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Q7L311

- ARMX2_HUMAN

UniProt

Q7L311 - ARMX2_HUMAN

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Protein

Armadillo repeat-containing X-linked protein 2

Gene

ARMCX2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo repeat-containing X-linked protein 2
Alternative name(s):
ARM protein lost in epithelial cancers on chromosome X 2
Short name:
Protein ALEX2
Gene namesi
Name:ARMCX2
Synonyms:ALEX2, KIAA0512
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:16869. ARMCX2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134985862.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 632632Armadillo repeat-containing X-linked protein 2PRO_0000191364Add
BLAST

Proteomic databases

MaxQBiQ7L311.
PaxDbiQ7L311.
PRIDEiQ7L311.

PTM databases

PhosphoSiteiQ7L311.

Expressioni

Tissue specificityi

Expressed at high levels ovary, heart, testis, prostate, brain, spleen and colon. Expressed at very low levels in liver and thymus. Not expressed in peripheral blood leukocytes. Not expressed in pancreas and ovarian carcinomas.1 Publication

Gene expression databases

BgeeiQ7L311.
CleanExiHS_ARMCX2.
ExpressionAtlasiQ7L311. baseline and differential.
GenevestigatoriQ7L311.

Organism-specific databases

HPAiHPA005761.

Interactioni

Protein-protein interaction databases

BioGridi115161. 4 interactions.
IntActiQ7L311. 2 interactions.
MINTiMINT-3980369.
STRINGi9606.ENSP00000328631.

Structurei

3D structure databases

ProteinModelPortaliQ7L311.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2519HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati376 – 41641ARM 1Add
BLAST
Repeati418 – 45740ARM 2Add
BLAST
Repeati498 – 53740ARM 3Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi77 – 277201Ala-richAdd
BLAST

Sequence similaritiesi

Contains 3 ARM repeats.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46779.
GeneTreeiENSGT00550000074488.
HOGENOMiHOG000231611.
HOVERGENiHBG057677.
InParanoidiQ7L311.
OMAiWYCVYKY.
PhylomeDBiQ7L311.
TreeFamiTF335652.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR006911. ARM-rpt_dom.
IPR016024. ARM-type_fold.
[Graphical view]
PfamiPF04826. Arm_2. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7L311-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRVRDAGCV AAGIVIGAGA WYCVYKYTRG RDQTKKRMAK PKNRAVAGTG
60 70 80 90 100
ARARAGLRAG FTIDLGSGFS PPTPVRAEAE DRAQDEASAL DTVGAEAVAP
110 120 130 140 150
AASSAEAQSG AGSQAQEADG AGVGPKAESV VGAAMASAIA PPPGVTEALG
160 170 180 190 200
AAEAPAMAGA PKVAEAPREA ETSRAAVPPG TVVPTEAAAP TEVTEGPGVA
210 220 230 240 250
APTKVAEAPG VASPTEAAEA PVPATPTGAA APTGAAESPG TSGSPRTAVV
260 270 280 290 300
PGTSAAKKAT PGAHTGAIPK ATSATGAVPK GGGKGVTRSR NGGKGKGKKS
310 320 330 340 350
KVEVDELGMG FRPGDGAAAA AAASANGGQA FLAEVPDSEE GESGWTDTES
360 370 380 390 400
DSDSEPETQR RGRGRRPVAM QKRPFPYEID EILGVRDLRK VLALLQKSDD
410 420 430 440 450
PFIQQVALLT LSNNANYSCN QETIRKLGGL PIIANMINKT DPHIKEKALM
460 470 480 490 500
AMNNLSENYE NQGRLQVYMN KVMDDIMASN LNSAVQVVGL KFLTNMTITN
510 520 530 540 550
DYQHLLVNSI ANFFRLLSQG GGKIKVEILK ILSNFAENPD MLKKLLSTQV
560 570 580 590 600
PASFSSLYNS YVESEILINA LTLFEIIYDN LRAEVFNYRE FNKGSLFYLC
610 620 630
TTSGVCVKKI RALANHHDLL VKVKVIKLVN KF
Length:632
Mass (Da):65,683
Last modified:July 5, 2004 - v1
Checksum:i7627CBFFE61C329B
GO

Sequence cautioni

The sequence BAA25438.2 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB011084 mRNA. Translation: BAA25438.2. Different initiation.
Z83131 Genomic DNA. Translation: CAI42019.1.
Z83131 Genomic DNA. Translation: CAI42022.1.
BC012541 mRNA. Translation: AAH12541.1.
BC015926 mRNA. Translation: AAH15926.1.
CCDSiCCDS14490.1.
PIRiT00084.
RefSeqiNP_001269160.1. NM_001282231.1.
NP_055597.1. NM_014782.6.
NP_808818.1. NM_177949.3.
XP_005278166.1. XM_005278109.1.
XP_005278167.1. XM_005278110.1.
XP_005278168.1. XM_005278111.1.
XP_005278170.1. XM_005278113.1.
XP_005278171.1. XM_005278114.1.
XP_005278172.1. XM_005278115.1.
XP_005278173.1. XM_005278116.1.
XP_005278174.1. XM_005278117.1.
UniGeneiHs.48924.

Genome annotation databases

EnsembliENST00000328766; ENSP00000331662; ENSG00000184867.
ENST00000330154; ENSP00000328631; ENSG00000184867.
ENST00000356824; ENSP00000349281; ENSG00000184867.
ENST00000440675; ENSP00000393778; ENSG00000184867.
GeneIDi9823.
KEGGihsa:9823.
UCSCiuc004eid.2. human.

Polymorphism databases

DMDMi74759000.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB011084 mRNA. Translation: BAA25438.2 . Different initiation.
Z83131 Genomic DNA. Translation: CAI42019.1 .
Z83131 Genomic DNA. Translation: CAI42022.1 .
BC012541 mRNA. Translation: AAH12541.1 .
BC015926 mRNA. Translation: AAH15926.1 .
CCDSi CCDS14490.1.
PIRi T00084.
RefSeqi NP_001269160.1. NM_001282231.1.
NP_055597.1. NM_014782.6.
NP_808818.1. NM_177949.3.
XP_005278166.1. XM_005278109.1.
XP_005278167.1. XM_005278110.1.
XP_005278168.1. XM_005278111.1.
XP_005278170.1. XM_005278113.1.
XP_005278171.1. XM_005278114.1.
XP_005278172.1. XM_005278115.1.
XP_005278173.1. XM_005278116.1.
XP_005278174.1. XM_005278117.1.
UniGenei Hs.48924.

3D structure databases

ProteinModelPortali Q7L311.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115161. 4 interactions.
IntActi Q7L311. 2 interactions.
MINTi MINT-3980369.
STRINGi 9606.ENSP00000328631.

PTM databases

PhosphoSitei Q7L311.

Polymorphism databases

DMDMi 74759000.

Proteomic databases

MaxQBi Q7L311.
PaxDbi Q7L311.
PRIDEi Q7L311.

Protocols and materials databases

DNASUi 9823.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000328766 ; ENSP00000331662 ; ENSG00000184867 .
ENST00000330154 ; ENSP00000328631 ; ENSG00000184867 .
ENST00000356824 ; ENSP00000349281 ; ENSG00000184867 .
ENST00000440675 ; ENSP00000393778 ; ENSG00000184867 .
GeneIDi 9823.
KEGGi hsa:9823.
UCSCi uc004eid.2. human.

Organism-specific databases

CTDi 9823.
GeneCardsi GC0XM100910.
HGNCi HGNC:16869. ARMCX2.
HPAi HPA005761.
MIMi 300363. gene.
neXtProti NX_Q7L311.
PharmGKBi PA134985862.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46779.
GeneTreei ENSGT00550000074488.
HOGENOMi HOG000231611.
HOVERGENi HBG057677.
InParanoidi Q7L311.
OMAi WYCVYKY.
PhylomeDBi Q7L311.
TreeFami TF335652.

Miscellaneous databases

GenomeRNAii 9823.
NextBioi 36996.
PROi Q7L311.
SOURCEi Search...

Gene expression databases

Bgeei Q7L311.
CleanExi HS_ARMCX2.
ExpressionAtlasi Q7L311. baseline and differential.
Genevestigatori Q7L311.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR006911. ARM-rpt_dom.
IPR016024. ARM-type_fold.
[Graphical view ]
Pfami PF04826. Arm_2. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta and Skin.
  4. "ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas."
    Kurochkin I.V., Yonemitsu N., Funahashi S., Nomura H.
    Biochem. Biophys. Res. Commun. 280:340-347(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiARMX2_HUMAN
AccessioniPrimary (citable) accession number: Q7L311
Secondary accession number(s): O60267, Q5H9D9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3