → A: Reduces the pro-apoptotic activity and interaction with VDAC1. 1 Publication1
Mutagenesisi120Q → A: No effect on interaction with VDAC1. 1 Publication1
Mutagenesisi122G → A: No effect on interaction with VDAC1. 1 Publication1
Mutagenesisi123D → A: Reduces the pro-apoptotic activity, no effect on interaction with VDAC1. 1 Publication1

Organism-specific databases

DisGeNETi79680
OpenTargetsiENSG00000215012
PharmGKBiPA145149415

Polymorphism and mutation databases

BioMutaiBOP
DMDMi74739166

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002959101 – 364Protein BopAdd BLAST364

Proteomic databases

EPDiQ7L3V2
MaxQBiQ7L3V2
PaxDbiQ7L3V2
PeptideAtlasiQ7L3V2
PRIDEiQ7L3V2

PTM databases

iPTMnetiQ7L3V2
PhosphoSitePlusiQ7L3V2

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000215012
ExpressionAtlasiQ7L3V2 baseline and differential
GenevisibleiQ7L3V2 HS

Organism-specific databases

HPAiHPA000721
HPA001419

Interactioni

Subunit structurei

Interacts (via BH3 domain) with VDAC1. Interacts with pro-survival Bcl-2 family members, BCL2, BCL2L1 isoform Bcl-X(L), MCL1, BCL2A1 and BCL2L2. Interacts with BAX and BAK.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi122804, 3 interactors
IntActiQ7L3V2, 9 interactors
STRINGi9606.ENSP00000330596

Structurei

3D structure databases

ProteinModelPortaliQ7L3V2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi114 – 128BH3Add BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi265 – 324Pro-richAdd BLAST60

Domaini

The BH3 motif is required for pro-apoptotic activity and for interaction with pro-survival Bcl-2 family members.1 Publication

Phylogenomic databases

eggNOGiENOG410JAJ3 Eukaryota
ENOG41117AG LUCA
GeneTreeiENSGT00510000050172
HOGENOMiHOG000112084
HOVERGENiHBG099854
InParanoidiQ7L3V2
OMAiLSRVCEI
OrthoDBiEOG091G02TH
PhylomeDBiQ7L3V2
TreeFamiTF342426

Family and domain databases

InterProiView protein in InterPro
IPR031298 Bop
IPR032549 DUF4939
IPR032567 LDOC1-rel
PANTHERiPTHR15503 PTHR15503, 1 hit
PTHR15503:SF4 PTHR15503:SF4, 1 hit
PfamiView protein in Pfam
PF16297 DUF4939, 1 hit

Sequencei

Sequence statusi: Complete.

Q7L3V2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRGRCRQQG PRIPIWAAAN YANAHPWQQM DKASPGVAYT PLVDPWIERP
60 70 80 90 100
CCGDTVCVRT TMEQKSTASG TCGGKPAERG PLAGHMPSSR PHRVDFCWVP
110 120 130 140 150
GSDPGTFDGS PWLLDRFLAQ LGDYMSFHFE HYQDNISRVC EILRRLTGRA
160 170 180 190 200
QAWAAPYLDG DLPLPDDYEL FCQDLKEVVQ DPNSFAEYHA VVTCPLPLAS
210 220 230 240 250
SQLPVAPQLP VVRQYLARFL EGLALDMGTA PRSLPAAMAT PAVSGSNSVS
260 270 280 290 300
RSALFEQQLT KESTPGPKEP PVLPSSTCSS KPGPVEPASS QPEEAAPTPV
310 320 330 340 350
PRLSESANPP AQRPDPAHPG GPKPQKTEEE VLETEGDQEV SLGTPQEVVE
360
APETPGEPPL SPGF
Length:364
Mass (Da):39,299
Last modified:May 24, 2005 - v1
Checksum:i28FD406757BE082A
GO

Sequence cautioni

The sequence BAB14998 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti124Y → H in BAF83951 (PubMed:14702039).Curated1
Sequence conflicti206A → V in CAE45984 (PubMed:17974005).Curated1
Sequence conflicti206A → V in CAE46001 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034590116R → H. Corresponds to variant dbSNP:rs17745302Ensembl.1
Natural variantiVAR_034591123D → Y1 PublicationCorresponds to variant dbSNP:rs34027839Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291262 mRNA Translation: BAF83951.1
BX640785 mRNA Translation: CAE45875.1
BX640969 mRNA Translation: CAE45984.1
BX640998 mRNA Translation: CAE46001.1
AC000076 Genomic DNA No translation available.
CH471176 Genomic DNA Translation: EAX03018.1
CH471176 Genomic DNA Translation: EAX03019.1
BC011679 mRNA Translation: AAH11679.2
AK024778 mRNA Translation: BAB14998.1 Different initiation.
CCDSiCCDS13769.1
RefSeqiNP_078903.3, NM_024627.5
UniGeneiHs.105642

Genome annotation databases

EnsembliENST00000328554; ENSP00000330596; ENSG00000215012
ENST00000405640; ENSP00000384924; ENSG00000215012
ENST00000407472; ENSP00000386111; ENSG00000215012
GeneIDi79680
KEGGihsa:79680
UCSCiuc002zqg.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiBOP_HUMAN
AccessioniPrimary (citable) accession number: Q7L3V2
Secondary accession number(s): A8K5E7
, D3DX21, Q6MZM8, Q6N000, Q9H7A0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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