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Q7L2Z9

- CENPQ_HUMAN

UniProt

Q7L2Z9 - CENPQ_HUMAN

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Protein

Centromere protein Q

Gene

CENPQ

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.1 Publication

GO - Biological processi

  1. CENP-A containing nucleosome assembly Source: Reactome
  2. mitotic cell cycle Source: Reactome
  3. nucleosome assembly Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_150425. Resolution of Sister Chromatid Cohesion.
REACT_150471. Separation of Sister Chromatids.
REACT_22186. Deposition of new CENPA-containing nucleosomes at the centromere.
REACT_682. Mitotic Prometaphase.

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere protein Q
Short name:
CENP-Q
Gene namesi
Name:CENPQ
Synonyms:C6orf139
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:21347. CENPQ.

Subcellular locationi

Nucleus 1 Publication. Chromosomecentromere 1 Publication
Note: Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.

GO - Cellular componenti

  1. chromosome, centromeric region Source: UniProtKB-KW
  2. cytoplasm Source: HPA
  3. cytosol Source: Reactome
  4. intermediate filament cytoskeleton Source: HPA
  5. nucleolus Source: HPA
  6. nucleoplasm Source: Reactome
  7. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134973276.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 268268Centromere protein QPRO_0000089534Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei31 – 311Phosphoserine1 Publication
Modified residuei50 – 501Phosphoserine1 Publication
Modified residuei249 – 2491Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ7L2Z9.
PaxDbiQ7L2Z9.
PRIDEiQ7L2Z9.

PTM databases

PhosphoSiteiQ7L2Z9.

Expressioni

Gene expression databases

BgeeiQ7L2Z9.
CleanExiHS_CENPQ.
GenevestigatoriQ7L2Z9.

Organism-specific databases

HPAiHPA046634.
HPA054965.

Interactioni

Subunit structurei

Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU.2 Publications

Protein-protein interaction databases

BioGridi120466. 12 interactions.
IntActiQ7L2Z9. 2 interactions.
MINTiMINT-4994384.
STRINGi9606.ENSP00000337289.

Structurei

3D structure databases

ProteinModelPortaliQ7L2Z9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili170 – 20637Sequence AnalysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG46012.
GeneTreeiENSGT00390000005599.
HOGENOMiHOG000111544.
HOVERGENiHBG081088.
InParanoidiQ7L2Z9.
KOiK11509.
OMAiNMLTFIE.
OrthoDBiEOG74XS8H.
PhylomeDBiQ7L2Z9.
TreeFamiTF336238.

Family and domain databases

InterProiIPR025212. CAD_CENP-Q.
[Graphical view]
PfamiPF13094. CENP-Q. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7L2Z9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGKANASKK NAQQLKRNPK RKKDNEEVVL SENKVRNTVK KNKNHLKDLS
60 70 80 90 100
SEGQTKHTNL KHGKTAASKR KTWQPLSKST RDHLQTMMES VIMTILSNSI
110 120 130 140 150
KEKEEIQYHL NFLKKRLLQQ CETLKVPPKK MEDLTNVSSL LNMERARDKA
160 170 180 190 200
NEEGLALLQE EIDKMVETTE LMTGNIQSLK NKIQILASEV EEEEERVKQM
210 220 230 240 250
HQINSSGVLS LPELSQKTLK APTLQKEILA LIPNQNALLK DLDILHNSSQ
260
MKSMSTFIEE AYKKLDAS
Length:268
Mass (Da):30,595
Last modified:July 5, 2004 - v1
Checksum:i5B3735279287B3E8
GO

Sequence cautioni

The sequence BAA91672.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti63 – 631G → R.
Corresponds to variant rs4267943 [ dbSNP | Ensembl ].
VAR_022857
Natural varianti266 – 2661D → G.
Corresponds to variant rs2501968 [ dbSNP | Ensembl ].
VAR_024303

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001407 mRNA. Translation: BAA91672.1. Different initiation.
AK293016 mRNA. Translation: BAF85705.1.
AL590244, AL590668 Genomic DNA. Translation: CAI13088.1.
AL590668, AL590244 Genomic DNA. Translation: CAI14313.1.
BC016279 mRNA. Translation: AAH16279.2.
CCDSiCCDS4925.1.
RefSeqiNP_060602.2. NM_018132.3.
XP_005249262.1. XM_005249205.1.
UniGeneiHs.88663.

Genome annotation databases

EnsembliENST00000335783; ENSP00000337289; ENSG00000031691.
GeneIDi55166.
KEGGihsa:55166.
UCSCiuc003ozh.1. human.

Polymorphism databases

DMDMi68565184.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001407 mRNA. Translation: BAA91672.1 . Different initiation.
AK293016 mRNA. Translation: BAF85705.1 .
AL590244 , AL590668 Genomic DNA. Translation: CAI13088.1 .
AL590668 , AL590244 Genomic DNA. Translation: CAI14313.1 .
BC016279 mRNA. Translation: AAH16279.2 .
CCDSi CCDS4925.1.
RefSeqi NP_060602.2. NM_018132.3.
XP_005249262.1. XM_005249205.1.
UniGenei Hs.88663.

3D structure databases

ProteinModelPortali Q7L2Z9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120466. 12 interactions.
IntActi Q7L2Z9. 2 interactions.
MINTi MINT-4994384.
STRINGi 9606.ENSP00000337289.

PTM databases

PhosphoSitei Q7L2Z9.

Polymorphism databases

DMDMi 68565184.

Proteomic databases

MaxQBi Q7L2Z9.
PaxDbi Q7L2Z9.
PRIDEi Q7L2Z9.

Protocols and materials databases

DNASUi 55166.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000335783 ; ENSP00000337289 ; ENSG00000031691 .
GeneIDi 55166.
KEGGi hsa:55166.
UCSCi uc003ozh.1. human.

Organism-specific databases

CTDi 55166.
GeneCardsi GC06P049431.
HGNCi HGNC:21347. CENPQ.
HPAi HPA046634.
HPA054965.
MIMi 611506. gene.
neXtProti NX_Q7L2Z9.
PharmGKBi PA134973276.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46012.
GeneTreei ENSGT00390000005599.
HOGENOMi HOG000111544.
HOVERGENi HBG081088.
InParanoidi Q7L2Z9.
KOi K11509.
OMAi NMLTFIE.
OrthoDBi EOG74XS8H.
PhylomeDBi Q7L2Z9.
TreeFami TF336238.

Enzyme and pathway databases

Reactomei REACT_150425. Resolution of Sister Chromatid Cohesion.
REACT_150471. Separation of Sister Chromatids.
REACT_22186. Deposition of new CENPA-containing nucleosomes at the centromere.
REACT_682. Mitotic Prometaphase.

Miscellaneous databases

ChiTaRSi CENPQ. human.
GenomeRNAii 55166.
NextBioi 58937.
PROi Q7L2Z9.
SOURCEi Search...

Gene expression databases

Bgeei Q7L2Z9.
CleanExi HS_CENPQ.
Genevestigatori Q7L2Z9.

Family and domain databases

InterProi IPR025212. CAD_CENP-Q.
[Graphical view ]
Pfami PF13094. CENP-Q. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Stomach and Teratocarcinoma.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  4. "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres."
    Okada M., Cheeseman I.M., Hori T., Okawa K., McLeod I.X., Yates J.R. III, Desai A., Fukagawa T.
    Nat. Cell Biol. 8:446-457(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN A COMPLEX WITH CENPH; CENPI; CENPK; CENPN; CENPO; CENPP; CENPR AND CENPU, FUNCTION, SUBCELLULAR LOCATION.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE CENPA-CAD COMPLEX WITH CENPI; CENPK; CENPL; CENPO; CENPP; CENPR AND CENPS.
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31 AND SER-249, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCENPQ_HUMAN
AccessioniPrimary (citable) accession number: Q7L2Z9
Secondary accession number(s): A8KAF1, Q6IN61, Q9NVS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3