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Protein

Probable proline--tRNA ligase, mitochondrial

Gene

PARS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-379726 Mitochondrial tRNA aminoacylation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable proline--tRNA ligase, mitochondrial (EC:6.1.1.15)
Alternative name(s):
Prolyl-tRNA synthetase
Short name:
ProRS
Gene namesi
Name:PARS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162396.5
HGNCiHGNC:30563 PARS2
MIMi612036 gene
neXtProtiNX_Q7L3T8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000162396
PharmGKBiPA142671198

Chemistry databases

DrugBankiDB00172 L-Proline

Polymorphism and mutation databases

BioMutaiPARS2
DMDMi73919761

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 29MitochondrionSequence analysisAdd BLAST29
ChainiPRO_000003581830 – 475Probable proline--tRNA ligase, mitochondrialAdd BLAST446

Proteomic databases

EPDiQ7L3T8
MaxQBiQ7L3T8
PaxDbiQ7L3T8
PeptideAtlasiQ7L3T8
PRIDEiQ7L3T8

PTM databases

iPTMnetiQ7L3T8
PhosphoSitePlusiQ7L3T8

Expressioni

Gene expression databases

BgeeiENSG00000162396
CleanExiHS_PARS2
GenevisibleiQ7L3T8 HS

Organism-specific databases

HPAiHPA028308
HPA028314
HPA028518

Interactioni

Protein-protein interaction databases

BioGridi1174578 interactors.
IntActiQ7L3T8 6 interactors.
MINTiQ7L3T8
STRINGi9606.ENSP00000360327

Structurei

3D structure databases

ProteinModelPortaliQ7L3T8
SMRiQ7L3T8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2324 Eukaryota
COG0442 LUCA
GeneTreeiENSGT00390000010922
HOGENOMiHOG000076894
HOVERGENiHBG056542
InParanoidiQ7L3T8
KOiK01881
OMAiIQPAELW
OrthoDBiEOG091G113P
PhylomeDBiQ7L3T8
TreeFamiTF105607

Family and domain databases

CDDicd00779 ProRS_core_prok, 1 hit
Gene3Di3.40.50.8001 hit
InterProiView protein in InterPro
IPR002314 aa-tRNA-synt_IIb
IPR006195 aa-tRNA-synth_II
IPR004154 Anticodon-bd
IPR036621 Anticodon-bd_dom_sf
IPR002316 Pro-tRNA-ligase_IIa
IPR033730 ProRS_core_prok
PfamiView protein in Pfam
PF03129 HGTP_anticodon, 1 hit
PF00587 tRNA-synt_2b, 1 hit
PRINTSiPR01046 TRNASYNTHPRO
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7L3T8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGLLTRCRA LPALATCSRQ LSGYVPCRFH HCAPRRGRRL LLSRVFQPQN
60 70 80 90 100
LREDRVLSLQ DKSDDLTCKS QRLMLQVGLI YPASPGCYHL LPYTVRAMEK
110 120 130 140 150
LVRVIDQEMQ AIGGQKVNMP SLSPAELWQA TNRWDLMGKE LLRLRDRHGK
160 170 180 190 200
EYCLGPTHEE AITALIASQK KLSYKQLPFL LYQVTRKFRD EPRPRFGLLR
210 220 230 240 250
GREFYMKDMY TFDSSPEAAQ QTYSLVCDAY CSLFNKLGLP FVKVQADVGT
260 270 280 290 300
IGGTVSHEFQ LPVDIGEDRL AICPRCSFSA NMETLDLSQM NCPACQGPLT
310 320 330 340 350
KTKGIEVGHT FYLGTKYSSI FNAQFTNVCG KPTLAEMGCY GLGVTRILAA
360 370 380 390 400
AIEVLSTEDC VRWPSLLAPY QACLIPPKKG SKEQAASELI GQLYDHITEA
410 420 430 440 450
VPQLHGEVLL DDRTHLTIGN RLKDANKFGY PFVIIAGKRA LEDPAHFEVW
460 470
CQNTGEVAFL TKDGVMDLLT PVQTV
Length:475
Mass (Da):53,263
Last modified:July 5, 2004 - v1
Checksum:iE3B1B07CB6225BA2
GO

Sequence cautioni

The sequence BAB15178 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05264428R → S. Corresponds to variant dbSNP:rs11577368Ensembl.1
Natural variantiVAR_034527235N → S. Corresponds to variant dbSNP:rs2270004Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025585 mRNA Translation: BAB15178.1 Different initiation.
AK289679 mRNA Translation: BAF82368.1
AL139244 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06669.1
BC007956 mRNA Translation: AAH07956.2
BC011758 mRNA Translation: AAH11758.2
AL117473 mRNA Translation: CAB55948.1
CCDSiCCDS597.1
PIRiT17258
RefSeqiNP_689481.2, NM_152268.3
UniGeneiHs.380169

Genome annotation databases

EnsembliENST00000371279; ENSP00000360327; ENSG00000162396
GeneIDi25973
KEGGihsa:25973
UCSCiuc001cxy.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSYPM_HUMAN
AccessioniPrimary (citable) accession number: Q7L3T8
Secondary accession number(s): A8K0W4, Q9H6S5, Q9UFT1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: July 5, 2004
Last modified: February 28, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome