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Q7L311

- ARMX2_HUMAN

UniProt

Q7L311 - ARMX2_HUMAN

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Protein
Armadillo repeat-containing X-linked protein 2
Gene
ARMCX2, ALEX2, KIAA0512
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo repeat-containing X-linked protein 2
Alternative name(s):
ARM protein lost in epithelial cancers on chromosome X 2
Short name:
Protein ALEX2
Gene namesi
Name:ARMCX2
Synonyms:ALEX2, KIAA0512
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:16869. ARMCX2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2519Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134985862.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 632632Armadillo repeat-containing X-linked protein 2
PRO_0000191364Add
BLAST

Proteomic databases

MaxQBiQ7L311.
PaxDbiQ7L311.
PRIDEiQ7L311.

PTM databases

PhosphoSiteiQ7L311.

Expressioni

Tissue specificityi

Expressed at high levels ovary, heart, testis, prostate, brain, spleen and colon. Expressed at very low levels in liver and thymus. Not expressed in peripheral blood leukocytes. Not expressed in pancreas and ovarian carcinomas.1 Publication

Gene expression databases

ArrayExpressiQ7L311.
BgeeiQ7L311.
CleanExiHS_ARMCX2.
GenevestigatoriQ7L311.

Organism-specific databases

HPAiHPA005761.

Interactioni

Protein-protein interaction databases

BioGridi115161. 4 interactions.
IntActiQ7L311. 2 interactions.
MINTiMINT-3980369.
STRINGi9606.ENSP00000328631.

Structurei

3D structure databases

ProteinModelPortaliQ7L311.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati376 – 41641ARM 1
Add
BLAST
Repeati418 – 45740ARM 2
Add
BLAST
Repeati498 – 53740ARM 3
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi77 – 277201Ala-rich
Add
BLAST

Sequence similaritiesi

Contains 3 ARM repeats.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46779.
HOGENOMiHOG000231611.
HOVERGENiHBG057677.
InParanoidiQ7L311.
OMAiWYCVYKY.
PhylomeDBiQ7L311.
TreeFamiTF335652.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR006911. ARM-rpt_dom.
IPR016024. ARM-type_fold.
[Graphical view]
PfamiPF04826. Arm_2. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7L311-1 [UniParc]FASTAAdd to Basket

« Hide

MSRVRDAGCV AAGIVIGAGA WYCVYKYTRG RDQTKKRMAK PKNRAVAGTG    50
ARARAGLRAG FTIDLGSGFS PPTPVRAEAE DRAQDEASAL DTVGAEAVAP 100
AASSAEAQSG AGSQAQEADG AGVGPKAESV VGAAMASAIA PPPGVTEALG 150
AAEAPAMAGA PKVAEAPREA ETSRAAVPPG TVVPTEAAAP TEVTEGPGVA 200
APTKVAEAPG VASPTEAAEA PVPATPTGAA APTGAAESPG TSGSPRTAVV 250
PGTSAAKKAT PGAHTGAIPK ATSATGAVPK GGGKGVTRSR NGGKGKGKKS 300
KVEVDELGMG FRPGDGAAAA AAASANGGQA FLAEVPDSEE GESGWTDTES 350
DSDSEPETQR RGRGRRPVAM QKRPFPYEID EILGVRDLRK VLALLQKSDD 400
PFIQQVALLT LSNNANYSCN QETIRKLGGL PIIANMINKT DPHIKEKALM 450
AMNNLSENYE NQGRLQVYMN KVMDDIMASN LNSAVQVVGL KFLTNMTITN 500
DYQHLLVNSI ANFFRLLSQG GGKIKVEILK ILSNFAENPD MLKKLLSTQV 550
PASFSSLYNS YVESEILINA LTLFEIIYDN LRAEVFNYRE FNKGSLFYLC 600
TTSGVCVKKI RALANHHDLL VKVKVIKLVN KF 632
Length:632
Mass (Da):65,683
Last modified:July 5, 2004 - v1
Checksum:i7627CBFFE61C329B
GO

Sequence cautioni

The sequence BAA25438.2 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB011084 mRNA. Translation: BAA25438.2. Different initiation.
Z83131 Genomic DNA. Translation: CAI42019.1.
Z83131 Genomic DNA. Translation: CAI42022.1.
BC012541 mRNA. Translation: AAH12541.1.
BC015926 mRNA. Translation: AAH15926.1.
CCDSiCCDS14490.1.
PIRiT00084.
RefSeqiNP_001269160.1. NM_001282231.1.
NP_055597.1. NM_014782.6.
NP_808818.1. NM_177949.3.
XP_005278166.1. XM_005278109.1.
XP_005278167.1. XM_005278110.1.
XP_005278168.1. XM_005278111.1.
XP_005278170.1. XM_005278113.1.
XP_005278171.1. XM_005278114.1.
XP_005278172.1. XM_005278115.1.
XP_005278173.1. XM_005278116.1.
XP_005278174.1. XM_005278117.1.
UniGeneiHs.48924.

Genome annotation databases

EnsembliENST00000328766; ENSP00000331662; ENSG00000184867.
ENST00000330154; ENSP00000328631; ENSG00000184867.
ENST00000356824; ENSP00000349281; ENSG00000184867.
ENST00000440675; ENSP00000393778; ENSG00000184867.
ENST00000596872; ENSP00000468899; ENSG00000268151.
ENST00000597565; ENSP00000470751; ENSG00000268151.
ENST00000597913; ENSP00000469815; ENSG00000268151.
ENST00000600085; ENSP00000473195; ENSG00000268151.
GeneIDi9823.
KEGGihsa:9823.
UCSCiuc004eid.2. human.

Polymorphism databases

DMDMi74759000.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB011084 mRNA. Translation: BAA25438.2 . Different initiation.
Z83131 Genomic DNA. Translation: CAI42019.1 .
Z83131 Genomic DNA. Translation: CAI42022.1 .
BC012541 mRNA. Translation: AAH12541.1 .
BC015926 mRNA. Translation: AAH15926.1 .
CCDSi CCDS14490.1.
PIRi T00084.
RefSeqi NP_001269160.1. NM_001282231.1.
NP_055597.1. NM_014782.6.
NP_808818.1. NM_177949.3.
XP_005278166.1. XM_005278109.1.
XP_005278167.1. XM_005278110.1.
XP_005278168.1. XM_005278111.1.
XP_005278170.1. XM_005278113.1.
XP_005278171.1. XM_005278114.1.
XP_005278172.1. XM_005278115.1.
XP_005278173.1. XM_005278116.1.
XP_005278174.1. XM_005278117.1.
UniGenei Hs.48924.

3D structure databases

ProteinModelPortali Q7L311.
ModBasei Search...

Protein-protein interaction databases

BioGridi 115161. 4 interactions.
IntActi Q7L311. 2 interactions.
MINTi MINT-3980369.
STRINGi 9606.ENSP00000328631.

PTM databases

PhosphoSitei Q7L311.

Polymorphism databases

DMDMi 74759000.

Proteomic databases

MaxQBi Q7L311.
PaxDbi Q7L311.
PRIDEi Q7L311.

Protocols and materials databases

DNASUi 9823.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000328766 ; ENSP00000331662 ; ENSG00000184867 .
ENST00000330154 ; ENSP00000328631 ; ENSG00000184867 .
ENST00000356824 ; ENSP00000349281 ; ENSG00000184867 .
ENST00000440675 ; ENSP00000393778 ; ENSG00000184867 .
ENST00000596872 ; ENSP00000468899 ; ENSG00000268151 .
ENST00000597565 ; ENSP00000470751 ; ENSG00000268151 .
ENST00000597913 ; ENSP00000469815 ; ENSG00000268151 .
ENST00000600085 ; ENSP00000473195 ; ENSG00000268151 .
GeneIDi 9823.
KEGGi hsa:9823.
UCSCi uc004eid.2. human.

Organism-specific databases

CTDi 9823.
GeneCardsi GC0XM100910.
HGNCi HGNC:16869. ARMCX2.
HPAi HPA005761.
MIMi 300363. gene.
neXtProti NX_Q7L311.
PharmGKBi PA134985862.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46779.
HOGENOMi HOG000231611.
HOVERGENi HBG057677.
InParanoidi Q7L311.
OMAi WYCVYKY.
PhylomeDBi Q7L311.
TreeFami TF335652.

Miscellaneous databases

GenomeRNAii 9823.
NextBioi 36996.
PROi Q7L311.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q7L311.
Bgeei Q7L311.
CleanExi HS_ARMCX2.
Genevestigatori Q7L311.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR006911. ARM-rpt_dom.
IPR016024. ARM-type_fold.
[Graphical view ]
Pfami PF04826. Arm_2. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta and Skin.
  4. "ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas."
    Kurochkin I.V., Yonemitsu N., Funahashi S., Nomura H.
    Biochem. Biophys. Res. Commun. 280:340-347(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiARMX2_HUMAN
AccessioniPrimary (citable) accession number: Q7L311
Secondary accession number(s): O60267, Q5H9D9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi