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Q7L2Z9

- CENPQ_HUMAN

UniProt

Q7L2Z9 - CENPQ_HUMAN

Protein

Centromere protein Q

Gene

CENPQ

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.1 Publication

    GO - Biological processi

    1. CENP-A containing nucleosome assembly Source: Reactome
    2. mitotic cell cycle Source: Reactome
    3. nucleosome assembly Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_150425. Resolution of Sister Chromatid Cohesion.
    REACT_150471. Separation of Sister Chromatids.
    REACT_22186. Deposition of new CENPA-containing nucleosomes at the centromere.
    REACT_682. Mitotic Prometaphase.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Centromere protein Q
    Short name:
    CENP-Q
    Gene namesi
    Name:CENPQ
    Synonyms:C6orf139
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:21347. CENPQ.

    Subcellular locationi

    Nucleus 1 Publication. Chromosomecentromere 1 Publication
    Note: Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.

    GO - Cellular componenti

    1. chromosome, centromeric region Source: UniProtKB-SubCell
    2. cytoplasm Source: HPA
    3. cytosol Source: Reactome
    4. intermediate filament cytoskeleton Source: HPA
    5. nucleolus Source: HPA
    6. nucleoplasm Source: Reactome
    7. nucleus Source: HPA

    Keywords - Cellular componenti

    Centromere, Chromosome, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134973276.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 268268Centromere protein QPRO_0000089534Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei31 – 311Phosphoserine1 Publication
    Modified residuei50 – 501Phosphoserine1 Publication
    Modified residuei249 – 2491Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ7L2Z9.
    PaxDbiQ7L2Z9.
    PRIDEiQ7L2Z9.

    PTM databases

    PhosphoSiteiQ7L2Z9.

    Expressioni

    Gene expression databases

    BgeeiQ7L2Z9.
    CleanExiHS_CENPQ.
    GenevestigatoriQ7L2Z9.

    Organism-specific databases

    HPAiHPA046634.
    HPA054965.

    Interactioni

    Subunit structurei

    Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU.2 Publications

    Protein-protein interaction databases

    BioGridi120466. 11 interactions.
    IntActiQ7L2Z9. 2 interactions.
    MINTiMINT-4994384.
    STRINGi9606.ENSP00000337289.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7L2Z9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili170 – 20637Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG46012.
    HOGENOMiHOG000111544.
    HOVERGENiHBG081088.
    InParanoidiQ7L2Z9.
    KOiK11509.
    OMAiNMLTFIE.
    OrthoDBiEOG74XS8H.
    PhylomeDBiQ7L2Z9.
    TreeFamiTF336238.

    Family and domain databases

    InterProiIPR025212. CAD_CENP-Q.
    [Graphical view]
    PfamiPF13094. CENP-Q. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7L2Z9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGKANASKK NAQQLKRNPK RKKDNEEVVL SENKVRNTVK KNKNHLKDLS    50
    SEGQTKHTNL KHGKTAASKR KTWQPLSKST RDHLQTMMES VIMTILSNSI 100
    KEKEEIQYHL NFLKKRLLQQ CETLKVPPKK MEDLTNVSSL LNMERARDKA 150
    NEEGLALLQE EIDKMVETTE LMTGNIQSLK NKIQILASEV EEEEERVKQM 200
    HQINSSGVLS LPELSQKTLK APTLQKEILA LIPNQNALLK DLDILHNSSQ 250
    MKSMSTFIEE AYKKLDAS 268
    Length:268
    Mass (Da):30,595
    Last modified:July 5, 2004 - v1
    Checksum:i5B3735279287B3E8
    GO

    Sequence cautioni

    The sequence BAA91672.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti63 – 631G → R.
    Corresponds to variant rs4267943 [ dbSNP | Ensembl ].
    VAR_022857
    Natural varianti266 – 2661D → G.
    Corresponds to variant rs2501968 [ dbSNP | Ensembl ].
    VAR_024303

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001407 mRNA. Translation: BAA91672.1. Different initiation.
    AK293016 mRNA. Translation: BAF85705.1.
    AL590244, AL590668 Genomic DNA. Translation: CAI13088.1.
    AL590668, AL590244 Genomic DNA. Translation: CAI14313.1.
    BC016279 mRNA. Translation: AAH16279.2.
    CCDSiCCDS4925.1.
    RefSeqiNP_060602.2. NM_018132.3.
    XP_005249262.1. XM_005249205.1.
    UniGeneiHs.88663.

    Genome annotation databases

    EnsembliENST00000335783; ENSP00000337289; ENSG00000031691.
    GeneIDi55166.
    KEGGihsa:55166.
    UCSCiuc003ozh.1. human.

    Polymorphism databases

    DMDMi68565184.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001407 mRNA. Translation: BAA91672.1 . Different initiation.
    AK293016 mRNA. Translation: BAF85705.1 .
    AL590244 , AL590668 Genomic DNA. Translation: CAI13088.1 .
    AL590668 , AL590244 Genomic DNA. Translation: CAI14313.1 .
    BC016279 mRNA. Translation: AAH16279.2 .
    CCDSi CCDS4925.1.
    RefSeqi NP_060602.2. NM_018132.3.
    XP_005249262.1. XM_005249205.1.
    UniGenei Hs.88663.

    3D structure databases

    ProteinModelPortali Q7L2Z9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120466. 11 interactions.
    IntActi Q7L2Z9. 2 interactions.
    MINTi MINT-4994384.
    STRINGi 9606.ENSP00000337289.

    PTM databases

    PhosphoSitei Q7L2Z9.

    Polymorphism databases

    DMDMi 68565184.

    Proteomic databases

    MaxQBi Q7L2Z9.
    PaxDbi Q7L2Z9.
    PRIDEi Q7L2Z9.

    Protocols and materials databases

    DNASUi 55166.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000335783 ; ENSP00000337289 ; ENSG00000031691 .
    GeneIDi 55166.
    KEGGi hsa:55166.
    UCSCi uc003ozh.1. human.

    Organism-specific databases

    CTDi 55166.
    GeneCardsi GC06P049431.
    HGNCi HGNC:21347. CENPQ.
    HPAi HPA046634.
    HPA054965.
    MIMi 611506. gene.
    neXtProti NX_Q7L2Z9.
    PharmGKBi PA134973276.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46012.
    HOGENOMi HOG000111544.
    HOVERGENi HBG081088.
    InParanoidi Q7L2Z9.
    KOi K11509.
    OMAi NMLTFIE.
    OrthoDBi EOG74XS8H.
    PhylomeDBi Q7L2Z9.
    TreeFami TF336238.

    Enzyme and pathway databases

    Reactomei REACT_150425. Resolution of Sister Chromatid Cohesion.
    REACT_150471. Separation of Sister Chromatids.
    REACT_22186. Deposition of new CENPA-containing nucleosomes at the centromere.
    REACT_682. Mitotic Prometaphase.

    Miscellaneous databases

    ChiTaRSi CENPQ. human.
    GenomeRNAii 55166.
    NextBioi 58937.
    PROi Q7L2Z9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q7L2Z9.
    CleanExi HS_CENPQ.
    Genevestigatori Q7L2Z9.

    Family and domain databases

    InterProi IPR025212. CAD_CENP-Q.
    [Graphical view ]
    Pfami PF13094. CENP-Q. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Stomach and Teratocarcinoma.
    2. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.
    4. "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres."
      Okada M., Cheeseman I.M., Hori T., Okawa K., McLeod I.X., Yates J.R. III, Desai A., Fukagawa T.
      Nat. Cell Biol. 8:446-457(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN A COMPLEX WITH CENPH; CENPI; CENPK; CENPN; CENPO; CENPP; CENPR AND CENPU, FUNCTION, SUBCELLULAR LOCATION.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE CENPA-CAD COMPLEX WITH CENPI; CENPK; CENPL; CENPO; CENPP; CENPR AND CENPS.
    6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31 AND SER-249, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCENPQ_HUMAN
    AccessioniPrimary (citable) accession number: Q7L2Z9
    Secondary accession number(s): A8KAF1, Q6IN61, Q9NVS5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3