Q7L311 (ARMX2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Armadillo repeat-containing X-linked protein 2

Alternative name(s):
ARM protein lost in epithelial cancers on chromosome X 2
Short name=Protein ALEX2

Gene names

Name:	ARMCX2
Synonyms:	ALEX2, KIAA0512

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	632 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Tissue specificity	Expressed at high levels ovary, heart, testis, prostate, brain, spleen and colon. Expressed at very low levels in liver and thymus. Not expressed in peripheral blood leukocytes. Not expressed in pancreas and ovarian carcinomas. Ref.4
Sequence similarities	Contains 3 ARM repeats.
Sequence caution	The sequence BAA25438.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Membrane
Domain	Repeat Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 632	632	Armadillo repeat-containing X-linked protein 2		PRO_0000191364
Regions
	Transmembrane	7 – 25	19	Helical; Potential
	Repeat	376 – 416	41	ARM 1
	Repeat	418 – 457	40	ARM 2
	Repeat	498 – 537	40	ARM 3
	Compositional bias	77 – 277	201	Ala-rich

Sequences

	Sequence		Length	Mass (Da)
	Q7L311 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 7627CBFFE61C329B	FASTA	632	65,683
	10 20 30 40 50 60 MSRVRDAGCV AAGIVIGAGA WYCVYKYTRG RDQTKKRMAK PKNRAVAGTG ARARAGLRAG 70 80 90 100 110 120 FTIDLGSGFS PPTPVRAEAE DRAQDEASAL DTVGAEAVAP AASSAEAQSG AGSQAQEADG 130 140 150 160 170 180 AGVGPKAESV VGAAMASAIA PPPGVTEALG AAEAPAMAGA PKVAEAPREA ETSRAAVPPG 190 200 210 220 230 240 TVVPTEAAAP TEVTEGPGVA APTKVAEAPG VASPTEAAEA PVPATPTGAA APTGAAESPG 250 260 270 280 290 300 TSGSPRTAVV PGTSAAKKAT PGAHTGAIPK ATSATGAVPK GGGKGVTRSR NGGKGKGKKS 310 320 330 340 350 360 KVEVDELGMG FRPGDGAAAA AAASANGGQA FLAEVPDSEE GESGWTDTES DSDSEPETQR 370 380 390 400 410 420 RGRGRRPVAM QKRPFPYEID EILGVRDLRK VLALLQKSDD PFIQQVALLT LSNNANYSCN 430 440 450 460 470 480 QETIRKLGGL PIIANMINKT DPHIKEKALM AMNNLSENYE NQGRLQVYMN KVMDDIMASN 490 500 510 520 530 540 LNSAVQVVGL KFLTNMTITN DYQHLLVNSI ANFFRLLSQG GGKIKVEILK ILSNFAENPD 550 560 570 580 590 600 MLKKLLSTQV PASFSSLYNS YVESEILINA LTLFEIIYDN LRAEVFNYRE FNKGSLFYLC 610 620 630 TTSGVCVKKI RALANHHDLL VKVKVIKLVN KF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta and Skin.
[4]	"ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas." Kurochkin I.V., Yonemitsu N., Funahashi S., Nomura H. Biochem. Biophys. Res. Commun. 280:340-347(2001) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB011084 mRNA. Translation: BAA25438.2. Different initiation. Z83131 Genomic DNA. Translation: CAI42019.1. Z83131 Genomic DNA. Translation: CAI42022.1. BC012541 mRNA. Translation: AAH12541.1. BC015926 mRNA. Translation: AAH15926.1.
IPI	IPI00006142.
PIR	T00084.
RefSeq	NP_055597.1. NM_014782.5. NP_808818.1. NM_177949.2.
UniGene	Hs.48924.
3D structure databases
ProteinModelPortal	Q7L311.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q7L311. 2 interactions.
MINT	MINT-3980369.
STRING	9606.ENSP00000328631.
PTM databases
PhosphoSite	Q7L311.
Polymorphism databases
DMDM	74759000.
Proteomic databases
PaxDb	Q7L311.
PRIDE	Q7L311.
Protocols and materials databases
DNASU	9823.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000328766; ENSP00000331662; ENSG00000184867. ENST00000330154; ENSP00000328631; ENSG00000184867. ENST00000356824; ENSP00000349281; ENSG00000184867. ENST00000440675; ENSP00000393778; ENSG00000184867. ENST00000596872; ENSP00000468899; ENSG00000268151. ENST00000597565; ENSP00000470751; ENSG00000268151. ENST00000597913; ENSP00000469815; ENSG00000268151. ENST00000600085; ENSP00000473195; ENSG00000268151.
GeneID	9823.
KEGG	hsa:9823.
UCSC	uc004eid.2. human.
Organism-specific databases
CTD	9823.
GeneCards	GC0XM100910.
HGNC	HGNC:16869. ARMCX2.
HPA	HPA005761.
MIM	300363. gene.
neXtProt	NX_Q7L311.
PharmGKB	PA134985862.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG46779.
HOGENOM	HOG000231611.
HOVERGEN	HBG057677.
InParanoid	Q7L311.
OMA	WYCVYKY.
OrthoDB	EOG4BRWKX.
PhylomeDB	Q7L311.
Gene expression databases
ArrayExpress	Q7L311.
Bgee	Q7L311.
CleanEx	HS_ARMCX2.
Genevestigator	Q7L311.
GermOnline	ENSG00000184867. Homo sapiens.
Family and domain databases
Gene3D	1.25.10.10. 1 hit.
InterPro	IPR011989. ARM-like. IPR006911. ARM-rpt_dom. IPR016024. ARM-type_fold. [Graphical view]
Pfam	PF04826. Arm_2. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit.
PROSITE	PS50176. ARM_REPEAT. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	9823.
NextBio	36996.
SOURCE	Search...

Entry information

Entry name

ARMX2_HUMAN

Accession

Primary (citable) accession number: Q7L311
Secondary accession number(s): O60267, Q5H9D9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.