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Protein

Zinc finger protein 771

Gene

ZNF771

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri63 – 85C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri91 – 113C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri119 – 141C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri147 – 169C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri175 – 197C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri203 – 225C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri231 – 253C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri259 – 281C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 771
Alternative name(s):
Mesenchymal stem cell protein DSC43
Gene namesi
Name:ZNF771
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000179965.11.
HGNCiHGNC:29653. ZNF771.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410347.

Polymorphism and mutation databases

BioMutaiZNF771.
DMDMi74759003.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002804391 – 317Zinc finger protein 771Add BLAST317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki33Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ7L3S4.
MaxQBiQ7L3S4.
PaxDbiQ7L3S4.
PeptideAtlasiQ7L3S4.
PRIDEiQ7L3S4.

PTM databases

iPTMnetiQ7L3S4.
PhosphoSitePlusiQ7L3S4.

Expressioni

Gene expression databases

BgeeiENSG00000179965.
CleanExiHS_ZNF771.
ExpressionAtlasiQ7L3S4. baseline and differential.
GenevisibleiQ7L3S4. HS.

Organism-specific databases

HPAiHPA030730.
HPA046672.
HPA059398.

Interactioni

Protein-protein interaction databases

BioGridi119480. 17 interactors.
STRINGi9606.ENSP00000323945.

Structurei

3D structure databases

ProteinModelPortaliQ7L3S4.
SMRiQ7L3S4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 35Glu-richAdd BLAST32

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri63 – 85C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri91 – 113C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri119 – 141C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri147 – 169C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri175 – 197C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri203 – 225C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri231 – 253C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri259 – 281C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00890000139349.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ7L3S4.
OMAiTYERSYQ.
OrthoDBiEOG091G02KC.
PhylomeDBiQ7L3S4.
TreeFamiTF337055.

Family and domain databases

InterProiView protein in InterPro
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 8 hits.
SUPFAMiSSF57667. SSF57667. 5 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.

Sequencei

Sequence statusi: Complete.

Q7L3S4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGEQQAEEE EEEEMQEEMV LLVKGEEDEG EEKYEVVKLK IPMDNKEVPG
60 70 80 90 100
EAPAPSADPA RPHACPDCGR AFARRSTLAK HARTHTGERP FGCTECGRRF
110 120 130 140 150
SQKSALTKHG RTHTGERPYE CPECDKRFSA ASNLRQHRRR HTGEKPYACA
160 170 180 190 200
HCGRRFAQSS NYAQHLRVHT GEKPYACPDC GRAFGGSSCL ARHRRTHTGE
210 220 230 240 250
RPYACADCGT RFAQSSALAK HRRVHTGEKP HRCAVCGRRF GHRSNLAEHA
260 270 280 290 300
RTHTGERPYP CAECGRRFRL SSHFIRHRRA HMRRRLYICA GCGRDFKLPP
310
GATAATATER CPECEGS
Length:317
Mass (Da):35,702
Last modified:July 5, 2004 - v1
Checksum:iBF752DE568010B88
GO

Sequence cautioni

The sequence AAF65445 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031150207D → N1 PublicationCorresponds to variant dbSNP:rs17852362Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC011870 mRNA. Translation: AAH11870.2.
BC026192 mRNA. Translation: AAH26192.2.
AF242768 mRNA. Translation: AAF65445.1. Different initiation.
CCDSiCCDS45460.1.
RefSeqiNP_001135777.1. NM_001142305.1.
NP_057727.2. NM_016643.3.
UniGeneiHs.148584.

Genome annotation databases

EnsembliENST00000319296; ENSP00000323945; ENSG00000179965.
ENST00000434417; ENSP00000416197; ENSG00000179965.
GeneIDi51333.
KEGGihsa:51333.
UCSCiuc002dyd.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN771_HUMAN
AccessioniPrimary (citable) accession number: Q7L3S4
Secondary accession number(s): Q8TAQ7, Q9NYI6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families