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Q7L311 (ARMX2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Armadillo repeat-containing X-linked protein 2
Alternative name(s):
ARM protein lost in epithelial cancers on chromosome X 2
Short name=Protein ALEX2
Gene names
Name:ARMCX2
Synonyms:ALEX2, KIAA0512
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length632 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Single-pass membrane protein Potential.

Tissue specificity

Expressed at high levels ovary, heart, testis, prostate, brain, spleen and colon. Expressed at very low levels in liver and thymus. Not expressed in peripheral blood leukocytes. Not expressed in pancreas and ovarian carcinomas. Ref.4

Sequence similarities

Contains 3 ARM repeats.

Sequence caution

The sequence BAA25438.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentMembrane
   DomainRepeat
Transmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 632632Armadillo repeat-containing X-linked protein 2
PRO_0000191364

Regions

Transmembrane7 – 2519Helical; Potential
Repeat376 – 41641ARM 1
Repeat418 – 45740ARM 2
Repeat498 – 53740ARM 3
Compositional bias77 – 277201Ala-rich

Sequences

Sequence LengthMass (Da)Tools
Q7L311 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 7627CBFFE61C329B

FASTA63265,683
        10         20         30         40         50         60 
MSRVRDAGCV AAGIVIGAGA WYCVYKYTRG RDQTKKRMAK PKNRAVAGTG ARARAGLRAG 

        70         80         90        100        110        120 
FTIDLGSGFS PPTPVRAEAE DRAQDEASAL DTVGAEAVAP AASSAEAQSG AGSQAQEADG 

       130        140        150        160        170        180 
AGVGPKAESV VGAAMASAIA PPPGVTEALG AAEAPAMAGA PKVAEAPREA ETSRAAVPPG 

       190        200        210        220        230        240 
TVVPTEAAAP TEVTEGPGVA APTKVAEAPG VASPTEAAEA PVPATPTGAA APTGAAESPG 

       250        260        270        280        290        300 
TSGSPRTAVV PGTSAAKKAT PGAHTGAIPK ATSATGAVPK GGGKGVTRSR NGGKGKGKKS 

       310        320        330        340        350        360 
KVEVDELGMG FRPGDGAAAA AAASANGGQA FLAEVPDSEE GESGWTDTES DSDSEPETQR 

       370        380        390        400        410        420 
RGRGRRPVAM QKRPFPYEID EILGVRDLRK VLALLQKSDD PFIQQVALLT LSNNANYSCN 

       430        440        450        460        470        480 
QETIRKLGGL PIIANMINKT DPHIKEKALM AMNNLSENYE NQGRLQVYMN KVMDDIMASN 

       490        500        510        520        530        540 
LNSAVQVVGL KFLTNMTITN DYQHLLVNSI ANFFRLLSQG GGKIKVEILK ILSNFAENPD 

       550        560        570        580        590        600 
MLKKLLSTQV PASFSSLYNS YVESEILINA LTLFEIIYDN LRAEVFNYRE FNKGSLFYLC 

       610        620        630 
TTSGVCVKKI RALANHHDLL VKVKVIKLVN KF 

« Hide

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta and Skin.
[4]"ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas."
Kurochkin I.V., Yonemitsu N., Funahashi S., Nomura H.
Biochem. Biophys. Res. Commun. 280:340-347(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB011084 mRNA. Translation: BAA25438.2. Different initiation.
Z83131 Genomic DNA. Translation: CAI42019.1.
Z83131 Genomic DNA. Translation: CAI42022.1.
BC012541 mRNA. Translation: AAH12541.1.
BC015926 mRNA. Translation: AAH15926.1.
CCDSCCDS14490.1.
PIRT00084.
RefSeqNP_001269160.1. NM_001282231.1.
NP_055597.1. NM_014782.6.
NP_808818.1. NM_177949.3.
XP_005278166.1. XM_005278109.1.
XP_005278167.1. XM_005278110.1.
XP_005278168.1. XM_005278111.1.
XP_005278170.1. XM_005278113.1.
XP_005278171.1. XM_005278114.1.
XP_005278172.1. XM_005278115.1.
XP_005278173.1. XM_005278116.1.
XP_005278174.1. XM_005278117.1.
UniGeneHs.48924.

3D structure databases

ProteinModelPortalQ7L311.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115161. 4 interactions.
IntActQ7L311. 2 interactions.
MINTMINT-3980369.
STRING9606.ENSP00000328631.

PTM databases

PhosphoSiteQ7L311.

Polymorphism databases

DMDM74759000.

Proteomic databases

MaxQBQ7L311.
PaxDbQ7L311.
PRIDEQ7L311.

Protocols and materials databases

DNASU9823.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000328766; ENSP00000331662; ENSG00000184867.
ENST00000330154; ENSP00000328631; ENSG00000184867.
ENST00000356824; ENSP00000349281; ENSG00000184867.
ENST00000440675; ENSP00000393778; ENSG00000184867.
ENST00000596872; ENSP00000468899; ENSG00000268151.
ENST00000597565; ENSP00000470751; ENSG00000268151.
ENST00000597913; ENSP00000469815; ENSG00000268151.
ENST00000600085; ENSP00000473195; ENSG00000268151.
GeneID9823.
KEGGhsa:9823.
UCSCuc004eid.2. human.

Organism-specific databases

CTD9823.
GeneCardsGC0XM100910.
HGNCHGNC:16869. ARMCX2.
HPAHPA005761.
MIM300363. gene.
neXtProtNX_Q7L311.
PharmGKBPA134985862.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG46779.
HOGENOMHOG000231611.
HOVERGENHBG057677.
InParanoidQ7L311.
OMAWYCVYKY.
PhylomeDBQ7L311.
TreeFamTF335652.

Gene expression databases

ArrayExpressQ7L311.
BgeeQ7L311.
CleanExHS_ARMCX2.
GenevestigatorQ7L311.

Family and domain databases

Gene3D1.25.10.10. 1 hit.
InterProIPR011989. ARM-like.
IPR006911. ARM-rpt_dom.
IPR016024. ARM-type_fold.
[Graphical view]
PfamPF04826. Arm_2. 1 hit.
[Graphical view]
SUPFAMSSF48371. SSF48371. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi9823.
NextBio36996.
PROQ7L311.
SOURCESearch...

Entry information

Entry nameARMX2_HUMAN
AccessionPrimary (citable) accession number: Q7L311
Secondary accession number(s): O60267, Q5H9D9
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM