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Protein

Probable proline--tRNA ligase, mitochondrial

Gene

PARS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS08668-MONOMER.
ReactomeiR-HSA-379726. Mitochondrial tRNA aminoacylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable proline--tRNA ligase, mitochondrial (EC:6.1.1.15)
Alternative name(s):
Prolyl-tRNA synthetase
Short name:
ProRS
Gene namesi
Name:PARS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:30563. PARS2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000162396.
PharmGKBiPA142671198.

Chemistry databases

DrugBankiDB00172. L-Proline.

Polymorphism and mutation databases

BioMutaiPARS2.
DMDMi73919761.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 29MitochondrionSequence analysisAdd BLAST29
ChainiPRO_000003581830 – 475Probable proline--tRNA ligase, mitochondrialAdd BLAST446

Proteomic databases

EPDiQ7L3T8.
MaxQBiQ7L3T8.
PaxDbiQ7L3T8.
PeptideAtlasiQ7L3T8.
PRIDEiQ7L3T8.

PTM databases

iPTMnetiQ7L3T8.
PhosphoSitePlusiQ7L3T8.

Expressioni

Gene expression databases

BgeeiENSG00000162396.
CleanExiHS_PARS2.
GenevisibleiQ7L3T8. HS.

Organism-specific databases

HPAiHPA028314.
HPA028518.

Interactioni

Protein-protein interaction databases

BioGridi117457. 7 interactors.
IntActiQ7L3T8. 5 interactors.
MINTiMINT-3079657.
STRINGi9606.ENSP00000360327.

Structurei

3D structure databases

ProteinModelPortaliQ7L3T8.
SMRiQ7L3T8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2324. Eukaryota.
COG0442. LUCA.
GeneTreeiENSGT00390000010922.
HOGENOMiHOG000076894.
HOVERGENiHBG056542.
InParanoidiQ7L3T8.
KOiK01881.
OMAiLMSPTHE.
OrthoDBiEOG091G113P.
PhylomeDBiQ7L3T8.
TreeFamiTF105607.

Family and domain databases

CDDicd00779. ProRS_core_prok. 1 hit.
Gene3Di3.40.50.800. 1 hit.
InterProiIPR002314. aa-tRNA-synt_IIb.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR002316. Pro-tRNA-ligase_IIa.
IPR004500. Pro-tRNA-synth_IIa_bac-type.
IPR033730. ProRS_core_prok.
[Graphical view]
PANTHERiPTHR11451:SF3. PTHR11451:SF3. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
[Graphical view]
PRINTSiPR01046. TRNASYNTHPRO.
SUPFAMiSSF52954. SSF52954. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7L3T8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGLLTRCRA LPALATCSRQ LSGYVPCRFH HCAPRRGRRL LLSRVFQPQN
60 70 80 90 100
LREDRVLSLQ DKSDDLTCKS QRLMLQVGLI YPASPGCYHL LPYTVRAMEK
110 120 130 140 150
LVRVIDQEMQ AIGGQKVNMP SLSPAELWQA TNRWDLMGKE LLRLRDRHGK
160 170 180 190 200
EYCLGPTHEE AITALIASQK KLSYKQLPFL LYQVTRKFRD EPRPRFGLLR
210 220 230 240 250
GREFYMKDMY TFDSSPEAAQ QTYSLVCDAY CSLFNKLGLP FVKVQADVGT
260 270 280 290 300
IGGTVSHEFQ LPVDIGEDRL AICPRCSFSA NMETLDLSQM NCPACQGPLT
310 320 330 340 350
KTKGIEVGHT FYLGTKYSSI FNAQFTNVCG KPTLAEMGCY GLGVTRILAA
360 370 380 390 400
AIEVLSTEDC VRWPSLLAPY QACLIPPKKG SKEQAASELI GQLYDHITEA
410 420 430 440 450
VPQLHGEVLL DDRTHLTIGN RLKDANKFGY PFVIIAGKRA LEDPAHFEVW
460 470
CQNTGEVAFL TKDGVMDLLT PVQTV
Length:475
Mass (Da):53,263
Last modified:July 5, 2004 - v1
Checksum:iE3B1B07CB6225BA2
GO

Sequence cautioni

The sequence BAB15178 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05264428R → S.Corresponds to variant rs11577368dbSNPEnsembl.1
Natural variantiVAR_034527235N → S.Corresponds to variant rs2270004dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025585 mRNA. Translation: BAB15178.1. Different initiation.
AK289679 mRNA. Translation: BAF82368.1.
AL139244 Genomic DNA. Translation: CAI18996.1.
CH471059 Genomic DNA. Translation: EAX06669.1.
BC007956 mRNA. Translation: AAH07956.2.
BC011758 mRNA. Translation: AAH11758.2.
AL117473 mRNA. Translation: CAB55948.1.
CCDSiCCDS597.1.
PIRiT17258.
RefSeqiNP_689481.2. NM_152268.3.
UniGeneiHs.380169.

Genome annotation databases

EnsembliENST00000371279; ENSP00000360327; ENSG00000162396.
GeneIDi25973.
KEGGihsa:25973.
UCSCiuc001cxy.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025585 mRNA. Translation: BAB15178.1. Different initiation.
AK289679 mRNA. Translation: BAF82368.1.
AL139244 Genomic DNA. Translation: CAI18996.1.
CH471059 Genomic DNA. Translation: EAX06669.1.
BC007956 mRNA. Translation: AAH07956.2.
BC011758 mRNA. Translation: AAH11758.2.
AL117473 mRNA. Translation: CAB55948.1.
CCDSiCCDS597.1.
PIRiT17258.
RefSeqiNP_689481.2. NM_152268.3.
UniGeneiHs.380169.

3D structure databases

ProteinModelPortaliQ7L3T8.
SMRiQ7L3T8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117457. 7 interactors.
IntActiQ7L3T8. 5 interactors.
MINTiMINT-3079657.
STRINGi9606.ENSP00000360327.

Chemistry databases

DrugBankiDB00172. L-Proline.

PTM databases

iPTMnetiQ7L3T8.
PhosphoSitePlusiQ7L3T8.

Polymorphism and mutation databases

BioMutaiPARS2.
DMDMi73919761.

Proteomic databases

EPDiQ7L3T8.
MaxQBiQ7L3T8.
PaxDbiQ7L3T8.
PeptideAtlasiQ7L3T8.
PRIDEiQ7L3T8.

Protocols and materials databases

DNASUi25973.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371279; ENSP00000360327; ENSG00000162396.
GeneIDi25973.
KEGGihsa:25973.
UCSCiuc001cxy.4. human.

Organism-specific databases

CTDi25973.
GeneCardsiPARS2.
HGNCiHGNC:30563. PARS2.
HPAiHPA028314.
HPA028518.
MIMi612036. gene.
neXtProtiNX_Q7L3T8.
OpenTargetsiENSG00000162396.
PharmGKBiPA142671198.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2324. Eukaryota.
COG0442. LUCA.
GeneTreeiENSGT00390000010922.
HOGENOMiHOG000076894.
HOVERGENiHBG056542.
InParanoidiQ7L3T8.
KOiK01881.
OMAiLMSPTHE.
OrthoDBiEOG091G113P.
PhylomeDBiQ7L3T8.
TreeFamiTF105607.

Enzyme and pathway databases

BioCyciZFISH:HS08668-MONOMER.
ReactomeiR-HSA-379726. Mitochondrial tRNA aminoacylation.

Miscellaneous databases

GenomeRNAii25973.
PROiQ7L3T8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162396.
CleanExiHS_PARS2.
GenevisibleiQ7L3T8. HS.

Family and domain databases

CDDicd00779. ProRS_core_prok. 1 hit.
Gene3Di3.40.50.800. 1 hit.
InterProiIPR002314. aa-tRNA-synt_IIb.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR002316. Pro-tRNA-ligase_IIa.
IPR004500. Pro-tRNA-synth_IIa_bac-type.
IPR033730. ProRS_core_prok.
[Graphical view]
PANTHERiPTHR11451:SF3. PTHR11451:SF3. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
[Graphical view]
PRINTSiPR01046. TRNASYNTHPRO.
SUPFAMiSSF52954. SSF52954. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYPM_HUMAN
AccessioniPrimary (citable) accession number: Q7L3T8
Secondary accession number(s): A8K0W4, Q9H6S5, Q9UFT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.