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Protein

Centromere protein Q

Gene

CENPQ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.1 Publication

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_150425. Resolution of Sister Chromatid Cohesion.
REACT_150471. Separation of Sister Chromatids.
REACT_22186. Deposition of new CENPA-containing nucleosomes at the centromere.
REACT_355252. RHO GTPases Activate Formins.
REACT_682. Mitotic Prometaphase.

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere protein Q
Short name:
CENP-Q
Gene namesi
Name:CENPQ
Synonyms:C6orf139
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21347. CENPQ.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134973276.

Polymorphism and mutation databases

BioMutaiCENPQ.
DMDMi68565184.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 268268Centromere protein QPRO_0000089534Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei31 – 311Phosphoserine1 Publication
Modified residuei50 – 501Phosphoserine1 Publication
Modified residuei249 – 2491Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ7L2Z9.
PaxDbiQ7L2Z9.
PRIDEiQ7L2Z9.

PTM databases

PhosphoSiteiQ7L2Z9.

Expressioni

Gene expression databases

BgeeiQ7L2Z9.
CleanExiHS_CENPQ.
GenevisibleiQ7L2Z9. HS.

Interactioni

Subunit structurei

Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU.2 Publications

Protein-protein interaction databases

BioGridi120466. 11 interactions.
IntActiQ7L2Z9. 2 interactions.
MINTiMINT-4994384.
STRINGi9606.ENSP00000337289.

Structurei

3D structure databases

ProteinModelPortaliQ7L2Z9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili170 – 20637Sequence AnalysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG46012.
GeneTreeiENSGT00390000005599.
HOGENOMiHOG000111544.
HOVERGENiHBG081088.
InParanoidiQ7L2Z9.
KOiK11509.
OMAiKEEIQYH.
OrthoDBiEOG74XS8H.
PhylomeDBiQ7L2Z9.
TreeFamiTF336238.

Family and domain databases

InterProiIPR025212. CAD_CENP-Q.
[Graphical view]
PfamiPF13094. CENP-Q. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7L2Z9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGKANASKK NAQQLKRNPK RKKDNEEVVL SENKVRNTVK KNKNHLKDLS
60 70 80 90 100
SEGQTKHTNL KHGKTAASKR KTWQPLSKST RDHLQTMMES VIMTILSNSI
110 120 130 140 150
KEKEEIQYHL NFLKKRLLQQ CETLKVPPKK MEDLTNVSSL LNMERARDKA
160 170 180 190 200
NEEGLALLQE EIDKMVETTE LMTGNIQSLK NKIQILASEV EEEEERVKQM
210 220 230 240 250
HQINSSGVLS LPELSQKTLK APTLQKEILA LIPNQNALLK DLDILHNSSQ
260
MKSMSTFIEE AYKKLDAS
Length:268
Mass (Da):30,595
Last modified:July 5, 2004 - v1
Checksum:i5B3735279287B3E8
GO

Sequence cautioni

The sequence BAA91672.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti63 – 631G → R.
Corresponds to variant rs4267943 [ dbSNP | Ensembl ].
VAR_022857
Natural varianti266 – 2661D → G.
Corresponds to variant rs2501968 [ dbSNP | Ensembl ].
VAR_024303

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001407 mRNA. Translation: BAA91672.1. Different initiation.
AK293016 mRNA. Translation: BAF85705.1.
AL590244, AL590668 Genomic DNA. Translation: CAI13088.1.
AL590668, AL590244 Genomic DNA. Translation: CAI14313.1.
BC016279 mRNA. Translation: AAH16279.2.
CCDSiCCDS4925.1.
RefSeqiNP_060602.2. NM_018132.3.
XP_005249262.1. XM_005249205.1.
UniGeneiHs.88663.

Genome annotation databases

EnsembliENST00000335783; ENSP00000337289; ENSG00000031691.
GeneIDi55166.
KEGGihsa:55166.
UCSCiuc003ozh.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001407 mRNA. Translation: BAA91672.1. Different initiation.
AK293016 mRNA. Translation: BAF85705.1.
AL590244, AL590668 Genomic DNA. Translation: CAI13088.1.
AL590668, AL590244 Genomic DNA. Translation: CAI14313.1.
BC016279 mRNA. Translation: AAH16279.2.
CCDSiCCDS4925.1.
RefSeqiNP_060602.2. NM_018132.3.
XP_005249262.1. XM_005249205.1.
UniGeneiHs.88663.

3D structure databases

ProteinModelPortaliQ7L2Z9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120466. 11 interactions.
IntActiQ7L2Z9. 2 interactions.
MINTiMINT-4994384.
STRINGi9606.ENSP00000337289.

PTM databases

PhosphoSiteiQ7L2Z9.

Polymorphism and mutation databases

BioMutaiCENPQ.
DMDMi68565184.

Proteomic databases

MaxQBiQ7L2Z9.
PaxDbiQ7L2Z9.
PRIDEiQ7L2Z9.

Protocols and materials databases

DNASUi55166.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335783; ENSP00000337289; ENSG00000031691.
GeneIDi55166.
KEGGihsa:55166.
UCSCiuc003ozh.1. human.

Organism-specific databases

CTDi55166.
GeneCardsiGC06P049431.
HGNCiHGNC:21347. CENPQ.
MIMi611506. gene.
neXtProtiNX_Q7L2Z9.
PharmGKBiPA134973276.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG46012.
GeneTreeiENSGT00390000005599.
HOGENOMiHOG000111544.
HOVERGENiHBG081088.
InParanoidiQ7L2Z9.
KOiK11509.
OMAiKEEIQYH.
OrthoDBiEOG74XS8H.
PhylomeDBiQ7L2Z9.
TreeFamiTF336238.

Enzyme and pathway databases

ReactomeiREACT_150425. Resolution of Sister Chromatid Cohesion.
REACT_150471. Separation of Sister Chromatids.
REACT_22186. Deposition of new CENPA-containing nucleosomes at the centromere.
REACT_355252. RHO GTPases Activate Formins.
REACT_682. Mitotic Prometaphase.

Miscellaneous databases

ChiTaRSiCENPQ. human.
GenomeRNAii55166.
NextBioi58937.
PROiQ7L2Z9.
SOURCEiSearch...

Gene expression databases

BgeeiQ7L2Z9.
CleanExiHS_CENPQ.
GenevisibleiQ7L2Z9. HS.

Family and domain databases

InterProiIPR025212. CAD_CENP-Q.
[Graphical view]
PfamiPF13094. CENP-Q. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Stomach and Teratocarcinoma.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  4. "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres."
    Okada M., Cheeseman I.M., Hori T., Okawa K., McLeod I.X., Yates J.R. III, Desai A., Fukagawa T.
    Nat. Cell Biol. 8:446-457(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN A COMPLEX WITH CENPH; CENPI; CENPK; CENPN; CENPO; CENPP; CENPR AND CENPU, FUNCTION, SUBCELLULAR LOCATION.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE CENPA-CAD COMPLEX WITH CENPI; CENPK; CENPL; CENPO; CENPP; CENPR AND CENPS.
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31 AND SER-249, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCENPQ_HUMAN
AccessioniPrimary (citable) accession number: Q7L2Z9
Secondary accession number(s): A8KAF1, Q6IN61, Q9NVS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2004
Last modified: July 22, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.