ID   ARMX2_HUMAN             Reviewed;         632 AA.
AC   Q7L311; O60267; Q5H9D9;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   24-JAN-2024, entry version 152.
DE   RecName: Full=Armadillo repeat-containing X-linked protein 2;
DE   AltName: Full=ARM protein lost in epithelial cancers on chromosome X 2;
DE            Short=Protein ALEX2;
GN   Name=ARMCX2; Synonyms=ALEX2, KIAA0512;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=9628581; DOI=10.1093/dnares/5.1.31;
RA   Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N.,
RA   Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. IX. The
RT   complete sequences of 100 new cDNA clones from brain which can code for
RT   large proteins in vitro.";
RL   DNA Res. 5:31-39(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA   Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA   Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA   Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA   Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA   Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA   Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA   Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA   Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA   Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA   Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA   Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA   Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA   Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA   Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA   Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA   Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA   Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA   Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA   Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA   Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA   Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA   Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA   Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA   Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA   Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA   Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA   Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA   Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA   Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA   Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA   Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA   d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA   Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA   Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA   Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA   Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA   Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA   Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA   Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta, and Skin;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   TISSUE SPECIFICITY.
RX   PubMed=11162520; DOI=10.1006/bbrc.2000.4125;
RA   Kurochkin I.V., Yonemitsu N., Funahashi S., Nomura H.;
RT   "ALEX1, a novel human armadillo repeat protein that is expressed
RT   differentially in normal tissues and carcinomas.";
RL   Biochem. Biophys. Res. Commun. 280:340-347(2001).
CC   -!- FUNCTION: May regulate the dynamics and distribution of mitochondria in
CC       neural cells. {ECO:0000250|UniProtKB:Q6A058}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q6A058}.
CC       Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q8BHS6}; Single-
CC       pass membrane protein {ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: Expressed at high levels ovary, heart, testis,
CC       prostate, brain, spleen and colon. Expressed at very low levels in
CC       liver and thymus. Not expressed in peripheral blood leukocytes. Not
CC       expressed in pancreas and ovarian carcinomas.
CC       {ECO:0000269|PubMed:11162520}.
CC   -!- SIMILARITY: Belongs to the eutherian X-chromosome-specific Armcx
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA25438.2; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC       Haematology;
CC       URL="https://atlasgeneticsoncology.org/gene/478/ALEX2Xq22";
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DR   EMBL; AB011084; BAA25438.2; ALT_INIT; mRNA.
DR   EMBL; Z83131; CAI42019.1; -; Genomic_DNA.
DR   EMBL; Z83131; CAI42022.1; -; Genomic_DNA.
DR   EMBL; BC012541; AAH12541.1; -; mRNA.
DR   EMBL; BC015926; AAH15926.1; -; mRNA.
DR   CCDS; CCDS14490.1; -.
DR   PIR; T00084; T00084.
DR   RefSeq; NP_001269160.1; NM_001282231.1.
DR   RefSeq; NP_055597.1; NM_014782.6.
DR   RefSeq; NP_808818.1; NM_177949.3.
DR   RefSeq; XP_005278166.1; XM_005278109.1.
DR   RefSeq; XP_005278167.1; XM_005278110.1.
DR   RefSeq; XP_005278168.1; XM_005278111.1.
DR   RefSeq; XP_005278170.1; XM_005278113.1.
DR   RefSeq; XP_005278171.1; XM_005278114.1.
DR   RefSeq; XP_005278172.1; XM_005278115.1.
DR   RefSeq; XP_005278173.1; XM_005278116.1.
DR   RefSeq; XP_005278174.1; XM_005278117.1.
DR   RefSeq; XP_011529373.1; XM_011531071.1.
DR   RefSeq; XP_011529374.1; XM_011531072.1.
DR   RefSeq; XP_016885476.1; XM_017029987.1.
DR   RefSeq; XP_016885477.1; XM_017029988.1.
DR   RefSeq; XP_016885478.1; XM_017029989.1.
DR   RefSeq; XP_016885479.1; XM_017029990.1.
DR   RefSeq; XP_016885480.1; XM_017029991.1.
DR   RefSeq; XP_016885481.1; XM_017029992.1.
DR   RefSeq; XP_016885482.1; XM_017029993.1.
DR   RefSeq; XP_016885483.1; XM_017029994.1.
DR   RefSeq; XP_016885484.1; XM_017029995.1.
DR   RefSeq; XP_016885485.1; XM_017029996.1.
DR   RefSeq; XP_016885486.1; XM_017029997.1.
DR   AlphaFoldDB; Q7L311; -.
DR   SMR; Q7L311; -.
DR   BioGRID; 115161; 28.
DR   IntAct; Q7L311; 5.
DR   STRING; 9606.ENSP00000349281; -.
DR   iPTMnet; Q7L311; -.
DR   PhosphoSitePlus; Q7L311; -.
DR   BioMuta; ARMCX2; -.
DR   DMDM; 74759000; -.
DR   EPD; Q7L311; -.
DR   jPOST; Q7L311; -.
DR   MassIVE; Q7L311; -.
DR   MaxQB; Q7L311; -.
DR   PaxDb; 9606-ENSP00000331662; -.
DR   PeptideAtlas; Q7L311; -.
DR   ProteomicsDB; 68769; -.
DR   Pumba; Q7L311; -.
DR   Antibodypedia; 28782; 173 antibodies from 26 providers.
DR   DNASU; 9823; -.
DR   Ensembl; ENST00000328766.9; ENSP00000331662.5; ENSG00000184867.14.
DR   Ensembl; ENST00000330154.6; ENSP00000328631.2; ENSG00000184867.14.
DR   Ensembl; ENST00000356824.9; ENSP00000349281.4; ENSG00000184867.14.
DR   GeneID; 9823; -.
DR   KEGG; hsa:9823; -.
DR   MANE-Select; ENST00000356824.9; ENSP00000349281.4; NM_177949.4; NP_808818.1.
DR   UCSC; uc004eid.3; human.
DR   AGR; HGNC:16869; -.
DR   CTD; 9823; -.
DR   DisGeNET; 9823; -.
DR   GeneCards; ARMCX2; -.
DR   HGNC; HGNC:16869; ARMCX2.
DR   HPA; ENSG00000184867; Tissue enhanced (epididymis).
DR   MIM; 300363; gene.
DR   neXtProt; NX_Q7L311; -.
DR   OpenTargets; ENSG00000184867; -.
DR   PharmGKB; PA134985862; -.
DR   VEuPathDB; HostDB:ENSG00000184867; -.
DR   eggNOG; ENOG502QQ2D; Eukaryota.
DR   GeneTree; ENSGT00940000163008; -.
DR   HOGENOM; CLU_028273_0_0_1; -.
DR   InParanoid; Q7L311; -.
DR   OMA; YNYREFN; -.
DR   OrthoDB; 2912889at2759; -.
DR   PhylomeDB; Q7L311; -.
DR   TreeFam; TF335652; -.
DR   PathwayCommons; Q7L311; -.
DR   SignaLink; Q7L311; -.
DR   BioGRID-ORCS; 9823; 9 hits in 767 CRISPR screens.
DR   ChiTaRS; ARMCX2; human.
DR   GenomeRNAi; 9823; -.
DR   Pharos; Q7L311; Tbio.
DR   PRO; PR:Q7L311; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   RNAct; Q7L311; Protein.
DR   Bgee; ENSG00000184867; Expressed in corpus epididymis and 189 other cell types or tissues.
DR   ExpressionAtlas; Q7L311; baseline and differential.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR006911; ARM-rpt_dom.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   PANTHER; PTHR15712; ARMADILLO REPEAT CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR15712:SF9; ARMADILLO REPEAT-CONTAINING X-LINKED PROTEIN 2; 1.
DR   Pfam; PF04826; Arm_2; 1.
DR   SMART; SM00185; ARM; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   Genevisible; Q7L311; HS.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion outer membrane; Reference proteome;
KW   Repeat; Signal-anchor; Transmembrane; Transmembrane helix.
FT   CHAIN           1..632
FT                   /note="Armadillo repeat-containing X-linked protein 2"
FT                   /id="PRO_0000191364"
FT   TOPO_DOM        1..6
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250|UniProtKB:Q8BHS6"
FT   TRANSMEM        7..25
FT                   /note="Helical; Signal-anchor"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        26..632
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q8BHS6"
FT   REPEAT          376..416
FT                   /note="ARM 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          418..457
FT                   /note="ARM 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          498..537
FT                   /note="ARM 3"
FT                   /evidence="ECO:0000255"
FT   REGION          1..6
FT                   /note="Mitochondrion outer membrane (MOM)-targeting
FT                   sequence"
FT                   /evidence="ECO:0000305"
FT   REGION          26..40
FT                   /note="Mitochondrion outer membrane (MOM)-targeting
FT                   sequence"
FT                   /evidence="ECO:0000305"
FT   REGION          68..124
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          160..304
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          335..369
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   632 AA;  65683 MW;  7627CBFFE61C329B CRC64;
     MSRVRDAGCV AAGIVIGAGA WYCVYKYTRG RDQTKKRMAK PKNRAVAGTG ARARAGLRAG
     FTIDLGSGFS PPTPVRAEAE DRAQDEASAL DTVGAEAVAP AASSAEAQSG AGSQAQEADG
     AGVGPKAESV VGAAMASAIA PPPGVTEALG AAEAPAMAGA PKVAEAPREA ETSRAAVPPG
     TVVPTEAAAP TEVTEGPGVA APTKVAEAPG VASPTEAAEA PVPATPTGAA APTGAAESPG
     TSGSPRTAVV PGTSAAKKAT PGAHTGAIPK ATSATGAVPK GGGKGVTRSR NGGKGKGKKS
     KVEVDELGMG FRPGDGAAAA AAASANGGQA FLAEVPDSEE GESGWTDTES DSDSEPETQR
     RGRGRRPVAM QKRPFPYEID EILGVRDLRK VLALLQKSDD PFIQQVALLT LSNNANYSCN
     QETIRKLGGL PIIANMINKT DPHIKEKALM AMNNLSENYE NQGRLQVYMN KVMDDIMASN
     LNSAVQVVGL KFLTNMTITN DYQHLLVNSI ANFFRLLSQG GGKIKVEILK ILSNFAENPD
     MLKKLLSTQV PASFSSLYNS YVESEILINA LTLFEIIYDN LRAEVFNYRE FNKGSLFYLC
     TTSGVCVKKI RALANHHDLL VKVKVIKLVN KF
//