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Q7L311

- ARMX2_HUMAN

UniProt

Q7L311 - ARMX2_HUMAN

Protein

Armadillo repeat-containing X-linked protein 2

Gene

ARMCX2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Armadillo repeat-containing X-linked protein 2
    Alternative name(s):
    ARM protein lost in epithelial cancers on chromosome X 2
    Short name:
    Protein ALEX2
    Gene namesi
    Name:ARMCX2
    Synonyms:ALEX2, KIAA0512
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:16869. ARMCX2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134985862.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 632632Armadillo repeat-containing X-linked protein 2PRO_0000191364Add
    BLAST

    Proteomic databases

    MaxQBiQ7L311.
    PaxDbiQ7L311.
    PRIDEiQ7L311.

    PTM databases

    PhosphoSiteiQ7L311.

    Expressioni

    Tissue specificityi

    Expressed at high levels ovary, heart, testis, prostate, brain, spleen and colon. Expressed at very low levels in liver and thymus. Not expressed in peripheral blood leukocytes. Not expressed in pancreas and ovarian carcinomas.1 Publication

    Gene expression databases

    ArrayExpressiQ7L311.
    BgeeiQ7L311.
    CleanExiHS_ARMCX2.
    GenevestigatoriQ7L311.

    Organism-specific databases

    HPAiHPA005761.

    Interactioni

    Protein-protein interaction databases

    BioGridi115161. 4 interactions.
    IntActiQ7L311. 2 interactions.
    MINTiMINT-3980369.
    STRINGi9606.ENSP00000328631.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7L311.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2519HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati376 – 41641ARM 1Add
    BLAST
    Repeati418 – 45740ARM 2Add
    BLAST
    Repeati498 – 53740ARM 3Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi77 – 277201Ala-richAdd
    BLAST

    Sequence similaritiesi

    Contains 3 ARM repeats.Curated

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46779.
    HOGENOMiHOG000231611.
    HOVERGENiHBG057677.
    InParanoidiQ7L311.
    OMAiWYCVYKY.
    PhylomeDBiQ7L311.
    TreeFamiTF335652.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    InterProiIPR011989. ARM-like.
    IPR006911. ARM-rpt_dom.
    IPR016024. ARM-type_fold.
    [Graphical view]
    PfamiPF04826. Arm_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7L311-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRVRDAGCV AAGIVIGAGA WYCVYKYTRG RDQTKKRMAK PKNRAVAGTG    50
    ARARAGLRAG FTIDLGSGFS PPTPVRAEAE DRAQDEASAL DTVGAEAVAP 100
    AASSAEAQSG AGSQAQEADG AGVGPKAESV VGAAMASAIA PPPGVTEALG 150
    AAEAPAMAGA PKVAEAPREA ETSRAAVPPG TVVPTEAAAP TEVTEGPGVA 200
    APTKVAEAPG VASPTEAAEA PVPATPTGAA APTGAAESPG TSGSPRTAVV 250
    PGTSAAKKAT PGAHTGAIPK ATSATGAVPK GGGKGVTRSR NGGKGKGKKS 300
    KVEVDELGMG FRPGDGAAAA AAASANGGQA FLAEVPDSEE GESGWTDTES 350
    DSDSEPETQR RGRGRRPVAM QKRPFPYEID EILGVRDLRK VLALLQKSDD 400
    PFIQQVALLT LSNNANYSCN QETIRKLGGL PIIANMINKT DPHIKEKALM 450
    AMNNLSENYE NQGRLQVYMN KVMDDIMASN LNSAVQVVGL KFLTNMTITN 500
    DYQHLLVNSI ANFFRLLSQG GGKIKVEILK ILSNFAENPD MLKKLLSTQV 550
    PASFSSLYNS YVESEILINA LTLFEIIYDN LRAEVFNYRE FNKGSLFYLC 600
    TTSGVCVKKI RALANHHDLL VKVKVIKLVN KF 632
    Length:632
    Mass (Da):65,683
    Last modified:July 5, 2004 - v1
    Checksum:i7627CBFFE61C329B
    GO

    Sequence cautioni

    The sequence BAA25438.2 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB011084 mRNA. Translation: BAA25438.2. Different initiation.
    Z83131 Genomic DNA. Translation: CAI42019.1.
    Z83131 Genomic DNA. Translation: CAI42022.1.
    BC012541 mRNA. Translation: AAH12541.1.
    BC015926 mRNA. Translation: AAH15926.1.
    CCDSiCCDS14490.1.
    PIRiT00084.
    RefSeqiNP_001269160.1. NM_001282231.1.
    NP_055597.1. NM_014782.6.
    NP_808818.1. NM_177949.3.
    XP_005278166.1. XM_005278109.1.
    XP_005278167.1. XM_005278110.1.
    XP_005278168.1. XM_005278111.1.
    XP_005278170.1. XM_005278113.1.
    XP_005278171.1. XM_005278114.1.
    XP_005278172.1. XM_005278115.1.
    XP_005278173.1. XM_005278116.1.
    XP_005278174.1. XM_005278117.1.
    UniGeneiHs.48924.

    Genome annotation databases

    EnsembliENST00000328766; ENSP00000331662; ENSG00000184867.
    ENST00000330154; ENSP00000328631; ENSG00000184867.
    ENST00000356824; ENSP00000349281; ENSG00000184867.
    GeneIDi9823.
    KEGGihsa:9823.
    UCSCiuc004eid.2. human.

    Polymorphism databases

    DMDMi74759000.

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB011084 mRNA. Translation: BAA25438.2 . Different initiation.
    Z83131 Genomic DNA. Translation: CAI42019.1 .
    Z83131 Genomic DNA. Translation: CAI42022.1 .
    BC012541 mRNA. Translation: AAH12541.1 .
    BC015926 mRNA. Translation: AAH15926.1 .
    CCDSi CCDS14490.1.
    PIRi T00084.
    RefSeqi NP_001269160.1. NM_001282231.1.
    NP_055597.1. NM_014782.6.
    NP_808818.1. NM_177949.3.
    XP_005278166.1. XM_005278109.1.
    XP_005278167.1. XM_005278110.1.
    XP_005278168.1. XM_005278111.1.
    XP_005278170.1. XM_005278113.1.
    XP_005278171.1. XM_005278114.1.
    XP_005278172.1. XM_005278115.1.
    XP_005278173.1. XM_005278116.1.
    XP_005278174.1. XM_005278117.1.
    UniGenei Hs.48924.

    3D structure databases

    ProteinModelPortali Q7L311.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115161. 4 interactions.
    IntActi Q7L311. 2 interactions.
    MINTi MINT-3980369.
    STRINGi 9606.ENSP00000328631.

    PTM databases

    PhosphoSitei Q7L311.

    Polymorphism databases

    DMDMi 74759000.

    Proteomic databases

    MaxQBi Q7L311.
    PaxDbi Q7L311.
    PRIDEi Q7L311.

    Protocols and materials databases

    DNASUi 9823.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000328766 ; ENSP00000331662 ; ENSG00000184867 .
    ENST00000330154 ; ENSP00000328631 ; ENSG00000184867 .
    ENST00000356824 ; ENSP00000349281 ; ENSG00000184867 .
    GeneIDi 9823.
    KEGGi hsa:9823.
    UCSCi uc004eid.2. human.

    Organism-specific databases

    CTDi 9823.
    GeneCardsi GC0XM100910.
    HGNCi HGNC:16869. ARMCX2.
    HPAi HPA005761.
    MIMi 300363. gene.
    neXtProti NX_Q7L311.
    PharmGKBi PA134985862.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46779.
    HOGENOMi HOG000231611.
    HOVERGENi HBG057677.
    InParanoidi Q7L311.
    OMAi WYCVYKY.
    PhylomeDBi Q7L311.
    TreeFami TF335652.

    Miscellaneous databases

    GenomeRNAii 9823.
    NextBioi 36996.
    PROi Q7L311.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7L311.
    Bgeei Q7L311.
    CleanExi HS_ARMCX2.
    Genevestigatori Q7L311.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    InterProi IPR011989. ARM-like.
    IPR006911. ARM-rpt_dom.
    IPR016024. ARM-type_fold.
    [Graphical view ]
    Pfami PF04826. Arm_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta and Skin.
    4. "ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas."
      Kurochkin I.V., Yonemitsu N., Funahashi S., Nomura H.
      Biochem. Biophys. Res. Commun. 280:340-347(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiARMX2_HUMAN
    AccessioniPrimary (citable) accession number: Q7L311
    Secondary accession number(s): O60267, Q5H9D9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3