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Protein

Armadillo repeat-containing X-linked protein 2

Gene

ARMCX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May regulate the dynamics and distribution of mitochondria in neural cells.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo repeat-containing X-linked protein 2
Alternative name(s):
ARM protein lost in epithelial cancers on chromosome X 2
Short name:
Protein ALEX2
Gene namesi
Name:ARMCX2
Synonyms:ALEX2, KIAA0512
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000184867.13.
HGNCiHGNC:16869. ARMCX2.
MIMi300363. gene.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6Mitochondrial intermembraneBy similarity6
Transmembranei7 – 25Helical; Signal-anchorSequence analysisAdd BLAST19
Topological domaini26 – 632CytoplasmicBy similarityAdd BLAST607

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000184867.
PharmGKBiPA134985862.

Polymorphism and mutation databases

DMDMi74759000.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001913641 – 632Armadillo repeat-containing X-linked protein 2Add BLAST632

Proteomic databases

EPDiQ7L311.
MaxQBiQ7L311.
PaxDbiQ7L311.
PeptideAtlasiQ7L311.
PRIDEiQ7L311.

PTM databases

iPTMnetiQ7L311.
PhosphoSitePlusiQ7L311.

Expressioni

Tissue specificityi

Expressed at high levels ovary, heart, testis, prostate, brain, spleen and colon. Expressed at very low levels in liver and thymus. Not expressed in peripheral blood leukocytes. Not expressed in pancreas and ovarian carcinomas.1 Publication

Gene expression databases

BgeeiENSG00000184867.
CleanExiHS_ARMCX2.
ExpressionAtlasiQ7L311. baseline and differential.
GenevisibleiQ7L311. HS.

Organism-specific databases

HPAiHPA005761.

Interactioni

Protein-protein interaction databases

BioGridi115161. 3 interactors.
IntActiQ7L311. 2 interactors.
MINTiMINT-3980369.
STRINGi9606.ENSP00000328631.

Structurei

3D structure databases

ProteinModelPortaliQ7L311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati376 – 416ARM 1Sequence analysisAdd BLAST41
Repeati418 – 457ARM 2Sequence analysisAdd BLAST40
Repeati498 – 537ARM 3Sequence analysisAdd BLAST40

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 6Mitochondrion outer membrane (MOM)-targeting sequenceCurated6
Regioni26 – 40Mitochondrion outer membrane (MOM)-targeting sequenceCuratedAdd BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi77 – 277Ala-richAdd BLAST201

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ18. Eukaryota.
ENOG41116WA. LUCA.
GeneTreeiENSGT00550000074488.
HOGENOMiHOG000231611.
HOVERGENiHBG057677.
InParanoidiQ7L311.
OMAiVIGASAW.
OrthoDBiEOG091G0PCU.
PhylomeDBiQ7L311.
TreeFamiTF335652.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiView protein in InterPro
IPR011989. ARM-like.
IPR006911. ARM-rpt_dom.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
PfamiView protein in Pfam
PF04826. Arm_2. 1 hit.
SMARTiView protein in SMART
SM00185. ARM. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7L311-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRVRDAGCV AAGIVIGAGA WYCVYKYTRG RDQTKKRMAK PKNRAVAGTG
60 70 80 90 100
ARARAGLRAG FTIDLGSGFS PPTPVRAEAE DRAQDEASAL DTVGAEAVAP
110 120 130 140 150
AASSAEAQSG AGSQAQEADG AGVGPKAESV VGAAMASAIA PPPGVTEALG
160 170 180 190 200
AAEAPAMAGA PKVAEAPREA ETSRAAVPPG TVVPTEAAAP TEVTEGPGVA
210 220 230 240 250
APTKVAEAPG VASPTEAAEA PVPATPTGAA APTGAAESPG TSGSPRTAVV
260 270 280 290 300
PGTSAAKKAT PGAHTGAIPK ATSATGAVPK GGGKGVTRSR NGGKGKGKKS
310 320 330 340 350
KVEVDELGMG FRPGDGAAAA AAASANGGQA FLAEVPDSEE GESGWTDTES
360 370 380 390 400
DSDSEPETQR RGRGRRPVAM QKRPFPYEID EILGVRDLRK VLALLQKSDD
410 420 430 440 450
PFIQQVALLT LSNNANYSCN QETIRKLGGL PIIANMINKT DPHIKEKALM
460 470 480 490 500
AMNNLSENYE NQGRLQVYMN KVMDDIMASN LNSAVQVVGL KFLTNMTITN
510 520 530 540 550
DYQHLLVNSI ANFFRLLSQG GGKIKVEILK ILSNFAENPD MLKKLLSTQV
560 570 580 590 600
PASFSSLYNS YVESEILINA LTLFEIIYDN LRAEVFNYRE FNKGSLFYLC
610 620 630
TTSGVCVKKI RALANHHDLL VKVKVIKLVN KF
Length:632
Mass (Da):65,683
Last modified:July 5, 2004 - v1
Checksum:i7627CBFFE61C329B
GO

Sequence cautioni

The sequence BAA25438 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011084 mRNA. Translation: BAA25438.2. Different initiation.
Z83131 Genomic DNA. Translation: CAI42019.1.
Z83131 Genomic DNA. Translation: CAI42022.1.
BC012541 mRNA. Translation: AAH12541.1.
BC015926 mRNA. Translation: AAH15926.1.
CCDSiCCDS14490.1.
PIRiT00084.
RefSeqiNP_001269160.1. NM_001282231.1.
NP_055597.1. NM_014782.6.
NP_808818.1. NM_177949.3.
XP_005278166.1. XM_005278109.1.
XP_005278167.1. XM_005278110.1.
XP_005278168.1. XM_005278111.1.
XP_005278170.1. XM_005278113.1.
XP_005278171.1. XM_005278114.1.
XP_005278172.1. XM_005278115.1.
XP_005278173.1. XM_005278116.1.
XP_005278174.1. XM_005278117.1.
XP_011529373.1. XM_011531071.1.
XP_011529374.1. XM_011531072.1.
XP_016885476.1. XM_017029987.1.
XP_016885477.1. XM_017029988.1.
XP_016885478.1. XM_017029989.1.
XP_016885479.1. XM_017029990.1.
XP_016885480.1. XM_017029991.1.
XP_016885481.1. XM_017029992.1.
XP_016885482.1. XM_017029993.1.
XP_016885483.1. XM_017029994.1.
XP_016885484.1. XM_017029995.1.
XP_016885485.1. XM_017029996.1.
XP_016885486.1. XM_017029997.1.
UniGeneiHs.48924.

Genome annotation databases

EnsembliENST00000328766; ENSP00000331662; ENSG00000184867.
ENST00000330154; ENSP00000328631; ENSG00000184867.
ENST00000356824; ENSP00000349281; ENSG00000184867.
GeneIDi9823.
KEGGihsa:9823.
UCSCiuc004eid.3. human.

Similar proteinsi

Entry informationi

Entry nameiARMX2_HUMAN
AccessioniPrimary (citable) accession number: Q7L311
Secondary accession number(s): O60267, Q5H9D9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 5, 2004
Last modified: November 22, 2017
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families